Tag: M.W=150-200

Huo, Jiaying published the artcileImmunomodulatory activity of a novel polysaccharide extracted from Huangshui on THP-1 cells through NO production and increased IL-6 and TNF-α expression, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is polysaccharide Huangshui Moringa monosaccharide Escherichia; Baijiu; Huangshui; Immunomodulatory activity; Polysaccharide; Structural characterization.

Huangshui (HS), the byproduct of Chinese Baijiu, has attracted considerable attention due to its nutrient and microbial composition; however, none of the studies has explored the polysaccharides in HS yet. Here, from HS, we isolated a novel polysaccharide, HSP-3, with an average mol. weight of 26.40 kDa. The structure was elucidated based on monosaccharide composition and methylation anal., NMR, FT-IR, and AFM anal. It is mainly composed of mannose (46.6%), galactose (17.3%), arabinose (11.2%), glucose (10.5%), xylose (8.2%), fucose (5.2%), and rhamnose (1.0%). The backbone of HSP-3 was made up of → 2-β-D-Manp-(1 → 2,6)-β-D-Manp-1 → 6-β-D-Galp-(1 → 3,6)-β-D-Galp-(1 → 4)-α-L-Rhap-1 → 3,4-α-L-Rhap-1 → . Moreover, stimulation of the production of ROS, NO, TNF-α and IL-6, upregulation of the mRNA and protein expression levels of TNF-α and IL-6 in THP-1 cells, and enhanced the pinocytic and phagocytic capacities of THP-1 cells exhibited significant immunomodulatory properties of HSP-3. Altogether, this study suggests that HSP-3 could be used as an active component in functional foods.

Food Chemistry published new progress about Cell survival. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gan, Jiapan published the artcileMicrowave assisted extraction with three modifications on structural and functional properties of soluble dietary fibers from grapefruit peel, Synthetic Route of 59-23-4, the main research area is grapefruit peel soluble dietary fiber microwave assisted extraction.

Microwave-sodium hydroxide treatment (MST), microwave-enzymic treatment (MET) and microwave-ultrasonic treatment (MUT) were used to treat grapefruit peel, then the structural and functional properties of extracted soluble dietary fibers (SDF), named as MST-SDF, MET-SDF and MUT-SDF, were investigated. The SEM, mol. weight, X-ray diffraction, FT-IR, thermal properties and monosaccharide composition were used to determine the structural properties. Compared to the grapefruit peel SDF without treatment (WT-SDF) and pure microwave treatment (PMT-SDF), MST-SDF, MET-SDF and MUT-SDF showed a more complex and loose structure. Moreover, they possessed higher mol. weight, crystallinity and thermal stability, and more diverse monosaccharide composition In addition, functional properties, including water holding capacity (WHC), oil holding capacity (OHC), cholesterol adsorption capacity (CAC), glucose adsorption capacity (GAC) and nitrite ion adsorption capacity (NIAC), were enhanced by the three different modification methods. Especially, MUT-SDF showed the highest WHC, OHC, CAC, GAC and NIAC as compared with the other samples. In summary, the present study suggested that the MUT could be used as the ideal modification method for grapefruit peel SDF, and MUT-SDF has great potential for the application in functional food industry.

Food Hydrocolloids published new progress about Crystallinity. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Synthetic Route of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mahmoudabadi, Samane Zarei published the artcileApplication of PC-SAFT EOS for Pharmaceuticals: Solubility, Co-Crystal, and Thermodynamic Modeling, Related Products of alcohols-buliding-blocks, the main research area is pharmaceuticals solubility cocrystal thermodn modeling PCSAFT EOS; Co-crystal; PC-SAFT EOS; Solubility; Thermodynamic; Thermodynamic modeling.

In this study, the applicability of the perturbed chain statistical associating fluid theory (PC-SAFT) was evaluated for pharmaceutical compounds For this purpose, the parameters of the PC-SAFT equation of state (EOS) were regressed by applying the exptl. solubility data of 54 pharmaceuticals in pure solvents. The reported errors for train and test data show the suitability of the PC-SAFT EOS. The applicability of the PC-SAFT EOS was explored by its prediction accuracy for the ternary system of medicine in solvent mixtures The model errors were 23 and 26% for two ternary systems of salicylic acid and lidocaine HCl in solvent mixtures of ethanol and water, resp. The co-crystal formation of salicylic acid-sulfamethazine in methanol was investigated by the PC-SAFT EOS. Finally, the reaction and crystallization sections for acetaminophen production from p-aminophenol were simulated by accompanying the PC-SAFT EOS and equilibrium assumption. The purification efficiencies for acetaminophen were obtained to be 93-98% for different temperatures

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about Crystals (Co). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khebri, Souad published the artcilePhytochemical Profile, Antimicrobial and Antioxidant Activities of Cistus clusii Essential oil From Algeria, Quality Control of 124-76-5, the main research area is Pseudomonas Staphylococcus essential oil phytochem antimicrobial antioxidant property Algeria.

Cistus clusii essential oil has been extracted using hydrodistillation method and characterized by GC/MS. The antioxidant activity was evaluated by two different methods DPPH free radical scavenging, and β-carotene bleaching test. The antimicrobial activity was carried out using disk diffusion method against reference strains; Pseudomonas aeruginosa (ATCC 27865), Escherichia coli (ATCC 25922), Staphylococcus aureus (ATCC 25923), clin. bacterial (Klebsiella pneumoniae, Proteus mirabilis, Staphylococcus aureus) and fungal (Candida albicans) isolates. The chem. profile of the oil showed 31 compounds This profile was dominated by the presence of monoterpene hydrocarbons (78.4%), oxygenated derivatives (18.8%) and sesquiterpene hydrocarbons as minor constituents of this essential oil (1.9%). The major constituents were Camphene (20.6%), γ-Terpinene (16.5%), Sabinene (12.8%), and Terpineol-4 (13.5%). Other compounds were found in moderately good amounts like α-Terpinene (8.9%), α-Thujene (5.9%), α-Pinene (4.2%), and α- Terpinolene (3.1%). The results of the antimicrobial activity showed that the highest activity was observed against C. albicans and it was higher than pos. control Fluconazole. Conclusion: This study indicates that Cistus clusii essential oil showed potent antioxidant and moderate antimicrobial activities which could be used to explain the use of this species in traditional medicine.

Current Bioactive Compounds published new progress about Candida albicans. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Quality Control of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Chihae published the artcileDo Similar Structures Have Similar No Observed Adverse Effect Level (NOAEL) Values? Exploring Chemoinformatics Approaches for Estimating NOAEL Bounds and Uncertainties, Related Products of alcohols-buliding-blocks, the main research area is adverse NOAEL chemoinformatic uncertainty.

Determination of the no observed adverse effect level (NOAEL) of a substance is an important step in safety and regulatory assessments. Application of conventional in silico strategies, for example, quant. structure-activity relationship (QSAR) models, to predict NOAEL values is inherently problematic. Whereas QSAR models for well-defined toxicity endpoints such as Ames mutagenicity or skin sensitization can be developed from mechanistic knowledge of mol. initiating events and adverse outcome pathways, QSAR is not appropriate for predicting a NOAEL value, a concentration at which “”no effect”” is observed This paper presents a chemoinformatics approach and explores how it can be further refined through the incorporation of toxicity endpoint-specific information to estimate confidence bounds for the NOAEL of a target substance, given exptl. determined NOAEL values for one or more suitable analogs. With a sufficiently large NOAEL database, we analyze how a difference in NOAEL values for pairs of structures depends on their pairwise similarity, where similarity takes both structural features and physicochem. properties into account. The width of the estimate NOAEL confidence interval is proportional to the uncertainty. Using the new threshold of toxicol. concern (TTC) database enriched with antimicrobials, examples are presented to illustrate how uncertainty decreases with increasing analog quality and also how NOAEL bounds estimation can be significantly improved by filtering the full database to include only substances that are in structure categories relevant to the target and analog.

Chemical Research in Toxicology published new progress about Chemoinformatics. 42822-86-6 belongs to class alcohols-buliding-blocks, name is 2-(2-Hydroxypropan-2-yl)-5-methylcyclohexanol, and the molecular formula is C10H20O2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Ting published the artcileCharacterization of polysaccharide structure in Citrus reticulate ′Chach′ peel during storage and their bioactivity, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Citrus polysaccharide arabinogalacturonan pectin storage; Glycosidic linkage; Immunomodulatory activity; Molecular weight; NMR; Pectin.

The peel of Citrus reticulate ′Chachiennsis′ (Chachi) is widely accepted as a functional food. It is generally recognized that its health benefits are dependent on storage time. However, the chems. responsible for this phenomonon remain unclear. As bioactive polysaccharides are dominant in Chachi, Chachi polysaccharides with various storage times (5-20 years) were prepared The monosaccharide composition was analyzed by GC-MS. NMR data revealed that Chachi polysaccharides were mainly consisted of arabinogalacturonan and another pectin with side chain of →4)-β-D-Galp-(1 → . α-L-Araf-(1→, →5)-α-L-Araf-(1→, →4)-α-D-GalpA-(1→, →4)-α-D-GalpAMe-(1→, →4)-β-D-Galp-(1→ and →4)-β-D-Glcp-(1→ were detected. The mol. weight of Chachi polysaccharides decreased along with the extension of storage time. However, the basic structure characteristics remained stable. The immumomodulatory activities of Chachi polysaccharides were improved as the storage time extended. The change of mol. weight was responsible for the improved immunomodulatory activity. The results explained how polysaccharides contributed to the enhanced health benefits of Chachi during storage.

Carbohydrate Research published new progress about Chinese medicine. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Wen-Juan published the artcileAntagonistic storage potential of Tagetes minuta, Eupatorium fortunei and Ocimum basilicum oils with volatile secondary metabolites against Tribolium castaneum and Lasioderma serricorne, Computed Properties of 124-76-5, the main research area is Tagetes Eupatorium Ocimum Tribolium Lasioderma volatile secondary metabolite.

Antagonistic storage potential of Tagetes minuta Linnaeus, Eupatorium fortunei Turcz. and Ocimum basilicum L. volatile oils hydrodistillated with main secondary metabolites against two storage pests, Tribolium castaneum and Lasioderma serricorne adults were evaluated. More than 95% volatile secondary metabolites obtained at different hydrodistillation time were identified by gas chromatog.-mass spectrometry (GC-MS), and analyzed with principal component anal. (PCA) and orthogonal partial least squares discriminant anal. (OPLS-DA). Further insecticidal assay exhibited interesting results that T. minuta oil showed the strongest fumigant toxicity against both T. castaneum (LC50 = 6.68 mg/L air) and L. serricorne (LC50 = 3.13 mg/L air) among the three essential oils. As one of the main volatile secondary metabolites, methylthymol was found to possess more powerful fumigant (LC50 = 2.42 mg/L air) and contact toxicity (LD50 = 5.43 μg/adult) against T. castaneum. While, precocene I exhibited the strongest insecticidal toxicity on L. serricorne with the LC50 value of 0.88 mg/L air and LD50 of 3.46 μg/adult, resp. During the repellent assay, T. minuta oil showed the same repellent rate against both T. castaneum and L. serricorne at the highest concentration of 78.63 nL/cm2. The results proved that the essential oils as well as the main volatile secondary metabolites have potential to be developed into novel natural botanical resources on antagonistic storage with traditional Chinese medicine (TCM).

Industrial Crops and Products published new progress about Chinese medicine. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hosseini, Seyed Saeid published the artcileOptimization and characterization of pectin extracted from sour orange peel by ultrasound assisted method, HPLC of Formula: 59-23-4, the main research area is Citrus peel pectin ultrasound assisted method; Monosaccharide composition; Optimization; Pectin; Sour orange; Ultrasound.

In this work, a Box-Behnken design (BBD) with three variables (ultrasound power, irradiation time and pH) in three levels was applied for pectin extraction optimization. The optimization process showed that the maximum extraction yield was 28.07 ± 0.67% in ultrasound power of 150 W, irradiation time of 10 min and pH of 1.5 (as optimum conditions). In these conditions, ash, moisture and protein contents of SOPP were 1.89 ± 0.51, 8.81 ± 0.68 and 1.45 ± 0.23%, resp. HPLC anal. indicated that 65.3% of the extracted pectin was galacturonic acid and approx. 72% of total neutral sugars was galactose. The optimized pectin had a total phenolic content of 39.95 ± 3.13 mg gallic acid equivalent/g pectin, the surface tension of 46.56 ± 0.23 and 42.14 ± 0.61 mN/m in concentrations of 0.1 and 0.5%w/v, water holding capacity and oil holding capacity of 3.10 ± 0.12 and 1.32 ± 0.21 g water or oil/g pectin with a suitable emulsifying and antioxidant properties. In addition, SOPP with degree of esterification of 6.77 ± 0.43% was classified as low methoxyl pectin, which confirmed by FTIR and 1H NMR anal.

International Journal of Biological Macromolecules published new progress about Citrus aurantium. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, HPLC of Formula: 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pinto, Joana published the artcileCharacterization of chemical compounds susceptible to be extracted from cork by the wine using GC-MS and 1H NMR metabolomic approaches, Application In Synthesis of 124-76-5, the main research area is wine maturation cork extractable compound geog origin; 1-Terpinen-4-ol (PubChem CID: 11230); Camphene (PubChem CID: 6616); Castalagin (PubChem CID: 168165); Cork; Friedelin (PubChem CID: 91472); GC-MS; Geographical origin; Metabolomics; NMR spectroscopy; Polyphenols; Pyrogallol (PubChem CID: 1057); Quinic acid (PubChem CID: 6508); Sitost-4-en-3-one (PubChem CID: 5484202); Vescalagin (PubChem CID: 5458626); Volatile compounds; o-Cymene (PubChem CID: 10703); trans-3-Pinanone (PubChem CID: 11038); trans-Squalene (PubChem CID: 638072).

This work presents a metabolomic study of cork by GC-MS and 1H-NMR spectroscopy to characterize compounds susceptible to be extracted from cork by the wine in an attempt to find a relationship between the content of these compounds and the geog. origin of cork. Cork from eleven geog. regions was studied, five from Portugal and six from Spain. Unsupervised pattern recognition techniques unveiled three main clusters of regions according to their chem. similarity but not related with geog. proximity. Nineteen compounds were found to be responsible for the clusters, including terpenes (trans-squalene, friedelin, camphene, trans-3-pinanone, 1-terpinen-4-ol, two sesquiterpenes), polyphenols (vescalagin, castalagin), among others (pyrogallol, glucosan, sitost-4-en-3-one, o-cymene, quinic acid, five unknowns). These preliminary results unveiled the potential for a more efficient selection of cork planks for stoppers production based on the compounds susceptible to be extracted from cork by the wine.

Food Chemistry published new progress about Cluster analysis. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application In Synthesis of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Portella, Roberto de Oliveira published the artcileKinetin establish the volatile chemical profile after rhizome dormancy is released in Curcuma zedoaria (Christm.) Roscoe, Synthetic Route of 124-76-5, the main research area is Curcuma rhizome dormancy volatile chem profile kinetin; Metabolic pattern; bud dormancy; monoterpene; terpenes; volatile substances.

The aim of this work was to provide information about kinetin effects on chem. volatile profile of Curcuma zedoaria (Christm.) Roscoe after several days of plant dormancy release. Rhizomes of C. zedoaria were immersed in four kinetin concentrations (0, 50, 100, 150 mg ml-1, n = 12 by each concentration) for 30 min. After 240 h of treatment, root length (mm), bud break (%) and bud speed index (BSI) were measured, and three rhizomes at 24 h and 240 h were collected for chem. volatile profile anal. by application of headspace solid-phase microextraction (HS-SPME) coupled with gas chromatog.-mass spectrometry (GC-MS). Kinetin does not alter morphol. aspects of the bud dormancy releasing, but drastically changes metabolic aspects of volatile production on C. zedoaria rhizomes, by the selection of several monoterpenes, such as camphene, sabinene, isoborneol, borneol, 1,8-cineole. We assume that kinetin application maintain monoterpene production as a consequence of its signaling over dormancy release.

Natural Product Research published new progress about Curcuma zedoaria. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts