Tag: M.W=100-150

Camacho Vergara, Edgar L. published the artcileOn the study of the vapor-liquid interface of associating fluids with classical density functional theory, SDS of cas: 111-87-5, the main research area is vapor liquid interface density functional theory.

Classical d. functional theory (DFT) is applied to study the vapor-liquid interface of associating fluids. Our classical DFT implementation uses a Helmholtz free energy functional that reduces to the perturbed-chain statistical associating fluid theory (PC-SAFT) equation of state in the bulk limit. We apply a new association functional, presented in one of our previous works, based on the weighted d. approximation to calculate the interfacial tension of associating fluids and compare them with two of the most used association functionals from literature. It is found that classical DFT with the three association functionals and the current mol. parameters of PC-SAFT is not able to predict satisfactorily the interfacial tension of alkanols. Therefore, the exptl. interfacial tension of alkanols and some associating fluids is included in the determination of the pure mol. parameters of PC-SAFT. With this approach the determination of interfacial tension of pure associating fluids can be greatly improved with the new parameters, but at the expense of slightly higher deviations in the vapor pressure. The new parameters are tested for the determination of vapor-liquid equilibrium (VLE) and the prediction of interfacial tension of binary mixtures containing at least one associating compound Good agreement is found between exptl. data of VLE and interfacial tension of the binary mixtures and the three association functionals. Furthermore, we discuss about the limitations and capabilities of the current classical DFT implementation in the study of the vapor-liquid interface of associating fluids.

Fluid Phase Equilibria published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Anuj published the artcileExtractive separation of levulinic acid using natural and chemical solvents, Name: n-Octanol, the main research area is extractive separation levulinic acid natural chem solvent.

Levulinic acid is an organic compound which has been replacing petroleum products in different sectors such as biofuel and chem. industry. It can be used in the manufacture of plastics, rubber, pharmaceuticals, pesticides, etc. Levulinic acid separation from aqueous streams, different types of solvents such as natural solvents (sunflower and groundnut oil), and various chem. solvents (benzene, iso-butanol, and iso-octanol) at 298.15 K were used. Using equilibrium data various parameters such as: efficiency of extraction, distribution coefficient, dimerization constant, and partition coefficient were calculated and correlated with typical physicochem. properties, mol. weight, d., dipole moment, viscosity, dielec. constant, solubility in water, octanol-water partition coefficient, refractive index, etc. The obtained exptl. extraction results for separation of levulinic acid were compared with various solvents used. The maximum value of distribution coefficient and efficiency of extraction of levulinic acid was obtained for iso-butanol (1.357, 57.276%) and min. value for sunflower oil (0.077, 7.086%) resp.

Chemical Data Collections published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Antony, Fiona Mary published the artcileEfficacy of tri-n-octylamine, tri-n-butyl phosphate and di-(2-ethylhexyl) phosphoric acid for reactive separation of protocatechuic acid, Recommanded Product: n-Octanol, the main research area is octylamine butyl ethylhexyl phosphate protocatechuic acid reactive separation.

Owing to its chem. and pharmacol. significances, the efficacy of reactive separation of protocatechuic acid (0.001-0.01 kmol m-3) from aqueous stream by means of tri-n-octylamine (TOA), di-2-ethylhexyl phosphoric acid (D2EHPA) as well as tri-Bu phosphate (TBP) in octanol has been investigated, in terms of extraction efficiency, loading ratio, equilibrium complexation constants, and distribution coefficients Extraction ability was obtained in the order TOA (91.2%) > TBP (88.64%) > D2EHPA (86.43%). In all cases, 1:1 protocatechuic acid:extractant complex is obtained. Further, diffusion coefficients, number of stages for extraction systems, and relative basicity model were used for relating the efficacy.

Separation Science and Technology (Philadelphia, PA, United States) published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bensard, Claire L. published the artcileRegulation of Tumor Initiation by the Mitochondrial Pyruvate Carrier, Product Details of C4H6O5, the main research area is Drosophila colorectal cancer mitochondrial pyruvate carrier Wnt beta catenin; cancer metabolism; carbohydrate metabolism; colon cancer; mitochondria; pyruvate metabolism; stem cell metabolism; tumor initiation.

Although metabolic adaptations have been demonstrated to be essential for tumor cell proliferation, the metabolic underpinnings of tumor initiation are poorly understood. We found that the earliest stages of colorectal cancer (CRC) initiation are marked by a glycolytic metabolic signature, including downregulation of the mitochondrial pyruvate carrier (MPC), which couples glycolysis and glucose oxidation through mitochondrial pyruvate import. Genetic studies in Drosophila suggest that this downregulation is required because hyperplasia caused by loss of the Apc or Notch tumor suppressors in intestinal stem cells can be completely blocked by MPC overexpression. Moreover, in two distinct CRC mouse models, loss of Mpc1 prior to a tumorigenic stimulus doubled the frequency of adenoma formation and produced higher grade tumors. MPC loss was associated with a glycolytic metabolic phenotype and increased expression of stem cell markers. These data suggest that changes in cellular pyruvate metabolism are necessary and sufficient to promote cancer initiation.

Cell Metabolism published new progress about Alleles. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Baytas, Ozan published the artcileMitochondrial enzyme GPT2 regulates metabolic mechanisms required for neuron growth and motor function in vivo, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is GPT2 mitochondrial enzyme neuron growth.

The metabolic needs for postnatal growth of the human nervous system are vast. Recessive loss-of-function mutations in the mitochondrial enzyme glutamate pyruvate transaminase 2 (GPT2) in humans cause postnatal undergrowth of brain, and cognitive and motor disability. We demonstrate that GPT2 governs critical metabolic mechanisms in neurons required for neuronal growth and survival. These metabolic processes include neuronal alanine synthesis and anaplerosis, the replenishment of tricarboxylic acid (TCA) cycle intermediates. We performed metabolomics across postnatal development in Gpt2-null mouse brain to identify the trajectory of dysregulated metabolic pathways: alterations in alanine occur earliest; followed by reduced TCA cycle intermediates and reduced pyruvate; followed by elevations in glycolytic intermediates and amino acids. Neuron-specific deletion of GPT2 in mice is sufficient to cause motor abnormalities and death pre-weaning, a phenotype identical to the germline Gpt2-null mouse. Alanine biosynthesis is profoundly impeded in Gpt2-null neurons. Exogenous alanine is necessary for Gpt2-null neuronal survival in vitro but is not needed for Gpt2-null astrocytes. Dietary alanine supplementation in Gpt2-null mice enhances animal survival and improves the metabolic profile of Gpt2-null brain but does not alone appear to correct motor function. In surviving Gpt2-null animals, we observe smaller upper and lower motor neurons in vivo. We also observe selective death of lower motor neurons in vivo with worsening motor behavior with age. In conclusion, these studies of the pathophysiol. of GPT2 Deficiency have identified metabolic mechanisms that are required for neuronal growth and that potentially underlie selective neuronal vulnerabilities in motor neurons.

Human Molecular Genetics published new progress about Alleles. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yuqi published the artcileAn exclusion mechanism is epistatic to an internal detoxification mechanism in aluminum resistance in Arabidopsis, SDS of cas: 97-67-6, the main research area is Arabidopsis aluminum resistance detoxification; ALMT1; Epistasis; Malate; NIP1;2; Organic acid; Resistance mechanism; Root cell wall.

In Arabidopsis, the aluminum (Al) exclusion mechanism is mainly facilitated by ALMT1-mediated malate exudation and MATE-mediated citrate releases from the root. Recently, we have demonstrated that coordinated functioning between an ALMT1-mediated Al exclusion mechanism, via exudation of malate from the root tip, and a NIP1;2-facilitated internal detoxification mechanism, via removal of Al from the root cell wall and subsequent root-to-shoot Al translocation, plays critical roles in achieving overall Al resistance. However, the genetic relationship between ALMT1 and NIP1;2 in these processes remained unclear. Through genetic and physiol. analyses, we demonstrate that unlike ALMT1 and MATE, which function independently and additively, ALMT1 and NIP1;2 show an epistatic relationship in Al resistance. These results indicate that ALMT1 and NIP1;2 function in the same biochem. pathway, whereas ALMT1 and MATE in different ones. The establishment of the epistatic relationship and the coordinated functioning between the ALMT1 and NIP1;2-mediated exclusion and internal detoxification mechanisms are pivotal for achieving overall Al resistance in the non-accumulating Arabidopsis plant. We discuss and emphasize the indispensable roles of the root cell wall for the implementation of the Al exclusion mechanism and for the establishment of an epistatic relationship between the ALMT1-mediated exclusion mechanism and the NIP1;2-facilitated internal detoxification mechanism.

BMC Plant Biology published new progress about Alleles. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

van Karnebeek, Clara D. M. published the artcileBi-allelic GOT2 Mutations Cause a Treatable Malate-Aspartate Shuttle-Related Encephalopathy, Synthetic Route of 97-67-6, the main research area is brain developmental defect seizure encephalopathy malate aspartate GOT2; EC 2.6.1.1.; GOT2; aspartate aminotransferase; encephalopathy; inborn error of metabolism; malate-aspartate shuttle; mitochondriopathy; pyridoxine responsive epilepsy; redox imbalance; treatment.

Whole-exome sequencing was used to investigate the disease etiol. in four children from independent families with intellectual disability and epilepsy, revealing bi-allelic GOT2 mutations. In-depth metabolic studies in individual 1 showed low plasma serine, hypercitrullinemia, hyperlactatemia, and hyperammonemia. The epilepsy was serine and pyridoxine responsive. Zebrafish and mouse models were used to validate brain developmental and functional defects and to test therapeutic strategies. GOT2 encodes the mitochondrial glutamate oxaloacetate transaminase. GOT2 enzyme activity was deficient in fibroblasts with bi-allelic mutations. GOT2, a member of the malate-aspartate shuttle, plays an essential role in the intracellular NAD(H) redox balance. De novo serine biosynthesis was impaired in fibroblasts with GOT2 mutations and GOT2-knockout HEK293 cells. Correcting the highly oxidized cytosolic NAD-redox state by pyruvate supplementation restored serine biosynthesis in GOT2-deficient cells. Knockdown of got2a in zebrafish resulted in a brain developmental defect associated with seizure-like electroencephalog. spikes, which could be rescued by supplying pyridoxine in embryo water. Both pyridoxine and serine synergistically rescued embryonic developmental defects in zebrafish got2a morphants. Our data provide a mechanistic basis for the biochem. abnormalities in GOT2 deficiency that may also hold for other MAS defects.

American Journal of Human Genetics published new progress about Alleles. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Balmaseda, Aitor published the artcileImpact of changes in wine composition produced by non-Saccharomyces on malolactic fermentation, Synthetic Route of 97-67-6, the main research area is Oenococcus Torulaspora Saccharomyces wine malolactic fermentation; Malolactic fermentation; Non-Saccharomyces; Oenococcus oeni; Wine.

Non-Saccharomyces yeasts have increasingly been used in vinification recently. This is particularly true of Torulaspora delbrueckii and Metschnikowia pulcherrima, which are inoculated before S. cerevisiae, to complete a sequential alc. fermentation This paper aims to study the effects of these two non-Saccharomyces yeasts on malolactic fermentation (MLF) carried out by two strains of Oenococcus oeni, under cellar conditions. Oenol. parameters, and volatile and phenolic compounds were analyzed in wines. The wines were tasted, and the microorganisms identified. In general, non-Saccharomyces created more MLF friendly conditions, largely because of lower concentrations of SO2 and medium chain fatty acids. The most favorable results were observed in wines inoculated with T. delbrueckii, that seemed to promote the development of O. oeni and improve MLF performance.

International Journal of Food Microbiology published new progress about Alleles. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kuerban, Mireadili published the artcileTargeting low-phytate soybean genotypes without compromising desirable phosphorus-acquisition traits, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is phytate phosphorus acquisition soybean genotype; carboxylates; phosphorus-acquisition efficiency; phytate; root morphology; soybean germplasm.

Phytate-phosphorus (P) in food and feed is not efficiently utilized by humans and nonruminant livestock, potentially contributing to high losses of P to the environment. Crops with high P-acquisition efficiency can access soil P effectively. It remains elusive whether crop genotypes with high P-acquisition efficiency can also have low seed phytate concentrations A core collection of 256 soybean [Glycine max (L.) Merr.] genotypes from China with diverse genetic background were grown in the same environment and seeds were sampled to screen for seed phytate-P concentration Some of these genotypes were also grown in a low-P soil in the glasshouse to measure root morphol. and physiol. traits related to P acquisition. Large genotypic variation was found in seed phytate-P concentration (0.69-5.49 mg P g-1 dry weight), total root length, root surface area, rhizosheath carboxylates, and acid phosphatase activity in rhizosheath soil. Geog., seed phytate-P concentration was the highest for the genotypes from Hainan Province, whereas it was the lowest for the genotypes from Inner Mongolia. Seed phytate-P concentration showed no correlation with any desirable root traits associated with enhanced P acquisition. Two genotypes (Siliyuan and Diliuhuangdou-2) with both low phytate concentrations and highly desirable P-acquisition traits were identified. This is the first study to show that some soybean genotypes have extremely low seed phytate concentrations, combined with important root traits for efficient P acquisition, offering material for breeding genotypes with low seed phytate-P concentrations

Frontiers in Genetics published new progress about Anatomy. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Park, Sang-Seo published the artcileExercise attenuates maternal separation-induced mood disorder-like behaviors by enhancing mitochondrial functions and neuroplasticity in the dorsal raphe, Formula: C4H6O5, the main research area is biomarker exercise animal behavior maternal separation neuroplasticity mood disorder; caspase Bax dorsal raphe mitochondrial dysfunction mood disorder; Apoptosis; Dorsal raphe; Exercise; Maternal separation; Mitochondria; Mood disorder.

Loss of the mother-infant relationship during early childhood affects infant development and is known to increase the infant’s vulnerability to neuropsychiatric disorders throughout life. Serotonin deficits and mitochondrial dysfunction in the dorsal raphe may underlie mood disorders such as anxiety and depression. Exercise is known to have a pos. effect on brain function. In this study, we investigated the effect of exercise on mitochondrial function, apoptosis, and serotonin levels in the dorsal raphe as well as behavioral changes in cases of maternal separation Exposure to the stress of maternal separation resulted in mitochondrial dysfunction in the dorsal raphe, including impaired Ca2+ homeostasis, an increase in reactive oxygen species such as H2O2, and a decrease in the O2 respiration rate. Exposure to maternal separation stress also decreased tryptophan hydroxylase and 5-hydroxytryptamine pos. cells and increased apoptosis, anxiety, and depression. The impairments in mitochondrial function, apoptosis, and serotonin in the dorsal raphe, as well as anxiety and depression, were all improved by exercise. Exercise might alter mitochondrial function, serotonin levels, and the rate of apoptosis in the dorsal raphe. Therefore, exercise might be an important non-pharmacol. intervention for the prevention and treatment of the adverse effects of maternal separation

Behavioural Brain Research published new progress about Anxiety. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts