Tag: M.W=100-150

Medina-Ramirez, Iliana E. published the artcileSilylated gallium and indium chalcogenide ring systems as potential precursors to ME (E = O, S) materials, Computed Properties of 597-52-4, the publication is Central European Journal of Chemistry (2013), 11(7), 1225-1238, database is CAplus.

The reaction of R₃M (M = Ga, In) with HESiR’₃ (E = O, S; R’₃=Ph₃, ⁱPr₃, Et₃, ^tBuMe₂) leads to the formation of (Me₂GaOSiPh₃)₂ (1); (Me₂GaOSi^tBuMe₂)₂ (2); (Me₂GaOSiEt₃)₂ (3); (Me₂InOSiPh₃)₂ (4); (Me₂InOSi^tBuMe₂)₂ (5); (Me₂InOSiEt₃)₂ (6); (Me₂GaSSiPh₃)₂ (7); (Et₂GaSSiPh₃)₂ (8); (Me₂GaSSiⁱPr₃)₂ (9); (Et₂GaSSiⁱPr₃)₂ (10); (Me₂InSSiPh₃)₃ (11); (Me₂InSSiⁱPr₃)_n (12), in high yields at room temperature The compounds have been characterized by multinuclear NMR and in most cases by x-ray crystallog. The mol. structures of (1), (4), (7) and (8) have been determined Compounds (3), (6) and (10) are liquids at room temperature In the solid state, (1), (4), (7) and (9) are dimers with central core of the dimer being composed of a M₂E₂ four-membered ring. VT-NMR studies of (7) show facile redistribution between four- and six-membered rings in solution The thermal decomposition of (1)-(12) was examined by TGA and range from 200 to 350°. Bulk pyrolysis of (1) and (2) led to the formation of Ga₂O₃; (4) and (5) In metal; (7)-(10) GaS and (11)-(12) InS powders, resp.

Central European Journal of Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bell, Mark published the artcileDiscovery of super soft-drug modulators of sphingosine-1-phosphate receptor 1, Related Products of alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(19), 3255-3259, database is CAplus and MEDLINE.

The oral S1PR1 agonist ponesimod demonstrated substantial efficacy in a phase II clin. trial of psoriasis. Unfortunately, systemic side effects were observed, which included lymphopenia and transient bradycardia. We sought to develop a topical soft-drug S1PR1 agonist with an improved therapeutic index. By modifying ponesimod, we discovered an ester series of S1PR agonists. To increase metabolic instability in plasma we synthesized esters described as specific substrates for paraoxonase and butyrylcholinesterases, esterases present in human plasma.

Bioorganic & Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rozsar, Daniel published the artcileBifunctional Iminophosphorane Catalyzed Enantioselective Sulfa-Michael Addition to Unactivated α,β-Unsaturated Amides, Application of 2-Phenylethanethiol, the publication is Journal of the American Chemical Society (2022), 144(2), 1006-1015, database is CAplus and MEDLINE.

The first metal-free catalytic intermol. enantioselective Michael addition to unactivated α,β-unsaturated amides was described. Consistently high enantiomeric excesses and yields were obtained over a wide range of alkyl thiol pronucleophiles and electrophiles under mild reaction conditions, enabled by a novel squaramide-based bifunctional iminophosphorane (BIMP) catalyst. Low catalyst loadings (2.0 mol %) were achieved on a decagram scale, demonstrating the scalability of the reaction. Computational anal. revealed the origin of the high enantiofacial selectivity via anal. of relevant transition structures and provided substantial support for specific noncovalent activation of the carbonyl group of the α,β-unsaturated amide by the catalyst.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marcinkowska, Monika published the artcileKey Odorants of Raw and Cooked Green Kohlrabi (Brassica oleracea var. gongylodes L.), Computed Properties of 4410-99-5, the publication is Journal of Agricultural and Food Chemistry (2021), 69(41), 12270-12277, database is CAplus and MEDLINE.

Volatile compounds of raw and cooked green kohlrabi were investigated using a sensomics approach. A total of 55 odor-active compounds were detected and identified in raw and cooked green kohlrabi using GC-O. Twenty-eight odor-active compounds with high flavor dilution (FD) factors ranging from 64 to 1024 were quantitated, and odor activity values (OAVs) were determined Eight compounds showed high OAVs in raw and cooked kohlrabi: five sulfur compounds (di-Me trisulfide, Me 2-methyl-3-furyl disulfide, and three isothiocyanates (1-isothiocyanato-3-(methylsulfanyl)propane, benzyl isothiocyanate, and 1-isothiocyanato-4-(methylsulfanyl)butane)), two lipid oxidation products (1-octen-3-one and trans-4,5-epoxy-(2E)-dec-2-enal), and 2-isopropyl-3-methoxypyrazine. Among these, the sulfur compounds contributed most to the overall smell of the raw and cooked vegetables. The quantitation anal. indicates that the eight odorants are the backbone compounds for raw and cooked kohlrabi. The OAVs for the backbone compounds and also for minor odorants are clearly higher in raw kohlrabi than in the cooked one. Differences can be explained by the influence of the cooking process.

Journal of Agricultural and Food Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Haibin published the artcileColloidal self-assembly based all-metal metasurface absorbers to achieve broadband, polarization-independent light absorption at UV-Vis frequencies, HPLC of Formula: 111-29-5, the publication is Applied Surface Science (2022), 152624, database is CAplus.

Here, we demonstrate a straightforward colloidal self-assembly strategy to fabricate metasurface absorbers (MAs) with efficient broadband light absorption from UV to visible (Vis) spectral range. In this study, high-index faceted colloidal Au nanocrystals (NCs), i.e., Au icosidodecahedron with active surface plasmonic modes, are innovatively designed as the meta-atoms, while a facile electrostatic self-assembly progress is implemented to arrange these meta-atoms onto a gold reflecting film, resulting in MAs with all-metal structures. Optical characterizations show that the well-designed MAs with a 28-32% surface coverage of Au meta-atoms exhibit an average light absorption above 94% within the wavelengths ranging from 200 to 600 nm. Moreover, the particular absorption behaviors of the designed MAs are inherently polarization-independent for a broad range of incident angles (0-45°) owing to the ultrathin structure and topol. symmetry of the devices. It has been inferred that the pos. localized surface plasmon and gap plasmon resonances excited from the adjacent Au meta-atoms and gold film are critical for self-assembled MAs with excellent absorbing performances. Overall, this work provide an alternative and simple pathway for the construction of scalable and practical UV-Vis MAs, which may facilitate the high-frequency optical applications of thermophotovoltaics, photoelec. devices and photochem. systems.

Applied Surface Science published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C20H32B2O4, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Qinghua published the artcile¹⁹F magnetic resonance imaging enabled real-time, non-invasive and precise localization and quantification of the degradation rate of hydrogel scaffolds in vivo, Name: 3,3,3-Trifluoropropan-1-ol, the publication is Biomaterials Science (2020), 8(12), 3301-3309, database is CAplus and MEDLINE.

The degradation behavior of hydrogel scaffolds is closely related to the controlled release of bioactive agents and matching with the proliferative demands of newly generated tissues. Here, for the first time, we presented the use of ¹⁹F magnetic resonance imaging (¹⁹F MRI) to precisely monitor the localization and quantify the degradation rate of implantable or injectable hydrogels in a real-time and noninvasive manner, with no interference of endogenous background signals and limitation of penetration depth. The total voxel and content in the region of interest (ROI) were linearly correlated to the injection amount, providing exact 3D stereoscopic and 2D anatomical information in the meantime. Moreover, a computational algorithm was established to present the real-time degradation rate in vivo as a function of time, which was implemented directly from the ¹⁹F MRI dataset. In addition, labeling with a zwitterionic ¹⁹F contrast agent demonstrated a facile and general applicability for multiple types of materials with no influence on their original gelation properties as well as ¹⁹F NMR properties in the hydrogel matrix. Therefore, this ¹⁹F MRI method offers a new approach to non-invasively track the degradation rate of hydrogel scaffolds in vivo in a precise localization and accurate quantification way, which will suffice the need for the evaluation of implants at deep depths in large animals or human objects.

Biomaterials Science published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Name: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Garces, Karin published the artcileIridium-Catalyzed Hydrogen Production from Hydrosilanes and Water, Formula: C6H16OSi, the publication is ChemCatChem (2014), 6(6), 1691-1697, database is CAplus.

The iridium(III) complex [Ir(H)(CF₃SO₃)(NSiN)(coe)] (NSiN=fac-coordinated bis(pyridine-2-yloxy)methylsilyl, coe=cyclooctene) has been proven to be an effective catalyst precursor for hydrogen production from the hydrolysis of hydrosilanes at room temperature The reaction performance depends both on the nature of the silane and the solvent. Interestingly, high turnover frequencies of around 10⁵ h^-1 were obtained by using Et₂SiH₂ or (Me₂HSi)₂O as hydrogen sources and THF as the solvent. Moreover a mechanistic insight into this Ir-catalyzed hydrogen generation process, based on both theor. calculations and NMR spectroscopy, is reported. The overall catalytic cycle can be viewed as a two-stage process that involves water-promoted Si-H bond activation followed by water splitting by a proton transfer.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martins, Marcia S. published the artcileOccurrence of Allergens in Cosmetics for Sensitive Skin, Quality Control of 111-29-5, the publication is Cosmetics (2022), 9(2), 32, database is CAplus.

Sensitive skin is characterized by symptoms such as stinging and tingling in response to stimuli that usually do not cause unpleasant sensations. Epidemiol. studies show that individuals with sensitive skin are more prone to developing skin allergies, although the link between both conditions is unknown. Aiming to evaluate the presence of allergens in facial-skin products for sensitive skin, a pool of 88 cosmetic products from international brands marketed in pharmacies and parapharmacies was analyzed. A list of allergens identified in product labels was compiled and grouped according to their function. Fragrances were the most common allergens, followed by skin-conditioning agents, surfactants, and preservatives. Fragrances presenting the highest use percentages were linalool, benzyl alc., geraniol, and citronellol. Overall, the majority of cosmetic formulations were absent of fragrance allergens, being present only in 7% of products. Other allergens were found in most products (95%). This finding should be interpreted with caution, since many of these compounds are rare sensitizers and studies demonstrating their risk for individuals with sensitive skin are lacking. With this study, useful information for health professionals is provided to support their advice and to help consumers choosing cosmetic products.

Cosmetics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bettinger, Holger F. published the artcileMetal-free conversion of methane and cycloalkanes to amines and amides by employing a borylnitrene, Synthetic Route of 25240-59-9, the publication is Angewandte Chemie, International Edition (2008), 47(25), 4744-4747, database is CAplus and MEDLINE.

C-H insertion: Borylnitrenes, which were generated in situ by photolysis of azides, convert unactivated alkanes by intermol. C-H insertion into aminoboranes, which in turn can be reacted further to give amines or amides. The boryl group serves two purposes: it converts the nitrene into a highly reactive BN vinylidene analog, and it is easily cleaved from the product. Caution: B azides may be explosive, and appropriate precautions must be taken when handling these compounds To study the reaction of catechol borylnitrene (C₆H₄O₂BN:, 1a) with methane, the authors isolated 2-azido-1,3,2-benzodioxaborole (C₆H₄O₂BN₃, 3a) in Ar doped with methane (1-2% CH₄ or CD₄) at 10 K. Photolysis of 3a using UV irradiation resulted in the complete disappearance of 3a, the concomitant formation of nitrene C₆H₄O₂BN: (1a) and of aminoborane C₆H₄O₂BN(H)Me (2a) according to IR spectra and DFT calculations of vibrational modes. Reaction of trimethylsilyl azide and 2-chloro-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (pinacolboron chloride (pinBCl)) gave 2-azido-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (3b, pinacolboron azide (pinBN₃)) in 96% yield. Photolysis of 3b in cycloalkane solutions at room temperature afforded the expected aminoboranes pinBN(H)R (R = cyclopentyl, cyclohexyl, cycloheptyl) in 79% to 85% yield. The aminoboranes can conveniently be transformed into the corresponding primary amines or amides by alcoholysis or acylation, resp. The mol. structures of pinBN(H)R (R = cyclopentyl, cyclohexyl) were determined by x-ray crystallog.

Angewandte Chemie, International Edition published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Synthetic Route of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Crozals, Gabriel published the artcileMethylene blue phosphoramidite for DNA labelling, Recommanded Product: 4-(Butylamino)butan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(21), 4458-4461, database is CAplus and MEDLINE.

We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochem. and optical properties of the resulting MB modified oligonucleotides were confirmed. This new mol. is an important breakthrough in the design of new probes labeled with MB.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Recommanded Product: 4-(Butylamino)butan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts