Tag: M.W=100-150

Masada, Koichiro published the artcileReductive Coupling of Carbon Dioxide and an Aldehyde Mediated by a Copper(I) Complex toward the Synthesis of α-Hydroxycarboxylic Acids, Related Products of alcohols-buliding-blocks, the publication is Organic Letters (2020), 22(13), 4922-4926, database is CAplus and MEDLINE.

Copper-mediated reductive coupling between CO₂ and an aldehyde to form α-hydroxycarboxylic acid was achieved using silylborane as a reductant. CO₂ cleanly inserted into a copper-carbon bond that was formed by the reaction between a silylcopper-NHC complex and an aldehyde. A series of reactions that regenerate the silylcopper complex were developed for the synthesis of an α-hydroxycarboxylic acid. After repeating each step iteratively for two cycles, 0.62 equiv of α-hydroxycarboxylic acid based on the copper complex was obtained.

Organic Letters published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileTautomerism of the monohydroxy derivatives of five-membered oxygen, nitrogen and sulfur heterocycles, Application of Thiophen-3-ol, the publication is Journal of the American Chemical Society (1989), 111(14), 5346-56, database is CAplus.

The O-deuterated enolic tautomers 3-deuteroxybenzofuran, 3-deuteroxybenzothiophene, 3-deuteroxyindole, 3-deuteroxy-1-methylindole, 3-deuteroxyfuran, 3-deuteroxythiophene, 2-deuteroxybenzothiophene, and 2-deuteroxythiophene were generated in solution in mixtures of CD₃COCD₃, CD₃CN, or CD₃SOCD₃ with D₂O by hydrolysis of their trimethylsilyl derivatives in the presence of DCl (10^-3-10^-1 M) and characterized by ¹H NMR spectroscopy. Solutions of 3-hydroxypyrrole and of 3-hydroxy-1-methylpyrrole were obtained by methanolysis of their trimethylsilyl derivatives, evaporation of the methanol, and immediate dissolution in DMSO-d₆. The carbocyclic analogs of the bicyclic heterocyclic enols 3-deuteroxyindene and 2-deuteroxyindene were also generated in solution Attempts to prepare solutions of 2-deuteroxyfuran, 2-deuteroxypyrrole, and 2-deuteroxy-1-methylpyrrole were unsuccessful. The kinetics of ketonization of the OH forms of these enols were investigated in water or aqueous acetonitrile solution The equilibrium constants for the keto-enol tautomerism were also determined either by direct measurement when sufficient enol was present at equilibrium or as the ratio of the rate constant for enolization of the keto form to that for ketonization of the enol form, the former being determined by the iodine-trapping technique. The effect of solvent on the equilibrium constants was also studied. Sufficient data were available for the equilibrium between 3-hydroxyindole and 3-ketoindole for them to be analyzed by the four-parameter equation of Mills and Beak to yield an a-value of 2.4 and a b-value of -3.0. The pK_as of the bicyclic enols were measured. 3-Hydroxybenzofuran and 3-hydroxybenzothiophene are stronger acids than 3-hydroxyindole and 3-hydroxy-1-methylindole. The ketonization reactions are general-acid and general-base catalyzed and their mechanisms are discussed.

Journal of the American Chemical Society published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileThe tautomerism of hydroxy derivatives of five-membered oxygen, nitrogen, and sulfur heterocycles [Erratum to document cited in CA106(19):155813y], SDS of cas: 17236-59-8, the publication is Tetrahedron Letters (1988), 29(3), 250, database is CAplus.

An error in a k_H⁺ value for ketonization of 2-hydroxyindene was corrected (3.48 M^-1s^-1, not 83 M^-1s^-1. The error was not reflected in the abstract or the index entries.

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capon, Brian published the artcileThe tautomerism of hydroxy derivatives of five-membered oxygen, nitrogen, and sulfur heterocycles, Formula: C4H4OS, the publication is Tetrahedron Letters (1986), 27(28), 3275-8, database is CAplus.

The unstable enolic tautomers 3-hydroxyfuran, 2- and 3-hydroxythiophene, 3-hydroxypyrrole, 3-hydroxy-1-methylpyrrole and their benzo derivatives have been generated in solution and the rate and equilibrium constants for their ketonization determined

Tetrahedron Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Formula: C4H4OS.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Leshina, M. N. published the artcileSpecific Features of N-Morpholinoethyl Methacrylate Synthesis, Application of 2-Morpholinoethanol, the publication is Russian Journal of Applied Chemistry (2018), 91(7), 1118-1122, database is CAplus.

Methods for synthesis of N-morpholinoethyl methacrylate were compared. It was shown that the monomer produced by acylation of N-morpholinoethanol with methacrylic acid anhydride or methacryloyl chloride spontaneously polymerizes in storage. The possible reasons for the spontaneous polymerization of N-morpholinoethyl methacrylate produced by the acylation method were considered. The conditions in which a stable-in-storage monomer can be obtained in 86-88% yield by the method of re-esterification of Me methacrylate with N-morpholinoethanol were determined

Russian Journal of Applied Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Application of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Worawit, Chanatda published the artcileCombining graphite with hollow-fiber liquid-phase microextraction for extraction of polar organic compounds, Quality Control of 111-87-5, the main research area is graphite hollow fiber liquid phase microextraction extraction polar; organic compound water sample analysis; Carbon nanosorbent; Gas chromatography; Graphite; Hollow-fiber liquid-phase microextraction; Nanomaterial; Trihalomethane.

In this study, we have developed a simple and effective hybrid extraction method based on the incorporation of raw carbon nanosorbents and octanol in the pores of a hollow-fiber membrane for improving the extraction efficiency of relatively polar organic compounds Trihalomethanes (THMs) were used as model analytes. Three types of carbon nanosorbents (graphite, graphene, and multi-walled carbon nanotubes) were studied. The carbon sorbent incorporating membrane was used in a two-phase mode liquid-phase microextraction, with 1-octanol as the acceptor solution Using a graphite-reinforced hollow-fiber membrane and an extraction time of 10 min, enrichment factors of 40-71 were obtained for trichloromethane, bromodichloromethane, bromoform, and chlorodibromomethane. Linear working ranges of 0.2-100μg L-1 and limits of detection ranging from 0.01μg L-1 (for CHCl2Br and CHClBr2) to 0.1μg L-1 (for CHCl3) were achieved. The min. detectable concentrations were far below the maximum concentration levels (60-200μg L-1) set by the WHO for drinking water. The carbon-sorbent-reinforced hollow-fiber liquid-phase microextraction afforded higher extraction efficiency and shorter extraction time compared with conventional hollow-fiber liquid-phase microextraction Finally, the method was applied to the anal. of real water samples, such as drinking water, tap water, and swimming pool water samples.

Talanta published new progress about Analysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hansen, Camilla published the artcileHigh metabolic substrate load induces mitochondrial dysfunction in rat skeletal muscle microvascular endothelial cells, Formula: C4H6O5, the main research area is mitochondrial dysfunction rat skeletal muscle microvascular endothelial cell; glucose; mitochondria; palmitic acid; reactive oxygen species; respirometry; vascular.

The influence of glucose and palmitic acid (PA) on mitochondrial respiration and emission of hydrogen peroxide (H2O2) was determined in skeletal muscle-derived microvascular endothelial cells. Measurements were assessed in intact and permeabilized (cells treated with 0.025% saponin) low passage endothelial cells with acute-or prolonged (3 days) incubation with regular (1.7 mM) or elevated (2.2 mM) PA concentrations and regular (5 mM) or elevated (11 mM) glucose concentrations In intact cells, acute incubation with 1.7 mM PA alone or with 1.7 mM PA + 5 mM glucose (p < .001) led to a lower mitochondrial respiration (p < 0.01) and markedly higher H2O2/O2 emission (p < 0.05) than with 5 mM glucose alone. Prolonged incubation of intact cells with 1.7 mM PA +5 mM glucose led to 34% (p < 0.05) lower respiration and 2.5-fold higher H2O2/O2 emission (p < 0.01) than incubation with 5 mM glucose alone. Prolonged incubation of intact cells with elevated glucose led to 60% lower (p < 0.05) mitochondrial respiration and 4.6-fold higher H2O2/O2 production than incubation with 5 mM glucose in intact cells (p < 0.001). All effects observed in intact cells were present also in permeabilized cells (State 2). In conclusion, our results show that acute and prolonged lipid availability, as well as prolonged hyperglycemia, induces mitochondrial dysfunction as evidenced by lower mitochondrial respiration and enhanced H2O2/O2 emission. Elevated plasma substrate availability may lead to microvascular dysfunction in skeletal muscle by impairing endothelial mitochondrial function. Physiological Reports published new progress about Animalia. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Corey, Elizabeth A. published the artcileInhibitory signaling in mammalian olfactory transduction potentially mediated by Gαo, Computed Properties of 111-87-5, the main research area is mammalian olfactory receptor neuron inhibition modulation transduction; Combinatorial coding; Inhibition; Modulation; Olfaction; Olfactory receptor neurons.

Olfactory GPCRs in mammalian olfactory receptor neurons mediate excitation through the Gαs family member Gαolf. Here we tentatively associate a second G protein, Gαo, with inhibitory signaling in mammalian olfactory transduction by first showing that odor evoked phosphoinositide 3-kinase-dependent inhibition of signal transduction is absent in the native ORNs of mice carrying a conditional OMP-Cre based knockout of Gαo. We then identify an OR from native rat ORNs that are activated by octanol through cyclic nucleotide signaling and inhibited by citral in a PI3K-dependent manner. We show that the OR activates cyclic nucleotide signaling and PI3K signaling in a manner that reflects its functionality in native ORNs. Our findings lay the groundwork to explore the interesting possibility that ORs can interact with two different G proteins in a functionally identified, ligand-dependent manner to mediate opponent signaling in mature mammalian ORNs.

Molecular and Cellular Neuroscience published new progress about Animalia. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Locci, Emanuela published the artcileMetabolomics improves the histopathological diagnosis of asphyxial deaths: an animal proof-of-concept model, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is metabolome histopathol diagnosis asphyxial death.

The diagnosis of mech. asphyxia remains one of the most difficult issues in forensic pathol. Asphyxia ultimately results in cardiac arrest (CA) and, as there are no specific markers, the differential diagnosis of primitive CA and CA secondary to asphyxiation relies on circumstantial details and on the pathologist experience, lacking objective evidence. Histol. examination is currently considered the gold standard for CA post-mortem diagnosis. Here we present the comparative results of histopathol. vs. those previously obtained by 1H NMR (NMR) metabolomics in a swine model, originally designed for clin. purposes, exposed to two different CA causes, namely ventricular fibrillation and asphyxia. While heart and brain microscopical anal. could identify the damage induced by CA without providing any addnl. information on the CA cause, metabolomics allowed the identification of clearly different profiles between the two groups and showed major differences between asphyxiated animals with good and poor outcomes. Minute-by-minute plasma sampling allowed to associate these modifications to the pre-arrest asphyxial phase showing a clear correlation to the cellular effect of mech. asphyxia reproduced in the experiment The results suggest that metabolomics provides addnl. evidence beyond that obtained by histol. and immunohistochem. in the differential diagnosis of CA.

Scientific Reports published new progress about Asphyxia. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Chao published the artcileRobust hydrogen production via pickering interfacial catalytic photoreforming of n-octanol-water biphasic system, COA of Formula: C8H18O, the main research area is hydrogen production octanol water pickering interfacial catalysis; Pt/TiO2 nanosheets; hydrogen production; microfluidics; photoreforming; pickering interfacial catalysis.

Pickerin g emu lsion offers a promis ing platform for conductin g interfa cial reaction s bet ween immis cible reagents ; it is part icularly suit able for hy drogen producti on by photo reforming of non-w ater soluble biomass liq uid and w ater. Here in, Pt-p romoted (001)-fa cet-domi nated anatase TiO2 nanosheets were synthesized by a hydrothermal route associated with microfluidic technol. for high activity and metal dispersion, and selective surface modification was carried out for preparing Janus particles. Photoreforming hydrogen production through n-octanol and water that formed O/W microemulsion with an average diameter of 540μm was achieved to obtain amphiphilic catalyst. The as-prepared 2D Janus-type catalysts exhibited remarkably stable emulsification performance as well as photocatalytic activity. This finding indicates that triethoxyfluorosilane had negligible impact on the catalytic performance, yet provided a remarkable benefit to large sp. surface area at microemulsion interface, thereby enhancing the H2 yield up to 2003μmol/g. The cyclic experiments indicate that the decrease in cyclic performance was more likely to be caused by the coalescence of the microemulsion rather than the decrease in catalytic activity, and the microemulsion could be easily recovered by simply hand shaking to more than 96% of the initial performance.

Frontiers in Chemistry (Lausanne, Switzerland) published new progress about Band gap. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts