Tag: M.W=150-200

Hu, Dongwen published the artcilePolysaccharide from Mulberry Fruit (Morus alba L.) Protects against Palmitic-Acid-Induced Hepatocyte Lipotoxicity by Activating the Nrf2/ARE Signaling Pathway, COA of Formula: C6H12O6, the main research area is mulberry fruit polysaccharide lipotoxicity oxidative stress signaling pathway; Nrf2/ARE signaling pathway; lipotoxicity; mulberry fruit; oxidative stress; palmitic acid; polysaccharide.

This study was aimed to investigate the protective effects of three different mulberry fruit polysaccharide fractions (MFP-I, MFP-II, and MFP-III) against palmitic acid (PA)-induced hepatocyte lipotoxicity and characterize the functional polysaccharide fraction using gel permeation chromatog., high-performance liquid chromatog., Fourier transform IR spectroscopy, and NMR analyses. MFP-I, MFP-II, and MFP-III were isolated from mulberry fruit by stepwise precipitation with 30, 60, and 90% ethanol, resp. MFP-II at 0.1 and 0.2 mg/mL dramatically attenuated PA-induced hepatic lipotoxicity, while MFP-I and MFP-III showed weak protection. It was demonstrated that MFP-II not only increased nuclear factor erythroid-2-related factor 2 (Nrf2) phosphorylation and its nuclear translocation, thereby activating the Nrf2/ARE signaling pathway, but also enhanced heme oxygenase 1, NAD(P)H:quinone oxidoreductase 1, and γ-glutamate cysteine ligase gene expressions and promoted catalase and glutathione peroxidase activities, which protected hepatocytes against PA-induced oxidative stress and lipotoxicity. Further investigation indicated that the mol. weight of MFP-II was 115.0 kDa, and MFP-II mainly consisted of galactose (30.5%), arabinose (26.2%), and rhamnose (23.1%). Overall, our research might provide in-depth insight into mulberry fruit polysaccharide in ameliorating lipid metabolic disorders.

Journal of Agricultural and Food Chemistry published new progress about Lipid metabolism disorders Role: BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, COA of Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Flynn, Ryan A. published the artcileSmall RNAs are modified with N-glycans and displayed on the surface of living cells, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is small noncoding RNA N glycan glycoRNA Siglec receptor; RNA biology; glycoRNA; glycobiology; siglec; small RNAs.

Glycans modify lipids and proteins to mediate inter- and intramol. interactions across all domains of life. RNA is not thought to be a major target of glycosylation. Here, we challenge this view with evidence that mammals use RNA as a third scaffold for glycosylation. Using a battery of chem. and biochem. approaches, we found that conserved small noncoding RNAs bear sialylated glycans. These “”glycoRNAs”” were present in multiple cell types and mammalian species, in cultured cells, and in vivo. GlycoRNA assembly depends on canonical N-glycan biosynthetic machinery and results in structures enriched in sialic acid and fucose. Anal. of living cells revealed that the majority of glycoRNAs were present on the cell surface and can interact with anti-dsRNA antibodies and members of the Siglec receptor family. Collectively, these findings suggest the existence of a direct interface between RNA biol. and glycobiol., and an expanded role for RNA in extracellular biol.

Cell (Cambridge, MA, United States) published new progress about 28S rRNA Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Leyva-Gutierrez, Francisco M. A. published the artcileCharacterization of by-products from commercial cannabidiol production, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is cannabidiol byproduct; cannabidiol; cannabinoids; chemical characterization; manufacturing by-products.

The chem. compositions of byproducts from com. cannabidiol (CBD) extraction were characterized and quantitated by employing gas chromatog. mass spectrometry (GC-MS) and GC flame-ionization detection (GC-FID). 2-Pentadecanone,isophytol. The four major byproducts included an ethanol-wax suspension (WAX), terpenoid distillate (DIST-A), tar-like residue (TAR), and red resin (RES). The composition of WAX consisted of 2̃8 wt% n-alkanes and 3̃3-38 wt% cannabidiolic acid and CBD combined. The DIST-A consisted of 4̃0 wt% sesquiterpenoids and 5̃8 wt% cannabinoids. The DIST-A terpenoid profile was compared to dried unprocessed inflorescences (HEMP) to observe changes in monoterpene content after the distillation process. The TAR was composed of 5̃-9 wt% higher n-alkanes and up to 91 wt% cannabinoids, while RES consisted of up to 99 wt% cannabinoids. Several impurities including cannabidibutol and dehydroabietic acid were identified in com. CBD samples. Compositional information of these byproducts may provide manufacturers with the opportunity to optimize processing conditions.

Journal of Agricultural and Food Chemistry published new progress about Distillation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Qi published the artcileA superchilling storage-ice glazing (SS-IG) of Atlantic salmon (Salmo salar) sashimi fillets using coating protective layers of Zanthoxylum essential oils (EOs), Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is superchilling storage ice coating protective layers zanthoxylum essential oil.

Sashimi is a perishable aquatic product. Low temperature offers a promising avenue to preserve sashimi, but traditional frozen methods can hardly avoid the undesirable effects caused by fluids’ freezing. The aim of this work is to establish a superchilling storage-ice glazing (SS-IG) approach using essential oils (EOs) from Zanthoxylum acanthopodium (ZA) and Zanthoxylum simulans (ZS) to preserve sashimi. Different compound of EOs were identified using GC-MS. Twelve main active compositions accounted for 52.85% and 63.19% of the total oils. Fresh salmon sashimi fillets were coated by 0.3% of EOs and stored at (-1 ± 0.2) °C for 25 days. EOs-based ice-glazing layers were formed on the surface of sashimi, while the fluids in sashimi samples still kept at liquid state. As the results, the microstructure and sensory quality of sashimi were maximally maintained. The growth of microbial populations and production of total volatile basic nitrogen (TVB-N) in sashimi were inhibited. The degree of lipid oxidation in sashimi was limited at a low range. The results revealed this SS-IG approach can effectively retain the overall quality of sashimi during storage and will be a promising means for the development of sushi industry.

Aquaculture published new progress about Oxygenated terpenes Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kutlu, Gozde published the artcileExtraction of a novel water-soluble gum from nettle (Urtica dioica) seeds: Optimization and characterization, Computed Properties of 59-23-4, the main research area is Urtica seed gum physicochem rheol property food formulation; Galactomannan; Nettle gum; Response Surface Methodology.

Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochem., rheol., functional and thermal properties. According to Response Surface Methodol., the maximum extraction yield was determined as 6.17% on dry basis. In order to clarify the structural information of the gum, the FT-IR anal. and monosaccharide composition determination were performed. In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1.15% total oil and 76.67% total carbohydrate. The FT-IR anal. revealed the existence of carboxyl groups, which gives the gum the capability of ion binding. Furthermore, Mannose/Galactose ratio was calculated as 1.07, indicating the water solubility of gum. DSC anal. showed that the NSG was highly stable in thermal process. Intrinsic viscosity, average viscosity and mol. weight values were determined as 8.56 ± 0.4 dL/g and 1.89 ± 0.1 x 106 g/mol, resp. The emulsification capacity, emulsion stability and foam formation capacity of the NSG were 48%, 40% and 4%, resp. The NSG exhibited shear thinning behavior while dynamic rheol. anal. indicated the NSG had viscoelastic properties and G′ (the storage modulus) was higher than G′′ (the loss modulus). In conclusion, the present study supplied novel knowledge on the NSG, which will be inestimable for clarifying its matchless functional properties.

International Journal of Biological Macromolecules published new progress about Emulsification. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Computed Properties of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Chang published the artcileLoss of the Golgi Matrix Protein 130 Cause Aberrant IgA1 Glycosylation in IgA Nephropathy, Product Details of C6H12O6, the main research area is IgA1 glycosylation GM130 chronic kidney disease nephropathy; Glycosylate deficiency IgA1; Golgi matrix protein 130; IgA nephropathy; Peripheral blood mononuclear cells; Tonsillar lymphocyte.

Aberrant O-glycosylation IgA1 production is a major factor in the pathogenesis of IgA nephropathy, but the underlying mechanism is still unclear. IgA1 glycosylation modification is in Golgi, and downregulation of the Golgi peripheral membrane protein Golgi matrix protein 130 (GM130) could lead to glycosylation deficiency. In this study, we aimed to explore the role of GM130 in glycosylate deficiency IgA1 (Gd-IgA1) production We enrolled 27 IgA nephropathy patients, 12 patients with chronic tonsillitis, 15 non-IgAN chronic kidney disease patients, and 15 healthy volunteers as healthy control. We explored GM130 expression in Tonsillar tissue by immunofluorescence staining and Western blotting and expression in peripheral blood mononuclear cells (PBMCs) by flow cytometry. The concentration of IgA1 and level of O-glycosylation were determined by ELISA and Vicia Villosa lectin-binding assay. Real-time PCR and Western blot were used to analyze the levels of β1,3-Gal transferase (C1GALT1) and ST6GalNAC2, resp. To explore the contribution of GM130 in IgA1 O-glycosylation modification, cells were subjected to experiments for evaluation of GM130 silencing by GM130-siRNA transfection. GM130 expression was significantly decreased in tonsil tissues and PBMC of IgAN patients; the expression of C1GALT1 decreased and Gd-IgA1 level increased significantly in patients with IgAN patients. The expression of GM130 was neg. related to Gd-IgA1 production By siRNA transfection, our results clearly indicated that the downregulation of GM130 can increase IgA1 O-glycosylation deficiency, which is thought to reduce C1GALT1 expression but not affect the expression of ST6GalNAC2. We identified and demonstrated that GM130 plays an important role in IgA1 O-glycans deficiency in IgAN patients, by neg. regulating C1GALT1 expression. We believe that this finding will provide theor. foundations for a new mechanism of Gd-IgA1 production in IgAN patients.

American Journal of Nephrology published new progress about CD19 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Product Details of C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wei, Enwei published the artcileMicrowave-assisted extraction releases the antioxidant polysaccharides from seabuckthorn (Hippophae rhamnoides L.) berries, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Hippophae berry antioxidant polysaccharide microwave assisted extraction; Antioxidant activity; Microwave power; Microwave-assisted extraction; Polysaccharide; Seabuckthorn berries.

Seabuckthorn berries are rich in various bioactive components and used as a traditional medicine for a long time. Until now, little information is available for the extraction of polysaccharides from seabuckthorn berries (PSB) by linking antioxidant activity and microwave power. In this study, microwave-assisted extraction, characterization, in vitro and in vivo antioxidant activities of PSB were explored. The maximum PSB extraction yield of 0.264 ± 0.005% was obtained under the optimal conditions as follows: microwave power 600 W, extraction time 6 min, liquid to material ratio 10: 1 mL/g, and extraction temperature 85 °C. Meanwhile, effects of microwave power on antioxidant activity of PSB was investigated and found that microwave at power of 600 W can facilitate the release of antioxidant PSB in a high yield. The main monosaccharides of PSB were Rha, Man, Glu, and Gal at a molar ratio of 1.00: 6.89: 1.62: 13.52, UV and FT-IR anal. coupled with mol. weight determination further indicated that PSB is a polydisperse polysaccharide. Moreover, PSB obtained under the optimal conditions equally exerted in vivo antioxidant activity through decreasing malonaldehyde and protein carbonyls and increasing superoxide dismutase and glutathione.

International Journal of Biological Macromolecules published new progress about Hippophae rhamnoides. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Ying published the artcileEffects of freeze drying and hot-air drying on the physicochemical properties and bioactivities of polysaccharides from Lentinula edodes, Application In Synthesis of 59-23-4, the main research area is freeze hot air drying polysaccharide Lentinula edodes; Characterization; Drying; Immunomodulatory; Lentinula edodes; Polysaccharides.

Fresh Lentinula edodes were dried using two process technologies-freeze drying (FD) and hot-air drying (HD). The physicochem., antioxidant and immunomodulatory properties of purified polysaccharides from dried L. edodes (LEP) were then comparatively investigated. Two neutral polysaccharides (FLEP-1 and HLEP-1) and two acidic polysaccharides (FLEP-2 and HLEP-2) were obtained by DEAE-52 cellulose column. The HD treated LEP had higher levels of uronic acid than that of the FD treated LEP. The molar ratios of monosaccharides in FLEP-1, FLEP-2, HLEP-1 and HLEP-2 were different. Moreover, HD treated LEP had more galactose and less glucose. The (1 → 3)-α-glucan structure was dominant in the two neutral polysaccharides, whereas the (1 → 6)-β-glucan was dominant in the two acidic polysaccharides. Hot-air drying could thus promote the α-configuration in neutral polysaccharides while reducing the β-configuration in acidic polysaccharides. FLEP-1, FLEP-2, HLEP-1 and HLEP-2 had potential scavenging capacity against the ABTS·+, whereas freeze-dried polysaccharides exhibited a stronger scavenging ability than that of hot-air dried polysaccharide. LEP could improve immunity by inducing the secretions of NO, TNF-α and IL-6, whereas hot-air drying improved the immunomodulatory activity of LEP. Our results suggested that freeze drying and hot air drying could be appropriately used to obtain functional polysaccharides from L. edodes.

International Journal of Biological Macromolecules published new progress about Acidic polysaccharides Role: BSU (Biological Study, Unclassified), BIOL (Biological Study) (HLEP-2). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kurnia, Irwan published the artcileSynthesis of p-menthane-3,8-diol from citronellal over lignin-derived carbon acid catalysts, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is menthanediol citronellal lignin carbon acid catalyst.

P-Menthane-3,8-diol (PMD) is receiving growing attention as a natural mosquito repellent with lower toxicity compared to the widely-used N,N-di-Et m-toluamide (DEET). In this study, sustainable carbon acid catalysts derived from alk. lignin (AL) were prepared for synthesizing PMD from a popular chem. (±)-citronellal in an environmentally friendly solvent of water. The catalytic performances of the AL-derived carbon acid catalysts prepared at different pyrolysis temperatures were better than those of other catalysts such as carbon black and H-USY. In particular, when the AL pyrolyzed at 500°C was used as the carbon acid catalyst, the conversion of (±)-citronellal was as high as 97% with a high PMD yield of 86%, indicating that waste alk. lignin from pulp and paper industries can be used as a source of acid catalysts. It is found that the formation of PMD is preferred over catalysts with weaker acid sites, whereas isopulegol was more easily formed over stronger acid sites. Moreover, the reaction route of the citronellal cyclization-hydration reaction was more dominant via the carbocation-hydration pathway rather than the isopulegol hydration route on the weaker carbon acid catalyst.

New Journal of Chemistry published new progress about Carbon black Role: CAT (Catalyst Use), SPN (Synthetic Preparation), USES (Uses), PREP (Preparation) (Vulcan XC 72C). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Safety of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cannon, Robert J. published the artcileIdentification, Synthesis, and Characterization of Novel Sulfur-Containing Volatile Compounds from the In-Depth Analysis of Lisbon Lemon Peels (Citrus limon L. Burm. f. cv. Lisbon), HPLC of Formula: 42822-86-6, the main research area is lemon peel flavor aroma volatile sulfur compound; GC-MS; GC-O; lemons; volatile sulfur compounds.

Lemons (Citrus limon) are a desirable citrus fruit grown and used globally in a wide range of applications. The main constituents of this sour-tasting fruit have been well quantitated and characterized. However, addnl. research is still necessary to better understand the trace volatile compounds that may contribute to the overall aroma of the fruit. In this study, Lisbon lemons (C. limon L. Burm. f. cv. Lisbon) were purchased from a grove in California, USA, and extracted by liquid-liquid extraction Fractionation and multidimensional gas chromatog.-mass spectrometry were utilized to sep., focus, and enhance unidentified compounds In addition, these methods were employed to more accurately assign flavor dilution factors by aroma extract dilution anal. Numerous compounds were identified for the first time in lemons, including a series of branched aliphatic aldehydes and several novel sulfur-containing structures. Rarely reported in citrus peels, sulfur compounds are known to contribute significantly to the aroma profile of the fruit and were found to be aroma-active in this particular study on lemons. The identification, synthesis, and organoleptic properties of these novel volatile sulfur compounds are discussed.

Journal of Agricultural and Food Chemistry published new progress about Citrus limon. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, HPLC of Formula: 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts