Tag: M.W=150-200

Dessy, V. J. published the artcileGC-MS analysis of bioactive compounds present in different extracts of rhizome of Curcuma aeruginosa Roxb., Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Curcuma rhizome bioactive compound GCMS.

To analyze and characterize the chem. composition of the different crude extracts from the rhizome of Curcuma aeruginosa Roxb a medicinal plant. The air-dried rhizomes were powd. and subjected to Soxhlet extraction using solvent n-hexane and Supercritical fluid extraction Then, each of the extracts was further subjected to gas chromatog.-mass spectrometry. Qual. determination of the different biol. active compounds from crude extracts of C aeruginosa Roxb using gas chromatog.-mass spectrometry revealed different types of high and low mol. weight chem. entities with varying quantities present in each of the extracts These chem. compounds are considered biol. and pharmacol. important. Furthermore, the two different extracts SCF and n-hexane possess unique physicochem. characteristics. The two extracts possess major bioactive compounds that were identified and characterized spectroscopically. Thus, identification of different biol. active compounds in the extracts of C aeruginosa Roxb warrants further biol. and pharmacol. studies.

Journal of Drug Delivery and Therapeutics published new progress about Bioactive agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Brunerie, P. published the artcileBioconversion of citronellol by Botrytis cinerea, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, the main research area is must citronellol metabolism Botrytis.

Bioconversion of citronellol (I) was studied with 4 strains of B. cinerea. Using grape must, predominant transformation of I to 2,6-dimethyl-1,8-octanediol (II) and (E)-2,6-dimethyl-2-octene-1,8-diol 3 was observed In minor amounts 2,6-dimethyl-2,8-octanediol (III), 2 p-menthane-3,8-diol isomers (IV and V), (Z)-2,6-dimethyl-2-octene-1,8-diol, isopulegol, 2-methyl-2-hepten-6-on-1-ol, and 2-methyl-γ-butyrolactone were found. Using a small amount of grape must in a synthetic medium the bioconversion products II, III, IV, and V were absent, but addnl. 2-methyl-2-heptene-6-one, 2-methyl-2-heptene-6-ol, and citronellic acid were detected. The results obtained were strongly dependent on the strains used; 1 strain did not show any metabolic activity against I.

Applied Microbiology and Biotechnology published new progress about Botrytis cinerea. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Application of 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Murthy, Sushma S. published the artcileMolecular docking studies of phytocompounds with transcriptional factors in hepatocellular carcinoma, Category: alcohols-buliding-blocks, the main research area is mol docking anticancer agent hepatocellular carcinoma.

Hepatocellular carcinoma is one of the majorly categorized forms of human malignancy and is the prime cause of cancer-related mortality. Transcription factors and co-factors play an important role in the cellular process performing as key regulators in the normal cell and in the cancerous cell. The present study investigates the potential interaction between the potent phytocompounds and key transcriptional factors involved in hepatocellular carcinoma (HCC) by using mol. docking studies. In the area of drug designing and development, computational modeling and simulation play a significant role. Screening of potent phytocompounds against targets by means of conventional methods is tedious and requires more time when compared to computational modeling and simulation studies. In the present study, the application of computational screening of phytocompounds against transcriptional factors was effectively used to determine their binding strength with the pythocompounds. Ten potential phytocompounds linalool, p-cymene, pelargonidin, harpagoside, 1, 8-cineole, afzelin, ginkgolide B, theophylline, bromelain and isoborneol and five transcription factors p53, AP-1, c-Myc, β-catenin and HIF-1α were selected for docking studies. The 3D structures of both phytocompounds and transcription factors were obtained from Pubchem and PDB databases resp. Docking studies were carried out by using AutoDockVina. On evaluating the docking results, it was found that phytocompounds Harpagoside, Bromelain and Afzelin showed strong binding affinity against their targets. These phytocompounds showed the binding free energy more than 6 kcal/mol and RMSD value between 4-7 A0 with targets and can be potential ligands against the selected targets for further mol. investigations.

Rasayan Journal of Chemistry published new progress about Antitumor agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Yan published the artcileStructural characteristics and anticancer/antioxidant activities of a novel polysaccharide from Trichoderma kanganensis, Formula: C6H12O6, the main research area is Trichoderma kanganensis anticancer antioxidant polysaccharide structure; Anticancer activity; Antioxidant activity; Polysaccharide; Structural characteristics; Trichoderma kanganensis.

A novel water-soluble polysaccharide designated as TPS was isolated from the fermentation mycelia of Trichoderma kanganensis. TPS had a weight-average mol. mass of 3.074 × 105 Da, and the monosaccharide composition was consisted of Man (45.5%), GlcA (5.5%), Glc (10%), and Gal (39%). The major backbone of TPS was →6-α-D-Galp-1→5-β-D-Manf-1→5,6-β-D-Manf-1→5,6-β-D-Manf-1→, and the side chains are α-D-Glcp-1→4-α-D-Glcp-1→, β-D-Galf-1→, and α-D-Glcp-1→. In addition, we demonstrated that TPS was non-toxic in normal cells (LO2 cells) and inhibited the proliferation of mouse colon cells (CT26 cells). TPS also showed free radical scavenging activity against hydrogen peroxide. Overall, these results suggested that TPS from Trichoderma kanganensis may have potential application in biomedical fields.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Formula: C6H12O6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Oliveira, Ruberney S. published the artcileStructure elucidation of a bioactive fucomannogalactan from the edible mushroom Hypsizygus marmoreus, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is fucomannogalactan mushroom Hypsizygus structure antitumor; Antimelanoma; B16-F10 cell; Chemical structure; Fucomannogalactan; Hypsizygus marmoreus; Mushroom.

A fucomannogalactan (FMG-Hm), with a mol. weight of 17.1 kDa, obtained from fruiting bodies of Hypsizygus marmoreus exhibited promising in vitro antimelanoma effects. FMG-Hm was not cytotoxic, nor did it alter the cell morphol. and proliferation, but was able to inhibit colony-forming ability and cell migration in B16-F10 murine melanoma cells. An anal. of the monosaccharide composition indicated that FMG-Hm was composed of fucose, mannose, and galactose in a ratio of 1.00:1.08:3.17. The FMG-Hm was structurally characterized based on methylation anal., partial acid hydrolysis, and NMR experiments The results indicated that FMG-Hm contained a α-(1→6)-linked galactopyranosyl main chain, partially substituted at O-2 by non-reducing ends of α-L-fucopyranose and β-D-mannopyranose. The predicted structure of the heteropolysaccharide was established.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Name: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Yi-yong published the artcileOptimization of microwave assisted extraction, chemical characterization and antitumor activities of polysaccharides from porphyra haitanensis, SDS of cas: 59-23-4, the main research area is microwave extraction antitumor polysaccharide porphyra; Antitumor; Chemical characterization; Microwave assisted extraction; Polysaccharides; Porphyra haitanensis.

Microwave assisted extraction (MAE) technol. was used to extract polysaccharides from Porphyra Haitanensis (PHP) with water. Polysaccharide yield was used as index to evaluate the extraction process. Effects of ratio of water to raw material (X1), microwave power (X2) and extraction time (X3) on polysaccharide yield were investigated. Based on single factor experiment, MAE process of PHP was optimized using response surface methodol. Chem. characterization of PHP was investigated based on anal. of chem. compositions, monosaccharide and thermal gravimetric. The antitumor activities of PHP in vivo and in vitro were evaluated. The results indicated that the optimal conditions for MAE of PHP were ratio of water to raw material 28.98(mL/g), microwave power 77.84 W and extraction time 14.14 min. MAE was a suitable and efficient technique for PHP extraction compared with traditional hot water extraction Anal. of chem. characterization showed that PHP contained 75.36 ± 1.48% of total carbohydrates, 24.63 ± 1.69% of uronic acid residue and no proteins with monosaccharides such as rhamnose, arabinose, xylose, mannose, glucose, and galactose in a molar ratio of 10.25:9.38:1:12.45:9.9:11.55. Thermal gravimetric anal. suggested that PHP was relatively stable below 170°C. PHP had obvious effect on inhibiting proliferation, inducing apoptosis of SGC-7901 tumor cells in vitro and antitumor effect on SGC-7901 tumor-bearing mice in vivo. The results suggested that PHP had the potential for clin. use in cancer prevention and treatment.

Carbohydrate Polymers published new progress about Antitumor agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, SDS of cas: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smither, Sophie J. published the artcileInvestigative study into whether an insect repellent has virucidal activity against SARS-CoV-2, SDS of cas: 42822-86-6, the main research area is COVID SARSCoV Mosi guard natural insect repellent virucidal activity; Citriodiol; SARS-CoV-2; anti-viral activity; insect repellent; skin.

A small-scale study with Mosi-guard Natural spray, an insect repellent containing Citriodiol, was performed to determine if it has virucidal activity against SARS-CoV-2. A liquid test examined the activity of the insect repellent and the individual components for virucidal activity. A surface contact test looked at the activity of the insect repellent when impregnated on a latex surface as a synthetic skin for potential topical prophylactic application. Both Mosi-guard Natural spray and Citriodiol, as well as other components of the repellent, had virucidal activity in the liquid contact test. On a latex surface used to simulate treated skin, the titer of SARS-CoV-2 was less over time on the Mosi-guard Natural-treated surface but virus was still recovered.

Journal of General Virology published new progress about Antiviral agents. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, SDS of cas: 42822-86-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yuqing published the artcileAntioxidant and immunomodulatory activities of polysaccharides from the rhizome of Dryopteris crassirhizoma Nakai, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Dryopteris rhizome polysaccharide antioxidant immunomodulation antiviral; Antioxidant activity; Dryopteris crassirhizoma Nakai polysaccharides; Immunomodulatory activity.

Rhizome of the fern Dryopteris crassirhizoma Nakai is used as an antiviral drug in China. The objective was to characterize physicochem. properties, structural features and antioxidant and immunol. activities of D. crassirhizoma polysaccharides. An acidic polysaccharide fraction (DCP-3) was obtained from Dryopteris crassirhizoma Nakai by purification with DEAE-52 and Sephadex G-100. DCP-3 was a novel triple-helical polysaccharide with an average MW of 273.2 kDa. This fraction was mainly composed of galactose (36.65%), xylose (34.75%), arabinose (17.07%) and mannose (9.22%). DCP-3 had strong activity for scavenging DPPH radical (IC50: 2.04 mg/mL), hydroxyl radical (IC50: 1.70 mg/mL), and superoxide anions (IC50: 4.20 mg/mL) and also was capable of reducing ferric ions. In addition, nitric oxide production was enhanced in RAW264.7 macrophages stimulated by DCP-3. Based on these bioactivities, we inferred that DCP-3 was a functional component of D. crassirhizoma and may confer antivirus activity, with potential applications in functional food and drug industries.

International Journal of Biological Macromolecules published new progress about Antiviral agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sokolova, Anastasiya S. published the artcileMonoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process, Computed Properties of 124-76-5, the main research area is preparation monoterpenoid filovirus entry inhibitor glycoprotein structure; Borneol; Camphor; Ebola virus; Glycoprotein; Marburg virus; Mutagenesis study.

In this study, we screened a large library of (+)-camphor and (-)-borneol derivatives to assess their filovirus entry inhibition activities using pseudotype systems. Structure-activity relationship studies revealed several compounds exhibiting submicromolar IC50 values. These compounds were evaluated for their effect against natural Ebola virus (EBOV) and Marburg virus. Compound 3b (As-358) exhibited the good antiviral potency (IC50 = 3.7 μM, SI = 118) against Marburg virus, while the hydrochloride salt of this compound 3b·HCl had a strong inhibitory effect against Ebola virus (IC50 = 9.1 μM, SI = 31) and good in vivo safety (LD50 > 1000 mg/kg). The results of mol. docking and in vitro mutagenesis analyses suggest that the synthesized compounds bind to the active binding site of EBOV glycoprotein similar to the known inhibitor toremifene.

European Journal of Medicinal Chemistry published new progress about Antiviral agents. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ponce, Nora M. A. published the artcileFucoidans from the phaeophyta Scytosiphon lomentaria: Chemical analysis and antiviral activity of the galactofucan component, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Scytosiphon fucoidan galactofucan antiviral; Antiviral; Brown seaweeds; Fucoidans; Galactofucans; Scytosiphon lomentaria.

The brown seaweed Scytosiphon lomentaria produces moderate amounts of fucoidans. By cetrimide fractionation, typical heavily sulfated galactofucans are obtained, with no major signs of chem. heterogeneity, together with fractions with higher proportions of xylose, mannose and uronic acids. Anyway, fucose is the most important monosaccharide in most of the subfractions of the subsequent extracts The fucan moieties appear to be mostly as 3-linked α-L-fucopyranosyl units, with several patterns of sulfate and branching. Galactose is mostly 6-linked, whereas mannose appears to be 2-linked, and xylose appears mostly as terminal stubs. Small amounts of 2-O-acetylated fucose units appear. A high and selective antiviral activity against HSV-1 and HSV-2 was determined for the galactofucan fractions whereas the uronofucoidans were inactive.

Carbohydrate Research published new progress about Antiviral agents. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts