Tag: M.W=100-150

Khodja, Maroua published the artcileTuning nanotubular structures by templateless electropolymerization with thieno[3,4-b]thiophene-based monomers with different substituents and water content, Synthetic Route of 2240-88-2, the publication is Journal of Colloid and Interface Science (2020), 19-27, database is CAplus and MEDLINE.

Here, templateless electropolymerization is employed to produce nanotubular structures from various thieno[3,4-b]thiophene-based monomers that differ in substituent structure and size, as well as the linker connecting the thieno[3,4-b]thiophene core and substituent. The formation of densely packed vertically aligned are obtained from monomers with a pyrene substituent and when a significant amount of water (CH₂Cl₂ + H₂O) is included in the solvent. The geometrical parameters of the nanotubes are highly dependent on the electopolymn. method. A significant amount of air is trapped within the structure of the densely packed open nanotubes obtained with Qs = 100 mC cm^-2 causing an increase in water contact angle (θ_w) up to 82.6° (intermediate state between the Wenzel and the Cassie-Baxter state), and θ_w can become even more hydrophobic by further modifying the deposition method or the electrolyte.

Journal of Colloid and Interface Science published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Lingxiao published the artcileHydrogen-Free Production of 4-Alkylphenols from Lignin via Self-Reforming-Driven Depolymerization and Hydrogenolysis, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2020), 10(24), 15197-15206, database is CAplus.

Lignin is constructed from methoxylated phenylpropanoid with plenty of hydroxy and methoxy groups. Its conversion to valuable products is extremely attractive but especially challenging without addnl. hydrogen sources. Herein we report a hydrogen-free production of 4-alkylphenols directly from native lignin via self-reforming-driven depolymerization and hydrogenolysis over Pt/NiAl₂O₄. This is the first example of acquiring 4-alkylphenols from native lignin. Using this strategy, high yields of 4-alkylphenols, 17.3 wt %, were obtained from birch lignin. Reaction pathway and mechanism studies revealed that this strategy initiates from the reforming of aliphatic hydroxys, followed by the cleavage of C-O linkages, and ends via demethoxylation over Pt/NiAl₂O₄. Moreover, the subsequent aqueous phase reforming of the as-formed methanol accelerates the whole process. This strategy realizes the one-pot production of 4-alkylphenols from lignin by fully utilizing the structural hydrogen in lignin and H₂O, providing a low-cost and safe method of lignin valorization.

ACS Catalysis published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marques, Michael A. published the artcileToward an understanding of the chemical etiology for DNA minor-groove recognition by polyamides, Safety of Thiophen-3-ol, the publication is Helvetica Chimica Acta (2002), 85(12), 4485-4517, database is CAplus.

Crescent-shaped polyamides composed of aromatic amino acids, i.e., 1-methyl-1H-imidazole Im, 1-methyl-1H-pyrrole Py, and 3-hydroxy-1H-pyrrole Hp, bind in the minor groove of DNA as 2:1 and 1:1 ligand/DNA complexes. DNA-Sequence specificity can be attributed to shape-selective recognition and the unique corners or pairs of corners presented by each heterocycle(s) to the edges of the base pairs on the floor of the minor groove. Here we examine the relationship between heterocycle structure and DNA-sequence specificity for a family of five-membered aromatic amino acids. By means of quant. DNase-I footprinting, the recognition behavior of polyamides containing eight different aromatic amino acids, i.e., 1-methyl-1H-pyrazole Pz, 1H-pyrrole Nh, 5-methylthiazole Nt, 4-methylthiazole Th, 3-methylthiophene Tn, thiophene Tp, 3-hydroxythiophene Ht, and furan Fr, were compared with the polyamides containing the parent-ring amino acids Py, Im, and Hp for their ability to discriminate between the four Watson-Crick base pairs in the DNA minor groove. Anal. of the data and mol. modeling showed that the geometry inherent to each heterocycle plays a significant role in the ability of polyamides to differentiate between DNA sequences. Binding appears sensitive to changes in curvature complementarity between the polyamide and DNA. The Tn/Py pair affords a modest 3-fold discrimination of T · A vs. A · T and suggests that an S-atom in the thiophene ring prefers to lie opposite T not A.

Helvetica Chimica Acta published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Safety of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Mei published the artcileNovel HIV-1 Protease Inhibitors with Morpholine as the P2 Ligand to Enhance Activity against DRV-Resistant Variants, Application of 2-Morpholinoethanol, the publication is ACS Medicinal Chemistry Letters (2020), 11(6), 1196-1204, database is CAplus and MEDLINE.

Flexible heterocyclic moieties as the P2 ligands of HIV-1 protease inhibitors may be adapted to the minimally distorted active site of mutations easily and enhance activity against DRV-resistant HIV-1 variants. Herein, the design, synthesis, and biol. evaluation of a new series of inhibitors containing morpholine derivatives as the P2 ligands were described, among which, carbamate inhibitor I and carbamido inhibitor II exhibited almost 4- and 2-fold superior activity with enzyme Ki of 0.092 nM and 0.21 nM, as well as antiviral IC50 values of 0.41 nM and 0.95 nM, resp., compared to DRV. Besides, they exhibited excellent activity with inhibition of 94% and 91%, resp. Furthermore, they also showed appreciable antiviral activity against DRV-resistant HIV-1 variants.

ACS Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H6BrF3S, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kassie, Abebu A. published the artcileSynthesis and Reactivity of Zr MOFs Assembled from P^NN^NP-Ru Pincer Complexes, Recommanded Product: Triethylsilanol, the publication is Organometallics (2019), 38(18), 3419-3428, database is CAplus.

Three isostructural Zr metal-organic frameworks were synthesized from P^NN^NP-Ru pincer metallolinkers bearing different combinations of ancillary ligands (1, Zr₆O₄(OH)₄(OAc)₄{cis-(P^NN^NP)RuCl₂(CO)}₂; 2, Zr₆O₄(OH)₄(O₂CH)₄{(P^NN^NP)RuCl(CO)₂}₂Cl₂; 3, Zr₆O₄(OH)₄(OAc)₄{cis-/trans-(P^NN^NP)RuCl₂(CO)}₂; P^NN^NP = 2,6-(HNPAr₂)₂C₅H₃N; Ar = p-C₆H₄CO₂^–). The structure and composition of the P^NN^NP-Ru pincer MOFs were determined using synchrotron X-ray powder diffraction, solid- and solution-state NMR spectroscopy, IR spectroscopy, and elemental anal. Reaction of 2 with KO^tBu results in deprotonation of an NH group of the P^NN^NP-RuCl(CO)₂ linkers. Subsequent treatment with Me₃NO removes a Ru-coordinated CO ligand, generating 2–b (5), which proved to be a recyclable catalyst for the hydrosilylation of aryl aldehydes with Et₃SiH. A similar postsynthetic treatment of 1 and 3 does not generate active catalysts, highlighting the importance of precatalyst design and activation. A homogeneous analog of 2–b also showed inferior catalytic performance, demonstrating the benefit of catalyst immobilization.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Pipeng published the artcileResonance energies and tautomerism of substituted aromatic heterocycles and their benzo derivatives, COA of Formula: C4H4OS, the publication is Youji Huaxue (1991), 11(6), 620-3, database is CAplus.

The recently developed quantified resonance theory (QRT) has been applied to substituted aromatic five- and six-membered heterocycles and their benzo derivatives The calculated resonance energy differences ΔRE between tautomeric forms agree with those estimated from tautomeric equilibrium data for the 2- and 4-pyridone, 2-quinolone and 1-isoquinolone series. For tautomerism of extensive heteroaromatic compounds in solution, the ΔRE and the differences in heats of atomization ΔΔH₃ calculated by QRT can be used to rationalize and predict the predominant tautomer and the shifting trend in the equilibrium for a series of similar compounds

Youji Huaxue published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C22H12F6O6S2, COA of Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Na published the artcileToward Alkylphenols Production: Lignin Depolymerization Coupling with Methoxy Removal over Supported MoS₂ Catalyst, Recommanded Product: 4-Propylphenol, the publication is Industrial & Engineering Chemistry Research (2020), 59(39), 17287-17299, database is CAplus.

Alkylphenols are indispensable chems. that are currently derived from fossil resources. Conversion of lignin into alkylphenols in a selective manner is highly desirable, while it represents one of the biggest challenges in biorefinery. Herein, lignin depolymerization coupling with methoxy removal over supported MoS₂ catalyst for the direct production of alkylphenols has been studied. The catalysts were prepared by incipient wetness impregnation and characterized by N₂ physisorption, XRD, NH₃-TPD, CO chemisorption, ICP, TEM, and XPS. The catalytic performance and the reaction mechanism were initially assessed by the hydrodeoxygenation (HDO) of eugenol. Among the catalysts with MoS₂ supported on different supports (HZSM-5, SAPO-34, SiO₂, Al₂O₃, and activated carbon (AC)), the acid-rich MoS₂/AC with high sp. surface areas and more exposed MoS₂ edge sites owed a complete conversion of eugenol and 64.8% yield of 4-propylphenol under 3 MPa H₂ at 300°C for 3 h. In the conversion of lignin-oil, MoS₂/AC catalyst also exhibited excellent activity in the removal of all the methoxy groups in various aromatic monomers, achieving alkylphenols with selectivity up to 76.2%. Notably, this catalytic system also showed potential in simultaneous hydrocracking coupling with methoxy removal of realistic lignin to afford alkylphenols, thus providing a direct strategy for the selective valorization of lignin.

Industrial & Engineering Chemistry Research published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manker, Lorenz P. published the artcileSustainable polyesters via direct functionalization of lignocellulosic sugars, Recommanded Product: Pentane-1,5-diol, the publication is Nature Chemistry, database is CAplus and MEDLINE.

The development of sustainable plastics from abundant renewable feedstocks was limited by the complexity and efficiency of their production, as well as their lack of competitive material properties. Here the authors demonstrate the direct transformation of the hemicellulosic fraction of nonedible biomass into a tricyclic diester plastic precursor at 83% yield (95% from com. xylose) during integrated plant fractionation with glyoxylic acid. Melt polycondensation of the resulting diester with a range of aliphatic diols led to amorphous polyesters (M_n = 30-60 kDa) with high glass transition temperatures (72-100°), tough mech. properties (ultimate tensile strengths of 63-77 MPa, tensile moduli of 2,000-2,500 MPa and elongations at break of 50-80%) and strong gas barriers (oxygen transmission rates (100 μm) of 11-24 cc m^-2 day^-1 bar^-1 and H₂O vapor transmission rates (100 μm) of 25-36 g m^-2 day^-1) that could be processed by injection molding, thermoforming, twin-screw extrusion and 3-dimensional printing. Although standardized biodegradation studies still need to be performed, the inherently degradable nature of facilitated their chem. recycling via methanolysis at 64°, and eventual depolymerization in room-temperature H₂O. [graphic not available: see fulltext].

Nature Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Woelke, Christian published the artcileUnderstanding the Effectiveness of Phospholane Electrolyte Additives in Lithium-Ion Batteries under High-Voltage Conditions, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is ChemElectroChem (2021), 8(5), 972-982, database is CAplus.

Six phospholane functional electrolyte additives that enable the formation of an effective cathode electrolyte interphase (CEI) via a polymerization reaction on the electrode surface were designed, synthesized, and comparatively analyzed by means of complementary exptl. and computational methods in order to understand their mode of action in NMC111||graphite battery cells under high voltage conditions. Two reaction mechanisms, namely a phosphate-based and a phosphonate-based mechanism, were postulated and, based on systematic anal., the phosphate mechanism was identified as the more likely. Direct correlation of the phospholane’s structural features and relevant properties impacting the direct correlation of the phospholane’s structural features and relevant properties impacting the overall cycling performance of NMC111||graphite cells, as depicted by capacity retention, stands for a vital example approach towards identifying promising electrolyte components for advanced, targeted applications.

ChemElectroChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C9H7NO4, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reed, John H. published the artcileA 1,3,2-Diazaphospholene-Catalyzed Reductive Claisen Rearrangement, Synthetic Route of 83706-94-9, the publication is Angewandte Chemie, International Edition (2019), 58(26), 8893-8897, database is CAplus and MEDLINE.

1,3,2-Diazaphospholenes (DAPs) are an emerging class of organic hydrides. In this work, we exploited them as efficient catalysts for very mild reductive Claisen rearrangements. The method is tolerant towards a wide variety of functional groups and operates at ambient temperature Besides being enantiospecific for substrates with existing stereogenic centers, the diastereoselectivity can be switched by varying solvents and DAP catalysts. The reaction kinetics show direct rearrangements of O-bound phospholene enolates and provide a proof-of-principle for catalytic enantioselective reactions.

Angewandte Chemie, International Edition published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Synthetic Route of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts