Tag: M.W=100-150

Du, Xiangsha published the artcileSingle-electron charging and ultrafast dynamics of bimetallic Au_144-xAg_x(PET)₆₀ nanoclusters, Application of 2-Phenylethanethiol, the publication is Nano Research (2022), 15(9), 8573-8578, database is CAplus.

Alloying is an important strategy in tailoring the functionality of materials. In metal nanoclusters (NCs), the introduction of a heterometal leads to alloy nanoclusters that often outperform the homometal ones in terms of the phys. and chem. properties. In this work, a series of four M₁₄₄(PET)₆₀ alloy NCs (where, M = Au/Ag, PET = -SCH₂CH₂Ph) are synthesized and characterized. The silver doping into the homogold template (Au₁₄₄) leads to more prominent optical absorption features in the steady-state spectrum in the visible range. Femtosecond transient absorption spectroscopy reveals the effect of Ag doping on the electronic relaxation dynamics compared to Au₁₄₄ and the pump fluence independent dynamics. Electrochem. results reflect a narrowing of HOMO-LUMO gap (Eg) induced by Ag doping. A temperature dependence of the single-electron charging is also observed for the series of alloy NCs, in which the E_g values of the alloy NCs enlarge as the temperature decreases, which is characteristic of semiconducting behavior. [graphic not available: see fulltext]

Nano Research published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application of 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Yu published the artcileSolution [2 + 2] photopolymerization of biomass-derived nonrigid biscinnamate monomers enabled by energy transfer catalysis, SDS of cas: 111-29-5, the publication is Polymer Chemistry (2022), 13(17), 2538-2544, database is CAplus.

The [2+2] photopolymerization has been known for more than fifty years and widely applied in many fields. However, this process is typically conducted in the solid state, while the corresponding [2 + 2] photopolymerization of simple non-rigid diolefinic monomers has been rarely achieved in solution under visible light, owing to the lack of monomer preassembly and low/no absorption of visible light. In fact, the [2 + 2] photopolymerization of simple biscinnamate monomers remains an unsolved problem. Here, we demonstrate that energy transfer catalysis could overcome the low efficiency in the intersystem crossing to the triplet states of monomers and enable the [2 + 2] photopolymerization of biomass-derived biscinnamate monomers in solution for the first time. As no preassembly is required, this solution polymerization protocol is applicable to biscinnamate monomers with different linker structures and allows copolymerization between different biscinnamate monomers to regulate polymer mech. properties. A series of cyclobutane-imbedded polyesters (Mw ranged from 25.3 kDa to 61.3 kDa) became accessible, which showed excellent solubility in organic solvents and good processability, in sharp contrast to the properties of the biscinnamate polymers obtained before via solid state photopolymerization methods.

Polymer Chemistry published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dong, Si published the artcileFunctional Amphiphilic Poly(2-oxazoline) Block Copolymers as Drug Carriers: the Relationship between Structure and Drug Loading Capacity, Recommanded Product: 2-Phenylethanethiol, the publication is Chinese Journal of Polymer Science (2021), 39(7), 865-873, database is CAplus.

Poly(2-oxazoline) (POx) is a kind of polymeric amides that can be viewed as conformational isomers of polypeptides with excellent cyto- and hemo-compatibility, and is promising to be used as drug carriers. However, the drug loading capacity (DLC) of POx for many drugs is still low except several hydrophobic ones including paclitaxel (PTX). Herein, we prepared a series of amphiphilic POx block copolymers with various functional groups, and investigated the relationship between functional structures and the DLC. Functional POxs with benzyl, carboxyl, and amino groups in the side-chain were synthesized based on a poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline-co-2-butenyl-2-oxazoline) (PMeOx-P(nBuOx-co-ButenOx), PMBEOx) precursor, followed by click reaction between vinyl and the 2-phenylethanethiol, thioglycolic acid and cysteamine. Using thin-film hydration method, eight commonly used drugs with various characteristics were encapsulated within these functional POx polymers. We found that amine-containing drugs were more easily encapsulated by POx with carboxyl groups, while amine functionalities in POx enhanced the loading capacity of drugs with carboxyl groups. In addition, ;π;π interactions resulted in enhanced DLC of most drugs, except several hydrophobic drugs with aromatic to total carbon ratios less than 0.5. In general, we could successfully encapsulate all the selected drugs with a DLC% over 10% using properly selected functional POxs. The above results confirm that the DLC of polymeric carriers can be adjusted by modifying the functional groups, and the prepared series of functional POxs provide an option for various drug loadings.

Chinese Journal of Polymer Science published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rueeger, Heinrich published the artcileDiscovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3364-3386, database is CAplus and MEDLINE.

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC₅₀ values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kautny, Paul published the artcileOxadiazole based bipolar host materials employing planarized triarylamine donors for RGB PHOLEDs with low efficiency roll-off, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Journal of Materials Chemistry C: Materials for Optical and Electronic Devices (2014), 2(11), 2069-2081, database is CAplus.

6 Novel triarylamine-containing oxadiazole compounds (o-PCzPOXD, o-ICzPOXD, o-TPATOXD, o-PCzTOXD, o-ICzTOXD, o-CzTOXD) were designed, synthesized and characterized concerning applications as host materials in PHOLED devices. To further improve the ortho-linkage concept, the impact of incorporating planarized electron-donating triarylamine (TAA) structures on intramol. charge transfer was examined The effect was evaluated for 2 series of electron-accepting oxadiazole scaffolds, realizing ortho-linkage on the benzene (POXD) and the thiophene (TOXD) cores. Thermal anal. shows increased glass-transition temperatures for planarized structures indicating an improved morphol. stability. A higher degree of planarization also results in significantly increased singlet and triplet energy values, revealing the impact on the intramol. charge transfer. Using the developed materials, red (o-TPATOXD: CE_max: 28.8 cd A^-1, EQE_max: 16.9%), green (o-PCzPOXD: CE_max: 62.9 cd A^-1, EQE_max: 17.1%) and blue (o-PCzPOXD: CE_max: 29.8 cd A^-1, EQE_max: 13.4%) devices were achieved showing remarkably low efficiency roll-off for planarized donors. This is the 1st report of efficient blue devices for this specific class of host materials. Probably the results correlate with an increasing ortho-linkage effect and decreasing donor strength of the TAA moiety by planarization and, thus, tackling 1 of the major challenges in PHOLED research: improving both triplet energy and compound stability.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Zhi published the artcileEfficient hydrodeoxygenation of phenolic compounds and raw lignin-oil under a temperature-controlled phase-transfer catalysis, Formula: C9H12O, the publication is Fuel (2021), 120091, database is CAplus.

An effective binary catalyst by using tungstic acid (H₂WO₄) and Ru/C was employed for the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin-oil. H2WO4 was presented as solid at ambient temperature, but it dissolved at high temperature above 100°C and therefore functioned as an active homogeneous catalyst. This phenomenon resulted in a temperature-controlled phase-transfer behavior in the HDO of phenolic compounds An efficient HDO performance and an exceptional reusability for guaiacol HDO were presented by this bifunctional catalyst, which can be reused more than 10 times with guaiacol conversion and cyclohexane selectivity over 90%. The comparison of traditional liquid organic and mineral acids, as well as solid acids, with H₂WO₄ confirmed the outstanding catalytic performance of H₂WO₄ and highlighted the advantages of H₂WO₄ as a homogeneous catalyst. Besides guaiacol, other phenolic compounds including various monomers and dimers all exhibited good HDO results, with 100% conversion and cycloalkanes selectivity. Moreover, the raw lignin-oil can be efficiently deoxygenated under the catalysis of this bifunctional catalyst 99.3% content of hydrocarbons was obtained in the upgraded lignin-oil, which was promising to be used as fuel directly. This catalytic system has great potential for the industrial application of lignin-oil upgrade.

Fuel published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C15H12O6, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fan, Lingling published the artcileSynthesis and antifungal activity of imidazo[1,2-b]pyridazine derivatives against phytopathogenic fungi, Safety of 2-Morpholinoethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2020), 30(14), 127139, database is CAplus and MEDLINE.

A series of 3,6-disubstituted imidazo[1,2-b]pyridazine derivatives were synthesized and characterized with spectroscopic analyses. The antifungal activities of these compounds against nine phytopathogenic fungi were evaluated by the mycelium growth rate method. The in vitro antifungal bioassays indicated that most of compounds displayed excellent and broad-spectrum antifungal activities. Especially, compounds 6-chloro-3-phenylimidazo[1,2-b]pyridazine, 6-chloro-3-(2-fluorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(2-chlorophenyl)imidazo[1,2-b]pyridazine, 6-chloro-3-(thiophen-3-yl)imidazo[1,2-b]pyridazine and 6-methoxy-3-phenylimidazo[1,2-b]pyridazine exhibited 1.9-25.5 fold more potent than the com. available fungicide hymexazol against Corn Curvalaria Leaf Spot (CL), Alternaria alternate (AA), Pyricularia oryzae (PO) and Alternaria brassicae (AB) strains. Structure-activity relation anal. showed that the enhanced antifungal activity is significantly affected by the substituents on the benzene ring and pyridazine ring.

Bioorganic & Medicinal Chemistry Letters published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Safety of 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sam, Brannon published the artcileRuthenium-Catalyzed C-C Coupling of Fluorinated Alcohols with Allenes: Dehydrogenation at the Energetic Limit of β-Hydride Elimination, Application In Synthesis of 2240-88-2, the publication is Angewandte Chemie, International Edition (2015), 54(18), 5465-5469, database is CAplus and MEDLINE.

Ruthenium(II) complexes catalyze the C-C coupling of 1,1-disubstituted allenes and fluorinated alcs. to form homoallylic alcs. bearing all-carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcs. are relatively abundant and tractable, the corresponding aldehydes are often not com. available because of their instability.

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application In Synthesis of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sam, Brannon published the artcileRuthenium-Catalyzed C-C Coupling of Fluorinated Alcohols with Allenes: Dehydrogenation at the Energetic Limit of β-Hydride Elimination, Product Details of C4H5F3O, the publication is Angewandte Chemie, International Edition (2015), 54(18), 5465-5469, database is CAplus and MEDLINE.

Ruthenium(II) complexes catalyze the C-C coupling of 1,1-disubstituted allenes and fluorinated alcs. to form homoallylic alcs. bearing all-carbon quaternary centers with good to complete levels of diastereoselectivity. Whereas fluorinated alcs. are relatively abundant and tractable, the corresponding aldehydes are often not com. available because of their instability.

Angewandte Chemie, International Edition published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Product Details of C4H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yaping published the artcileSynthesis, characterization and catalytic oxidation of organosilanes with a novel multilayer polyoxomolybdate containing mixed-valence antimony, Recommanded Product: Triethylsilanol, the publication is Molecular Catalysis (2018), 167-174, database is CAplus.

Oxidation of organosilanes is one of the pivotal reactions in organic synthesis and the corresponding products of silanols are widely as raw materials in industrial processes. A new type of polyoxomolybdate containing mixed-valence Sb, [Sb(V)Sb(III)₄Mo₁₈O₆₆]^7- (1a), was isolated as tetra-Me ammonium salt in aqueous solution The compound was structurally characterized by FTIR, XPRD, TG, XPS, ESI-MS etc. It is the 1st time that the containing mixed-valence Sb polyoxomolybdate was used as a heterogeneous catalyst to efficaciously catalyze the oxidation of organosilanes to silanols under mild reaction conditions. Also, the catalyst was stable and maintained its catalytic activity after three reaction cycles.

Molecular Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C12H13F2N3O4S, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts