Tag: M.W=100-150

Authors Verma, A; Hazra, S; Dolui, P; Elias, AJ in WILEY-V C H VERLAG GMBH published article about CARBOXYLIC-ACID SALTS; SECONDARY ALCOHOLS; DEHYDROGENATIVE OXIDATION; DIRECT FUNCTIONALIZATION; CROSS-COUPLINGS; COMPLEX BEARING; N-ALKYLATION; PPM LEVELS; WATER; COBALT in [Verma, Ashutosh; Hazra, Susanta; Dolui, Pritam; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2021, Cited 118. Computed Properties of C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Herein, we report a simple, efficient, and sustainable method for the synthesis of alpha-alkylated ketones and quinolines using a hydrogen-borrowing strategy, which has emerged as a greener alternative in organic transformation reactions. Synthesis of a range of alpha-alkylated ketones and quinoline derivatives was achieved by using the water-soluble [Ru(8-AQ)Cl(p-cym.)]Cl-+(-) [Ru]-1 (AQ=aminoquinoline) catalyst with water as the reaction medium. By adopting this strategy, we have synthesized alpha-alkylated ketones and quinolines using ketones or secondary alcohols as starting materials and the primary alcohol as a green and naturally abundant alkylating agent.

Computed Properties of C8H10O2. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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An article Mimicking transition metals in borrowing hydrogen from alcohols WOS:000652242100001 published article about CATALYZED N-ALKYLATION; C-C; AMINES; PHENALENYL; SPIN; EFFICIENT; AMIDES; HYDROAMINATION; ARYLAMINES; CHEMISTRY in [Banik, Ananya; Ahmed, Jasimuddin; Sil, Swagata; Mandal, Swadhin K.] Indian Inst Sci Educ & Res Kolkata, Dept Chem Sci, Mohanpur 741246, India in 2021, Cited 68. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Recommanded Product: 105-13-5

Borrowing hydrogen from alcohols, storing it on a catalyst and subsequent transfer of the hydrogen from the catalyst to an in situ generated imine is the hallmark of a transition metal mediated catalytic N-alkylation of amines. However, such a borrowing hydrogen mechanism with a transition metal free catalytic system which stores hydrogen molecules in the catalyst backbone is yet to be established. Herein, we demonstrate that a phenalenyl ligand can imitate the role of transition metals in storing and transferring hydrogen molecules leading to borrowing hydrogen mediated alkylation of anilines by alcohols including a wide range of substrate scope. A close inspection of the mechanistic pathway by characterizing several intermediates through various spectroscopic techniques, deuterium labelling experiments, and DFT study concluded that the phenalenyl radical based backbone sequentially adds H+, H and an electron through a dearomatization process which are subsequently used as reducing equivalents to the C-N double bond in a catalytic fashion.

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In 2021 J AM CHEM SOC published article about FRIEDEL-CRAFTS REACTIONS; ONE-POT SYNTHESIS; COUPLING REACTIONS; ALKYL-HALIDES; OXIDATIVE ADDITION; ZINC REAGENTS; ARYL HALIDES; DIARYLMETHANES; BROMIDES; ETHERS in [Guo, Peng; Wang, Ke; Jin, Wen-Jie; Xie, Hao; Qi, Liangliang; Liu, Xue-Yuan; Shu, Xing-Zhong] Lanzhou Univ, Coll Chem & Chem Engn, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China in 2021, Cited 104. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Recommanded Product: (4-Methoxyphenyl)methanol

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

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Product Details of 105-13-5. Authors Zhou, ZY; Xie, YN; Zhu, WZ; Zhao, HY; Yang, NJ; Zhao, GH in ELSEVIER published article about in [Zhou, Zhaoyu; Xie, Ya-Nan; Zhu, Wenze; Zhao, Hongying; Zhao, Guohua] Tongji Univ, Shanghai Tongji Hosp, Sch Chem Sci & Engn, Inst Translat Res, Shanghai 200092, Peoples R China; [Yang, Nianjun] Univ Siegen, Inst Mat Engn, D-57076 Siegen, Germany in 2021, Cited 55. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Hydrogen production can be promoted by replacing sluggish oxygen evolution reaction (OER) with a thermodynamically more favorable reaction, the primary oxidation reaction of benzyl alcohol to benzaldehyde. On a Bi2MoO6@TiO(2)NTA photocathode, the conversion of benzyl alcohol to benzaldehyde is realized with the selectivity of 100 %. This is originated from enhanced adsorption and activation of benzyl alcohol on this photoanode, as confirmed from tested by in situ FTIR techniques. The electrons generated during such a controllable and selective primary oxidation reaction is then utilized as the source for synergistical hydrogen production. The amount of generated hydrogen is then 5.5 times higher than that when OER is used. The efficiency for such hydrogen production is as high as 85 %. The proposed strategy combines solar energy and biomass for the efficient production of the valuable raw material – benzaldehyde as well as green energy source – hydrogen.

Product Details of 105-13-5. Welcome to talk about 105-13-5, If you have any questions, you can contact Zhou, ZY; Xie, YN; Zhu, WZ; Zhao, HY; Yang, NJ; Zhao, GH or send Email.

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I found the field of Chemistry very interesting. Saw the article Palladium-Catalyzed Oxidative Coupling of the Allenic C-H Bond with alpha-Diazo Esters: Synthesis of [3]Dendralenes published in 2021. Product Details of 105-13-5, Reprint Addresses Wang, JB (corresponding author), Peking Univ, Coll Chem, Beijing Natl Lab Mol Sci BNLMS, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China.. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol

A palladium-catalyzed highly regio- and stereoselective allenic C-H oxidative coupling with alpha-diazo esters is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes bearing various functional groups.

Welcome to talk about 105-13-5, If you have any questions, you can contact Li, SC; Hou, B; Wang, JB or send Email.. Product Details of 105-13-5

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An article Zirconium and hafnium polyhedral oligosilsesquioxane complexes – green homogeneous catalysts in the formation of bio-derived ethers via a MPV/etherification reaction cascade WOS:000609012400016 published article about PONNDORF-VERLEY REDUCTION; EPOXIDATION CATALYSTS; STRUCTURAL-CHARACTERIZATION; TRANSFER HYDROGENATION; OLEFIN POLYMERIZATION; QUINONE METHIDES; ACTIVE-SITES; BETA ZEOLITE; EFFICIENT; ETHERIFICATION in [Garg, Shipra; Unruh, Daniel K.; Krempner, Clemens] Texas Tech Univ, Dept Chem & Biochem, Mem Dr & Boston, Lubbock, TX 79409 USA in 2021, Cited 53. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. Safety of (4-Methoxyphenyl)methanol

The polyhedral oligosilsesquioxane complexes, {[(isobutyl)(7)Si7O12]ZrOPri center dot(HOPri)}(2) (I), {[(cyclohexyl)(7)Si7O12]ZrOPri center dot(HOPri)}(2) (II), {[(isobutyl)(7)Si7O12]HfOPri center dot(HOPri)}(2) (III) and {[(cyclohexyl)(7)Si7O12]HfOPri center dot(HOPri)}(2) (IV), were synthesized in good yields from the reactions of M(OPri)(4) (M = Zr, Hf) with R-POSS(OH)(3) (R = isobutyl, cyclohexyl), resp. I-IV were characterized by H-1, C-13 and Si-29 NMR spectroscopy and their dimeric solid-state structures were confirmed by X-ray analysis. I-IV catalyze the reductive etherification of 2-hydroxy- and 4-hydroxy and 2-methoxy and 4-methoxybenzaldehyde and vanillin to their respective isopropyl ethers in isopropanol as a green solvent and reagent. I-IV are durable and robust homogeneous catalysts operating at temperatures of 100-160 degrees C for days without significant loss of catalytic activity. Likewise, I-IV selectively catalyze the conversion of 5-hydroxymethylfurfural (HMF) into 2,5-bis(isopropoxymethyl)furane (BPMF), a potentially high-performance fuel additive. Similar results were achieved by using a combination of M(OPri)(4) and ligand R-POSS(OH)(3) as a catalyst system demonstrating the potential of this in situ approach for applications in biomass transformations. A tentative reaction mechanism for the reductive etherification of aldehydes catalysed by I-IV is proposed.

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Authors Luo, NH; Zhong, YH; Wen, HL; Shui, HL; Luo, RS in WILEY-V C H VERLAG GMBH published article about in [Luo, Nianhua; Zhong, Yuhong; Wen, Huiling; Shui, Hongling; Luo, Renshi] Gannan Med Univ, Sch Pharmaceut Sci, Ganzhou 341000, Jiangxi, Peoples R China in 2021, Cited 94. Formula: C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Ketones are of great importance in synthesis, biology, and pharmaceuticals. This paper reports an iridium complexes-catalyzed cross-coupling of alcohols via hydrogen borrowing, affording a series of alpha-alkylated ketones in high yield (86 %-95 %) and chemoselectivities (>99 : 1). This methodology has the advantages of low catalyst loading (0.1 mol%) and environmentally benign water as the solvent. Studies have shown the amount of base has a great impact on chemoselectivities. Meanwhile, deuteration experiments show water plays an important role in accelerating the reduction of the unsaturated ketones intermediates. Remarkably, a gram-scale experiment demonstrates this methodology of iridium-catalyzed cross-coupling of alcohols has potential application in the practical synthesis of alpha-alkylated ketones.

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Recommanded Product: 105-13-5. Recently I am researching about PHOTOCATALYTIC ACTIVITY; AEROBIC OXIDATION; TITANIUM-DIOXIDE; FACILE SYNTHESIS; ANATASE TIO2; BENZALDEHYDE; ENHANCEMENT; HETEROSTRUCTURE; NANOCOMPOSITES; NANOPARTICLES, Saw an article supported by the Science Achievement Scholarship of Thailand; Chiang Mai University; Global Partnership Research Fund through Center of Excellence in Materials Science and Technology and Office of National Higher Education Science Research and Innovation Policy Council (NXPO); TRF Distinguished Research Professor Award [DPG6080002]; ARCAustralian Research Council [DE160100504, CE140100012]; Graduate School. Published in ELSEVIER in AMSTERDAM ,Authors: Japa, M; Tantraviwat, D; Phasayavan, W; Nattestad, A; Chen, J; Inceesungvorn, B. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol

N-doped TiO2, denoted as T_400, was prepared simply by the facile thermal hydrolysis of TiOSO4 using NH4OH as both a precipitating agent and a nitrogen source. Compared to TiO2 without nitrogen doping, T_400 provides superior photocatalytic activity toward the selective oxidation of benzyl alcohol and benzylamine under visible light irradiation, with > 85 % conversion and > 95 % selectivity to benzaldehyde and N-benzylidenebenzylamine products, respectively. The increased photoactivity of T_400 is ascribed to enhanced visible-light absorption and efficient photogenerated charge transfer and separation as supported by UV-vis DRS, photoelectrochemical and VB-XPS results. The catalyst can tolerate the presence of substituent groups in benzyl alcohol and benzelamine molecules as > 80 % conversion and > 95 % selectivity are still achieved, which expands the scope of substrates and catalyst utilization. Band energy level of N-doped TiO2 compared to that of undoped TiO2 is determined using Mott-Schottky and UV-vis DRS measurements. Possible mechanisms for the formation of benzaldehyde and N-benzylidenebenzylamine over N-doped TiO2 are proposed. This work presents a simple synthesis of N-doped TiO2, using a low-cost and easily handled inorganic titanium salt instead of air/moisture-sensitive alkoxide precursors and reveals its potential application toward photocatalytic synthesis of organic fine chemicals under visible light.

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Safety of (4-Methoxyphenyl)methanol. Recently I am researching about GROWTH-FACTOR RECEPTOR; 1ST-LINE TREATMENT; BRAIN METASTASES; OPEN-LABEL; PHASE-II; RESISTANCE; CHEMOTHERAPY; GEFITINIB; ERLOTINIB; MULTICENTER, Saw an article supported by the . Published in DOVE MEDICAL PRESS LTD in ALBANY ,Authors: Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ. The CAS is 105-13-5. Through research, I have a further understanding and discovery of (4-Methoxyphenyl)methanol

Purpose: As a third-generation EGFR TKI has been taken orally, Osimertinib effectively inhibits mutant EGFR, including T790M EGFR resistance mutations. Here, we examined real-world efficacy and tolerability of Osimertinib among Chinese patients with advanced EGFR T790M-mutant NSCLC. Patients and Methods: A total of 106 advanced NSCLC patients who were taking Osimertinib following disease progression after EGFR-TKIs or other treatments were retro-spectively recruited in this study. The PFS and OS after Osimertinib treatment were analyzed as the primary endpoints. Results: Osimertinib was used as a second line and >= 3rd line treatment in 22.6% and 77.4% of the patients, respectively. DCR and ORR were 93.4% and 57.5%, respectively. Median PFS was 12.4 12 (95% CI, 10.5-13.5) months. The PFS was 11 (8.0, 14.0) and 12 (10.3,13.7) months (p = 0.373), in patients with and without CNS metastasis, respectively. PFS in 2nd and >= 3rd line treatment was 11 (9.0, 13.0) and 12.4 12 (8.9, 15.1) months (p = 0.799), respectively. In patients with EGFR exon 19 deletion and exon 21 L858 mutation, the median PFS was 11 (9.2, 12.8) and 12 (9.2, 14.8) months, respectively (p = 0.833). Median PFS in the monotherapy group and combined anti-angiogenesis group was 11 (9.9,12.1) and 14 (11.2,16.8) months, respectively. Median OS after Osimertinib initiation was 27 (19.6, 34.4) months: 15 (6.9, 23.1) and 27 (22, 32) months in patients with and without CNS metastasis (p=0.027), 27 (20.3,33.7) months and (undefined) as second line or >= 3rd line of treatment (p = 0.421), respectively. In patients with exon 19 deletion, the median OS was not reached, and in patients with exon 21 L858 mutations, the median OS was 23 (19.1,29.9) months (p=0.027). Median OS in the monotherapy group was 27 (21.7,32.3) months, and in combined anti-angiogenesis group was not reached (p=0.68). Conclusion: Osimertinib can effectively treat advanced NSCLC with T790M mutations independently of previous treatment lines.

Welcome to talk about 105-13-5, If you have any questions, you can contact Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ or send Email.. Safety of (4-Methoxyphenyl)methanol

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HPLC of Formula: C8H10O2. Authors Wu, SP; Zhang, H; Cao, QE; Zhao, QH; Fang, WH in ROYAL SOC CHEMISTRY published article about in [Wu, Shipeng; Zhang, Hao; Cao, Qiue; Zhao, Qihua; Fang, Wenhao] Yunnan Univ, Sch Chem Sci & Technol, Key Lab Med Chem Nat Resource, Minist Educ,Funct Mol Anal & Biotransformat Key L, 2 North Cuihu Rd, Kunming 650091, Yunnan, Peoples R China; [Cao, Qiue; Fang, Wenhao] Yunnan Univ, Natl Demonstrat Ctr Expt Chem & Chem Engn Educ, Kunming 650091, Yunnan, Peoples R China in 2021, Cited 46. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Direct oxidative coupling of alcohols with amines using a non-precious metal oxide catalyst under mild conditions is highly desirable for imine synthesis. In this work, a mesoporous Mn1ZrxOy solid solution catalyst prepared by a co-precipitation method showed excellent catalytic performance in imine synthesis from primary alcohols and amines without base additives in an air atmosphere. XRD, N-2 physisorption, H-2-TPR, O-2-TPD, EPR and XPS were comprehensively used to unravel its structural, redox and amphoteric properties that closely depended on the interaction between MnOy and ZrO2 with a variable Zr ratio. The Mn1Zr0.5Oy catalyst presented the highest fractions of Mn3+ ions and reactive oxygen species on the surface, and the highest concentrations of acidic-basic sites, which were disclosed to play important roles in activating alcohols and molecular O-2 in the rate-determining step. In the model reaction of oxidative coupling of benzyl alcohol with aniline, such enhanced features of the Mn1Zr0.5Oy catalyst can promote the intrinsic catalytic activity (iTOF of 1.87 h(-1)) and boost benzylideneaniline formation (5.56 mmol g(cat).(-1) h(-1)) based on a >99% yield at 80 degrees C respectively at a fast response. It can also work effectively at a room temperature of 30 degrees C, as well as for the gram-grade synthesis. This is one of the best results among all the MnOy-based catalysts in the literature. Moreover, this catalyst showed good stability and a wide substrate scope with good to excellent yields of imines.

Welcome to talk about 105-13-5, If you have any questions, you can contact Wu, SP; Zhang, H; Cao, QE; Zhao, QH; Fang, WH or send Email.. HPLC of Formula: C8H10O2

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