Tag: M.W=100-150

Nurjuliana, M. published the artcileRapid identification of pork for halal authentication using the electronic nose and gas chromatography mass spectrometer with headspace analyzer, SDS of cas: 17236-59-8, the publication is Meat Science (2011), 88(4), 638-644, database is CAplus and MEDLINE.

The volatile compounds of pork, other meats and meat products were studied using an electronic nose and gas chromatog. mass spectrometer with headspace analyzer (GCMS-HS) for halal verification. The zNose was successfully employed for identification and differentiation of pork and pork sausages from beef, mutton and chicken meats and sausages which were achieved using a visual odor pattern called VaporPrint, derived from the frequency of the surface acoustic wave (SAW) detector of the electronic nose. GCMS-HS was employed to sep. and analyze the headspace gases from samples into peaks corresponding to individual compounds for the purpose of identification. Principal component anal. (PCA) was applied for data interpretation. Anal. by PCA was able to cluster and discriminate pork from other types of meats and sausages. It was shown that PCA could provide a good separation of the samples with 67% of the total variance accounted by PC1.

Meat Science published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, SDS of cas: 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bagherzadeh, Sharareh published the artcileCatalyst Control of Selectivity in CO₂ Reduction Using a Tunable Heterobimetallic Effect, COA of Formula: C6H13BO3, the publication is Journal of the American Chemical Society (2015), 137(34), 10898-10901, database is CAplus and MEDLINE.

A tunable bimetallic effect on product selectivity in catalytic CO₂ reduction was identified using N-heterocyclic carbene-ligated Cu complexes. While the monometallic Cu-only system catalyzes hydroboration of CO₂ with pinacolborane to produce formate exclusively, introducing a bimetallic effect with analogous Cu-Fe, Cu-W, and Cu-Mo catalysts produces mixtures of formate and CO. Within a series of isosteric catalysts, the selectivity of CO vs. formate was controlled by tuning the electronic nature of the Cu/M pairing, with high selectivity for CO being achieved using a Cu-Mo catalyst.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, COA of Formula: C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cooper, Anna G. published the artcileAlkyl indole-based cannabinoid type 2 receptor tools: Exploration of linker and fluorophore attachment, COA of Formula: C6H13NO2, the publication is European Journal of Medicinal Chemistry (2018), 770-789, database is CAplus and MEDLINE.

Cannabinoid type 2 (CB₂) receptor continues to emerge as a promising drug target for many diseases and conditions. New tools for studying CB₂ receptor are required to further inform how this receptor functions in healthy and diseased states. The alkyl indole scaffold is a well-recognized ligand for cannabinoid receptors, and in this study the indole C5-7 positions were explored for linker and fluorophore attachment. A new high affinity, CB₂ receptor selective inverse agonist was identified (16b, 3-(4-methoxybenzoyl)-1-[(oxan-4-yl)methyl]-7-propoxy-1H-indole) along with a general trend of C5-substituted indoles acting as agonists vs. C7-substituted indoles acting as inverse agonists. The indole C7 position was found to be the most tolerant to linker extension and resulted in a high affinity inverse agonist with a medium length linker (19, Me 5-[[3-(4-methoxybenzoyl)-1-[(oxan-4-yl)methyl]-1H-indol-7-yl]oxy]pentanoate). Although a high affinity fluorescent ligand for CB₂ receptor was not identified in this study, the indole C7 position shows great promise for fluorophore or probe attachment.

European Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, COA of Formula: C6H13NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ford, M. C. published the artcile3-Hydroxythiophene, Computed Properties of 17236-59-8, the publication is Journal of the Chemical Society (1956), 4985-7, database is CAplus.

The Grignard reagent from 3-bromothiophene (I) was treated with O with the production of a crude phenolic material, and two distillations gave the pure 3-hydroxythiophene (II), which was unstable, developing a reddish tinge and a disagreeable odor within a day, and finally resinifying. EtBr (18.5 g.) and 37 g. I (b₇₅₉ 157-8.5°) in 150 ml. Et₂O added to a briskly reacting mixture of 18.5 g. EtBr, 13.7 g. Mg, and 200 ml. Et₂O, the whole refluxed 18 hrs. under N and a solution of iso-PrMgBr (from 35 g. iso-PrBr) added, the mixture cooled to -10° and dry O passed in, the temperature maintained below 5°, after absorption had ceased the product set aside 20 hrs. at 5°, and then poured onto solid CO₂, after addition of chilled 2N H₂SO₄, the Et₂O layer separated, and the product purified gave 2.12 g. black product, which was stored over P₂O₅ and then distilled from glass wool giving II, yellow liquid, b_0.01 38-9°, redistilled at 0.02 mm. to a colorless oil with a phenolic odor. With aqueous FeCl₃ II gave an intense red color, and with diazotized PhNH₂ in the presence of alkali, a dark red precipitate; benzoate (prepared by the Schotten-Baumann method), irregular prisms, m. 40° (from ligroine); 3,5-dinitrobenzoate, yellow prisms, m. 150° (from MeOH); phenylcarbamate, felted needles, m. 120° (from ligroine). These derivatives were stable. I (20 g.) was recovered from the Et₂O solution of alkali-insoluble material. The infrared absorption curves were given for II in liquid film, 15% by volume CCl₄, and 8% by volume CCl₄. The absorption characteristic of an unsat. CO group definitely established the presence of the tautomeric 2,3-dihydro-3-oxothiophene (III). With increasing dilution the equilibrium was in favor of III; however, the strength of the OH band and the odor suggested that the pure substance must contain much II.

Journal of the Chemical Society published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Computed Properties of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jin, Jian published the artcileAlcohols as alkylating agents in heteroarene C-H functionalization, Computed Properties of 2240-88-2, the publication is Nature (London, United Kingdom) (2015), 525(7567), 87-90, database is CAplus and MEDLINE.

Primary alcs., diols containing at least one primary alc. moiety, and tetrahydrofurans acted as alkylating agents for six-membered nitrogen heterocycles such as isoquinolines, quinolines, and pyridines in the presence of an iridium photocatalyst Ir(ppy)₂(dtbbp)PF₆ (ppy = 1,2′-phenylpyridinediyl; dtbpy = 4,4′-di-tert-butyl-2,2-bipyridine), a thiol such as α-mercaptopropanoic acid, and p-toluenesulfonic acid in DMSO under blue LED light to yield alkylated heterocycles such as 1-methylisoquinoline in 43-98% yields. The medicinal agents fasudil dihydrochloride and milrinone were methylated and 3-phenylpropylated, resp., using this method in 82% and 43% yields. The method avoids the use of thermal conditions or stoichiometric oxidants. The mechanism was studied using fluorescence quenching experiments; the key step in the process is proposed to be the spin-center shift of a hydroxyalkylheteroaryl radical to yield an alkylheteroaryl radical with loss of water, precedented in biol. and synthetic settings. In the absence of a thiol, the radical generated from 1-isoquinolinemethanol coupled with two alkenes and two 1-pyrrolecarboxylates to yield dihydrobenzoisoquinolines and pyrrolylmethylisoquinolines, resp., in 25-65% yields.

Nature (London, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Computed Properties of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Amitrano, Alice published the artcileEstrogenic activity of lignin-derivable alternatives to bisphenol A assessed via molecular docking simulations, Synthetic Route of 645-56-7, the publication is RSC Advances (2021), 11(36), 22149-22158, database is CAplus and MEDLINE.

Lignin-derivable bisphenols are potential alternatives to bisphenol A (BPA), a suspected endocrine disruptor; however, a greater understanding of structure-activity relationships (SARs) associated with such lignin-derivable building blocks is necessary to move replacement efforts forward. This study focuses on the prediction of bisphenol estrogenic activity (EA) to inform the design of potentially safer BPA alternatives. To achieve this goal, the binding affinities to estrogen receptor alpha (ERα) of lignin-derivable bisphenols were calculated via mol. docking simulations and correlated to median effective concentration (EC50) values using an empirical correlation curve created from known EC50 values and binding affinities of com. (bis)phenols. Based on the correlation curve, lignin-derivable bisphenols with binding affinities weaker than ∼-6.0 kcal mol-1 were expected to exhibit no EA, and further anal. suggested that having two methoxy groups on an aromatic ring of the bio-derivable bisphenol was largely responsible for the reduction in binding to ERα. Such dimethoxy aromatics are readily sourced from the depolymerization of hardwood biomass. Addnl., bulkier substituents on the bridging carbon of lignin-bisphenols, like di-Et or dimethoxy, were shown to weaken binding to ERα. And, as the bio-derivable aromatics maintain major structural similarities to BPA, the resultant polymeric materials should possess comparable/equiv thermal (e.g., glass transition temperatures, thermal decomposition temperatures) and mech. (e.g., tensile strength, modulus) properties to those of polymers derived from BPA. Hence, the SARs established in this work can facilitate the development of sustainable polymers that maintain the performance of existing BPA-based materials while simultaneously reducing estrogenic potential.

RSC Advances published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Synthetic Route of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hoque, Anamul Md. published the artcileModes of interaction and thermodynamic behavior of aggregation of CTAB + BSA mixtures in diols media: effects of diols composition and temperature, Category: alcohols-buliding-blocks, the publication is Chemical Engineering Communications, database is CAplus.

The micellization of cetyltrimethylammonium bromide (CTAB) and bovine serum albumin (BSA) mixture has been studied conductometrically in aqueous solutions of different diols (1,2-propanediol (1,2-PrD), 2,3-butanediol (2,3-BD), and 1,5-pentanediol (1,5-PD)) media over the temperature range from 298.15 K to 323.15 K to gain insight into the mode and degree of interaction amongst the investigated constituents. The critical micelle concentration (cmc) values of the CTAB + BSA mixtures were attained initially low but enhanced with the rise in temperature in all the media studied. The values of the CTAB + BSA mixtures in the different diols media followed the order: The degree of micelle ionization (α) increased with increasing carbon chain length of diols and temperature The Gibbs free energy values associated with the micellization of the CTAB + BSA mixture were neg. and revealed a lowering of the spontaneity of micellization with increasing carbon chain length of the diols. The enthalpy and entropy changes of micellization revealed that the micellization was exothermic and mainly an enthalpy-controlled process in aqueous 1,2-PrD and 2,3-BD media while the process being endothermic, and entropy controlled in the 1,5-PD medium. The contribution of the solvent to the thermodn. parameters was assessed from free energy of transfer, enthalpy of transfer, and entropy of transfer values. The enthalpy-entropy compensation parameters were also studied and discussed with proper reasoning.

Chemical Engineering Communications published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dumitrescu, Lidia published the artcileSynthesis and cytotoxic activity of fluorinated analogs of Goniothalamus lactones. Impact of fluorine on oxidative processes, Safety of (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is European Journal of Medicinal Chemistry (2010), 45(7), 3213-3218, database is CAplus and MEDLINE.

Novel fluorinated analogs of goniothalamin I (R = Ph) and howiinol A II (R = Ph) were prepared from trifluorocrotonate derivatives Trifluoromethyl-goniothalamin (R/S) derivative I (R = CF₃) showed a slightly lower activity than 1, while the trifluoromethyl-howiinol A derivative II (R = CF₃) exhibited similar activities on several cell lines in the micromolar range. Unlike (R)-goniothalamin and howiinol A, trifluoromethyl parent compounds remained unchanged when submitted to biomimetic oxidative systems.

European Journal of Medicinal Chemistry published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Safety of (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dindarloo Inaloo, Iman published the artcileN-Arylation of (hetero)arylamines using aryl sulfamates and carbamates via C-O bond activation enabled by a reusable and durable nickel(0) catalyst, Safety of Thiophen-3-ol, the publication is New Journal of Chemistry (2020), 44(31), 13266-13278, database is CAplus.

An effective and general aryl amination protocol has been developed using a magnetically recoverable Ni(0) based nanocatalyst. This new stable catalyst was prepared on Fe₃O₄@SiO₂ modified by EDTA and investigated by FT-IR, EDX, TEM, XRD, DLS, FE-SEM, XPS, NMR, TGA, VSM, ICP and elemental anal. techniques. The reaction proceeded via carbon-oxygen bond cleavage of (hetero)aryl carbamates and sulfamates under simple and mild conditions without the use of any external ligands. This method demonstrated functional group tolerance in the N-arylation of various nitrogen-containing compounds as well as aliphatic amines, anilines, pyrroles, pyrazoles, imidazoles, indoles, and indazoles with good to excellent yields. Furthermore, the catalyst could be easily recovered by using an external magnetic field and directly reused at least six times without notable reduction in its activity.

New Journal of Chemistry published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Safety of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tawfic, Medhat L. published the artcileNatural abundant prodegradant for Oxo-degradation of polymers, Recommanded Product: Pentane-1,5-diol, the publication is Journal of Polymer Research (2022), 29(2), 60, database is CAplus.

In the present study, novel polypentane maleate (PPM)/linear low-d. polyethylene (LLPE) composites for potential medical disposables application as biodegradable pads were prepared Polypentane maleate as biodegradable polyester was prepared by adding stoichiometric amounts of maleic acid and pentane diol in presence of titanium tetrabutoxide as a catalyst. FT-IR, ¹HNMR and GPC were performed to elucidate the chem. structure of the prepared polymer. Preparation of oxo-degradable polymers (OBP) were achieved by compounding PPM, cellulosic fibers (CF) and LLPE. Synthetic prodegradant such as benzophenone and promising natural prodegradant such as extracted chlorophyll were added to the prepared composites. The polymeric composites were exposed to UV irradiation for different period to evaluate their oxo-degradation behavior. Carbonyl indexes were calculated for oxo-degradable polymers using FT-IR spectroscopy. Furthermore, X- Ray diffraction and differential scanning calorimetry (DSC) were conducted to follow up the crystallinity of the prepared samples. Mech. properties for polymeric composites were evaluated before and after UV exposure. Morphol. of the polymeric composites was investigated by scanning electron microscope. DSC anal. showed that chlorophyll enhances the decrease of crystallinity rather than benzophenone. As well as, mech. results revealed that chlorophyll lowers tensile strengths after 20 days of UV exposure less than in case of benzophenone. These results confirm that chlorophyll is efficient prodegradant.

Journal of Polymer Research published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C7H10O4, Recommanded Product: Pentane-1,5-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts