Tag: M.W=150-200

Hikawa, Hidemasa published the artcileA borrowing hydrogen methodology: palladium-catalyzed dehydrative N-benzylation of 2-aminopyridines in water, Name: (4-Butoxyphenyl)methanol, the main research area is benzyl aminopyridine green preparation KIE; aminopyridine benzyl alc dehydrative monobenzylation palladium catalyst base free.

A greener borrowing hydrogen methodol. using the π-benzylpalladium system, which offered an efficient and environmentally friendly preparation of N-benzyl aminopyridines I [R1 = H, 5-F, 3-Me, etc.; R2 = H, 3-Me, 4-t-BuO, etc.; R3 = H, Me] via dehydrative N-monobenzylation of 2-aminopyridines with benzylic alcs. in the absence of base was demonstrated. The crossover experiment using benzyl-α,α-d2 alc. and 3-methylbenzyl alc. afforded H/D scrambled products, suggesting that the dehydrative N-benzylation in the catalytic system involved a borrowing hydrogen pathway. KIE experiments showed that C-H bond cleavage at the benzylic position of benzyl alc. was involved in the rate-determining step (KIE = 2.9). This simple base-free protocol could be achieved under mild conditions in an atom-economic process, affording the desired products in moderate to excellent yields.

Green Chemistry published new progress about Benzylation. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Name: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Abolghasemi, Reza published the artcileTranscriptome architecture reveals genetic networks of bolting regulation in spinach, SDS of cas: 59-23-4, the main research area is transcriptome architecture genetic network bolting regulation Spinacia; Bolting; Flowering time; RNA-Seq; Spinach.

Bolting refers to the early flowering stem production on agricultural and horticultural crops before harvesting. Indeed, bolting is an event induced by the coordinated effects of various environmental factors and endogenous genetic components, which cause a large reduction in the quality and productivity of vegetable crops like spinach. However, little is known about the signaling pathways and mol. functions involved in bolting mechanisms in spinach. The genetic information regarding the transition from vegetative growth to the reproductive stage in spinach would represent an advantage to regulate bolting time and improvement of resistant cultivars to minimize performance loss. To investigate the key genes and their genetic networks controlling spinach bolting, we performed RNA-seq anal. on early bolting accession Kashan and late-bolting accession Viroflay at both vegetative and reproductive stages and found a significant number of differentially expressed genes (DEGs) ranging from 195 to 1230 in different comparisons. These genes were mainly associated with the signaling pathways of vernalization, photoperiod/circadian clock, gibberellin, autonomous, and aging pathways. Gene ontol. anal. uncovered terms associated with carbohydrate metabolism, and detailed anal. of expression patterns for genes of Fructose-1, 6-bisphosphate aldolase, TREHALOSE-6-PHOSPHATE SYNTHASE 1, FLOWERING PROMOTING FACTOR 1, EARLY FLOWERING, GIGANTEA, and MADS-box proteins revealed their potential roles in the initiating or delaying of bolting. This study is the first report on identifying bolting and flowering-related genes based on transcriptome sequencing in spinach, which provides insight into bolting control and can be useful for mol. breeding programs and further study in the regulation of the genetic mechanisms related to bolting in other vegetable crops.

BMC Plant Biology published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (metabolism). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

dos Santos, Anai L. published the artcileAnalysis of the seasonal variation in chemical profile of Piper glabratum Kunth essential oils using GCxGC/qMS and their antioxidant and antifungal activities, Related Products of alcohols-buliding-blocks, the main research area is Piper essential oil antioxidant antifungal seasonal variation.

Piper glabratum is a plant native from South America, which has been little studied, despite its use in folk medicine. In this study, chem. composition, antioxidant and antifungal activities of essential oils (EOs) from leaves of P. glabratum were investigated. The influence of seasonality on its chem. composition was also evaluated. The chem. characterization was performed by twodimensional gas chromatog. coupled with quadrupole mass spectrometry (GC×GC/qMS). Altogether, 199 compounds were identified in the EOs and their composition varied during the seasonal cycle. The main compounds found were sesquiterpenes and their oxygenated analogs. EOs showed antioxidant activity, measured by 2,2-diphenyl-1-picrylhydrazyl-DPPH (from 28.1 to 33.4 μg mL-1) and β-carotene assays (from 57.4 to 66.4%), and inhibitory action against C. albicans. The oils provided expressive properties; however, the yield of EO from winter was not enough for activities assays, remarking the influence of the seasonality on the biol. activities of this plant.

Journal of the Brazilian Chemical Society published new progress about Fungicides. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zha, Gao-Feng published the artcileSO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes, Application of 2-(3,5-Dichlorophenyl)ethanol, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, internal Role: SPN (Synthetic Preparation), PREP (Preparation). 93427-13-5 belongs to class alcohols-buliding-blocks, name is 2-(3,5-Dichlorophenyl)ethanol, and the molecular formula is C8H8Cl2O, Application of 2-(3,5-Dichlorophenyl)ethanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Shuang published the artcileCharacterization of polysaccharide from Helicteres angustifolia L. and its immunomodulatory activities on macrophages RAW264.7, Application In Synthesis of 59-23-4, the main research area is Helicteres polysaccharide immunomodulatory agent macrophage; Helicteres angustifolia L.; Immunomodulatory activity; Macrophages; Polysaccharide.

Helicteres angustifolia L. (H. angustifolia) has been widely used as a remedy against various types of illness relating to immune response, such as inflammations and fever. In order to characterize the structure and identify the immunomodulatory activity of polysaccharide from H. angustifolia, a polysaccharide fraction (SPF3-1) was purified from H. angustifolia by using DEAE Sepharose Fast Flow and Sephacry S-400 chromatog., successively. Physicochem. anal. demonstrated that SPF3-1 is an acidic heteropolysaccharide with a mol. weight of about 13.36 kDa; in vitro immunomodulatory assay reflects that SPF3-1 could significantly (p < 0.05) enhance the proliferation of macrophages, stimulate the macrophages phagocytic capacity, as well as induce NO and immunomodulatory cytokines generation. All the results suggest that SPF3-1 from H. angustifolia possesses potent immunomodulatory activity and could be further developed as new products for medicines or functional foods. Biomedicine & Pharmacotherapy published new progress about Cell proliferation. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Benmansour, Nassima published the artcileEssential oil and hydrosol extract chemical composition, phytochemicals of algerian Rhus pentaphylla Desf. and its antioxidant activity, SDS of cas: 124-76-5, the main research area is Rhus pentaphylla phytochem essential oil hydrosol extract antioxidant activity.

Rhus pentaphylla Desf. (Anacardiaceae) widely grown in Algeria, is an underutilized plant and remains poorly studied. To investigate for the first time, the chem. composition profile of essential oil and hydrosol extract; besides Total Phenolic (TPC), Flavonoid (TFC) and Condensed Tannins Contents (CTC) of fruits, leaves and roots, the fatty acid composition was assessed. The radical scavenging activity of R. pentaphylla extracts was then evaluated. Essential oil and hydrosol extract were isolated resp. by hydrodistillation and liquidliquid-extraction from the aerial parts of R. pentaphylla. The antioxidant activity was evaluated using 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) radical and ferric reducing antioxidant power (FRAP). Chem. compositions of various extracts were investigated using Gas Chromatog. (GC) and GC-Mass Spectrometry (GC-MS). The results of GC and GC-MS anal. revealed 83 components in essential oil and 75 components in hydrosol extract representing resp. 96.9% and 92.5% of the total extract composition The main constituents were hexadecanoic acid (31.5%) followed by spathulenol (14.9%) in the oil while the higher amount present in the hydrosol extract was of spathulenol (14.2%). Otherwise, 13 and 18 fatty acids were identified in roots and fruits resp. The highest levels of TPC and CTC were found in roots extracts while the highest quantity of TFC has been recorded in the leaves extract Besides, hydrosol extract was able to scavenge DPPH and FRAP free radicals more efficiently than essential oil. R. pentaphylla contains bioactive substances that could be used as a new promising source of antioxidant compounds in different applications.

Current Bioactive Compounds published new progress about Antioxidants. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, SDS of cas: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lopez, Jhon J. published the artcileNew convergent one pot synthesis of amino benzyl ethers bearing a nitrogen-containing bicycle, Recommanded Product: (4-Butoxyphenyl)methanol, the main research area is benzyl alc azabicyclooctanyl alc one pot etherification; benzyloxy azabicyclooctane preparation.

A new convergent one pot method for the synthesis of amino benzyl ethers containing a bicyclic amines, derived from different substituted benzyl alcs. and bicyclic amino alcs. such as tropine, pseudotropine and 3-quinuclidinol using chlorotrimethylsilane and sodium iodide was reported. In order to avoid the competitive reaction with the nitrogen atom, a solution of the sep. prepared alkoxide of tropine, pseudotropine and 3-quinuclidinol was added to the preformed substituted benzyl iodides and allowed to reflux at 90° for 15 h under nitrogen atm. This method provided an efficient alternative of the preparation of amino benzyl ethers in organic synthesis with good yields in comparison with existed methods.

Synthetic Communications published new progress about Benzaldehydes Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Recommanded Product: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Machado Querido, Micaela published the artcileAuto-Disinfectant Acrylic Paints Functionalised with Triclosan and Isoborneol-Antibacterial Assessment, Computed Properties of 124-76-5, the main research area is autodisinfectant acrylic paint triclosan isoborneol antibacterial isocyanate; acrylic paint; auto-disinfectant; functionalised; isoborneol; triclosan.

Environmental surface contamination with microorganisms is a serious concern worldwide. Triclosan and isoborneol present good antimicrobial activity. Their immobilization to paint substrates allows for development of a material that stays effective over a longer time. In this work, we disclosed the preliminary studies to evaluate the antimicrobial activity of the active mol. after being functionalized with isocyanates for further immobilization on the paint substrate. Overall, the newly developed non-release antimicrobial coating provides an effective way of preventing the spread of diseases and has been proven to inhibit bacterial growth and with a considerable antimicrobial activity towards S. aureus, E. coli, and K. variicola at the tested concentrations

Polymers (Basel, Switzerland) published new progress about Antibacterial agent resistance. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakayama, Taku published the artcilePalladium-Catalyzed Dehydrogenative Synthesis of Imidazoquinolines in Water, Quality Control of 6214-45-5, the main research area is imidazoquinoline preparation green chem; benzylic alc diaminoquinoline dehydrogenative coupling reaction palladium catalyst.

A synthesis of imidazoquinolines I (R = Me, iso-Bu, Ph, etc.; Ar = Ph, 3-fluorophenyl, naphthalen-1-yl, etc.) via dehydrogenative coupling of 3,4-diaminoquinolines II with benzylic alcs. ArCH2OH utilizing π-benzylpalladium(II) system in water was reported. Readily available benzylic alcs. initially undergo catalytic dehydrogenation to form benzaldehydes, which are then reacted with 3,4-diaminoquinolines II via sequential cyclocondensation/aromatization, leading to the formation of imidazoquinolines I. This exptl. simple and practical one-pot procedure provides direct access to the desired products I without adding strong bases, toxic oxidants or other additives. Several experiments were carried out toward an understanding of the reaction mechanism to propose plausible catalytic cycles. The dehydrogenative coupling was found to be first order with respect to the benzyl alc. and Pd catalyst, and zero order with respect to the 3,4-diaminoquinoline substrate. A kinetic isotope effect of 3.1 was observed by sep. determining the reaction rates of benzyl alc. and benzyl-α,α-d2 alc. Water mols. accelerate the catalytic dehydrogenative coupling, suggesting that they act as a proton donor to activate the benzylic alcs. by a hydrogen-bonding network.

Asian Journal of Organic Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Quality Control of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Liang published the artcileCombined effects of glycosylation precursors and lactate on the glycoprofile of IgG produced by CHO cells, Application In Synthesis of 59-23-4, the main research area is CHO cell monoclonal antibodies IgG; Chinese hamster ovary cells (CHO cells); Glycosylation; IgG; Monoclonal antibody; Sugars; mAbs.

The glycosylation profile of therapeutic monoclonal antibodies (mAbs) is a crucial quality parameter for industrial IgG (IgG) production Several alternative carbon sources, which function as glycosylation precursors, have been reported to impact the glycosylation pattern. Since the cells give priority to glucose uptake, the presence of this substrate can lower the effects of alternative sugars on the glycosylation. In order to get a better understanding of the influence of alternative sugars on the glycosylation and to investigate how they impact each other, combinations of mannose, fructose, galactose and fucose were fed to Chinese hamster ovary (CHO) cells in batch culture when the glucose became depleted and the lactate, accumulated in the culture, was used as carbon source. Feeding with a feed containing mannose or glucose decreased by 3-7% the percentage of high mannose glycans compared to a feed without mannose or glucose. Feeding with a feed containing galactose led to 8-20% increase of monogalactoglycans (G1) glycans and 2-6% rise of digalactoglycans (G2) glycans compared to feeding without galactose or glucose. The cells fed with fucose exhibited a significantly higher concentration of intracellular GDP-Fucose. This work indicates that a feeding strategy based on non-glucose sugars and potentially lactate, could be adopted to obtain a targeted glycosylation profile.

Journal of Biotechnology published new progress about Carbon sources, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts