Tag: M.W=100-150

Shao, Xuefei published the artcilePreparation of zinc-coordinated-DPA functionalized polyesters for gene condensation, SDS of cas: 111-29-5, the publication is Journal of Applied Polymer Science (2021), 138(34), 50843, database is CAplus.

Cationic polyesters have been widely utilized as efficient gene delivery carriers. Their ability in binding genes was majorly based on the electrostatic effect between the pos. charges of polymers and the negatives charges of genes. It has been well known that large numbers of pos. charges on the polymers would lead to undesired toxicity although strong gene binding capability. It was of great interest to developed a polymer with reduced pos. charges while enhanced gene condensation ability. In this work, a library of polyesters functionalized by zinc-coordinated-dimethylpyridinium amine (DPA-Zn) have been successfully prepared by the polycondensation method starting from di-Me 1,3-acetonedicarboxylate and 10 diols, followed by the post-modification using dimethylpyridinium amine and zinc nitrate. The post-modification efficiency was systemically evaluated and the optimized functionalization efficiency could reach around 50%. The gene condensation ability of the targeting polymers was also evaluated using gel retardation assay and dynamic light scatting. The results indicated that DPA-Zn functionalized polyesters could bind gene into nanocomplexes with the sizes around 200 nm.

Journal of Applied Polymer Science published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C15H10O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Xiao published the artcileEngineering of reversible luminescent probes for real-time intravital imaging of liver injury and repair, Related Products of alcohols-buliding-blocks, the publication is CCS Chemistry (2022), 4(1), 356-368, database is CAplus.

As the major organ for drug metabolism and detoxification, the liver is prone to damage and severely impaired functionality. The treatment of liver diseases is based on a clear understanding of the process underlying liver injury and repair. However, intravital real-time imaging of liver injury and repair is still limited due to the lack of in vivo reversible visualization methods. To this end, we proposed a rational design strategy for the development of a reversible upconversion luminescence nanoprobe that allows real-time and in vivo imaging of liver injury and repair processes. As a proof of concept, we first developed a small mol. probe NB3 which can reversibly respond to related analytes of early liver injury [peroxynitrite (ONOO^–)] and liver repair [glutathione (GSH)]. The small mol. probe was then integrated with a core-shell upconversion nanoparticle to form a sophisticated nanoprobe. Compared with traditional small mol. probes, this nanoprobe exhibited a higher selectivity to ONOO^–, longer retention time in liver, and wider dynamic response range to GSH after oxidation by ONOO^–. The novel nanoprobe facilitated the successful monitoring and discrimination among the different degrees of liver injury and repair in a mouse model.

CCS Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ervin, Samantha M. published the artcileTargeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases, SDS of cas: 622-40-2, the publication is ACS Chemical Biology (2019), 14(12), 2737-2744, database is CAplus and MEDLINE.

Regorafenib (Stivarga) is an oral small mol. kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from the reactivation of the inactive regorafenib-glucuronide to regorafenib by gut microbial β-glucuronidase (GUS) enzymes in the gastrointestinal tract. We sought to unravel the mol. basis of regorafenib-glucuronide processing by human intestinal GUS enzymes and to examine the potential inhibition of these enzymes. Using a panel of 31 unique gut microbial GUS enzymes derived from the 279 mapped from the human gut microbiome, we found that only four were capable of regorafenib-glucuronide processing. Using crystal structures as a guide, we pinpointed the mol. features unique to these enzymes that confer regorafenib-glucuronide processing activity. Furthermore, a pilot screen identified the FDA-approved drug raloxifene as an inhibitor of regorafenib reactivation by the GUS proteins discovered. Novel synthetic raloxifene analogs exhibited improved potency in both in vitro and ex vivo studies. Taken together, these data establish that regorafenib reactivation is exclusively catalyzed by gut microbial enzymes and that these enzymes are amenable to targeted inhibition. Our results unravel key mol. details of regorafenib reactivation in the GI tract and provide a potential pathway to improve clin. outcomes with regorafenib.

ACS Chemical Biology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oppegard, Martin published the artcileDetermination of C₀-C₉ alkyl phenols in produced-water-exposed fish eggs using gas chromatography/tandem mass spectrometry, Recommanded Product: 4-Propylphenol, the publication is Rapid Communications in Mass Spectrometry (2020), 34(24), e8950, database is CAplus and MEDLINE.

Rationale: Produced water (PW) discharge from the oil and gas industry represents the largest intentional marine waste volume Alkyl phenols (APs) are one of the main toxic component groups found in PW, with concentration of APs in discharged PW from the Norwegian Sector of the North Sea up to >16 mg/L. Several species of fish spawn in direct proximity to offshore production platforms and may be at risk of AP exposure. Therefore, a sensitive method to determine the potential for bioaccumulation of APs in fish eggs is needed. Methods: Fish eggs were extracted using liquid-solid extraction followed by gel permeation chromatog. cleanup. Anal. was performed by gas chromatog. coupled to triple quadrupole mass spectrometry. Extraction and anal. conditions were optimized for anal. of phenol and 30 APs (C₁-C₉) with different degrees of branching in the alkyl chain. The method was verified and applied to analyze the body residue of APs in PW-exposed marine fish (Atlantic cod, Gadus morhua) eggs. Results: A comprehensive and sensitive method for the determination of C₀-C₉ APs was developed. Detection limits were in the range 0.03-8 ng. Apart from a few compounds with poor recovery, the method generally provided reliable results with good precision (<15%). Conclusions: We demonstrate the successful application of an optimized extraction method for APs in fish eggs and show first results of AP accumulation in cod embryos exposed to PW in the laboratory

Rapid Communications in Mass Spectrometry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Bowen published the artcileFluorinated paclitaxel prodrugs for potentiated stability and chemotherapy, SDS of cas: 2240-88-2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(48), 9971-9979, database is CAplus and MEDLINE.

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Da-Hua published the artcileSynthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine, COA of Formula: C3H5F3O, the publication is European Journal of Organic Chemistry (2016), 2016(16), 2842-2850, database is CAplus.

In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synthesis of their anticipated precursor 3-(methylsulfonyl)-1,2,4 triazine was also optimized. The reactivity of 3-(methylsulfonyl)-1,2,4-triazine towards alkyl and aryl thiols, primary and secondary alkylamines, phenols, and alcs. was explored, and the reactions were optimized to maximize the isolation of the corresponding 3-substituted 1,2,4-triazine. Good yields were obtained for the products of the reactions with all of the aforementioned nucleophiles, with the exception of alcs., by using alkali metal carbonates. Higher yields of 3-(alkoxy)-1,2,4-triazines were obtained by using the appropriate magnesium alkoxide as the nucleophile.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C16H12O, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Doura, Tomohiro published the artcileAn adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(97), 11421-11423, database is CAplus and MEDLINE.

We report a new strategy for designing a signal off-to-on-type ¹⁹F MRI chem. probe that operates in biol. environments. The present strategy is based on the control of adherence of a ¹⁹F MRI chem. probe to certain blood proteins, accompanied by a change in transverse relaxation time of ¹⁹F nuclei.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mascharak, P. K. published the artcileStructural distortions of the [Fe₄S₄]²⁺ core of [Fe₄S₄(S-tert-C₄H₉)₄]^2- in different crystalline environments and detection and instability of oxidized ([Fe₄S₄]³⁺) clusters, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Inorganica Chimica Acta (1983), 80(3), 157-70, database is CAplus.

The structural and redox chem. of the clusters [Fe₄S₄(SR)₄]^2- with R = tert-alkyl were investigated for the purpose of determining the structures of the same cluster in different environments and the stability of the oxidized species [Fe₄S₄(SR)₄]^1-. (Me₃NCH₂Ph)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the monoclinic space group P2₁/c with no imposed symmetry. (Et₄N)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the tetragonal space group I4̅2m with D_2d symmetry imposed on the cluster. The [Fe₄S₄]²⁺ cluster cores in both compounds exhibit compressed tetragonal structures with different extents of distortion from T_d symmetry. These structures are compared to those of other [Fe₄S₄]²⁺ clusters by means of core shape parameters. Clusters with R = tert-alkyl (tert-Bu, C(CH₃)₂CH₂OH, C(CH₃)₂CH₂NHPh) in DMF exhibit, in addition to the usual 2-/3- and 3-/4- redox reactions common to all [Fe₄S₄(SR)₄]^2- species, discrete 1-electron oxidations near -0.1 V vs. SCE. Cyclic voltammetry of [Fe₄S₄(S-tert-Bu)₄]^2- reveals an essentially reversible 1-/2- couple with E_1/2 = -0.12 V, supporting the authenticity of clusters containing an oxidized ([Fe₄S₄]³⁺) core. This couple cannot be electrochem. resolved from multi-electron oxidation in the case of clusters in DMF with other types of R substituents, a behavior apparently due to cathodic potential shifts by tert-alkyl groups. Stability of oxidized clusters is low, and [Fe₄S₄(S-tert-Bu)₄]^1- could not be generated in appreciable concentrations at longer times by coulometric or chem. oxidation The relative stabilities of analog and protein [Fe₄S₄]³⁺ clusters are discussed. Preparations of 4 new [Fe₄S₄(SR)₄]^2- cluster salts are described including water-soluble (Et₄N)₂[Fe₄S₄(SC(CH₃)₂CH₂OH)₄].

Inorganica Chimica Acta published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smoum, Reem published the artcileFenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential, Application In Synthesis of 645-56-7, the publication is Molecules (2022), 27(4), 1382, database is CAplus and MEDLINE.

A series of novel cannabinoid-type derivatives was synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(-)-fenchones I (R = H, Me, n-pentyl, 2-methylbutan-2-yl, etc.; R¹ = H, hexyl; R² = H, OMe) with various resorcinols RC₆H₃(OH)₂/phenols RC₆H₄OH. The fenchone-resorcinol derivatives I were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in DMF (DMF). The absolute configurations of four compounds were determined by X-ray single crystal diffraction. The fenchone-resorcinol analogs I possessed high affinity and selectivity for the CB2 cannabinoid receptor. One of the analogs synthesized, I (R = 2-methyloctan-2-yl, R¹ = H, R² = OMe (II)), had a high affinity (K_i = 3.51 nM) and selectivity for the human CB2 receptor (hCB2). In the [³⁵S]GTPγS binding assay, the lead compound was found to be a highly potent and efficacious hCB2 receptor agonist (EC₅₀ = 2.59 nM, E_(max) = 89.6%). Two of the fenchone derivatives I were found to possess anti-inflammatory and analgesic properties. Mol.-modeling studies elucidated the binding interactions of (II) within the CB2 binding site.

Molecules published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C3H6BrNaO3S, Application In Synthesis of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Byun, Jaewon published the artcileImpact of uncertainty in technological cycle on circular economy: Bio-based jet fuel range alkenes and pentanediols production, HPLC of Formula: 111-29-5, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 356-361, database is CAplus.

In terms of circular economy (CE), the coprodn. of biofuels and bio-based chems. could be a feasible strategy to improve the biorefinery economics. However, this approach is significantly affected by the variation of the techno-economic parameters. Thus, we evaluated the techno-economic feasibility of an integrated strategy through deterministic and stochastic models for the coprodn. of biofuels (jet fuel range alkenes (JFA)) and bio-based chems. (pentanediols and pentane) to identify the impact of uncertainty in technol. cycle on the CE action plan. The deterministic anal. estimated the min. JFA selling price (MJSP) expressed per gasoline gal equivalent (GGE) and led to the identification of six major techno-economic parameters having a significant impact on the economics. Stochastic anal. was performed based on the Monte Carlo simulation, leading to probabilistic results on the economic feasibility of the integrated strategy, taking into account the uncertainty in the six identified parameters. In five of the six scenarios developed considering each uncertainty, the chances of MJSP being lower than the maximum biofuel price (USD 3.10 GGE^-1) in the last three years (2017-2019) were higher than 50% (53.2-88.1%), implying that, despite the uncertainties reflected in the major techno-economic parameters, the integrated strategy could be a risk-averse investment.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts