Tag: M.W=150-200

Wang, Mingjia published the artcilePurified fraction of polysaccharides from Fuzhuan brick tea modulates the composition and metabolism of gut microbiota in anaerobic fermentation in vitro, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Fuzhuan brick tea gut microbiota anaerobic fermentation metabolism; Fuzhuan brick tea; Gut microbiota; KEGG pathway; Metagenomics; Polysaccharide.

One purified fraction from crude Fuzhuan brick tea polysaccharides (FBTPS), FBTPS-3, was obtained through column chromatog. of DEAE Sepharose Fast Flow. The chem. properties and probiotic effects of FBTPS-3 were evaluated by fermentation in vitro. Moreover, the effects of FBTPS-3 on the function and metabolic pathway of gut microbiota were investigated by metagenomic sequencing. The results showed that FBTPS-3 was an heteropolysaccharide with mol. weight of 741 kDa, which was mainly composed of Man, Rha, GalA, Gal and Ara in molar ratio of 8.7:15.5:42.2:19.7:13.9. The contents of carbohydrates and uronic acid in FBTPS-3 were 44.78 ± 2.85% and 40.4 ± 2.11%, resp. After fermentation, the mol. weight of FBTPS-3 and content of carbohydrates were significantly decreased, indicating that FBTPS-3 could be utilized by gut microbiota. Furthermore, the relative abundances of Bacteroides, Megasphaera and Prevotella were significantly increased by FBTPS-3. FBTPS-3 also significantly promoted the production of acetic, propionic and n-butyric acids. Based on the metagenomic sequencing, it was found that FBTPS-3 significantly enriched the metabolic pathway of starch and sucrose. All the results suggest that FBTPS-3 is expected to be developed as functional ingredients or foods to improve the host health through regulating the gut microbiota and physiol. metabolic functions.

International Journal of Biological Macromolecules published new progress about Acidaminococcaceae. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Tejinder published the artcileComparison of glycoprofiles of rituximab versions licensed for sale in India and an analytical approach for quality assessment, Synthetic Route of 59-23-4, the main research area is glycoprofile rituximab analytical approach quality assessment; Biosimilars; Glycosylation; Monoclonal antibodies; N-Glycans; Rituximab.

Glycosylation affects clin. efficacy and safety; therefore, is a critical quality attribute of therapeutic monoclonal antibodies. Glycans are often labile and complex in patterns, giving rise to macro- and micro-heterogeneity. Recombinant production, diverse geog. locations, associated transportation and storage conditions further compound the problem. Two-way studies comparing glycoprofile of the originator and its given biosimilar are aplenty. However, the extent of anal. variation and similarity in glycoprofile across all approved versions of a drug is hardly explored. Using UHPLC and mass spectrometry, we compared the glycoprofiles of eight rituximab drug samples licensed for sale in India. While the types of glycans were found identical, the abundance of some glycans varied significantly within the tested population. The quality range of glycosylation parameters of the tested sample population differed significantly from the previously established values for US/EU licensed rituximab. As the mean abundance of the 90% of identified glycans falls within ±3SD, the extent of mutual variations amongst tested lots is less significant compared to the extreme deviation from previously established QR limits. Thus, we propose this approach as an orthogonal method to capture glycan variations in licensed versions of mAbs for quality surveillance and in cases where originator samples′ are limiting. As fluctuation in glycosylation may be of clin. significance, we identify that a one-to-one comparison with originator alone is insufficient in sensing the extent of variations in glycosylation parameters in licensed biosimilars of a given therapeutic mAb. Here we propose that future biosimilarity anal. may include an orthogonal approach of generating an addnl. combined QR range representing variations across the originator and its biosimilars. The glycosylation profiles of eight rituximab drug samples of different make obtained from the point of sale in India were found identical amongst the tested rituximab versions. However, the QR limits corresponding to important glycosylation parameters differed significantly across all tested samples from the previously established QR limits of US- and EU-licensed rituximab in statistical terms. Such an approach may be useful in defining the true range of glycan variations in licensed versions of therapeutic mAbs.

Journal of Proteomics published new progress about Antibody mimetics Role: ANT (Analyte), ANST (Analytical Study). 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Giboulot, Steven published the artcileFlat and Efficient HCNN and CNN Pincer Ruthenium Catalysts for Carbonyl Compound Reduction, Quality Control of 124-76-5, the main research area is arylpyridinylmethanamine benzoquinoline aminomethylpyridine HCNN CNN pincer ruthenium catalyst preparation; carbonyl compound reduction HCNN CNN pincer ruthenium catalyzed; aminomethylbenzoquinoline ruthenium phosphine carbonyl preparation crystal mol structure catalyst; aryl methyl ketone transfer hydrogenation catalyst preparation.

The bidentate HCNN dicarbonyl ruthenium complexes trans,cis-[RuCl2(HCNN)(CO)2] (1-3) and trans,cis-[RuCl2(ampy)(CO)2] (1a) were prepared by reaction of [RuCl2(CO)2]n with 1-[6-(4′-methylphenyl)pyridin-2-yl]methanamine, benzo[h]quinoline (HCNN), and 2-(aminomethyl)pyridine (ampy) ligands. Alternatively, the derivatives 1-3 were obtained from the reaction of RuCl3 hydrate with HCO2H and HCNN. The pincer CNN cis-[RuCl(CNN)(CO)2] (4) was isolated from 1 by reaction with NEt3. The monocarbonyl complexes trans-[RuCl2(HCNN)(PPh3)(CO)] (5-7) were synthesized from [RuCl2(dmf)(PPh3)2(CO)] and HCNN ligands, while the diacetate trans-[Ru(OAc)2(HCNN)(PPh3)(CO)] (8) was obtained from [Ru(OAc)2(PPh3)2(CO)]. Carbonylation of cis-[RuCl(CNN)(PPh3)2] with CO afforded the pincer derivatives [RuCl(CNN)(PPh3)(CO)] (9-11). Treatment of 9 with Na[BArf]4 and PPh3 gave the cationic complex trans-[Ru(CNN)(PPh3)2(CO)][BArf4] (12). The dicarbonyl derivatives 1-4, in the presence of PPh3 or PCy3, and the monocarbonyl complexes 5-12 catalyzed the transfer hydrogenation (TH) of acetophenone (a) in 2-propanol at reflux (S/C = 1000-100000 and TOF up to 100000 h-1). Compounds 1-3, with PCy3, and 6 and 8-10 were proven to catalyze the TH of carbonyl compounds, including α,β-unsaturated aldehydes and bulky ketones (S/C and TOF up to 10000 and 100000 h-1, resp.). The derivatives 1-3 with PCy3 and 5 and 6 catalyzed the hydrogenation (HY) of a (H2, 30 bar) at 70° (S/C = 2000-10000). Complex 5 was active in the HY of diaryl ketones and aryl Me ketones, leading to complete conversion at S/C = 10000.

Organometallics published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gong, Lingzhen published the artcileSelective construction of fused heterocycles by an iridium-catalyzed reductive three-component annulation reaction, Product Details of C10H18O, the main research area is chromenoquinolinone preparation diastereoselective; cyclohexanedione quinolinium bromide selective reductive annulation iridium catalyzed; chromenopyranoquinolinone preparation diastereoselective; hydroxycoumarin quinolinium bromide selective reductive annulation iridium catalyzed.

Here, through an initial pretreatment of N-heteroarenes with alkyl bromide, a syn-selective construction of functional fused heterocycles, chromenoquinolinones I [R1 = H, 7-Br, 10-NO2, etc.; R2 = CH2CH=CH2, Ph, 4-MeC6H4, etc.; R3 = H, Me; R4 = Me, Ph, 2-furyl] and chromenopyranoquinolinones II [R5 = H, 10-Me, 7-Br, etc.; R6 = H, 3-MeO, 2-Br, etc.] via iridium catalyzed reductive annulation of N-heteroarenium salts with formaldehyde and cyclic 1,3-diketones or 4-hydroxycoumarins, proceeding with broad substrate scope, good functional group compatibility, readily available feedstocks, and high step and atom efficiency was described.

Chemical Communications (Cambridge, United Kingdom) published new progress about Benzopyrans Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Product Details of C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kaur, Nirmaljeet published the artcileSynthesis and Application of (S)-Nicotine-Based Chiral Ionic Liquids in Enantiomeric Recognition by Using Fluorescence Spectroscopy, Related Products of alcohols-buliding-blocks, the main research area is nicotine enantiomeric recognition fluorescence spectroscopy synthesis.

The present report discusses the synthesis, characterization and application of novel chiral ionic liquids (CILs) derived from an enantiopure alkaloid (S)-nicotine. The synthesis of the CILs was initiated by the preparation of (-)-bornyl chloroacetate from (-)-borneol and monochloroacetic acid and then used for the quaternization of (S)-nicotine. The derivatives of the parent CIL were obtained via anion-metathesis reactions with sodium salts of dicyanamide and dioctyl sulfosuccinate. The synthesis of the resp. compounds was confirmed through NMR (1H,13C) spectroscopy, mass spectrometry, and FTIR. The thermal stability and optical activity of the CILs were analyzed through TGA, DTG and polarimetry. All the CILs obtained were liquid at room temperature and exhibited thermal stability up to 150 °C. The potential of chiral ionic liquids as enantiomeric recognizing agents for six amino acids (phenylalanine, proline, valine, alanine, leucine, histidine) was determined through fluorescence spectroscopy. CILs performed well against enantiomers of all amino-acid with maximum selectivity 1.22 (phenylalanine) and fluorescence enhancement 24.90 : 23.79 (ID/Io : IL/Io) for enantiomers of leucine.

ChemistrySelect published new progress about Alkaloids Role: SPN (Synthetic Preparation), PREP (Preparation). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Shengdong published the artcileSilver-Catalyzed Hydrogenation of Ketones under Mild Conditions, Computed Properties of 124-76-5, the main research area is silver catalyst hydrogenation ketone aliphatic aromatic; alc preparation.

The silver-catalyzed hydrogenation of ketones using H2 as hydrogen source is reported. Silver nanoparticles are generated from simple silver (I) salts and operate at 25 °C under 20 bar of hydrogen pressure. Various aliphatic and aromatic ketones, including natural products were reduced into the corresponding alcs. in high yields. This silver catalyst allows for the selective hydrogenation of ketones in the presence of other functional groups.

Advanced Synthesis & Catalysis published new progress about Aryl aldehydes Role: RCT (Reactant), RACT (Reactant or Reagent). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kochansky, Jan published the artcileSubstituent effects on chemosterilant activity of 2,4-di-tert-butyl-6-(4′-substituted benzyl)phenols in the house fly (Musca domestica L.), Recommanded Product: (4-Butoxyphenyl)methanol, the main research area is chemosterilant butylbenzylphenol fly structure; Musca chemosterilant butylbenzylphenol structure.

A series of 2,4-di-tert-butyl-6-(4′-X-benzyl)phenols was prepared, analogous to the compound Jurd 2644 (X = OMe) in an attempt to establish a Hammett relationship between the 4′-substituent and the chemosterilant activity of the compounds after oral administration to adult Musca domestica. Fourteen compounds of this type were prepared, 12 of them new. Jurd 2419 (X = H) was found to be as active in our bioassay as Jurd 2644, as were four new compounds [X = N(CH3)2, CH3, SCH3, Cl]. All prevented successful reproduction at 30 mg/kg of diet. There was no correlation between Hammett σ and activity. Active compounds all had small substituents and mol. weights below 350. The activity seemed to be determined by the bulk of X rather than by its electronic properties.

Journal of Agricultural and Food Chemistry published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Recommanded Product: (4-Butoxyphenyl)methanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adib, Mehdi published the artcileTBHP/n-Bu4PBr-Promoted Oxidative Cross-Dehydrogenative Coupling of Aryl Methanols: A Facile Synthesis of Symmetrical Carboxylic Anhydride Derivatives, Category: alcohols-buliding-blocks, the main research area is carboxylic anhydride preparation aryl methanol oxidative dehydrogenative coupling.

A transition-metal-free oxidative cross-dehydrogenative coupling reaction was developed for the preparation of sym. carboxylic anhydrides through self-coupling dual C-O bond formations of aryl methanols. In the presence of a catalytic amount of tetrabutylphosphonium bromide (TBPB) as transfer agent and aqueous tert-Bu hydroperoxide (TBHP) as oxidant and reactant, methylene groups of aryl methanols were efficiently oxidized to C:O and coupled with the peroxide oxygen from TBHP to form a diverse array of sym. carboxylic anhydride derivatives

Synlett published new progress about Anhydrides Role: SPN (Synthetic Preparation), PREP (Preparation). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Lingjuan published the artcileIron-catalyzed cross etherification of alcohols to form unsymmetrical benzyl ethers, HPLC of Formula: 6214-45-5, the main research area is iron catalyst cross etherification alc; unsym benzyl ether preparation mechanism.

A Fe(II)-catalyzed direct synthesis of unsym. benzyl ethers, e.g. I, from two different alcs. has been developed. In the presence of a catalyst in situ generated by combining Fe(OTf)2 (OTf = trifluomethanesulfonate) with a pyridine bis-imidazoline ligand, benzyl alcs. underwent cross dehydrative etherification with a wide range of aliphatic alcs. in good to excellent yields under mild, operationally simple conditions with low catalyst loading. The catalyst tolerates a number of functional groups in both coupling partners, and is highly chemoselective, affording no sym. ether byproducts. Ligand is shown to play a crucial role to the success of this dehydrative transformation, and preliminary mechanistic studies indicate that a benzylic cation is involved in the cross etherification.

Molecular Catalysis published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, HPLC of Formula: 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hikawa, Hidemasa published the artcilePalladium-Catalyzed Benzylic C-H Benzylation via Bis-Benzylpalladium(II) Complexes in Water: An Effective Pathway for the Direct Construction of N-(1,2-Diphenylethyl)anilines, Computed Properties of 6214-45-5, the main research area is aniline diphenylethyl preparation; benzyl alc aniline benzylation palladium catalyst.

A strategy for the N-benzylation/benzylic C-H benzylation cascade of anilines by the π-benzylpalladium system using a water-soluble palladium(0)/sodium diphenylphosphinobenzene-3-sulfonate (TPPMS) catalyst and benzyl alc. in water has been developed. The nucleophilic ν1-σ-benzyl anion ligand attacks the electrophilic ν3-π-benzyl ligand to give a dibenzylated product. The intermol. competition between mono-N-benzylaniline and its monodeuterated form (monodeuterated at the benzylic group) with benzyl alc. gave a KIE = 4.6, suggesting that C-H bond cleavage was involved in the rate-determining step. Hammett studies on the rate constants of benzylation by various substituted anthranilic acids and mono-N-benzylanilines show a good correlation between the log(kX/kH) and the σ values of the resp. substituents. From the slope, neg. ρ values were obtained, suggesting that there is a build-up of pos. charge in the transition state. The reaction of anilines R1C6H4NH2 (R1 = 4-Me, 3-COOEt, 2-OPh, etc.) with electron-donating and electron-withdrawing groups R2C6H4CH2 (R2 = H, 4-MeO, 3-Me, etc.) afforded the corresponding N-(1,2-diphenylethyl)anilines I in moderate to good yields (54-86%). Interestingly, the reaction of anthranilic acids R3C6H3(COOH)NH2 (R3 = 6-Me, 5-NHAc, H, etc.) with benzylic alcs. R4CH2OH (R4 = Ph, naphthyl, 4-MeC6H4, 3-MeC6H4) proceeded smoothly to give only the corresponding dibenzylated products II in good to excellent yields (70-87%) in which carboxyl group of the anthranilic acids acts as a directing group.

Advanced Synthesis & Catalysis published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts