Tag: M.W=150-200

Ait Amiri, Sabrina published the artcileIdentification of First-in-Class Inhibitors of Kallikrein-Related Peptidase 6 That Promote Oligodendrocyte Differentiation, SDS of cas: 86-48-6, the publication is Journal of Medicinal Chemistry (2021), 64(9), 5667-5688, database is CAplus and MEDLINE.

Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biol. evaluation of KLK6′s low-mol.-weight inhibitors, para-aminobenzyl derivatives Interestingly, selected hit compounds were selective of the KLK6 proteolytic network encompassing KLK1 and plasmin that also participate in the development of MS physiopathol. Moreover, hits were found noncytotoxic on primary cultures of murine neurons and oligodendrocyte precursor cells (OPCs). Among them, two compounds (32 and 42) were shown to promote the differentiation of OPCs into mature oligodendrocytes in vitro constituting thus emerging leads for the development of regenerative therapies.

Journal of Medicinal Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Acimovic, Milica G. published the artcileBiological activity and profiling of Salvia sclarea essential oil obtained by steam and hydrodistillation extraction methods via chemometrics tools, SDS of cas: 106-25-2, the publication is Flavour and Fragrance Journal (2022), 37(1), 20-32, database is CAplus.

Salvia sclarea L. or clary sage is cultivated worldwide in temperate and sub-tropical climates, as an ornamental and essential oil (EO) bearing plant. EO is obtained from fresh spikes in full flowering stage and is recognized as an important com. product for food, beverage and cosmetic industries. This study investigated the EO composition of S. sclarea grown in Serbia (Southeast Europe) obtained by two different methods, steam (SD) and hydrodistillation (HD). GC-MS anal. identified oxygenated monoterpenes as the main class of compounds for all EOs (between 81.8% and 88.2% depending on the distillation process). The most abundant oxygenated monoterpenes were linalyl acetate and linalool. In addition, in vitro antimicrobial (modified resazurin microtitre-plate assay) and antioxidant activities (DPPH· assay) and total polyphenol content of obtained EOs were also evaluated. According to the assay used for the evaluation of the antibacterial activity, Gram-neg. bacteria were more sensitive to S. sclarea EO in comparison to Gram-pos. bacteria. EOs exhibited low antioxidant capacity, below 3% neutralized DPPH· radicals, reaching up to approx. 400 μg AAE mL-1. This study also investigated a possibility for predicting retention indexes (RIs) of compounds isolated from EOs. In total, 78 exptl. obtained RIs were applied to construct the prediction model. The quant. structure-chromatog. retention relationship (QSRR) model was used to anticipate the exptl. obtained RIs. Five mol. descriptors were selected by factor anal. and genetic algorithm to predict RIs. The obtained accuracy of the QSRR model reached r2 = .912, which showed that these models might be applied for predicting retention indexes.

Flavour and Fragrance Journal published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, SDS of cas: 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileFunctionalized multi-walled carbon nanotubes as an efficient reusable heterogeneous catalyst for green synthesis of N-substituted pyrroles in water, Computed Properties of 23351-09-9, the publication is RSC Advances (2015), 5(93), 76221-76228, database is CAplus.

In this protocol, the functionalization of multiwalled carbon nanotubes (MWCNTs) was carried out and the resulting sulfonated MWCNTs were characterized by FT-IR, XRD, SEM, BET, EDX, XPS and Raman spectroscopy that are each discussed sep. in the text. Then, the MWCNT-SO₃H composite was applied as an efficient, recyclable heterogeneous catalyst for the synthesis of N-substituted pyrroles via the reaction of 2,5-dimethoxy THF with primary amines under clean and mild conditions. In this reaction, the N-substituted pyrroles were obtained as beneficial and significant products in short reaction times (30-65 min) and good to excellent yields (40-92%) with high purity. The products were obtained through a simple work up procedure and characterized by FT-IR, ¹H NMR and ¹³C NMR. After the end of the reaction, the nanocatalyst was recovered and reused several times without efficient loss of its activity for the preparation of N-substituted pyrroles.

RSC Advances published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Computed Properties of 23351-09-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileEfficient and green synthesis of N-aryl pyrroles catalyzed by ionic liquid [H-NMP] [HSO₄] in Water at room temperature, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is Journal of the Chinese Chemical Society (Weinheim, Germany) (2014), 61(10), 1127-1132, database is CAplus.

A suitable and efficient method for the synthesis of N-aryl pyrroles I [Ar = C₆H₅, 4-CH₃C₆H₄, 4-OHC₆H₄, etc.] by using 2,5-dimethoxy THF and several primary aromatic amines in the presence of the catalytic amount of [H-NMP][HSO₄] under room temperature was described. This method has the advantages such as; easy reaction workup, absolutely separated of catalyst from the reaction mixture and smoothly recyclability of catalyst. The compound I were obtained as desired products in excellent yields and short reaction times via green and one-pot procedure.

Journal of the Chinese Chemical Society (Weinheim, Germany) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Naeimi, Hossein published the artcileFacile sonochemical heterocyclization of 2,5-dimethoxy tetrahydrofuran with primary amines using sulfonated MWCNTs as a recyclable catalyst in aqueous media, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Green Chemistry Letters and Reviews (2017), 10(4), 412-419, database is CAplus.

A set of N-substituted pyrrole derivatives was designed and synthesized using sulfonated multi-walled carbon nanotubes as a recyclable heterogeneous catalyst under ultrasound irradiation This reaction was carried out between 2,5-dimethoxy THF and primary amines in water under green conditions. This method has some advantages such as: short reaction times, excellent product yields, simplicity of the procedure, easy work-up and high purity of products.

Green Chemistry Letters and Reviews published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hao, Qian-Qian published the artcileModulation of Solid-State Optical Properties of o-Hydroxynaphthoic Acids through Formation of Charge Transfer Cocrystals with TCNB, Formula: C11H8O3, the publication is Crystal Growth & Design (2020), 20(11), 7492-7500, database is CAplus.

Charge transfer cocrystals offer an opportunity to alter the photophys. characteristics of organic chromophores in the solid state. A set of new charge transfer cocrystals of three positional isomers of o-hydroxynaphthoic acid with 1,2,4,5-tetracyanobenzene (TCNB) as the electron acceptor was prepared and subjected to single-crystal and powder X-ray diffraction, thermal anal., vibrational, and UV-vis absorption and fluorescence spectroscopic measurements. Crystal structure analyses reveal that the donor and acceptor mols. are combined in a 2:1 stoichiometric ratio and stacked alternately through a typical mixed face-to-face arrangement (DAD···DAD), forming a columnlike charge transfer structure involving π-stacking interactions. All of the cocrystals exhibit distinct tunable emission colors and photoluminescence characteristics due to the charge transfer transition states. This research indicates that the cocrystal strategy can be applied to effectively modulate the optical properties of o-hydroxynaphthoic acid compounds, which have a great research value in optoelectronic applications. A set of new charge transfer cocrystals of three positional isomers of o-hydroxynaphthoic acid with TCNB as the electron acceptor was successfully prepared and fully characterized, and they exhibit distinct tunable photoluminescence characteristics due to the mixed DAD···DAD columnlike charge transfer structures.

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Formula: C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koner, Anamika published the artcileAttraction of the Biocontrol Agent, Galerucella placida Towards Volatile Blends of Two Polygonaceae Weeds, Rumex dentatus and Polygonum glabrum, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Journal of Chemical Ecology (2022), 48(2), 165-178, database is CAplus and MEDLINE.

The Polygonaceae weed, Rumex dentatus L. grows in association with wheat, mustard and potato, while Polygonum glabrum Willd. grows in association with rice in India. Both larvae and adults of Galerucella placida Baly (Coleoptera: Chrysomelidae) voraciously consume these weeds. Applications of synthetic herbicides to control weeds are harmful to the environment including beneficial organisms. We propose to find volatile organic compounds (VOCs) from both weeds causing attraction of the biocontrol agent, G. placida, in order to attempt to use the insect as a biol. weed control. Behavioral responses of G. placida towards volatile blends characteristic of undamaged (UD), insect-damaged (ID), jasmonic acid-treated (JA) or mech.-damaged (MD) plants were conducted by Y-tube olfactometer bioassays. Cuminaldehyde was predominant in VOCs of UD R. dentatus, ID P. glabrum, and both JA and MD R. dentatus and P. glabrum. Geraniol was predominant in VOCs of UD P. glabrum, while 1,3-diethylbenzene predominated in VOCs of ID R. dentatus. Females were more attracted towards volatile blends of ID plants compared to UD or JA plants. Females did not show attraction towards volatile blends of JA plants. We identified two bioactive synthetics blends, one comprised of seven compounds – 16.65μg 1,3-diethylbenzene, 10.72μg acetophenone, 6.52μg 2,6-(E,Z)-nonadienal, 2.46μg 1-nonanol, 4.19μg decanal, 9.86μg 4-ethylacetophenone and 3.34μg 1-hexadecene dissolved in 25μl CH₂Cl₂ and the other containing five compounds – 2.50μg 2-octanol, 6.84μg limonene, 0.64μg dodecane, 6.63μg 4-ethylacetophenone and 0.24μg geranyl acetone dissolved in 25μl CH₂Cl₂. These two blends of volatile compounds could be used to attract the biocontrol agent during early vegetative period of these two weeds, which could lead to eradication of weeds from crop fields.

Journal of Chemical Ecology published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Safety of cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vaillant, Fabrice published the artcilePlasma Metabolome Profiling by High-Performance Chemical Isotope-Labelling LC-MS after Acute and Medium-Term Intervention with Golden Berry Fruit (Physalis peruviana L.), Confirming Its Impact on Insulin-Associated Signaling Pathways, Application of 3-Hydroxyphenylacetic acid, the publication is Nutrients (2021), 13(9), 3125, database is CAplus and MEDLINE.

Golden berry (Physalis peruviana L.) is an exotic fruit exported from Colombia to different countries around the world. A review of the literature tends to demonstrate a hypoglycemic effect with an improvement in insulin sensitivity after oral ingestion of fruit extracts in animal models. However, little is known about their potential effects in humans, and very little is known about the mechanisms involved. This study aimed at identifying discriminant metabolites after acute and chronic intake of golden berry. An untargeted metabolomics strategy using high-performance chem. isotope-labeling LC-MS was applied. The blood samples of eighteen healthy adults were analyzed at baseline, at 6 h after the intake of 250 g of golden berry (acute intervention), and after 19 days of daily consumption of 150 g (medium-term intervention). Forty-nine and 36 discriminant metabolites were identified with high confidence, resp., after the acute and medium-term interventions. Taking into account up- and downregulated metabolites, three biol. networks mainly involving insulin, epidermal growth factor receptor (EGFR), and the phosphatidylinositol 3-kinase pathway (PI3K/Akt/mTOR) were identified. The biol. intracellular networks identified are highly interconnected with the insulin signalling pathway, showing that berry intake may be associated with insulin signalling, which could reduce some risk factors related to metabolic syndrome. Primary registry of WHO.

Nutrients published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C7H10O4, Application of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Malheiros, Jessica Moraes published the artcileComparative untargeted metabolome analysis of ruminal fluid and feces of Nelore steers (Bos indicus), Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Scientific Reports (2021), 11(1), 12752, database is CAplus and MEDLINE.

We conducted a study to identify the fecal metabolite profile and its proximity to the ruminal metabolism of Nelore steers based on an untargeted metabolomic approach. Twenty-six Nelore were feedlot with same diet during 105 d. Feces and rumen fluid were collected before and at slaughter, resp. The metabolomics anal. indicated 49 common polar metabolites in the rumen and feces. Acetate, propionate, and butyrate were the most abundant polar metabolites in both bio-samples. The rumen presented significantly higher concentrations of the polar compounds when compared to feces (P < 0.05); even though, fecal metabolites presented an accentuated representability of the ruminal fluid metabolites. All fatty acids present in the ruminal fluid were also observed in the feces, except for C20:2n6 and C20:4n6. The identified metabolites offer information on the main metabolic pathways (higher impact factor and P < 0.05), as synthesis and degradation of ketone bodies; the alanine, aspartate and glutamate metabolisms, the glycine, serine; and threonine metabolism and the pyruvate metabolism The findings reported herein on the close relationship between the ruminal fluid and feces metabolic profiles may offer new metabolic information, in addition to facilitating the sampling for metabolism investigation in animal production and health routines.

Scientific Reports published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rosenbaum, Anton I. published the artcileThiadiazole Carbamates: Potent Inhibitors of Lysosomal Acid Lipase and Potential Niemann-Pick Type C Disease Therapeutics, HPLC of Formula: 30165-97-0, the publication is Journal of Medicinal Chemistry (2010), 53(14), 5281-5289, database is CAplus and MEDLINE.

Niemann-Pick type C (NPC) disease is a lysosomal storage disorder characterized at the cellular level by abnormal accumulation of cholesterol and other lipids in lysosomal storage organelles. Lysosomal acid lipase (LAL) has been recently identified as a potential therapeutic target for NPC. LAL can be specifically inhibited by a variety of 3,4-disubstituted thiadiazole carbamates. An efficient synthesis of the C(3) oxygenated/C(4) aminated analogs has been developed that furnishes the products in high yields and high degrees of purity. Common intermediates can also be used for the synthesis of the C(3) carbon substituted derivatives Herein we tested various thiadiazole carbamates, amides, esters, and ketones for inhibition of LAL. In addition, we tested a diverse selection of com. available non-thiadiazole carbamates. Our studies show that, among the compounds examined herein, only thiadiazole carbamates are effective inhibitors of LAL. We present a mechanism for LAL inhibition by these compounds whereby LAL transiently carbamoylates the enzyme similarly to previously described inhibition of acetylcholinesterase by rivastigmine and other carbamates as well as acylation of various lipases by orlistat.

Journal of Medicinal Chemistry published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, HPLC of Formula: 30165-97-0.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts