Tag: M.W=100-150

Agrawal, Aparna published the artcileFabrication and Characterization of Re-Entrant Honeycomb Polyurethane Aerogels, Name: Pentane-1,5-diol, the publication is ACS Applied Polymer Materials (2022), 4(5), 3791-3801, database is CAplus.

In this work, polyurethane aerogels are fabricated in re-entrant honeycomb forms to achieve auxeticity and much higher flexibility than corresponding aerogel monoliths. For this purpose, a set of re-entrant honeycomb-shaped hollow molds is first printed from high-impact polystyrene (HIPS) using a fused filament fabrication technique and subsequently filled with polyurethane sol synthesized from an aliphatic triisocyanate and a diol selected from among butanediol, pentanediol, hexanediol, or octanediol. A sol-gel transition process yields the gel in a re-entrant honeycomb shape, which is isolated by dissolving the HIPS mold and supercritically dried using carbon dioxide. The effects of diol chain length on the properties of aerogels, such as bulk d., pore size, and tensile properties are investigated. The auxetic aerogels show different deformation behavior and much higher elongation at break than dog bone-shaped aerogel monoliths. Such unique properties of auxetic structures can extend applications of aerogels as acoustic absorbers and smart bandages that require high porosity, tunable pore structures, and high flexibility.

ACS Applied Polymer Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Name: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yadav, B. P. published the artcileSynthesis of some novel pyrimidine derivatives and compared to available antimicrobial (MTCC inhibitors) drugs, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is IOSR Journal of Pharmacy (2021), 11(9-1), 23-28, database is CAplus.

A new series of pyrimidine derivatives I (R¹ = trifluoromethyl, Cl; R² = Me, Et, i-Pr) have been synthesized by reacting substituted pyrimidine carboxylic acids II with 3-methoxyaniline, de-methylation using BBr₃ to form hydroxy derivatives, which were then alkylated with resp. alkyl halides R²I to synthesize substituted pyrimidine derivatives I. The synthesized compounds I were screened for their in vitro growth inhibiting activity against different strains.

IOSR Journal of Pharmacy published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C15H10O2, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Gracia Lux, Caroline published the artcileBiocompatible Polymeric Nanoparticles Degrade and Release Cargo in Response to Biologically Relevant Levels of Hydrogen Peroxide, SDS of cas: 25240-59-9, the publication is Journal of the American Chemical Society (2012), 134(38), 15758-15764, database is CAplus and MEDLINE.

Oxidative stress is caused predominantly by accumulation of hydrogen peroxide and distinguishes inflamed tissue from healthy tissue. Hydrogen peroxide could potentially be useful as a stimulus for targeted drug delivery to diseased tissue. However, current polymeric systems are not sensitive to biol. relevant concentrations of H₂O₂ (50-100 μM). Here we report a new biocompatible polymeric capsule capable of undergoing backbone degradation and thus release upon exposure to such concentrations of hydrogen peroxide. Two polymeric structures were developed differing with respect to the linkage between the boronic ester group and the polymeric backbone: either direct (1) or via an ether linkage (2). Both polymers are stable in aqueous solution at normal pH, and exposure to peroxide induces the removal of the boronic ester protecting groups at physiol. pH and temperature, revealing phenols along the backbone, which undergo quinone methide rearrangement to lead to polymer degradation Considerably faster backbone degradation was observed for polymer 2 over polymer 1 by NMR and GPC. Nanoparticles were formulated from these novel materials to analyze their oxidation triggered release properties. While nanoparticles formulated from polymer 1 only released 50% of the reporter dye after exposure to 1 mM H₂O₂ for 26 h, nanoparticles formulated from polymer 2 did so within 10 h and were able to release their cargo selectively in biol. relevant concentrations of H₂O₂. Nanoparticles formulated from polymer 2 showed a 2-fold enhancement of release upon incubation with activated neutrophils, while controls showed a nonspecific response to ROS producing cells. These polymers represent a novel, biol. relevant, and biocompatible approach to biodegradable H₂O₂-triggered release systems that can degrade into small mols., release their cargo, and should be easily cleared by the body.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, SDS of cas: 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, Jung-Hun published the artcileComparative study on carbon dioxide-cofed catalytic pyrolysis of grass and woody biomass, Safety of 4-Propylphenol, the publication is Bioresource Technology (2021), 124633, database is CAplus and MEDLINE.

This study investigated the mechanistic functions of CO₂ on the pyrolysis of two different biomasses to elucidate the effect of CO₂ on syngas formations during pyrolysis. To this end, CO₂-assisted pyrolysis of cellulosic biomass (barnyard grass, Echinochloa) and lignin-rich woody biomass (retinispora, Chamaecyparis obtusa) were compared. The confirmed mechanistic effectiveness of CO₂ on pyrolysis of biomass was gas phase reactions between CO₂ and volatile matters from biomass pyrolysis. Lignin-rich biomass had more CO₂ susceptibility, resulting in more enhanced CO formation via the gas phase reactions. To expedite the slow reaction rate of the gas phase reactions during biomass pyrolysis, earth-abundant catalysts (Co/SiO₂ and Ni/SiO₂) were employed for pyrolysis of two biomass substrates. With Co and Ni catalysts, the syngas formations were 2 and 3 times higher comparing to the pyrolysis of without catalyst. The cumulative formations of syngas from lignin-rich biomass was nearly doubled than that from cellulosic biomass.

Bioresource Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sakthivel, Naga Arjun published the artcileSize Exclusion Chromatography: An Indispensable Tool for the Isolation of Monodisperse Gold Nanomolecules, Recommanded Product: 2-Phenylethanethiol, the publication is Analytical Chemistry (Washington, DC, United States) (2021), 93(8), 3987-3996, database is CAplus and MEDLINE.

Highly monodisperse and pure samples of atomically precise gold nanomols. (AuNMs) are essential to understand their properties and to develop applications using them. Unfortunately, the synthetic protocols that yield a single-sized nanomol. in a single-step reaction are unavailable. Instead, we observe a polydisperse product with a mixture of core sizes. This product requires post-synthetic reactions and separation techniques to isolate pure nanomols. Solvent fractionation based on the varying solubility of different sizes serves well to a certain extent in isolating pure compounds It becomes tedious and offers less control while separating AuNMs that are very similar in size. Here, we report the versatile and the indispensable nature of using size exclusion chromatog. (SEC) as a tool for separating nanomols. and nanoparticles. We have demonstrated the following: (1) the ease of separation offered by SEC over solvent fractionation; (2) the separation of a wider size range (~5-200 kDa or ~1-3 nm) and larger-scale separation (20-100 mg per load); (3) the separation of closely sized AuNMs, demonstrated by purifying Au₁₃₇(SR)₅₆ from a mixture of Au₃₂₉(SR)₈₄, Au₁₄₄(SR)₆₀, Au₁₃₇(SR)₅₆, and Au₁₃₀(SR)₅₀, which could not be achieved using solvent fractionation; (4) the separation of AuNMs protected by different thiolate ligands (aliphatic, aromatic, and bulky); and (5) the separation can be improved by increasing the column length. Mass spectrometry was used for analyzing the SEC fractions.

Analytical Chemistry (Washington, DC, United States) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabovskiy, S. A. published the artcileOxidation of Triorganosilanes and Related Compounds by Chlorine Dioxide, Recommanded Product: Triethylsilanol, the publication is Russian Journal of General Chemistry (2021), 91(12), 2391-2402, database is CAplus.

Oxidation of triethylsilane, tert-butyldimethylsilane, dimethylphenylsilane, triphenylsilane, 1,1,1,2-tetramethyl-2-phenyldisilane, tris(trimethylsilyl)silane, hexamethyldisilane, tetrakis(trimethylsilyl)silane, 1,1,3,3-tetraisopropyldisiloxane with chlorine dioxide was carried out. The reaction products of studied triorganosilanes with chlorine dioxide in an acetonitrile solution were the corresponding silanols and siloxanes. A mechanism explaining the formation of products and the observed regularities of the oxidation of silanes with chlorine dioxide has been proposed. A thermochem. anal. of some possible pathways in the gas phase using methods G4, G3, M05, and in an acetonitrile solution by the SMD-M05 method was carried out. The oxidation process can occur both with the participation of ionic and radical intermediates, depending on the structure of the oxidized substrate and medium.

Russian Journal of General Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Songwen published the artcileDiscovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis, Synthetic Route of 622-40-2, the publication is Journal of Medicinal Chemistry (2019), 62(19), 8873-8879, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease, and its mol. pathogenesis remains poorly understood. Recently, emerging evidence demonstrates that the PI3K signaling transduction pathway is linked to the pathol. of IPF. In this work, we rationally designed a new series of 4-methylquinazoline derivatives as highly potent PI3K inhibitors that significantly suppress the phosphorylation of the main PI3K downstream effectors and displays marked antiproliferative activity in mouse MLg2908 lung fibroblasts. In a bleomycin-induced mouse pulmonary fibrosis model, 5d from the series improved mouse lung function and slowed the progression of pulmonary fibrosis. Overall, this work promises a therapeutic potential for PI3K inhibitors to treat IPF.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Shengping published the artcileNickel-catalyzed oxidative dehydrogenative coupling of alkane with thiol for C(sp³)-S bond formation, SDS of cas: 4410-99-5, the publication is Tetrahedron Letters (2021), 152950, database is CAplus.

A nickel-catalyzed oxidative dehydrogenative coupling reaction of alkanes RH (R = 1-phenylethan-1-yl, cyclohexyl, tetrahydrofuran-2-yl, 1,4-dioxan-2-yl, etc.) with thiols R¹SH (R¹ = 4-methylphenyl, 2-naphthyl, octan-1-yl, benzo[d]thiazol-2-yl, etc.) for the construction of C(sp³)-S bond has been established, affording more than 50 alkyl thioethers RSR¹. Notably, pharmaceutical and agrochems., such as Provigil, Chlorbenside and Pyridaben, were readily synthesized by this approach. The sterically hindered ligand bathocuproine (BC) and disulfide which was formed in situ oxidation of thiol, efficiently avoiding nickel-catalyst poisoning. A set of mechanistic experiments disclose both Ni-catalyzed and Ni-free HAA processes.

Tetrahedron Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayashi, Ryuji published the artcileSynthesis and evaluation of novel heterocyclic MMP inhibitors, Synthetic Route of 17236-59-8, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(24), 6864-6870, database is CAplus and MEDLINE.

A variety of novel heterocyclic compounds, e.g., I, were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.

Bioorganic & Medicinal Chemistry Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Synthetic Route of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Mengmeng published the artcileHighly Efficient Generation of Hydrogen from the Hydrolysis of Silanes Catalyzed by [RhCl(CO)₂]₂, Computed Properties of 597-52-4, the publication is Inorganic Chemistry (2013), 52(19), 10741-10743, database is CAplus and MEDLINE.

Catalytic hydrolysis of silanes mediated by chlorodicarbonylrhodium(I) dimer [RhCl(CO)₂]₂ to produce silanols and dihydrogen efficiently under mild conditions is reported. Second-order kinetics and activation parameters are determined by monitoring the rate of dihydrogen evolution. The mixing of [RhCl(CO)₂]₂ and HSiCl₃ results in rapid formation of a rhodium silane σ complex.

Inorganic Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C11H14O2, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts