Tag: M.W=100-150

Qiao, Lin published the artcileScreening of ToxCast Chemicals Responsible for Human Adverse Outcomes with Exposure to Ambient Air, COA of Formula: C9H12O, the publication is Environmental Science & Technology (2022), 56(11), 7288-7297, database is CAplus and MEDLINE.

Air pollution poses a major threat to global public health. Although there have been a few investigations into the relationships between organic pollutants and adverse outcomes, the responsible components and mol. mechanisms may be ignored. In this study, a suspect screening method combining comprehensive two-dimensional gas chromatog. – time-of-flight mass spectrometry (GC x GC-TOFMS) with Toxicity Forecaster (ToxCast) database was applied to analyze complex hydrophobic compounds in ambient air and prospectively figure out toxicol. significant compounds 76 ToxCast compounds were screened, including 7 pollutants receiving less attention and 5 chems. never published in the air previously. Given the concentrations, bioactivities, as well as absorption, distribution, metabolism, and excretion properties in vivo, 29 contaminants were assigned high priority since they had active biol. effects in the vascular, lung, liver, kidney, prostate and bone tissues. Phenotypic linkages of key pollutants to potential mechanistic pathways were explored by systems toxicol. A total of 267 chem.-effect pathways involving 29 toxicants and 31 mol. targets were mapped in bipartite network, in which 12 key pathogenic pathways were clarified, which not only provided the evidence supporting previous hypothesis but also provided new insights into the mol. targets. The results would facilitate the development of pollutant priority control, population intervention and clin. therapeutic strategies so as to substantially reduce human health hazards induced by urban air.

Environmental Science & Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tongfei published the artcileCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups, Computed Properties of 4410-99-5, the publication is RSC Advances (2021), 11(32), 19832-19835, database is CAplus and MEDLINE.

Here, a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans was developed, thioketal mols. I [R = Et, i-Pr, allyl, etc.; RR = (CH₂)₂; R² = Me, Ph] had been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment had been performed giving over 95% yield. This work allowed the straightforward formation of thioketals I containing CF₃ groups and unsaturated double bonds.

RSC Advances published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C7H15NO, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez, Tania published the artcileCatalytic CO₂ hydrosilylation with [Mn(CO)₅Br] under mild reaction conditions, Name: Triethylsilanol, the publication is Polyhedron (2021), 115242, database is CAplus.

Carbon dioxide hydrosilylation with earth-abundant transition-metal catalysts is an attractive alternative for the design of greener and cost-effective synthetic strategies. Herein, simple [Mn(CO)₅Br] is an efficient precatalyst in the hydrosilylation of carbon dioxide with Et₃SiH under mild reaction conditions. Using THF as a solvent, triethylsilylformate Et₃SiCH(O)O was obtained in 67% yield after 1 h at 50°C and 4 bar of CO₂ pressure. The selectivity of the reaction was tuned by changing the solvent to a mixture of THF and toluene producing bis(triethylsilyl)acetal (Et₃SiO)₂CH₂ in 86% yield. The CO₂ hydrosilylation was also effective at room temperature and atm. pressure using either THF or the mixture THF/toluene as the solvent resulting in high Et₃SiH conversion (92%-99%) but with a decrease in the selectivity. Radical trapping experiments indicated the participation of radical species in the catalytic mechanism. To the best of our knowledge, this is the first report on CO₂ hydrosilylation catalyzed by transition-metal radical intermediates.

Polyhedron published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Xiao-Ling published the artcileNetwork pharmacology study on mechanism of Zhen-Wu decoction for chronic heart failure treatment, Recommanded Product: 2-Phenylethanethiol, the publication is Drug Combination Therapy (2021), 3(1), 1, database is CAplus.

To explore and predict the mechanism of classic ancient prescription of Chinese medicine Zhen-Wu decoction for chronic heart failure treatment based on network pharmacol. Traditional Chinese medicine systems pharmacol. database was used to search the effective components and targets of herbs in classic ancient prescription of Chinese medicine Zhen-Wu decoction. Relevant target genes of chronic heart failure were obtained from GeneCards and Online Mendelian Inheritance in Man databases. Then we obtained the intersection target genes of classic ancient prescription of Chinese medicine Zhen-Wu decoction in treating chronic heart failure, constructing the classic ancient prescription of Chinese medicine Zhen-Wu decoction-active ingredient-chronic heart failure-targets network using Cytoscape, and performing network anal. using a network ananlyzer plug-in to acquire hub compounds and key targets. Proton pump inhibitor network was constructed through STRING database. Gene ontol. function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment anal. were carried out in Database for Annotation, Visualization and Integrated Discovery. There are 61 active ingredients and 134 action targets in classic ancient prescription of Chinese medicine Zhen-Wu decoction, among which 49 target genes and 11 important compounds related to the chronic heart failure treatment. After network anal., we obtained 12 key targets, 77 gene ontol. entries and 22 signal pathways, including tumor necrosis factor signaling pathway, NF-kappaB signal pathway, PI3K-Akt signal pathway, et al. Classic ancient prescription of Chinese medicine Zhen-Wu decoction was used for chronic heart failure treatment for the multi-component, multi-target and multi-channel interaction. The components such as kaempferol and β-sitosterol were combined with target proteins such as CHRM1 and AChE, involving biol. processes such as DNA transcription regulation, cholinergic synaptic transmission and apoptosis regulation, as well as signal pathways such as tumor necrosis factor signaling pathway, NF-kappa B signal pathway, PI3K-Akt signal pathway, et al.

Drug Combination Therapy published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileA catalyst- and additive-free synthesis of alkoxyhydrosiloxanes from silanols and alkoxyhydrosilanes, Safety of Triethylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(59), 8218-8221, database is CAplus and MEDLINE.

A convenient method for the selective synthesis of alkoxyhydrosiloxanes that bear SiH and SiOR² groups on the same silicon atom, R¹₃Si-O-SiR³_2-n(OR²)_nH (n = 0, 1, or 2), via a simple catalyst- and additive-free dealcoholization reaction between silanols and alkoxyhydrosilanes has been developed. These alkoxyhydrosiloxanes can be easily converted into Si(OR²)₃-containing siloxanes by zinc catalyzed alkoxylation and alkoxy-containing silphenylene polymers by platinum catalyzed hydrosilylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Safety of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeong, Jaeyoung published the artcileSelective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway, Quality Control of 111-29-5, the publication is ChemCatChem (2022), 14(3), e202101499, database is CAplus.

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields.

ChemCatChem published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ojha, Devi Prasan published the artcileGeneration of Hydrogen from Water: A Pd-Catalyzed Reduction of Water Using Diboron Reagent at Ambient Conditions, Application In Synthesis of 25240-59-9, the publication is Organic Letters (2016), 18(19), 5062-5065, database is CAplus and MEDLINE.

Production of hydrogen from renewable sources, particularly from water, is an intensive area of research, which has far-reaching relevance in hydrogen economy. A homogeneous catalytic method is presented for producing clean hydrogen gas from water, in a reaction of water with a diboron compound as the reductant, under ambient reaction conditions. The Pd-catalytic system is stable in water and displays excellent recyclability. Hydroxy analogs such as alcs. are compatible with the Pd/B₂Pin₂ system and generate hydrogen gas efficiently. The B₂Pin₂-H₂O system, in the presence of palladium, is an excellent catalytic system for selective hydrogenation of olefins.

Organic Letters published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Application In Synthesis of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lewandowska, Aneta published the artcileThiol-ene ionogels based on polymerizable imidazolium ionic liquids, Computed Properties of 111-29-5, the publication is Polymer Chemistry (2022), 13(21), 3154-3170, database is CAplus.

In this work, we report the synthesis of polymerizable ionic liquids (PILs) and the synthesis of ionogels by thiol-ene photopolymerization A series of gemini imidazolium-based bis(trifluoromethylsulfonyl)imide polymerizable ionic liquids with ene functional groups, reactive in thiol-ene polymerization, were synthesized. The obtained polymerizable ionic liquids differ by (i) type of reactive group: vinyl, allyl, (ii) length of hydrocarbon chain spacer (from C2 to C12) between two imidazole rings in cations in the vinyl series of PILs (divinyl-PIL), and (iii) type of substituent (-H or -CH₃) at C(2) position at the imidazole ring in diallyl-PILs. Then ionogel systems on the basis of the prepared PILs used as ene, 1,3,5-trimethylolpropane trimethacrylate (TMPTM), difunctional aliphatic polyester urethane acrylate (DAPU), and tris(3-mercaptobutyloxethyl)-1,3,5-triazine-2,4,6(1H,3H,5H)-trione (TMTT) were synthesized in 70 wt% of ionic liquid 1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide (EMImNTf₂). The mech. properties (tensile strength), ionic conductivity (electrochem. impedance spectroscopy), and thermal properties (differential scanning calorimetry, thermogravimetric anal.) of the prepared ionogels as well as the course of photopolymerization by the photo-DSC method were studied. The resulting ionogels are fully transparent, highly flexible, with no leakage (also at an elevated temperature 80 °C and during mech. testing), all thanks to the presence of PILs in the polymer matrix of ionogels. Interestingly, DSC studies have shown that the ionic liquid EMImNTf₂ does not crystallize in the synthesized ionogels in a broad range of temperatures (-170 – 30 °). The PIL structure influences the polymerization kinetics as well as properties of ionogels. All synthesized ionogels are stable in the temperature range 304 °C-325 °C, and ionogels with allyl-PILs have higher thermal stability than ionogels with vinyl-PILs. The strength (for the ionogels with PILs C2-C6) and Young′s modulus of the obtained ionogels increase with the length of the hydrocarbon chain of the spacer in vinyl-PILs but elongation and ionic conductivity decrease. However, the conductivity of ionogels is greater than 1 mS cm^-1, which allows the use of the obtained materials, e.g., in electrochem. capacitors.

Polymer Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Computed Properties of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Castellanos-Blanco, Nahury published the artcileNickel-catalyzed reduction of ketones with water and triethylsilane, Application of Triethylsilanol, the publication is Inorganica Chimica Acta (2017), 324-332, database is CAplus.

The acetophenone reduction using catalytically active nickel complexes and water as an efficient and sustainable method to access a new methodol. of transfer hydrogenation of ketones were reported. When triethylsilane (Et₃SiH) was used as sacrificial agent that promoted the transfer hydrogenation from water, 1-phenylethanol was obtained in excellent yield along with silanol (Et₃SiOH) as the reaction’s driving force. Deuterium labeling studies were made using Et₃SiD or D₂O and these studies showed that both compounds participated as hydride sources for the ketone reduction A scope of substrates was assessed, including a variety of mono/diketones, and α,β-unsaturated ketones, to yield the corresponding secondary alcs. and saturated ketones. Addnl., asym. transfer hydrogenation of mono-ketones was studied for the mixture of nickel/(bisphosphine or phospholane) as catalyst precursor, using H₂O/Et₃SiO system and ethanol as hydrogen sources.

Inorganica Chimica Acta published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez-Sebastian, Lucero published the artcileNickel-Catalyzed Hydrosilylation of CO₂ in the Presence of Et₃B for the Synthesis of Formic Acid and Related Formates, Formula: C6H16OSi, the publication is Organometallics (2013), 32(23), 7186-7194, database is CAplus.

The reaction of CO₂ with Et₃SiH catalyzed by the nickel complex [(dippe)Ni(μ-H)]₂ (1) afforded the reduction products Et₃SiOCH₂OSiEt₃ (12%), Et₃SiOCH₃ (3%), and CO, which were characterized by standard spectroscopic methods. Part of the generated CO was found as the complex [(dippe)Ni(CO)]₂ (2), which was characterized by single-crystal x-ray diffraction. When the same reaction was carried out in the presence of a Lewis acid, such as Et₃B, the hydrosilylation of CO₂ efficiently proceeded to give the silyl formate (Et₃SiOC(O)H) in high yields (85-89%), at 80° for 1 h. Further reactivity of the silyl formate to yield formic acid, formamides, and alkyl formates was also investigated.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts