Tag: M.W=100-150

Nikolic, Vladimir published the artcileBiodegradation of copolymer obtained by grafting reaction between methacrylic acid and starch, Synthetic Route of 622-40-2, the publication is Polymer Bulletin (Heidelberg, Germany) (2019), 76(5), 2197-2213, database is CAplus.

Biodegradation of methacrylic acid and starch graft copolymers was investigated for the first time in this manuscript. Synthesized copolymer was characterized by ¹H NMR spectroscopy (NMR), Fourier transformed IR spectroscopy (FTIR), SEM (SEM) and elemental anal. Copolymers with different percentage of grafting, G (%), were buried in three different types of soil. Biodegradation was monitored by measuring mass loss of the samples and using FTIR and SEM. The highest weight loss was in soil for the orchid growth (all samples had biodegradation higher than 89%), followed by soil for the cactus growth (mass loss higher than 70%) and soil rich in humus where some of the samples had biodegradation rate near or less than 50%. The correlation between G (%) and percent of weight loss after biodegradation was not significant in any types of soil. FTIR and SEM showed that after biodegradation, samples still contained both building components. Respiration test showed higher O₂ consumption and CO₂ production comparing to polystyrene which confirmed biodegradability of the accessible starch in copolymer. Based on the obtained results, degradation mechanism is proposed. First step is biodegradation of easily accessible starch followed by dissolution of the poly(methacrylic acid). This mechanism confirmed that biodegradation depends not only on the percentage of grafting, but also on mol. packaging, chains arrangement and the number and types of microorganisms present in the specific types of soils.

Polymer Bulletin (Heidelberg, Germany) published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Si-Shun published the artcileVisible-light photoredox-catalyzed selective carboxylation of C(sp³)-F bonds with CO₂, COA of Formula: C6H16OSi, the publication is Chem (2021), 7(11), 3099-3113, database is CAplus.

A novel selective carboxylation of C(sp³)-F bonds with CO₂ via visible-light photoredox catalysis. A variety of mono-, di-, and trifluoroalkylarenes as well as α,α-difluorocarboxylic esters and amides undergo such reactions to give important aryl acetic acids and α-fluorocarboxylic acids, including several drugs and analogs, under mild conditions. Notably, mechanistic studies and DFT calculations demonstrate the dual role of CO₂ as an electron carrier and electrophile during this transformation. The fluorinated substrates would undergo single-electron reduction by electron-rich CO₂ radical anions, which were generated in situ from CO₂ via sequential hydride-transfer reduction and hydrogen-atom-transfer processes.

Chem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C18H12ClNO, COA of Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Min published the artcileCooperative Gold/Zinc-catalyzed Cascade Approach to Tryptophan Derivatives from N-arylhydroxylamines and Alkynes, Related Products of alcohols-buliding-blocks, the publication is Asian Journal of Organic Chemistry (2022), 11(4), e202200054, database is CAplus.

A cooperative gold/zinc catalyzed strategy for the synthesis of tryptophan derivatives from easily prepared N-arylhydroxylamines and chiral amino acid tethered alkynes with high efficiency has been developed. The structurally diverse tryptophan derivatives including pharmaceutical relevant mols. can be readily prepared by this method. This tandem transformation starts from acyclic simple materials rather than the existing methods by modifying indole skeletons.

Asian Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C11H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Feng, Shanshan published the artcileLow temperature catalytic hydrodeoxygenation of lignin-derived phenols to cyclohexanols over the Ru/SBA-15 catalyst, Product Details of C9H12O, the publication is RSC Advances (2022), 12(15), 9352-9362, database is CAplus and MEDLINE.

Cyclohexanol and its derivatives are widely used as chem. intermediates and fuel additives. Herein, Ru/SBA-15 catalysts were prepared via impregnation, and used for the production of cyclohexanols from lignin-derived phenols. The catalyst samples were characterized by XRD, XPS, TEM, etc., where the Ru⁰ species was speculated as the active phase. 5 wt% Ru/SBA-15 with small Ru particle size (4.99 nm) and high Ru dispersion (27.05%) exhibited an excellent hydrogenation activity. A high cyclohexanol yield of >99.9% was achieved at 20°C for 5 h in an aqueous phase, and the catalyst indicated stable activity and selectivity after five runs. Crucially, Ru/SBA-15 exhibited a zero-order reaction rate with an apparent activation energy (Ea) as low as 10.88 kJ mol^-1 and a TON of 172.84 at 80°C. Simultaneously, demethoxylation activity was also observed in the hydrodeoxygenation (HDO) of G- and S-type monophenols, and a high yield of 37.4% of cyclohexanol was obtained at 80°C and 4 h when using eugenol as substrate.

RSC Advances published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Product Details of C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Guanyi published the artcileInvestigation on catalytic hydrodeoxygenation of eugenol blend with light fraction in bio-oil over Ni-based catalysts, Safety of 4-Propylphenol, the publication is Renewable Energy (2020), 456-465, database is CAplus.

In this work, HZSM-5, Al-SBA-15 and Al-SBA-15/HZSM-5 were adopted as supporting materials for the nickel-based catalysts used in hydrodeoxygenation process. Incipient wetness impregnation method was employed to load nickel species onto these materials. The physicochem. characterization was carried out using advanced instruments. The effect of composition of nickel-based catalysts on hydrodeoxygenation (HDO) reaction was studied. Support materials of nickel-based catalyst have a significantly impact on HDO activity. The highest selectivity (67.9%) of propyl-cyclohexane was obtained over nickel based Al-SBA-15/HZSM-5 catalyst, and nearly all the eugenol was completely hydrodeoxygenated after reaction. The impact of light fractions existed in bio-oil on phenols upgrading process was investigated. The conversion of eugenol mixed with light fractions reached nearly 100% for all the reactions. Eugenol mixed with light fractions as reactant could reduce ring break reaction during hydrodeoxygenation process. The selectivity of alkanes remained nearly unchanged after adding ethylene glycol into the reactant. However, the selectivity of propyl-cyclohexane was significantly decreased by mixing furfural or acetic acid with eugenol as reactant.

Renewable Energy published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Safety of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sun, Ying-Jie published the artcileRegioselective synthesis and anticancer evaluation of H₂O₂-activable nucleosides, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(48), 6484-6487, database is CAplus and MEDLINE.

We describe here the design, synthesis, and biol. evaluation of H₂O₂-activatable dioxaboronalyl nucleosides via an efficient and regioselective functionalization of unprotected precursors. Biol. evaluation of a H₂O₂-specific responsive prodrug of gemecitabin demonstrates an extremely fast activation, low toxicity and enhanced anticancer effects in two cell lines.

Chemical Communications (Cambridge, United Kingdom) published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C18H17N5O3, Recommanded Product: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tsai, Charng-Sheng published the artcileDevelopment of trifunctional probes for glycoproteomic analysis, Safety of 3-(Methylamino)phenol, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(30), 5575-5577, database is CAplus and MEDLINE.

Here the authors examine the applications of two trifunctional probes with different linkers for their abilities in both target detection via 3-azido-7-aminocoumarin and enrichment via biotin, when reacting with alkynyl sugars. Probe I carries an azido group for both conjugation and fluorescent triggering. When the 1,2,3-triazole ring was formed by Cu(I)-catalyzed Azide-Alkyne (3 +2) Cycloaddition, it activated the fluorescent property of 3-azido-7-aminocoumarin to provide a high fluorescent signal for rapid and sensitive target detection, while the biotin group in probe I offered the advantage of glycoprotein enrichment. To increase the elution yield of labeled targets that bind to streptavidin matrixes, the authors further introduced a cleavable linker (cystamine) between 3-azido-7-aminocoumarin and biotin in probe II. Thus after binding to streptavidin matrixes, the labeled targets can be recovered by treatment with reducing agents such as dithiothreitol or tris(2-carboxyethyl)phosphine to break the disulfide bond and give fluorescent labeled biomols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C6H12O2, Safety of 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Pengzhi published the artcileSynthesis of AD-Dihydrodipyrrins Equipped with Latent Substituents of Native Chlorophylls and (Bacterio)chlorophylls, Application of Pentane-1,5-diol, the publication is Journal of Organic Chemistry (2021), 86(17), 11794-11811, database is CAplus and MEDLINE.

Native chlorophylls and bacteriochlorophylls share a common trans-substituted pyrroline ring D (17-propionic acid, 18-methyl), whereas diversity occurs in ring A particularly at the 3-position. Two dihydrodipyrrins equipped with native-like D-ring substituents and A-ring substituents have been synthesized. The synthesis relies on a Schreiber-modified Nicholas reaction to construct the stereochem. defined precursor to ring D, a dialkyl-substituted pent-4-ynoic acid. The carboxylic acid group of the intact propionic acid proved unworkable, whereupon protected propionate (-CO₂^tBu) and several latent Pr ethers were examined The tert-butyldiphenylsilyl-protected propanol substituent proved satisfactory for reaction of the chiral N-acylated oxazolidinone, affording (2S,3S)-2-(3-((tert-butyldiphenylsilyl)oxy)propyl)-3-methylpent-4-ynoic acid in ~30% yield over 8 steps. Two variants for ring A, 2-tert-butoxycarbonyl-3-Br/H-5-iodo-4-methylpyrrole, were prepared via the Barton-Zard route. Dihydrodipyrrin formation from the pyrrole and pentynoic acid entailed Jacobi Pd-mediated lactone formation, Petasis methenylation, and Paal-Knorr-type pyrroline formation. The two AD-dihydrodipyrrins bear the D-ring Me and protected propanol groups with a stereochem. configuration identical to that of native (bacterio)chlorophylls, and a bromine or no substitution in ring A corresponding to the 3-position of (bacterio)chlorophylls. The analogous β-position of a lactone-pyrrole intermediate on the path to the dihydrodipyrrin also was successfully brominated, opening opportunities for late-stage diversification in the synthesis of (bacterio)chlorophylls.

Journal of Organic Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C9H8O4, Application of Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Tairan published the artcileCu-catalyzed carboboration of acetylene with Michael acceptors, Category: alcohols-buliding-blocks, the publication is Chemical Science (2022), 13(25), 7604-7609, database is CAplus and MEDLINE.

A copper-catalyzed three-component carboboration of acetylene with B₂Pin₂ and Michael acceptors is reported. In this reaction, a cheap and abundant C2 chem. feedstock, acetylene, was used as a starting material to afford cis-alkenyl boronates bearing a homoallylic carbonyl group. The reaction was robust and could be reliably performed on the molar scale. Furthermore, the resulting cis-alkenyl boronates could be converted to diverse functionalized mols. with ease.

Chemical Science published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mamat, Marhaba published the artcileA visible-light-induced thiol addition/aerobic oxidation cascade reaction of epoxides and thiols for the synthesis of β-hydroxylsulfoxides, Safety of 2-Phenylethanethiol, the publication is Organic & Biomolecular Chemistry (2021), 19(45), 9855-9859, database is CAplus and MEDLINE.

A photochem. thiol addition/aerobic oxidation cascade reaction had been developed. This protocol enabled efficient oxidative coupling of epoxides and thiols to access structurally valuable β-hydroxylsulfoxides RSO₂CH₂C(R¹R²)OH [R = 4-MeC₆H₄, 4-ClC₆H₄, 4-MeOC₆H₄, etc.; R¹ = H, Me; R² = Me, Et, CO₂Et, etc.]. A broad range of functional groups were compatible to obtain moderate to good yields of the target products. Mechanistic studies revealed a sequential reaction pathway involving base-promoted thiol addition of thiols to epoxides and visible-light-induced aerobic oxygenation of thioethers.

Organic & Biomolecular Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Safety of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts