Tag: M.W=100-150

Maharvi, Ghulam M. published the artcileA synthesis of the γ-secretase inhibitor BMS-708163, SDS of cas: 2240-88-2, the publication is Tetrahedron Letters (2010), 51(50), 6542-6544, database is CAplus.

A concise, convergent racemic synthesis of BMS-708163 (I) was reported. Two fragments consisting of N-4-chlorophenylsulfonyl-3,3,3-trifluoropropylglycine and a 1,2,4-oxadiazole derivative of 2-fluorobenzyl alc. were prepared in sep. pots and then coupled together via a Mitsunobu reaction. Since a convenient chiral synthesis of optically pure (D)-3,3,3-trifluoropropyl glycine Me ester was developed using Schoellkopf reagent alkylation, this methodol. can also be adopted for the enantioselective synthesis of BMS-708163.

Tetrahedron Letters published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jintao published the artcileCopper-catalyzed aerobic oxidation of silanes to silanols, Computed Properties of 597-52-4, the publication is Changzhou Daxue Xuebao, Ziran Kexueban (2016), 28(1), 43-47, database is CAplus.

The Cu(OAc)₂-catalyzed selective hydrolytic oxidation of silanes toward the silanols using water as the oxidant was achieved. All the products were characterized by ¹H NMR, ¹³C NMR and GCMS. Compared with other methods, this silane hydrolysis protocol is featured with the solvent-free mild reaction conditions using H₂O as clean oxidant with good substrate compatibility. This work provides a new approach toward the synthesis of silanols.

Changzhou Daxue Xuebao, Ziran Kexueban published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C15H12O6, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaoman published the artcileCatalyst- and Metal-Free Photo-Oxidative Coupling of Thiols with BrCCl₃, Recommanded Product: 2-Phenylethanethiol, the publication is European Journal of Organic Chemistry (2022), 2022(23), e202200340, database is CAplus.

This paper reported a catalyst- and metal-free method to construct disulfide bond with BrCCl₃ under light irradiation This clean and mild reaction promoted the oxidative coupling of thiols with wide substrate scope, and was applicable to benzylic, aryl and aliphatic thiols, especially cysteine derivative The disulfides were obtained in high yields up to 98%, avoiding the use of heating, strong oxidant, metal reagent or catalyst. This facile strategy facilitated the synthesis of disulfide compounds

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang Teo, Alan Kay published the artcileA novel iron complex for highly efficient catalytic hydrogen generation from the hydrolysis of organosilanes, Name: Triethylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(54), 7191-7194, database is CAplus and MEDLINE.

Hydrolytic oxidation of organosilanes based on an iron catalyst is described for the first time. The novel iron complex, [Fe(C₆H₅N₂O)(CO)(MeCN)₃][PF₆], exhibits excellent mediating power in the catalytic hydrolysis of organosilanes to produce dihydrogen and organosilanols with turnover numbers approaching 10⁴ and turnover frequencies in excess of 10² min^-1 under ambient conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Pin published the artcileEnantioselective Radical Trifluoromethylation of Benzylic C-H Bonds via Cooperative Photoredox and Copper Catalysis, Quality Control of 645-56-7, the publication is Journal of the American Chemical Society (2022), 144(30), 13468-13474, database is CAplus and MEDLINE.

The first enantioselective radical trifluoromethylation of benzylic C-H bonds has been established by a cooperative photoredox and copper catalysis system, providing straightforward access to structurally diverse benzylic trifluoromethylation products RCH(CF₃)CH₂R¹ [R = Ph, 2-phenyl-1,3-benzothiazol-6-yl, 4-cyclopropylphenyl, etc.; R¹ = H, n-Pr, 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl, 2-chloroethyl, etc.] in good yields with excellent enantioselectivities under mild conditions. A broad substrate scope and excellent functional group compatibility were reported. Merging the cooperative photoredox catalysis with copper catalysis is essential for the reaction, where the photoredox catalysis is used for the generation of benzylic radicals from alkyl arenes alkyl arenes RCH₂CH₂R¹ through a hydrogen atom transfer process and the copper catalysis is used for the enantioselective trifluoromethylation of the benzylic radicals.

Journal of the American Chemical Society published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C16H14O6, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Shuting published the artcileDNA-compatible diversification of indole π-activated alcohols via a direct dehydrative coupling strategy, Quality Control of 4410-99-5, the publication is Organic Letters (2022), 24(4), 1022-1026, database is CAplus and MEDLINE.

Indole-based diversification is highly desired in the DNA-encoded chem. library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alc. formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely com. available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C3H3Br2ClO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dindarloo Inaloo, Iman published the artcileNickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride, Application of Thiophen-3-ol, the publication is ChemCatChem (2020), 12(21), 5486-5491, database is CAplus.

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates ArNHC(O)OR (Ar = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R = Pr, cyclohexyl, allyl, etc.) through the reaction between alcs. ROH and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C-O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

ChemCatChem published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolano, Tamara published the artcileAn Acyl-NHC Osmium Cooperative System: Coordination of Small Molecules and Heterolytic B-H and O-H Bond Activation, Name: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Organometallics (2015), 34(15), 3902-3908, database is CAplus.

The hexahydride complex OsH₆(PⁱPr₃)₂ (1) activates the C-OMe bond of 1-(2-methoxy-2-oxoethyl)-3-methylimidazolium chloride (2), in addition to promoting the direct metalation of the imidazolium group, to afford a five-coordinate OsCl(acyl-NHC)(PⁱPr₃)₂ (3) compound The latter coordinates carbon monoxide, oxygen, and mol. hydrogen to give the corresponding carbonyl (4), dioxygen (5), and dihydrogen (6) derivatives Complex 3 also promotes the heterolytic bond activation of pinacolborane (HBpin), using the acyl oxygen atom as a pendant Lewis base. The hydride ligand and the Bpin substituent of the Fischer-type carbene of the resulting complex 7 activate the O-H bond of alcs. and water. As a consequence, complex 3 is a metal ligand cooperating catalyst for the generation of mol. hydrogen, by both the alcoholysis and hydrolysis of pinacolborane, via the intermediates 7 and 6.

Organometallics published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Name: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sparkes, Emily I. published the artcileBiocatalytic Silylation: The Condensation of Phenols and Alcohols with Triethylsilanol, Category: alcohols-buliding-blocks, the publication is Catalysts (2021), 11(8), 879, database is CAplus.

Silicatein-α (Silα), a hydrolytic enzyme derived from siliceous marine sponges, is one of the few enzymes in nature capable of catalyzing the metathesis of silicon-oxygen bonds. It is therefore of interest as a possible biocatalyst for the synthesis of organosiloxanes. To further investigate the substrate scope of this enzyme, a series of condensation reactions with a variety of phenols and aliphatic alcs. were carried out. In general, it was observed that Silα demonstrated a preference for phenols, though the conversions were relatively modest in most cases. In the two pairs of chiral alcs. that were investigated, it was found that the enzyme displayed a preference for the silylation of the S-enantiomers. Addnl., the enzyme′s tolerance to a range of solvents was tested. Silα had the highest level of substrate conversion in the nonpolar solvents n-octane and toluene, although the inclusion of up to 20% of 1,4-dioxane was tolerated. These results suggest that Silα is a potential candidate for directed evolution toward future application as a robust and selective biocatalyst for organosiloxane chem.

Catalysts published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C11H11BFNO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kreevoy, Maurice M. published the artcileEffect of structure on mercaptan dissociation constants, HPLC of Formula: 73303-88-5, the publication is Journal of Organic Chemistry (1964), 29(6), 1641-2, database is CAplus.

A redetn. of the K_A for PhSH, and also a number of other K_A values, some new and some redtd., were reported. It was concluded that there was no Baker-Nathan effect, but that there was a resonance exaltation of mercaptan dissociation constants of ∼1.3 log units for conjugated mercaptans. These results were given in a table for RSH when R was as follows: Ac, Ph, (2-pyridyl)methyl, EtO₂CCH₂CH₂, HOCH₂CMe₂ Me, tert-Bu, and tert-Am. These results were discussed.

Journal of Organic Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, HPLC of Formula: 73303-88-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts