Tag: M.W=100-150

Andrade, Brenda published the artcileNonionic Surfactant Properties of Amphiphilic Hyperbranched Polyglycerols, Category: alcohols-buliding-blocks, the main research area is nonionic surfactant amphiphilic hyperbranched polyglycerol.

The surfactant properties of amphiphilic hyperbranched polyglycerols (HPGs) were investigated. The HPGs were prepared by ring-opening multibranching polymerization of glycidol using hydrophobic initiators of varying size and structure. The cloud points for all HPG surfactants were found to be >80 °C in deionized water with >1 wt % NaCl. The HPG surfactants with hydrophilic-lipophilic balance values between 16 and 18 were found to form stable octanol/water (o/w) emulsions within a 24 h period. Several surface properties, including critical micelle concentration (CMC), efficiency of surface tension reduction (pC20), effectiveness of surface tension reduction (γCMC), surface excess concentration at the CMC (Γmax), min. area/mol. at the interface (Amin), and the CMC/C20 ratio of the HPG surfactants were measured in deionized water at 22.6 °C. In general, increasing HPG size was marked by an increase in min. surface area per mol. (Amin) at the aqueous liquid/air interface. This increase in size also led to lower CMC and greater pC20 values of HPG surfactants prepared with Tergitol 15-S-7 initiator (HPG 5a-5d), a com. available ethylene glycol oligomer with a branched hydrophobic tail.

Langmuir published new progress about Cloud point. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sibirtsev, Stephan published the artcileAutomation of a Procedure for the Experimental Investigation of Liquid-Liquid Phase Separation, Formula: C8H18O, the main research area is octanol water liquid phase separation automation process.

Optimal design of a liquid-liquid settler requires exptl. investigation on phase separation behavior of the used material system under the same operating conditions as in the tech. application. Performing these experiments and evaluating the obtained data is highly time-consuming. To reduce manual effort, the procedure was largely automated. In this work, the exptl. setup, the automated procedure, and its validation results at various operating temperatures are presented. The results show the suitability of the automated procedure and the influence of temperature on phase separation behavior of the liquid-liquid system 1-octanol/water.

Chemie Ingenieur Technik published new progress about Coalescence. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, Shaio Wen published the artcileCatalysis in competing isocyanate reactions, COA of Formula: C7H18N2O, the main research area is phenyl isocyanate butanol esterification kinetics; dipropylenetriamine catalyst isocyanate butanol esterification; organotin catalyst isocyanate butanol esterification; amine catalyst isocyanate butanol esterification.

The effects of various organotin and tertiary amine catalysts on the product distributions in the esterification of Ph isocyanate (I) [103-71-9] with n-BuOH (II) [71-36-3] as model reaction for the preparation of polyurethanes were determined The esterification in the presence of N,N,N’,N’,N”-pentamethyldipropylenetriamine (III) [66537-05-1] catalyst in MeCN at 50° was first order with respect to I and III concentrations and half order with respect to II concentration with an apparent activation energy of 22.9 kcal/mol. Tri-Ph isocyanurate (IV) [1785-02-0], Bu phenylcarbamate  [1538-74-5], and Bu α,γ-diphenylallophanate  [21367-12-4] were formed by the reaction with IV being the major reaction product. The presence of H2O delayed the reaction rate and inhibited the formation of IV.

Polimeri (Zagreb, Croatia) published new progress about Cyclization. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, COA of Formula: C7H18N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hussain, Mulla Althafh published the artcileTotal synthesis of (±)-aspidostomide B, C, regioisomeric N-methyl aspidostomide D and their derivatives, HPLC of Formula: 22483-09-6, the main research area is aspidostomide B C D analog regioselective synthesis; cyclization total synthesis aspidostomide B C D; dehydration total synthesis aspidostomide B C D; regioselective ring opening total synthesis aspidostomide B C D.

A full account of the total synthesis of aspidostomide B, C, their analogs and our synthetic efforts towards the synthesis of aspidostomide D, which led to the synthesis of regioisomeric N-Me aspidostomide D, its analogs via epoxide opening strategy is presented. The synthesis of regioisomeric N-Me aspidostomide D involves an efficient, five-step sequence, with 36.3% overall yield, starting from 3,4,5-tribromo-1H-pyrrole-2-carboxylic acid. The key features of this protocol are intramol. cyclization, dehydration, oxidation, and a Lewis acid-mediated regioselective epoxide ring opening by C-3 position of 2,5-dibromo-1H-indole to furnish the title compounds

Tetrahedron Letters published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Xianheng published the artcilePreparation of Dolutegravir Intermediate Diastereomer, Safety of 2,2-Dimethoxyethanamine, the main research area is dolutegravir tricyclic intermediate diastereoselective preparation.

A convenient method was developed to prepare the diastereomer of dolutegravir tricyclic intermediate in the catalysis of EDCI/DMAP in up to 87% yield. Different solvents, temperature, and times were optimized. The synthesized diastereomer 6′ could be used as a standard for the industrial manufacture requirement of dolutegravir active pharmaceutical ingredient.

Journal of Heterocyclic Chemistry published new progress about Cyclization. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shumeiko, Bogdan published the artcileSemi-Batch Hydrotreatment of Lignin-Derived Phenolic Compounds over Raney-Ni with a Continuous Regeneration of the H-Donor Solvent, HPLC of Formula: 645-56-7, the publication is ChemSusChem (2022), 15(1), e202102099, database is CAplus and MEDLINE.

Lignin can be converted into useful precursors of fuels and fine chems. by thermochem. conversion followed by catalytic hydrogenation using metal catalysts at severe reaction conditions. Thus, mild hydrogenation would significantly improve the sustainability of lignin valorization. Here, hydrogenation of phenols, alkylphenols, and methoxyphenols was achieved at mild reaction conditions (70° and atm. pressure) via H-transfer hydrogenation over Raney-Ni catalyst in iso-PrOH and 2-butanol solvents. The transfer hydrogenation was feasible at the mild conditions, but the complexity of the reactant greatly decreased or even completely suppressed its reactivity. The position of the functional group (o-, m-, p-position) had a great effect on the reactivity of phenols. Also, 2-butanol enhanced the conversion of phenols in comparison with iso-PrOH. When comparing classic hydrogenation with H-transfer hydrogenation in presence of external H₂, external H₂ not only regenerated H-donor solvent and ensured stable performance but also increased conversion of phenols and alkylphenols. However, the absence of external H₂ boosted the conversion of methoxy phenols. Finally, phenols extracted from a pyrolysis oil aqueous phase were hydrogenated. The conversion of phenols was greatly affected by competitive adsorption of different compounds present in the reaction mixture External H₂ promoted hydrogenation of the complex reaction mixture and prevented condensation of the reactive species in contrast to the H-transfer hydrogenation.

ChemSusChem published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H5F3O, HPLC of Formula: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shimizu, Ken-ichi published the artcileSurface Oxygen-Assisted Pd Nanoparticle Catalysis for Selective Oxidation of Silanes to Silanols, SDS of cas: 597-52-4, the publication is Chemistry – A European Journal (2012), 18(8), 2226-2229, S2226/1-S2226/12, database is CAplus and MEDLINE.

Oxygen-adsorbed Pd surfaces show higher reactivity for water dissociation than clean Pd surfaces. Thus, carbon-supported Pd nanoparticles with surface oxygen atoms show higher activity for hydrolytic oxidation of silanes than previously reported catalysts. The synthetic utility of this catalyst is quite high because the catalyst, readily prepared from com. Pd/C, is easily recovered and reused, and shows high activity in oxidation of various silanes. This is a surface-science driven strategy of catalyst design for green organic synthesis. E.g., hydration of Et₃SiH in presence of carbon-supported Pd nanoparticles covered with O gave >99% Et₃SiOH, with TON = 20,000.

Chemistry – A European Journal published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C4HN5, SDS of cas: 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kazmierczak, Joanna published the artcileRu-Catalyzed Dehydrogenative Silylation of POSS-Silanols with Hydrosilanes: Its Introduction to One-Pot Synthesis, Category: alcohols-buliding-blocks, the publication is Inorganic Chemistry (2019), 58(2), 1201-1207, database is CAplus and MEDLINE.

A com. available and stable ruthenium dodecacarbonyl catalyst Ru₃(CO)₁₂ allows very efficient and convenient access to functionalized silsesquioxanes (SQs) containing siloxane moiety (Si-O-Si) via dehydrogenative coupling of POSS-silanols with hydrosilanes. With the aid of SiH-containing silsesquioxanes, an unprecedented one-pot procedure has been revealed, and the usefulness of this approach was demonstrated by the synthesis of various derivatives via O-silylation, as well as C:C and C:N hydrosilylation.

Inorganic Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oleszek, Sylwia published the artcileMitigation of bromine-containing products during pyrolysis of polycarbonate-based tetrabromobisphenol A in the presence of copper(I) oxide, Name: 4-Propylphenol, the publication is Journal of Hazardous Materials (2021), 124972, database is CAplus and MEDLINE.

Polycarbonate (PC) is an engineering thermoplastic that is widely used in elec. and electronic equipment. This plastic often contains tetrabromobisphenol A (TBBA), the most common brominated flame retardant. Thermal degradation of the PC-TBBA leads to generation of numerous bromo-organic products in the pyrolytic oil, hindering its appropriate utilization, as well as corrosive hydrogen bromide gas. The purpose of this study was to exptl. investigate and compare the pyrolysis products of PC-TBBA and PC-TBBA + Cu₂O at various temperatures, with an emphasis on the yield and distribution of brominated compounds In pyrolysis of PC-TBBA + Cu₂O, at the maximum degradation temperature (600 °C), as much as 86% of total Br was trapped in the residue, while 3% and 11% were distributed in the condensate and gas fractions, resp. In contrast, the distribution of Br from non-catalytic pyrolysis of PC-TBBA (600 °C) was 0.5% residue, 40% condensate, and 60% gas. The results of this study revealed that in the presence of Cu₂O, organo-bromine products were most likely involved in Ullman-type coupling reactions, leading to early crosslinking of the polymer network that efficiently hinders their vaporization. HBr in the gas fraction was suppressed due to effective fixation of bromine in residue in the form of CuBr.

Journal of Hazardous Materials published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Le, Thuy G. published the artcileStructure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development, Product Details of C3H5F3O, the publication is Journal of Medicinal Chemistry (2019), 62(2), 1036-1053, database is CAplus and MEDLINE.

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC₅₀ value of 0.03 μM while displaying good selectivity, with an IC₅₀ of 37.9 μM for cytotoxicity. As a promising mol. template for medicinal chem. optimization, we undertook anthelmintic structure-activity relationships for this chem. Modifications of the left-hand side (LHS), right-hand side (RHS), and middle section of the scaffold were explored to produce a set of 57 analogs. Analogs I, II, and III were shown to be the most potent compounds of the series, with IC₅₀ values at a subnanomolar level of potency against the chemotherapeutically relevant fourth larval (L4) stage of H. contortus. Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes, such as hookworms and whipworms.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts