Tag: M.W=150-200

Di Carluccio, Cristina published the artcileCharacterisation of the Dynamic Interactions between Complex N-Glycans and Human CD22, Related Products of alcohols-buliding-blocks, the main research area is autoimmune disease B cell malignancy CD22 N glycan; N-glycans; NMR spectroscopy; Siglecs; molecular recognition; sialic acids.

CD22 (Siglec-2) is a B-cell surface inhibitory protein capable of selectively recognising sialylated glycans, thus dampening autoimmune responses against self-antigens. Here we have characterised the dynamic recognition of complex-type N-glycans by human CD22 by means of orthogonal approaches including NMR spectroscopy, computational methods and biophys. assays. We provide new mol. insights into the binding mode of sialoglycans in complex with h-CD22, highlighting the role of the sialic acid galactose moieties in the recognition process, elucidating the conformational behavior of complex-type N-glycans bound to Siglec-2 and dissecting the formation of CD22 homo-oligomers on the B-cell surface. Our results could enable the development of addnl. therapeutics capable of modulating the activity of h-CD22 in autoimmune diseases and malignancies derived from B-cells.

ChemBioChem published new progress about Autoimmune disease. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Becerra, Jaime-Andres published the artcileTechno-Economic Evaluation of d-Limonene and α-Pinene Separation from Citrus and Turpentine Oils, Quality Control of 124-76-5, the main research area is techno economic limonene alpha pinene Citrus turpentine oil.

The evaluation of the tech. and economic separation of the monoterpenes α-pinene and d-limonene from essential oils, carried out by computational simulation of the vacuum fractional distillation in continuous and batch mode from samples of turpentine and citrus oils, was developed using Aspen Plus software combined with estimations of operational expenses (OPEX) and capital expenses (CAPEX) based on the Guthrie method. The production of d-limonene and α-pinene with high purity from the essential oils is a tech. feasible process. From the economic point of view and based on the average annual import costs of turpentine and orange oils in Colombia, it was found that the selling prices of α-pinene and d-limonene obtained from the distillation module cost anal. depend on the daily production and can be minimized if essential oils are preliminary extracted from local industrial wastes.

Chemical Engineering & Technology published new progress about Batch distillation. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nasution, R. published the artcileIsolation of the active compound from the bark of Cinnamomum burmannii as a sunscreen, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Cinnamomum sunscreen bark stem.

Our research aimed to extract Cinnamomum burmannii stem barks usingethyl acetate solvent, which further followed by the investigation of for the sunscreen potential of the extract Crude extract, subfraction, and pure isolate were used to prepare lotion formulations and tested for their sun protection factor (SPF) values. The results showed that lotions prepared from the crude extract or its subfraction had effecacious sunscreen activity, reaching 38.15 ± 0.51. The pure isolate obtained was elucidated by analyzing the spectral data from 1H-NMR (1HNMR), 13C-NMR, Mass Spectrometry, and Fourier-TransformInfrared Spectroscopy. The pure isolate was found to be 2-Propenoic acid, 3-(2-hydroxyphenyl)-, euro- having an SPF value of 33.62 ± 0.62, where its lotion formulation had an SPF value of32.14 ± 0.97. Viscosity and pH properties of the prepared lotion met the criteria from the Indonesian National Standard with spreadability and adhesiveness that are convenient for topical application. Taken altogether, the lotions prepared from Et acetate extract of C. burmannii could potentially be used as sunscreen agents.

Rasayan Journal of Chemistry published new progress about Adhesion, physical. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Taktak, Nehad E. M. published the artcileNanoemulsions containing some plant essential oils as promising formulations against Culex pipiens (L.) larvae and their biochemical studies, Computed Properties of 124-76-5, the main research area is Culex larva essential oils nanoemulsions formulations larvicidal; Biochemical studies; Culex pipiens; Essential oils; GC/MS; Larvicidal activity; Nanoemulsions.

The chem. composition of cypress, lavender, lemon eucalyptus, and tea tree oils has been investigated using gas chromatog./mass spectrometry (GC/MS). These oils were tested for larvicidal activity against Culex pipiens alongside their nanoemulsions (NEs) and conventional emulsifiable concentrates (ECs). Oil-in-water (O/W) NEs preparation was based on a high-energy ultra-sonication technique. The effect of independent variables of preparation on the different outputs was studied using the response surface method to obtain the optimum preparation technique. The droplet sizes of prepared NEs were significantly different (71.67, 104.55, 211.07, and 70.67 for cypress, lavender, lemon eucalyptus, and Tea tree NEs, resp.). The zeta potentials of NEs were recorded to have a high neg. charge (-28.4, -22.2, -23.6, and – 22.3 mV for cypress, lavender, lemon eucalyptus, and tea tree NEs, resp.). The results showed that the tea tree oil has the most significant effect with LC50 = 60.02 and 57.10 mg/L after 24 and 48 h of exposure, resp. In comparison, cypress oil proved the lowest toxicity with LC50 values of 202.24 and 180.70 mg/L after 24 and 48 h, resp. However, lavender oil does not show any effect against larvae at tested concentrations In addition, pure oil exhibited the lowest larvicidal activity. However, the EC of all tested insecticides slightly improved the toxic action against the larvae. While the NEs showed significantly high toxicity compared to the EO and EC. An in vivo assessment of acetylcholine esterase (AChE), ATPase (ATPase), and gamma-aminobutyric acid transaminase (GABA-T) revealed that the NEs exhibited higher activity than the pure oils and ECs. This work describes these oils with potential use against C. pipiens larvae as eco-friendly products.

Pesticide Biochemistry and Physiology published new progress about Corymbia citriodora. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bhattacharjee, Apurba K. published the artcileIn Silico Stereo-Electronic Analysis of PMD (p-Menthane-3-8-Diol) and its Derivatives for Pharmacophore Development May Aid Discovery of Novel Insect Repellents, Formula: C10H20O2, the main research area is menthanediol derivative electrostatic potential model insect repellent.

PMD (p-menthane-3-8-diol) is an insect repellent that can be synthesized chem. or derived from a steam distillate residue of the leaves of lemon eucalyptus, Corymbia citriodora. It is one of the few natural product endorsed by the Center for Disease Control (USA) for topical application to protect against mosquitoes though it is not as effective as the common repellent DEET (N,N-diethyl-1,3-toluamide). However, DEET has several undesirable side effects and toxicity too. Thus, although PMDs are comparatively safer than DEET, no quant. structure activity relationship (QSAR) and pharmacophore modeling studies have been reported in literature to improve efficacy and aid further development of more effective PMD analogs. In this study, we report results of quantum chem. anal. of stereoelectronic properties and pharmacophore modeling of PMD and eight of its synthetic derivatives to aid discovery and design of more effective PMD analogs. Stereo-electronic anal. indicates that lower aqueous stabilization (favorable lipophilicity) and larger separation of electrostatic potential energy together with a large localized neg. electrostatic potential region by the oxygen atom play important roles for repellent activity. Consistent to these properties, the generated pharmacophore model of the PMDs showed two aliphatic hydrophobic and a hydrogen-bond donor features for potent activity. These results aided us to design more effective PMD repellents which are currently under further investigations.

Current Computer-Aided Drug Design published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Formula: C10H20O2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kirton, L. G. published the artcileLaboratory and field tests of the effectiveness of the lemon-eucalyptus extract, citriodiol, as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is citriodiol Corymbia citriodora extract land leech repellent.

Citridiol is an extract of the leaves of Corymbia citriodora (Myrtaceae), the lemon eucalyptus, and mostly consists of p-menthane-3,8-diol isomers. The effectiveness of this extract as a repellent against land leeches of the genus Haemadipsa (Haemadipsidae), primarily H. sylvestris, was tested in the laboratory and field, in Peninsular Malaysia. The formulation tested, Mosi-guard Natural spray, contained 40% (weight/weight) citriodiol in a base of EtOH, water, and isopropanol. In the laboratory test, specimens of H. sylvestris that were placed within moist, untreated arenas enclosed by treated paper rings made numerous attempts to cross the rings but were prevented or delayed from crossing over, in a dose-dependent manner. Mortality was high among the leeches that attempted to cross over the paper rings that had been sprayed to saturation point but low among the leeches that attempted to cross over paper rings that had only been partially treated, with a droplet-spray. The field study was carried out using indexes that were formulated to reflect the severity of leech attack and the degree of repellency. Heavy or moderate spraying of footwear and trouser legs (tucked into socks) not only gave complete protection against bites by H. sylvestris and H. picta but also provided high enough repellency to keep the treated footwear virtually free of leeches. Even a light spray greatly reduced the numbers of leeches on footwear and delayed their progression toward biting the test subjects, although it failed to prevent bites completely. There was no decline in the repellency of the citriodiol when hourly assessments were made over a 6-h test period in the field. The results of the study show that citriodiol is highly repellent as well as toxic to leeches, and can be effectively used to prevent leech bites in the field.

Annals of Tropical Medicine & Parasitology published new progress about Corymbia citriodora. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Minqian published the artcileStructural characterization and immunological activity of pectin polysaccharide from kiwano (Cucumis metuliferus) peels, Application In Synthesis of 59-23-4, the main research area is Cucumis peel macrophage immunol pectin polysaccharide; Immunological activity; Kiwano (Cucumis metuliferus) peels; Pectin polysaccharide; Structural characterization.

Two novel polysaccharides, namely CMPP-1 and CMPP-2, from kiwano (Cucumis metuliferus) peels were isolated through hot-water extraction, followed by ethanol precipitation and column chromatog. The results showed that CMPP-1 and CMPP-2 were hetero-galacturonans with different mol. weights of 7.35 kDa and 6.90 kDa, resp. Both of CMPP-1 and CMPP-2 were mainly composed of glucuronic acid (45.93% and 51.75%, resp.), and other monosaccharides including rhamnose, arabinose, galactose, glucose, xylose, fucose, mannose, galacturonic acid, and mannuronic acid. The results of structural characterization from FT-IR and NMR confirmed that CMPP-1 and CMPP-2 were pectin with highly branched structure. Furthermore, both CMPP-1 and CMPP-2 possessed immune-enhancing activity and could enhance the secretion of nitric oxide and cytokines (TNF-α, IL-6) in a dose-dependent manner. Especially, CMPP-1 had higher immune activity than CMPP-2 as the min. effective concentration were 0.78μg/mL and 6.25μg/mL, resp. These findings provide a scientific basis for further utilization of polysaccharide from kiwano peels.

Carbohydrate Polymers published new progress about Cucumis metuliferus. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Verma, Ram Swaroop published the artcileEssential oil composition of the sub-aerial parts of eight species of Cymbopogon (Poaceae), Computed Properties of 124-76-5, the main research area is cymbopogon essential oil sub aerial pinane carane myrcane.

The genus Cymbopogon (Poaceae) comprised of many species of grasses that grow in tropical and subtropical regions around the world. Some of the com. important aromatic species of Cymbopogon are cultivated for the extraction of the essential oils from their aerial-parts. In spite of wide distribution and large scale cultivation, the essential oils of the sub-aerial parts (root/rhizome) of these species have not been systematically studied so far. In this study, the hydro-distilled essential oils from the sub-aerial parts of eight species, including a hybrid of Cymbopogon, namely C. flexuosus (Nees ex Steud.) W.Watson, C. khasianus (Hack.) Stapf ex Bor, C. pendulus Nees ex Steud., C. khasianus × C. pendulus, C. winterianus Jowitt ex Bor, C. martini (Roxb.) W.Watson, C. distans (Nees ex Steud.) W.Watson, and C. jwarancusa (Jones) Schult. and their varieties/chemotypes were analyzed by gas chromatog.-flame ionization detector (GC-FID) and gas chromatog.-mass spectrometry (GC-MS). A total of thirty-three terpene C-skeleton types (six monoterpene skeletons, twenty-seven sesquiterpene skeletons) were identified. A multivariate statistical comparison by principal component anal. and agglomerative hierarchical clustering grouped the examined essential oils in to four clusters (cluster I: geraniol, and piperitone/ geraniol chemotypes; cluster II: high elemol and low elemol chemotypes; cluster III: limonene chemotype; and cluster IV: 5-epl-7-epl-α-eudesmol/eudesmanediol/hinesol, and cis-p-menth-2-en-1-ol/trans-p-menth-2-en-1-ol/eudesmanediol chemotypes).

Industrial Crops and Products published new progress about Cymbopogon citratus. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lin, Derong published the artcileStudy on the functional properties and structural characteristics of soybean soluble polysaccharides by mixed bacteria fermentation and microwave treatment, HPLC of Formula: 59-23-4, the main research area is Neurospora soybean soluble polysaccharide fermentation microwave treatment; Functional properties; Soybean soluble polysaccharides; Structural characteristics.

The soybean soluble polysaccharide was prepared by mixed fermentation of lactic acid bacteria and Neurospora crassa and microwave treatment. The functional properties and structure characteristics of soybean soluble polysaccharide before and after modification were compared. Results revealed that after fermentation treatment, the content of soybean soluble polysaccharide increased to 7.09%, which was 3.16 times that of raw materials, and the microwave treatment was further increased to 7.69%. The glucose adsorption capacity, glucose dialysis retardation index and the α-amylase activity inhibition ration of soybean soluble polysaccharides increased significantly, promotes intestinal flora growth in vitro after fermentation of mixed bacteria and microwave treatment. At the same time, the anal. of monosaccharide compound and structural characteristics showed that the monosaccharide components of soybean soluble polysaccharide were redistributed after modification treatment, SEM showed that modified soybean soluble polysaccharide has a larger surface area; Fourier Transform IR spectroscopy and X-ray Diffraction proved that the modification has slight changes in the functional groups and crystal structure of soybean soluble polysaccharide. These results suggested that okara may be a potentially inexpensive source of natural soybean soluble polysaccharide and a potential functional food ingredient.

International Journal of Biological Macromolecules published new progress about Dehydration process. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hashemi, Seyed Mohammad Bagher published the artcileBasil seed gum edible films incorporated with Artemisia sieberi and Achillea santolina essential oils: Physical, antibacterial, and antioxidant properties, Application In Synthesis of 124-76-5, the main research area is Artemisia Achillea antibacterial antioxidant essential oil basil seed gum.

Active edible films were prepared by incorporating Artemisia sieberi and Achillea santolina essential oils (EOs) in basil seed gum (BSG) films. The results showed an increase in opacity, contact angel, and water vapor permeability of the films by the addition of EOs, whereas the moisture content, water absorption capacity, and water solubility declined. The presence of EOs significantly improved the DPPH and ABTS radical scavenging activities of BSG films. The agar diffusion disk method was carried out to evaluate the antibacterial activity of the films against Staphylococcus aureus, Bacillus cereus, Listeria monocytogenes, Shigella dysenteriae, Salmonella Typhi, and Pseudomonas aeruginosa. BSG film containing A. santolina + A. sieberi (1:2 volume/volume) demonstrated the highest antibacterial activity against the selected bacteria. It can be concluded that BSG film loaded with A. santolina + A. sieberi (1:2 volume/volume) EOs have the potential to be used as an active edible film and improve the shelf life of food products by delaying the oxidation and the microbial growth. Novelty impact statement : Active edible films were prepared by incorporation of Artemisia sieberi and Achillea santolina essential oils (EO) into basil seed gum (BSG) films. EOs significantly increased the opacity, water contact angel, and water vapor permeability of BSG films. Films incorporated with the mixture of EOs (A. santolina + A. sieberi (1:2 volume/volume)) showed the highest antibacterial and antioxidant activities. BSG films that contained these EOs have the potential to be used as active packaging to increase the shelf life of food products.

Journal of Food Processing and Preservation published new progress about Achillea santolina. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts