Tag: M.W=100-150

Xu, Shiyang published the artcileRh(I)-Catalyzed Coupling of Azides with Boronic Acids Under Neutral Conditions, Category: alcohols-buliding-blocks, the publication is Organic Letters (2022), 24(30), 5546-5551, database is CAplus and MEDLINE.

A neutral amination reaction using azides RN₃ (R = Ph, 4-nitrophenyl, 4-bromophenyl, etc.) as the nitrogen source and arylboronic acids ArB(OH)₂ (Ar = 4-cyanobutyl, cyclooctyl, Ph, etc.) with a rhodium(I) catalyst to afford alkyl-aryl and aryl-aryl secondary amines RNHAr was presented. Natural products and pharmaceutical derivatives were applied, and gram-scale reactions were performed, which demonstrated the utility. Mechanistic experiments and DFT calculations suggested that the reaction involves a metal-nitrene intermediate.

Organic Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C4H8Cl2S2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Langford, Vaughan S. published the artcileSelected ion flow tube studies of several siloxanes, HPLC of Formula: 597-52-4, the publication is Rapid Communications in Mass Spectrometry (2013), 27(6), 700-706, database is CAplus and MEDLINE.

People are using increasing amounts of siloxanes which ultimately end up in landfills, then in landfill gas and biogas digesters. Their presence poses difficulties for industries to use the energy content of landfill gas and biogas because the combustion process oxidizes Si to SiO₂ which in turn damages engine parts. Rapid, efficient, accurate methods are needed to quantify the presence of siloxanes. Selected ion flow tube mass spectrometry (SIFTMS), an emerging real-time technique, is used to monitor trace volatile compounds in air. Samples containing the trace volatile compounds are drawn into the flow tube and convected in a He stream. Chem. ionization reactions from mass-selected reagent ions with the volatile compounds occur. To quantify volatile compounds in the sample, the ion chem. of the reagent ion with each volatile must be known. Rate coefficients and product ion branching ratios were determined for dodecamethylpentasiloxane, decamethylcyclopentasiloxane, decamethyltetrasiloxane, octamethylcyclotetrasiloxane, triethylsilanol, tetramethylsilane, and hexamethyldisilazane. The ion/mol. reactions of these 7 Si-containing compounds were fast, occurring at or near the collision rate, allowing for low concentration detection. The very simple reaction chem. of proton transfer, electron transfer, and Me loss enables easy siloxane quantitation in landfill gas and biogas by SIFTMS. Copyright © 2013 John Wiley & Sons, Ltd.

Rapid Communications in Mass Spectrometry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, HPLC of Formula: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Riva, Beatrice published the artcilePyrtriazoles, a Novel Class of Store-Operated Calcium Entry Modulators: Discovery, Biological Profiling, and in Vivo Proof-of-Concept Efficacy in Acute Pancreatitis, Formula: C6H13NO2, the publication is Journal of Medicinal Chemistry (2018), 61(21), 9756-9783, database is CAplus and MEDLINE.

In recent years, channels that mediate store-operated calcium entry (SOCE, i.e., the ability of cells to sense a decrease in endoplasmic reticulum luminal calcium and induce calcium entry across the plasma membrane) have been associated with a number of disorders, spanning from immune disorders to acute pancreatitis and have been suggested to be druggable targets. In the present contribution, we exploited the click chem. approach to synthesize a class of SOCE modulators where the arylamide substructure that characterizes most inhibitors so far described is substituted by a 1,4-disubstituted 1,2,3-triazole ring. Within this series, inhibitors of SOCE were identified and the best compound I proved effective in an animal model of acute pancreatitis, a disease characterized by a hyperactivation of SOCE. Strikingly, two enhancers of the process were discovered, affording invaluable research tools to further explore the (patho)physiol. role of capacitative calcium entry.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Formula: C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stec, Wojciech J. published the artcileDiastereomers of Nucleoside 3′-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of the American Chemical Society (1995), 117(49), 12019-29, database is CAplus.

Diastereomerically pure 5′-O-DMT-nucleoside 3′-O-(2-thio-1,3,2-oxathiaphospholanes) I ( B = T, Ade^bz, Cyt^bz) were used for the synthesis of stereo-regular oligo(nucleoside phosphorothioate)s (S-Oligos). The oxathiaphospholane ring-opening condensation requires the presence of strong organic base, preferably DBU. The yield of a single coupling step is ca. 95% and resulting S-Oligos are free of nucleobase- and sugar-phosphorothioate backbone modifications. The diastereomeric purity of products was estimated on the basis of diastereoselective degradation with Nuclease P1 and a mixture of snake venom phosphodiesterase and Serratia marcescens endonuclease. Thermal dissociation studies of hetero-duplexes S-Oligos/DNA and S-Oligos/RNA showed that their stability is stereochem.- and sequence-dependent.

Journal of the American Chemical Society published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C5H10Cl3O3P, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gogoi, Nibedita published the artcileGrafting of Ru(III) complex onto nanosilica and its implication as heterogeneous catalyst for aerobic oxidative hydroxylation of arylboronic acids, Application In Synthesis of 17236-59-8, the publication is Tetrahedron Letters (2016), 57(36), 4050-4052, database is CAplus.

An ecofriendly and highly efficient protocol for aerobic oxidative hydroxylation of aryl and heteroaryl boronic acids catalyzed by Ru(III) amidine complex immobilized on nanosilica, derived from rice husk, has been developed. The main significance of this protocol is the base free and aerobic reaction condition at room temperature, short reaction time, aqueous reaction medium, and excellent yield of the product. This heterogeneous catalyst is reusable up to sixth cycle without loss in activity.

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application In Synthesis of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeminejs, Andris published the artcileApplication of Azide-Tetrazole Tautomerism and Arylsulfanyl Group Dance in the Synthesis of Thiosubstituted Tetrazoloquinazolines, Synthetic Route of 4410-99-5, the publication is Synthesis (2021), 53(8), 1443-1456, database is CAplus.

Nucleophilic aromatic substitution reaction between 4-arylthio-2-chloroquinazolines I (Ar = C₆H₅, 4-BrC₆H₄, 4-FC₆H₄, 4-ClC₆H₄, 4-CH₃C₆H₄) and NaN₃ takes place with an unusual sulfanyl group dance and leads to the formation of 5-(arylthio)tetrazolo[1,5-c]-quinazolines II, which do not form the azide tautomer and do not undergo CuAAC reactions with alkynes. On the other hand, 5-azidotetrazolo[1,5-a]quinazoline (formally described as 2,4-diazidoquinazoline) undergoes regioselective nucleophilic aromatic substitution with thiols at C5 and forms 5-(alkyl/arylthio)tetrazolo[1,5-a]quinazolines III (R¹ = cyclopentyl, C₆H₅, CH₂C₆H₅, etc.), the structure of which has been proved by X-ray crystallog. The latter exist in tautomeric equilibrium with their 2-azidoquinazoline form, which provides possibility for copper-catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction, leading to the 4-alkyl/arylthio-2-(1H-1,2,3-triazol-1-yl)quinazolines IV (R² = C₆H₅, cyclopropyl, Bu, etc.).

Synthesis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cavaca, Lidia A. S. published the artcilePreparation of Thioaminals in Water, Product Details of C8H10S, the publication is Molecules (2022), 27(5), 1673, database is CAplus and MEDLINE.

In this work, the formation of thioaminals RSCH(R¹)N(R²)(R³) [R = Ph, benzyl, Pr, etc.; R¹ = furan-2-yl, Ph, 4-bromophenyl, etc. ; R² = benzyl; R³ = benzyl ; R²R³ = -(CH₂)₅-, -(CH₂)₂O(CH₂)₂-, -(CH₂)₂N(CH₃)(CH₂)₂-] in water promoted by copper(II) triflate was described.

Molecules published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Product Details of C8H10S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arzumanyan, Ashot V. published the artcileCopper-Catalyzed Oxidation of Hydrosilanes: A New Method for the Synthesis of Alkyl- and Siloxysilanols, Formula: C6H16OSi, the publication is Synlett (2018), 29(4), 489-492, database is CAplus.

A simple method for the preparation of silanols from the corresponding hydrosilanes is reported. The method employs a com. available oxidizing system based on CuCO ₃/ t-BuOOH _(aq)under relatively mild conditions (80 °C, atm. pressure) with acetonitrile as the solvent. Furthermore, we present a method that permits the Si-H group to be oxidized to a Si-OH group not only in triethylsilane, but also in bis(trimethylsiloxy)methylsilane, a siloxy derivative of hydrosilane. The products were isolated in gram amounts in yields of 61-73%.

Synlett published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arzumanyan, Ashot V. published the artcileAerobic Co or Cu/NHPI-catalyzed oxidation of hydride siloxanes: synthesis of siloxanols, HPLC of Formula: 597-52-4, the publication is Green Chemistry (2018), 20(7), 1467-1471, database is CAplus.

A highly efficient preparative method for the synthesis of siloxanols based on aerobic Co(OAc)₂ or Cu(OAc)₂/NHPI-catalyzed oxidation of hydrosilanes and hydrosiloxanes using “green”, com. available, simple inexpensive reagents and mild reaction conditions has been proposed. This is a general reaction for the synthesis of mono-, oligo- and polymeric siloxanols with various structures (linear, branched and cyclic).

Green Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, HPLC of Formula: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Peng published the artcileSolvent-free, B(C₆F₅)₃-Catalyzed S-H Insertion of Thiophenols and Thiols with α-Diazoesters, Quality Control of 4410-99-5, the publication is Chemistry – An Asian Journal (2022), 17(16), e202200465, database is CAplus and MEDLINE.

A B(C₆F₅)₃-catalyzed S-H insertion reaction of thiophenols and thiols with α-diazoesters to access valuable α-thioesters was described. With the established protocol, an array of α-thioester products were generated in moderate to good yields with broad scope and functional group tolerance. In addition, this reaction maintained its high efficiency on gram scale and the product can be easily transformed into other useful motifs. This reaction proceeded under solvent-free conditions at room temperature, and generally finished in twenty minutes upon magnet stirring, which offers an expedient way for synthesis of thioether-containing compounds

Chemistry – An Asian Journal published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H11NO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts