Tag: M.W=150-200

Wu, Pu published the artcileBioactivity-guided discovery of quality control markers in rhizomes of Curcuma wenyujin based on spectrum-effect relationship against human lung cancer cells, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Curcuma wenyujin rhizome quality control human lung cancer cell; Curcuma wenyujin; bioactive compounds-based fingerprint; quality control; spectrum-effect relationship.

Due to the diversity of the ingredients, the complexity of the mechanism of action, the uncertainty of the effective ingredients, coupled with the multiple species and multiple growing areas, the quality control (QC) of Traditional Chinese Medicines (TCMs) is challenging. Discovering and identifying effective compounds from the complex extracts of TCMs and then establishing a scientific QC method is the key to the holistic QC of TCMs. To develop an anti-lung-cancer-guided spectrum-effect relationship approach for the discovery of QC markers of the rhizome of Curcuma wenyujin (WEZ) and establish a bioactive compounds-based holistic QC method. The chem. profiling of the volatile oil (WVO) from 42 batches of WEZ collected from different growing areas was performed by GC-MS. The anti-lung cancer activity of different WVO samples was determined by CCK-8 assay against human lung cancer cells (A549). The apoptosis and cell cycle anal. under different concentrations of WVO were detected by flow cytometry. SIMCA-P software was used to perform multivariate statistical anal. on the chem. composition of different WVO samples and to find the different components. Active compounds were screened using a PLSR model of the spectrum-effect relationship. Bioactive compounds-based fingerprint and quantification of the leading bioactive compounds were developed by GC-MS and GC-FID, resp. Seventy-eight compounds were detected in WVO and 54 were successfully identified. The multivariate statistical anal. uncovered that WVO components and the anti-A549 activity of WVO at the concentration of 60 nl/mL differ greatly according to the origin of the plant. The WVO at the concentration of 60 nl/mL (IC50) increased A549 cells apoptosis significantly with late and early apoptosis of 15.61% and 7.80%, and the number of cells in the G2/M phase were also increased significantly under this concentration The spectrum-effect relationship anal. revealed that 44 compounds were pos. correlated with their activities, and the result was verified by A549 cell viability assay. Sixteen pos. correlated compounds were further selected as QC markers according to their relative amount > 0.5% and anticancer activity. Finally, the 16 QC markers-based GC-MS fingerprint was established to holistically control the quality of WEZ, and a GC-FID method was developed for the quantification of leading bioactive compounds, β-elemene and β-caryophyllene. Based on an anti-lung-cancer-guided spectrum-effect relationship approach, the bioactive compounds-based holistic QC method was successfully developed for WEZ, which could provide a valuable reference for the QC of TCMs.

Phytomedicine published new progress about Antitumor agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Recommanded Product: rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dong, Xiao-dan published the artcileA novel polysaccharide from Castanea mollissima Blume: Preparation, characteristics and antitumor activities in vitro and in vivo, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is antitumor castanea polysaccharide CMP90 proliferation apoptosis cytokines immune cells; Antitumor; Castanea mollissima Blume; Characteristics; Polysaccharide.

A new water-soluble polysaccharide, CMP90, with a mol. weight of 23.9 kDa was isolated from Castanea mollissima Blume and the preliminary structural characteristics and antitumor effects of CMP90 in vitro and in vivo were investigated in the research. CMP90 consists of arabinose, galactose, glucose, xylose and mannose (molar ratio: 0.08:0.11:5.14:0.12:0.08) with α- and β-anomeric units. The results of in vitro experiments indicated that CMP90 exhibited a significant inhibitory effect on the proliferation of HL-60 cells with typical apoptotic characteristics by inducing cell cycle arrested at G1/M phase. Addnl., the results in vivo suggested CMP90 was able to inhibit the growth of S180 solid tumors via protecting immune organs, improving the levels of serum cytokines (TNF-α, IL-2 and IFN-γ), enhancing the activities of immune cells (macrophages, lymphocytes and NK cells) and inducing cell apoptosis or death. Taken together, these combined data clearly indicated that CMP90 may be used as a potential candidate agent for cancer therapy.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Ying-ying published the artcilePolysaccharide extracted from Atractylodes macrocephala Koidz (PAMK) induce apoptosis in transplanted H22 cells in mice, SDS of cas: 59-23-4, the main research area is Atractylodes macrocephala Koidz polysaccharide apoptosis; Antitumor activity; Atractylodes macrocephala Koidz; Characteristics; Polysaccharide.

Polysaccharide of Atractylodes macrocephala Koidz (PAMK) was extracted by alc. sedimenting ranging from 60% to 90% and purified by ultrafiltration membrane. The high-performance gel permeation chromatog. (HPGPC), Fourier-transform IR spectroscopy (FT-IR), gas chromatog. (GC) and NMR (NMR) revealed that PAMK was a 4.1KDa neutral heteropolysaccharide composed of galactose, arabinose and glucose with a-configuration (molar ratio, 1: 1.5: 5). Results of determination of chem. components suggested that PAMK contained 96.47% of polysaccharide and little protein, nucleic acid and uronic acid. Antitumor experiments in vivo could be concluded that PAMK had a significantly cytotoxic and anti-tumor effect by blocking tumor cells in S phase. And not only that, PAMK could protect immune organ efficiently, comparing with cyclophosphamide. The research provided a potential antineoplastic drug component for tumor treatment.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Uzzan, Bernard published the artcileEfficacy of four insect repellents against mosquito bites: a double-blind randomized placebo-controlled field study in Senegal, Synthetic Route of 42822-86-6, the main research area is icaridine DEET paramenthanediol insecticide repellent topical skin mosquito bite.

Insect-borne diseases represent a worldwide threat. In addition to fight against vectors (insecticides) and disease prevention (vaccination against yellow fever, chemoprophylaxis against malaria), insect repellents applied on the skin could help reduce the heavy burden related to these diseases. In a field study performed in Senegal, we compared the efficacy of one skin application between 3 and 4 p.m. of four spray repellents [icaridine 20%, para-menthane-diol (PMD) 20% and 50% and DEET 50%] against placebo, among 100 healthy male and female volunteers experienced with mosquito capture. Double-blind randomized cross-over placebo-controlled study (Latin-square design) during five consecutive nights (7 p.m. to midnight) in two villages was conducted. To avoid residual effect, right or left leg was alternately exposed during consecutive nights and the exposed leg was washed before next night. The statistical model was random and mixed effects ANOVA. All four active repellents provided a significant and similar protection compared with placebo, lasting 8 h. However, there was a non-significant trend for a higher protection by DEET 50% than by PMD 20% (P = 0.07). Duration of protection was similar for all repellents. Their effects were similar among men and women, and against Anopheles or other species. No serious adverse drug reaction was noticed. Using a rigorous methodol. and a large number of volunteers, our well-controlled study demonstrated an important and similar protective effect of all four repellents compared with placebo. Such field studies should be required before approval of any newly developed repellent.

Fundamental & Clinical Pharmacology published new progress about Culicidae (bites). 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Synthetic Route of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bober, Josef R. published the artcileGalactose to tagatose isomerization at moderate temperatures with high conversion and productivity, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Lactobacillus sakei arabinose isomerase galactose tagatose.

There are many industrially-relevant enzymes that while active, are severely limited by thermodn., kinetic, or stability issues (isomerases, lyases, transglycosidases). In this work, we study Lactobacillus sakei L-arabinose isomerase (LsLAI) for D-galactose to D-tagatose isomerization-that is limited by all three reaction parameters. The enzyme demonstrates low catalytic efficiency, low thermostability at temperatures > 40°C, and equilibrium conversion < 50%. After exploring several strategies to overcome these limitations, we show that encapsulating LsLAI in gram-pos. Lactobacillus plantarum that is chem. permeabilized enables reactions at high rates, high conversions, and elevated temperatures In a batch process, this system enables ∼ 50% conversion in 4 h starting with 300 mM galactose (an average productivity of 37 mM h-1), and 85% conversion in 48 h. We suggest that such an approach may be invaluable for other enzymic processes that are similarly kinetically-, thermodynamically-, and/or stability-limited. Nature Communications published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ge, Xinyan published the artcileProduction, structure, and bioactivity of polysaccharide isolated from Tremella fuciformis XY, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Tremella fuciformis; Antioxidant activity; Fermentation optimization; Structure characterization; Tremella fuciformis polysaccharide.

Tremella fuciformis polysaccharide (TFP) is an important bioactive substance in Tremella, that contributes to its use as medicine and food. In this study, a novel fungus Tremella fuciformis XY was isolated and introduced to produce macromol. polysaccharides (TFPB). The fermentation conditions were optimized and results demonstrates that the initial pH, optimal temperature and liquid volume were 6.0, 26°C and 80 mL in a 500 mL flask, resp. The maximum yield of TFPB was 9.05 ± 0.05 g/L, which is 59.05% higher than the basic yield (5.69 ± 0.02 g/L). The TFPB, purified by DEAE column, had a mol. weight (Mw) of 1.14 × 103 kDa and consisted mainly of mannose, glucuronic acid, glucose, galactose, xylose, and rhamnose at a molar ratio of 3.5:1.2:2:1.6:1.4:3. The structure of TFPB was preliminarily investigated by methylation anal., IR spectroscopy, and NMR anal. The main linkage types were identified as 1,4-xylp, 1,4-manp, 1-xylp, 1-manp, 1,4-glcp, and 1,3,4-galp. Moreover, the antioxidant assays showed that TFPB could scavenge reactive oxygen species and hydroxyl radicals.

International Journal of Biological Macromolecules published new progress about Growth, microbial. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Rugang published the artcileCharacterization of polysaccharide fractions from fruit of Actinidia arguta and assessment of their antioxidant and antiglycated activities, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Actinidia antioxidant AGE; Actinidia argute; Antiglycation; Antioxidation; Characterization; Polysaccharide.

A novel cell-wall polysaccharides (AAPs) were extracted from the fruits of Actinidia arguta and separated into four parts which were named water-eluted polysaccharide (WPS), salt-eluted polysaccharide (SPS)-1, SPS-2 and SPS-3. The monosaccharide composition and structural anal. showed that SPS-3 and SPS-2 were homogalacturonan (HG)-rich pectin, SPS-1 was rhamnogalacturonan (RG)-rich pectin and WPS was starch-like polysaccharides. All four kinds of polysaccharides displayed the ability to scavenge free radicals, chelate iron ion, inhibit lipid peroxidation and inhibit protein glycation, but SPS was obviously stronger than WPS. Especially SPS-3 displayed the strongest antioxidant and anti-glycated activities. In addition, the inhibitory effect of AAPs on AGEs formation is attributed to the inhibitory activity on the production of protein carbonyl group and the protective effects on the protein thiol group but not the scavenging capacity of dicarbonyl compounds, suggesting that its mechanisms of antiglycated effects may be of concern to their antioxidant activities.

Carbohydrate Polymers published new progress about Actinidia arguta. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhu, Rugang published the artcilePectin oligosaccharides from fruit of Actinidia arguta: Structure-activity relationship of prebiotic and antiglycation potentials, Category: alcohols-buliding-blocks, the main research area is Actinidia fruit pectin oligosaccharide prebiotic antiglycation; Actinidia arguta; Antiglycation activity; Pectin oligosaccharides; Prebiotic activity; Structure-activity relationship.

Pectin oligosaccharides (POSs) have prebiotic and antiglycation activities in vitro, but the specific structure-activity relationship is unclear. In this study, POSs were obtained by enzymic and ultrasound-assisted enzymic degradation of pectin polysaccharide (PPS), resp. Based on the chem. characterization, the antiglycation in vitro and prebiotic activities of POSs were compared and the structure-activity relationship was studied. The results showed that the antiglycation activity of POSs in vitro was proportional to the galacturonic acid content and GalA:Rha molar ratios except for the low mol. weight POSs (LM-POSs), and inversely proportional to its branching degree, such as Ara:Rha and Gal:Rha molar ratios. In addition, it was also found that the prebiotic activity of POSs was pos. correlated with Ara:Rha and Gal:Rha molar ratios in mol. composition and the neutral sugar content, especially galactose and arabinose. The degree of esterification (DE) was less important for both antiglycation and prebiotic activity of POSs. These results provided an important theor. basis for POSs application in food.

Carbohydrate Polymers published new progress about Actinidia arguta. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nikitina, Liliya E. published the artcileStructural details on the interaction of biologically active sulfur-containing monoterpenoids with lipid membranes, Formula: C10H18O, the main research area is monoterpenoid lipid membrane dodecylphosphocholine POPC NMR.

In this work, we propose the synthesis of new thioterpenoids of a bornane series and study the influence of these compounds on hemostasis. The results from this study suggest that among all investigated terpenoids, sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetate may be the most promising for further development due to enhanced inhibition of the spontaneous aggregation compared with isoborneol, and because of its higher solubility in water compared with ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetic acid, which has approx. the same antiaggregatory and anticoagulant properties. In accordance with one hypothesis, the distribution of the studied bioactive mols. within the cellular lipid membrane can directly influence the anticoagulant properties. In the current work, the interactions of thioterpenoids with phospholipid membranes have been studied using various NMR techniques. The findings of this study indicate that sodium ([(1R,2R,4R)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]thio) acetateexhibits a membrane location, which is shifted somewhat in the direction of the lipid-water interface. Such a location may shield the compound from interactions with hydrophobic lipid segments. These results represent an initial step toward developing new drugs based on the synthesized thioterpenoids in order to increase the effectiveness of treatment and prevention of several human diseases accompanying disorders in the hemostasis system.

Journal of Molecular Liquids published new progress about Action potential. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Formula: C10H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Costa, Carina Pedrosa published the artcileMetabolomics profiling of human exhaled breath condensate by SPME/GC × GC-ToFMS: Exploratory study on the use of face masks at the level of lipid peroxidation volatile markers, Application In Synthesis of 124-76-5, the main research area is human EBC volatile metabolomic lipid peroxidation SPME GC ToFMS.

Metabolomics encompasses the acquisition of large-scale datasets from a single sample to identify and/or elucidate physiol. or pathol. mechanisms, or even to assess environmental exposure, being sample preparation and instrumental anal. two fundamental steps in the construction of a metabolomics workflow. The study of the human exhaled breath condensate (EBC) has gained tremendous interest recently owing to the advances in anal. techniques. Thus, this study aims to develop a methodol. for EBC metabolites profiling based on headspace solid phase microextraction (SPME) combined with comprehensive two-dimensional gas chromatog. (GC × GC). Metabolite′s extraction efficiency was improved by the optimization of four SPME parameters using a real EBC matrix: fiber coating, sample pH and volume, and extraction temperature The EBC anal. was performed according to the optimized parameters, using aliquots of 500 μL of EBC, at its physiol. pH, with the DVB/CAR/PDMS fiber coating, at 40.0 ± 0.1 °C, being able to detect analytes at pg/mL, with acceptable reproducibility. The EBC volatile composition was provided, with around 400 chem. features detected, in which 130 were putatively identified as belonging to hydrocarbons, aldehydes, alcs., ketones, esters, monoterpenic and sesquiterpenic compounds, ethers, norisoprenoids and furans, revealing therefore its high complexity. This research represents the most detailed study on the volatile composition of EBC and allows the assessment of a broad range of endogenous and exogenous metabolites, with further relevance on clin. or environmental exposure studies. To test the applicability of this methodol., an exploratory study was carried out to assess the impact of the use of surgical facemasks on young researcher′s lipid peroxidation volatile markers during a normal working day in a laboratory In young healthy adults (age ≤ 32), the use of surgical facemasks seems not significantly affect the levels of the volatile markers of lipid peroxidation (aliphatic alkanes and aldehydes), neither the O2 saturation level – SpO2. This methodol. shows promise as a convenient way to follow specific physiol. or pathol. conditions based on EBC metabolome and may be paired as part of an aggregate anal. structure.

Microchemical Journal published new progress about Adult, mammalian. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts