Tag: M.W=150-200

Seyfi, Roxana published the artcileIsolation and structural characterization of a polysaccharide derived from a local gum: Zedo (Amygdalus scoparia Spach), Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is local gum polysaccharide structural property.

In this study, a novel polysaccharide was isolated from a local gum, zedo (Amygdalus scoparia Spach). Chem. composition of the gum and elemental anal. of the isolated polysaccharide were determined The polysaccharide and its fragments were examined by gas chromatog.-mass spectrometry, GC-MS, viscometry, 1H NMR, and13CNMR spectroscopy. Results obtained from different methods, revealed that a hetero-polysaccharide is the main component of the gum. The amounts of moisture, minerals, protein and lipid were 9.42, 2.23, 1.05, and 0.03 (weight/weight %), resp. The amounts of carbon, hydrogen, oxygen and nitrogen obtained from elemental anal. were 38.5, 5.8, 35.3, and 0.3 (weight/weight %), resp. The presence of arabinose, galactose, rhamnos, mannose, β- D-glucose, fructose, galacturonic and glucuronic acids residues were measured by GC-MS anal. However, conversion of glucose into fructose probably occurred during the anal., because the temperature of the anal. is high enough. Both carboxylic groups and minerals/salts had a major influence on the rheol. properties of the gum. The gum exhibited polyelectrolyte behavior, and its solutions did not follow Newtonian flow behavior. It can be naturally occurred as an anionic polysaccharide. The gum was a highly branched polysaccharide and a member of arabinogalactans family. The main chain contains α- L-arabinofuranosyl, α- L-Araf, and β-D-galactopyranonyl, β-D-Galp, units. The following residues were identified: → 3,4) β-D-Galp (1→; → 3,4,6) β-D-Galp (1→; →3)- α- L-Araf-(1→; → 4) β-D-GlcpA (1 → .; glucosyl residues; and α-L- Rhap, (1 → . Terminal residues were: α-L- Rhap; and α- L-Araf.

Food Hydrocolloids published new progress about Arachis hypogaea. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Xiang published the artcileStructural characterization of a heteropolysaccharide from fruit of Chaenomelese speciosa (Sweet) Nakai and its antitumor activity, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Chaenomelese fruit heteropolysaccharide antitumor; Antitumor; Chaenomeles Speciosa (Sweet) Nakai; Heteropolysaccharide; Structural characteristics.

The present study aimed at investigating the structural features and antitumor properties of a novel heteropolysaccharide (CSP-W-2) obtained from the fruit of Chaenomeles Speciosa (Sweet) Nakai. CSP-W-2 demonstrate that they mainly contain glucose, galactose, arabinose, mannose, xylose in a ratio of 3.7: 3.2: 1.7: 0.9: 0.4, with the mol. weight of 8.7 kDa. Its backbone is predominantly composed of 1,4 linked β-D-Galp, 1,4 linked α-D-Glcp, 1,4 linked β-D-Glcp, and 1,4,6-β-D-Glcp, addnl. some branches contained 1,5 linked α-L-Araf, 1,4 linked β-D-Glcp, 1,3 linked α-L-Araf, and T linked β-D-Manp according to the results of partial acid hydrolysis anal., methylation anal., IR and NMR spectra. The antitumor properties study results demonstrated that CSP-W-2 had an inhibitory effect on HepG2 growth by enhancing the nucleus shrinkage and apoptosis. These findings indicate that CSP-W-2 had antitumor potential in the treatment of human liver tumor.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Safety of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yu, Juan published the artcileRelationship between structural properties and antitumor activity of Astragalus polysaccharides extracted with different temperatures, SDS of cas: 59-23-4, the main research area is Astragalus polysaccharide structure antitumor temperature; Antitumor activity; Astragalus membranaceus polysaccharides; Structural characterization.

This study investigated the effects of different temperatures on structural characterization and antitumor activity of polysaccharides from Astragalus membranaceus. APS4 and APS90 were extracted at 4°C and 90°C, resp., and purified by Sephadex G-200 column. APS4-90 were obtained from APS4 after treatment at 90°C for 6 h. MTT results showed that APS4 possessed the highest inhibitory effects on MGC-803, A549 and HepG2 cells. HPGPC anal. showed that the average mol. weights of these polysaccharides were approx. 1.5 × 106 Da, while the asym. peak of APS4-90 suggested heat degradation and configuration changes of APS4. GC, NMR and methylation results showed that these three polysaccharides had similar monosaccharide components (mainly contain glucose), and their backbones were composed of (1→2)-α-D-Glcp. However, APS4 showed higher content of (1→2,6)-α-D-Glcp compared to APS4-90 and APS90, which indicated that higher branched degree would be responsible for the stronger in vitro antitumor activity in APS4. These results were also confirmed by sp. rotation and SEM anal. Our study suggested that APS4 had the potential application for cancer treatment.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Datta, Hemanta Kumar published the artcileStructural elucidation of a heteropolysaccharide from the wild mushroom Marasmiellus palmivorus and its immune-assisted anticancer activity, Related Products of alcohols-buliding-blocks, the main research area is Marasmiellus heteropolysaccharide structure immunity anticancer activity; Anticancer activity; Heteropolysaccharide; Immunomodulation; Macrofungi; Marasmiellus palmivorus; Structure.

The biol. activity of macrofungal polysaccharides (MFPS) depends on their structural features and is a topic of keen interest for researchers since long time. We report a water-soluble macrofungal heteropolysaccharide (MFPS1) with a molar weight of ∼145,000 g/mol, obtained through alkali extraction, of the wild mushroom, Marasmiellus palmivorus, with significant immunomodulatory properties. In cancer, after the induction of metastasis, the anticancer immune system becomes unresponsive. By studying cytokine secretion and immune phenotyping, it was observed that MFPS1 reactivated the anticancer immune surveillance system. MFPS1 executed T-cell maturation and activation via M1Φ; and also stimulated natural killer (NK) cell and B-cell population. The entire immune activation pathway corroborates its anticancer activity. The RP-HPLC anal. of hydrolyzed MFPS1 showed arabinose, glucose, galactose, and mannose as monosaccharide units. The proposed structure of repeating unit was established from methylation anal., 1D- and 2D NMR study, HR-MS and MALDI-TOF MS anal.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zichao published the artcileEfficient biosynthesis of anticancer polysaccharide by a mutant Chaetomium globosum ALE20 via non-sterilized fermentation, Formula: C6H12O6, the main research area is fermentation Chaetomium globosum polysaccharide batch fermentation; Adaptive laboratory evolution; Anticancer polysaccharide; Methanol-resistant strain.

The sterilization process, due to its immense energy consumption, high facilities investment, and loss of raw materials by caramelization, during industrial production has drawn much attention. In this study, a methanol-resistant mutant strain, Chaetomium globosum ALE20, was obtained following 20 cycles of adaptive laboratory evolution process. The titer of anticancer polysaccharide (GCP-M) from C. globosum ALE20 reached 9.2 g/L with glycerol as sole carbon source using non-sterilized and fed-batch fermentation strategy. This titer represents a 200% increase compared with the 3.3 g/L attained with batch fermentation The GCP-M monosaccharide was comprised of galactose, glucose, mannose and glucuronic acid, in a molar ratio of 3.83:66.37:3.26:1.95, resp., and its weight-average mol. weight and polydispersity were 3.796 × 104 Da and 1.060, resp. This work presents an ideal alternative and safer fermentation process without sterilization, and a useful approach for enhancing industrial production

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liao, Deng-wei published the artcileCharacterization and antitumor activities of polysaccharides obtained from ginger (Zingiber officinale) by different extraction methods, SDS of cas: 59-23-4, the main research area is Zingiber colon breast cervical cancer cell polysaccharide antitumor; Antitumor activity; Ginger polysaccharide; Structure characterization.

Three different extraction technologies including hot water extraction (HWE), enzyme assisted extraction (EAE) and ultrasonic cell grinder extraction (UCGE) were employed to extract crude ginger polysaccharides (GPs) under their resp. best parameters, then crude GPs were purified by DEAE cellulose-52 and Sephadex G-200 size-exclusion chromatog. in that order. Five GPs fractions (HGP, EGP1, EGP2, UGP1, and UGP2, resp.) were obtained. The differences of five GPs in chem. composition, characterization and antitumor activities were further compared. The mol. weights were different in five GPs, varying from 11.81 to 1831.75 kDa. Mannose and glucose as the main monosaccharide and the glycosidic linkage of →4)-α-D-Glc(1→ and -α-Manp-(1→ existed in both five GPs. While EGP2 and UGP1 possessed specific structure of →6)-β-D-Galp-(1→ and UGP1 contained more sulfate group. Moreover, UGP1 exhibited strong inhibitory effect on three tumor cells especially the colon cancer. The inhibition rates of UGP1 on H1975, HCT116 and MCF-7 were 23.339 ± 2.285%, 56.843 ± 2.405% and 21.061 ± 1.920% resp. The study indicated GPs extracted by UCGE could reserve more active structure and inhibit colon cancer more significantly.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Du, Baoxiang published the artcileIsolation, purification, structural analysis and biological activities of water-soluble polysaccharide from Glehniae radix, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Glehniae lung cancer polysaccharide antiinflammatory anticancer; Biological activities; Glehniae radix polysaccharide; Structural analysis.

A new polysaccharide named GRP (Glehniae radix polysaccharide) was isolated and purified from Glehniae radix by hot water extraction, ethanol precipitation, anion-exchange and gel-filtration chromatog. GRP was homogeneous, with a mol. weight of 1.33 × 104 Da, as determined by high-performance size-exclusion chromatog.-refractive index detector anal. Its structural characteristics were investigated and elucidated by methylation anal., gas chromatog. mass spectrometry, Fourier transform IR and NMR spectroscopy. Based on obtained data, GRP was found to be a-D-glucan containing (1-6)-linked and (1-3)-linked backbone with a branch of one (1-6)-linked and terminal glucoses submitting at the C-4 position every fourteen residues. The biol. activities of GRP upon proliferation of splenic lymphocyte, RAW264.7 cells and A549 cell, and production of nitric oxide (NO) were investigated in vitro. The results showed that GRP exhibited inhibition against A549 cells proliferation and NO production in RAW264.7 cells, and displayed promotion for proliferation of mouse spleen lymphocytes and RAW264.7 cells, which suggested that GRP may have potential immunoregulation, anti-inflammatory and anti-tumor activity.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Hai-yu published the artcileEffects of Heat Treatment on the Structural Characteristics and Antitumor Activity of Polysaccharides from Grifola frondosa, HPLC of Formula: 59-23-4, the main research area is Grifola polysaccharide antitumor agent heat treatment hepatocellular carcinoma; Antitumor; Heat treatment; Polysaccharides from Grifola frondosa; Structure.

This study investigated the effects of heat treatment on structural characteristics and in vitro antitumor activity of polysaccharides from Grifola frondosa. GFP-4 (extracted at 4°C), GFP-4-80 (80°C treatment on GFP-4) and GFP-80 (extracted at 80°C) were prepared, and the chem. composition anal. showed that their total sugar contents were all higher than 90%, high-performance gel-permeation chromatog. (HPGPC), ion chromatog. (IC) and Fourier-transform IR spectroscopy (FTIR) results demonstrated that GFP-4 were degraded and denatured after 80°C heat treatment, MTT and JC-1 results showed that GFP-4 exhibited higher inhibitory effects on HepG2 cells in vitro than GFP-4-80 and GFP-80. Our study suggested that heat treatment at 80°C on polysaccharides from Grifola frondosa would destroy their structure and attenuate their antitumor effects.

Applied Biochemistry and Biotechnology published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Usoltseva, Roza V. published the artcileComparison of structure and in vitro anticancer activity of native and modified fucoidans from Sargassum feldmannii and S. duplicatum, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Sargassum colon cancer cell fucoidan cytotoxicity anticancer; Anticancer activity; Fucoidan; Sargassum.

Fucoidans are valuable biol. active polysaccharides of brown algae. The aim of this study was to investigate the structure of fucoidan from Sargassum feldmannii and the anticancer effects of native and modified polysaccharides from S. feldmannii and S. duplicatum. The structure of sulfated (25.3%) galactofucan SfF2 (Fuc/Gal = 72/28 mol%) from S. feldmannii was investigated by NMR spectroscopy of desulfated derivative and mass spectrometry of fucoidan fragments labeled with 18O. SfF2 was shown to contain the main chain from 1,3-linked a-L-fucopyranose and b-D-galactopyranose residues with fucose branches at C4 and C6 of galactose residues and C2 of fucose residues. The following fragments were also identified in SfF2: Fuc-(1,4)-Fuc, Gal-(1,3)-Gal, and Gal-(1,4)-Gal. The sulfate groups occupied positions C2, C3, and C4 of fucose residues and C2, C3, C4, and C6 of galactose residues. The galactofucans from S. feldmannii, S. duplicatum, and their derivatives exhibited no cytotoxicity in vitro. The native and deacetylated fucoidans (200 microg/mL) inhibited colony formation of human colon cancer cells (DLD-1, HT-29, and HCT-116). Both desulfated fucoidans possessed weak anticancer activity.

International Journal of Biological Macromolecules published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hisama, Masayoshi published the artcileSuppression of mutagens-induced SOS response by phytoncide solution using Salmonella typhimurium TA1535/pSK1002 umu test, Computed Properties of 42822-86-6, the main research area is antimutagen phytoncide solution SOS response Salmonella umu gene.

Four types of phytoncide solution (A-Type, AB-Type, D-Type and G-Type) were evaluated as anti-mutagenic agents with suppressive effects on the SOS-inducing activity of the mutagen 2-(2-furyl)-3-(5-nitro-2-furyl) acrylamide (furylfuramide) using Salmonella typhimurium TA1535/pSK1002 umu test. The A-Type, AB-Type, D-Type and G-Type of phytoncide solution suppressed the SOS-inducing activity on furylfuramide at a concentration of 100 μg/mL by 86.1%, 74.7%, 69.5% and 55.4%, resp., and the ID50 (50% ID) values were 9.0 μg/mL, 22.5 μg/mL, 36.0 μg/mL and 72.8 μg/mL. They also showed the suppression of SOS-inducing activity against other chem. mutagens, such as 4-nitroquinoline 1-oxide (4NQO) and N-methyl-N’-nitro-N-nitrosoguanidine (MNNG), which do not require liver metabolizing enzymes, and against 2-aminoanthracene (2AA) and 3-amino-1,4-dimethyl-5H-pyrido[4,3-b]indole (Trp-P-1), which require these enzymes, and against UV irradiation, which is a well known phys. mutagen. In the search for the component-activity relationship, the A-Type of phytoncide solution suppressed the SOS-inducing activity greater than the other types of phytoncide solution for furylfuramide, 4NQO and MNNG. However, in case of 2AA and Trp-P-1, the D-Type of phytoncide solution was most effective in suppressing the SOS-inducing activity in the umu test. From these results, the four types of phytoncide solutions showed the suppressive effect of SOS-inducing activity against chem. and phys. mutagens.

Journal of Oleo Science published new progress about Antitumor agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Computed Properties of 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts