Tag: M.W=150-200

Wang, Jiatong published the artcileInsights into crucial odourants dominating the characteristic flavour of citrus-white teas prepared from citrus reticulata Blanco ‘Chachiensis’ and Camellia sinensis ‘Fudingdabai’, HPLC of Formula: 124-76-5, the main research area is Citrus Camellia white tea odorant flavor; Aroma quantification; Characterized odourants; Citrus-white tea; Odour activity value; SBSE-GC-O/MS.

Citrus-white teas (CWs), which possess a balanced flavor of tea and citrus, are becoming more popular worldwide; however, their characteristic flavor and odourants received limited research. Volatile components of two types of CWs prepared from Citrus reticulata Blanco’Chachiensis’ and Camellia sinensis ‘Fudingdabai’ were comprehensively investigated using a combination of stir bar sorptive extraction and gas chromatog.-mass spectrometry (GC-MS). Ninety-nine crucial odourants in the CWs were quantified by applying GC-olfactometry/MS, significant differences were compared, and their odor activity values (OAVs) were calculated Twenty-two odourants (in total 2628.09 and 1131.18 mg/kg resp.) were further confirmed as traditional CW (CW-A) and innovated CW (CW-B) characteristic flavor crucial contributors which all possessed > 1 OAVs, particularly limonene (72919 in CW-A) and trans-β-ionone (138953 in CW-B). The unravelling of CWs aroma composition will greatly expanding our understanding of tea aroma chem. and the potential aroma interactions will offer insights into tea blending technologies.

Food Chemistry published new progress about Alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Zhihui published the artcileComparative analysis of lipid profiles and flavor composition of marinated eggs from different species, Synthetic Route of 124-76-5, the main research area is chicken quail pigeon marinated egg flavor lipid.

This study compared lipid profiles and volatile composition in marinated eggs from different species (chicken, quail, and pigeon) using LC-ESI-MS/MS, and GC-MS, resp. The three marinated eggs showed significant differences in phosphatidylcholine, phosphatidylethanolamine (PE), and neutral lipid profiles of the three marinated eggs. Pigeon-eggs contained the highest content of PE but the lowest content of triglycerides. Seventy-six potential lipid metabolites such as Cer(d18:1/21:0), DG(15:0/18:2), and PE-O(16:1/18:2) were selected for the discrimination of all three groups. Pigeon-eggs contained the highest contents of C18:2 and C22:6, as well as n-3 and n-6 PUFA than quail-eggs and chicken-eggs. Major compounds including 2-Nonanone, 1-Octen-3-ol, and cyclic octaat. sulfur have greatly contributed to the distinction of eggs from different species. The highest levels of aldehydes, acids, and ketones were found in chicken-eggs. This study reported that lipidomic and volatile composition anal. are promising approaches for discriminating of marinated eggs from different species. Novelty impact statement : This is the first study that aiming at comparing the lipid profiles and volatile composition in marinated eggs from different species (chicken, quail, and pigeon) using LC-ESI-MS/MS and GC-MS. Pigeon-eggs contained the highest contents of glycerol phospholipid, n-3, and n-6 PUFA. The predominating volatile compositions of marinated eggs were alcs. aldehydes acids and ketones. Therefore, this study provides a better understanding of the quality of marinated eggs, and help customers to better choose higher nutritional values of marinated eggs.

Journal of Food Processing and Preservation published new progress about Alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gbenou, Joachin D. published the artcilePhytochemical composition of Cymbopogon citratus and Eucalyptus citriodora essential oils and their anti-inflammatory and analgesic properties on Wistar rats, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is Cymbopogon Eucalyptus essential oil antiinflammatory analgesic.

Cymbopogon citratus and Eucalyptus citriodora are widely used herbs/plants as a source of ethnomedicines in tropical regions of the world. In this work, the authors studied the anti-inflammatory and gastroprotective effects of C. citratus and E. citriodora essential oils on formol-induced edema, and acetic acid induced abdominal cramps in Wistar rats. To fully understand the chem. induced anti-inflammatory properties of these plants, the authors first analyzed the chem. composition of the essential oils. A total of 16 chem. constituents accounting for 93.69 % of the oil, were identified in C. citratus among which, Geranial (27.04 %), neral (19.93 %) and myrcene (27.04 %) were the major constituents. For E. citriodora, 19 compounds representing 97.2 % of the extracted oil were identified. The dominant compound of E. citriodora essential oil was citronellal (83.50 %). In vivo anal. and histol. assay showed that the 2 essential oils displayed significant dose dependent edema inhibition effect over time. They displayed strong analgesic and antipyretic properties similar to that induced by 50 mg/kg of acetylsalicylate of lysine. However, the E. citriodora essential oil was more effective than that of C. citratus. The authors identified significant numbers of aldehyde mols. in both essential oils mediating antioxidant activity that may contribute to the anti-inflammatory effects observed on the rats. Altogether, this work demonstrates the anti-inflammatory property of C. citratus and E. citriodora suggesting their potential role as adjuvant therapeutic alternatives in dealing with inflammatory-related diseases.

Molecular Biology Reports published new progress about Aldehydes Role: BSU (Biological Study, Unclassified), PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Black, Alyson P. published the artcileA Novel Mass Spectrometry Platform for Multiplexed N-Glycoprotein Biomarker Discovery from Patient Biofluids by Antibody Panel Based N-Glycan Imaging, SDS of cas: 59-23-4, the main research area is mass spectrometry imaging glycoprotein biomarker antibody panel.

A new platform for N-glycoprotein anal. from serum that combines matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) workflows with antibody slide arrays is described. Antibody panel based (APB) N-glycan imaging allows for the specific capture of N-glycoproteins by antibodies on glass slides and N-glycan anal. in a protein-specific and multiplexed manner. Development of this technique has focused on characterizing two abundant and well-studied human serum glycoproteins, alpha-1-antitrypsin and IgG. Using purified standard solutions and 1 μL samples of human serum, both glycoproteins can be immunocaptured and followed by enzymic release of N-glycans. N-Glycans are detected with a MALDI FT-ICR mass spectrometer in a concentration-dependent manner while maintaining specificity of capture. Importantly, the N-glycans detected via slide-based antibody capture were identical to that of direct anal. of the spotted standards As a proof of concept, this workflow was applied to patient serum samples from individuals with liver cirrhosis to accurately detect a characteristic increase in an IgG N-glycan. This novel approach to protein-specific N-glycan anal. from an antibody panel can be further expanded to include any glycoprotein for which a validated antibody exists. Addnl., this platform can be adapted for anal. of any biofluid or biol. sample that can be analyzed by antibody arrays.

Analytical Chemistry (Washington, DC, United States) published new progress about Blood analysis. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rout, P. K. published the artcileFractional hydrodistillation of Citronella (Cymbopogon winterianus Jowitt), Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is hydrodistillation Citronella oil.

Fractional hydro-distillation of Citronella Grass (C. winterianus Jowitt) and anal. of the decanted oil fractions showed that citronellal-rich fractions and sesquiterpenoid-rich fractions can be separated at the hydrodistillation stage itself. About 6% essential oil is lost in the aqueous layer. Further, 4 constituents, 6-methyl-5-hepten-2-one, benzyl alc., 2-[2-hydroxy-2-propyl]-5-menthylcyclohexanol and terpin hydrate present in significant quantities in the aqueous layer are not detected in any of the decanted oil fractions.

Fafai Journal published new progress about Sesquiterpenes Role: ANT (Analyte), NPO (Natural Product Occurrence), ANST (Analytical Study), BIOL (Biological Study), OCCU (Occurrence). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Recommanded Product: 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Xiaolong published the artcileAn acidic polysaccharide from Ziziphus Jujuba cv. Muzao: Purification and structural characterization, Category: alcohols-buliding-blocks, the main research area is acidic polysaccharide Ziziphus purification structure; Characterization; Polysaccharide; Purification; Ziziphus Jujuba cv. Muzao.

A novel acidic polysaccharide fraction (PZMP2-2) was isolated from Ziziphus Jujuba cv. Muzao fruit via hot water extraction and purified by DEAE-Sepharose FF and Sephacryl S-300 column chromatog. PZMP2-2 consisted of rhamnose, arabinose, xylose, galactose, and galacturonic acid in a ratio of 1.18: 5.23: 0.22: 2.68: 2.20, with a mol. weight of 62.73 kDa. Structural features of PZMP2-2 were investigated using FT-IR, SEM, AFM, GC-MS anal. and NMR spectroscopy. Methylation and GC-MS anal. revealed that the main glycosidic bonds in PZMP2-2 comprised 1-linked Galp, 1,3-linked Araf, 1,2,4-linked Rhap, 1,3-linked Galp, 1,4-linked GalpA and 1,3,5-linked Araf. NMR anal. indicate that PZMP 2-2 has a linear backbone of (1 → 4)-linked GlcpA and (1 → 2,4)-linked Rhap residues, with branches at the O-4 position, consisting of Araf and Galp residues.

Food Chemistry published new progress about Liquid chromatography. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murugesan, Kathiravan published the artcileVisible-Light-Promoted Metal-Free Synthesis of (Hetero)Aromatic Nitriles from C(sp3)-H Bonds, HPLC of Formula: 124-76-5, the main research area is photocatalytic cyanation methylarene aldehyde alc oxime; visible light promoted synthesis heteroaromatic aromatic nitrile; C−H functionalization; ammoxidation; methylarenes; nitriles; photoredox catalysis.

The metal-free activation of C(sp3)-H bonds to value-added products is of paramount importance in organic synthesis. We report the use of the com. available organic dye 2,4,6-triphenylpyrylium tetrafluoroborate (TPP) for the conversion of methylarenes to the corresponding aryl nitriles via a photocatalytic process. Applying this methodol., a variety of cyanobenzenes have been synthesized in good to excellent yield under metal- and cyanide-free conditions. We demonstrate the scope of the method with over 50 examples including late-stage functionalization of drug mols. (celecoxib) and complex structures such as L-menthol, amino acids, and cholesterol derivatives Furthermore, the presented synthetic protocol is applicable for gram-scale reactions. In addition to methylarenes, selected examples for the cyanation of aldehydes, alcs. and oximes are demonstrated as well. Detailed mechanistic investigations have been carried out using time-resolved luminescence quenching studies, control experiments, and NMR spectroscopy as well as kinetic studies, all supporting the proposed catalytic cycle.

Angewandte Chemie, International Edition published new progress about Alkylarenes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (methylarenes). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

D’Amato, Alfonsina published the artcileFaecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Microbiome (2020), 8(1), 140, database is CAplus and MEDLINE.

The gut-brain axis and the intestinal microbiota are emerging as key players in health and disease. Shifts in intestinal microbiota composition affect a variety of systems; however, evidence of their direct impact on cognitive functions is still lacking. We tested whether faecal microbiota transplant (FMT) from aged donor mice into young adult recipients altered the hippocampus, an area of the central nervous system (CNS) known to be affected by the ageing process and related functions. Young adult mice were transplanted with the microbiota from either aged or age-matched donor mice. Following transplantation, characterization of the microbiotas and metabolomics profiles along with a battery of cognitive and behavioral tests were performed. Label-free quant. proteomics was employed to monitor protein expression in the hippocampus of the recipients. We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behavior and locomotor activity remained unaffected. This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed Finally, the detrimental effect of FMT from aged donors on the CNS was confirmed by the observation that microglia cells of the hippocampus fimbria, acquired an ageing-like phenotype; on the contrary, gut permeability and levels of systemic and local (hippocampus) cytokines were not affected. These results demonstrate that age-associated shifts of the microbiota have an impact on protein expression and key functions of the CNS. Furthermore, these results highlight the paramount importance of the gut-brain axis in ageing and provide a strong rationale to devise therapies aiming to restore a young-like microbiota to improve cognitive functions and the declining quality of life in the elderly.

Microbiome published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bresciani, Letizia published the artcileIn vitro (poly)phenol catabolism of unformulated- and phytosome-formulated cranberry (Vaccinium macrocarpon) extracts, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is Food Research International (2021), 110137, database is CAplus and MEDLINE.

Cranberries (Vaccinium macrocarpon) represent an important source of anthocyanins, flavan-3-ols and flavonols. This study aimed at investigating in vitro the human microbial metabolism of (poly)phenols, principally flavan-3-ols, of unformulated- and phytosome-formulated cranberry extracts After powder characterization, a 24-h fermentation with human faecal slurries was performed, standardizing the concentration of incubated proanthocyanidins. Cranberry (poly)phenol metabolites were quantified by uHPLC-MS2 analyses. The native compounds of both unformulated- and phytosome-formulated cranberry extracts were metabolized under faecal microbiota activity, resulting in twenty-four microbial metabolites. Although some differences appeared when considering different classes of colonic metabolites, no significant differences in the total amount of metabolites were established after 24 h of incubation period. These results suggested that a different formulation had no effect on flavan-3-ol colonic metabolism of cranberry and both unformulated- and phytosome-formulated extract Both formulations displayed the capability to be a potential source of compounds which could lead to a wide array of gut microbiota metabolites in vitro.

Food Research International published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lunyera, Joseph published the artcileUrine tricarboxylic acid cycle signatures of early-stage diabetic kidney disease, Related Products of alcohols-buliding-blocks, the publication is Metabolomics (2022), 18(1), 5, database is CAplus and MEDLINE.

Urine tricarboxylic acid (TCA) cycle organic anions (OAs) are elevated in diabetes and may be biomarkers for diabetic kidney disease (DKD) progression. We assessed associations of 10 urine TCA cycle OAs with estimated glomerular filtration rate (eGFR) and eGFR slope. This study is ancillary to the Simultaneous Risk Factor Control Using Telehealth to SlOw Progression of Diabetic Kidney Disease (STOP-DKD) Trial-a randomized trial of pharmacist-led medication and behavior management in 281 patients with early to moderate DKD at Duke from 2014 to 2015. We used linear mixed models to assess associations of urine TCA cycle OAs with outcomes and modelled TCA cycle OAs as: (1) the average of z-scores for each OA; and (2) principal component (PC) scores derived by principal component anal. (PCA). Untargeted urine metabolomics were added for addnl. discovery. Among 132 participants with 24 h urine samples (50% men; 58% Black; mean age 64 years [SD 9]; mean eGFR 74 mL/min/1.73m² [SD 21] and median urine albumin-to-creatinine [UACR] 20 mg/g [IQR 8-95]), PCA identified 3 OA metabolite PCs. Malate, fumarate, pyruvate, α-ketoglutarate, lactate, succinate and citrate/isocitrate loaded pos. on PC1; methylsuccinate, ethylmalonate and succinate loaded pos. on PC2; and methylmalonate, ethylmalonate and citrate/isocitrate loaded neg. on PC3. Over a median follow-up of 1.8 years (IQR, 1.2 to 2.2), higher average OA z-score was strongly associated with higher eGFR after covariate adjustment (p = 0.01), but not with eGFR slope (p = 0.9). Higher PC3, but not other PCs, was associated with lower eGFR (p < 0.001). Conditional random forests and smooth clipped absolute deviation models confirmed methylmalonate, citrate/isocitrate, and ethylmalonate, and added lactate as top ranked metabolites in models of baseline eGFR (R-squared 0.32 and 0.33, resp.). Untargeted urine metabolites confirmed association of urine TCA cycle OAs with kidney function. Thus, lower urine TCA cycle OAs, most notably lower methylmalonate, ethylmalonate and citrate/isocitrate, are potential indicators of kidney impairment in early stage DKD.

Metabolomics published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts