Tag: M.W=100-150

Authors Aydin, BO; Anil, D; Demir, Y in WILEY-V C H VERLAG GMBH published article about in [Aydin, Busra O.; Anil, Derya] Ataturk Univ, Dept Chem, Fac Sci, Erzurum, Turkey; [Anil, Derya] Ataturk Univ, Tech Sci Vocat Sch, Dept Chem & Chem Proc Technol, Erzurum, Turkey; [Demir, Yeliz] Ardahan Univ, Nihat Delibalta Gole Vocat Sch, Dept Pharm Serv, Ardahan, Turkey in 2021, Cited 53. Application In Synthesis of (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

Fused pyrimidines, especially pyrazolo[3,4-d]pyrimidines, are among the most preferred building blocks for pharmacology studies, as they exhibit a broad spectrum of biological activity. In this study, new derivatives of pyrazolo[3,4-d]pyrimidine were synthesized by alkylation of the N1 nitrogen atom. We synthesized 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine 2 from commercially available aminopyrazolopyrimidine 1 using N-iodosuccinimide as an iodinating agent. The synthesis of compound 2 started with nucleophilic substitution of 3-iodo-1H-pyrazolo[3,4-d]pyrimidin-4-amine with R-X (X: -OMs, -Br, -Cl), affording N-alkylated pyrazolo[3,4-d]pyrimidine. We performed this synthesis using a weak inorganic base and the mild temperature was also used for a two-step procedure to generate N-alkylated pyrazolo[3,4-d]pyrimidine derivatives. Also, all compounds were tested for their ability to inhibit acetylcholinesterase (AChE) and the human carbonic anhydrase (hCA) isoforms I and II, with K-i values in the range of 15.41 +/- 1.39-63.03 +/- 10.68 nM for AChE, 17.68 +/- 1.92-66.27 +/- 5.43 nM for hCA I, and 8.41 +/- 2.03-28.60 +/- 7.32 nM for hCA II. Notably, compound 10 was the most selective and potent CA I inhibitor with a significant selectivity ratio of 26.90.

Application In Synthesis of (4-Methoxyphenyl)methanol. Welcome to talk about 105-13-5, If you have any questions, you can contact Aydin, BO; Anil, D; Demir, Y or send Email.

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Garg, S; Unruh, DK; Krempner, C in [Garg, Shipra; Unruh, Daniel K.; Krempner, Clemens] Texas Tech Univ, Dept Chem & Biochem, Mem Dr & Boston, Lubbock, TX 79409 USA published Zirconium and hafnium polyhedral oligosilsesquioxane complexes – green homogeneous catalysts in the formation of bio-derived ethers via a MPV/etherification reaction cascade in 2021, Cited 53. Name: (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

The polyhedral oligosilsesquioxane complexes, {[(isobutyl)(7)Si7O12]ZrOPri center dot(HOPri)}(2) (I), {[(cyclohexyl)(7)Si7O12]ZrOPri center dot(HOPri)}(2) (II), {[(isobutyl)(7)Si7O12]HfOPri center dot(HOPri)}(2) (III) and {[(cyclohexyl)(7)Si7O12]HfOPri center dot(HOPri)}(2) (IV), were synthesized in good yields from the reactions of M(OPri)(4) (M = Zr, Hf) with R-POSS(OH)(3) (R = isobutyl, cyclohexyl), resp. I-IV were characterized by H-1, C-13 and Si-29 NMR spectroscopy and their dimeric solid-state structures were confirmed by X-ray analysis. I-IV catalyze the reductive etherification of 2-hydroxy- and 4-hydroxy and 2-methoxy and 4-methoxybenzaldehyde and vanillin to their respective isopropyl ethers in isopropanol as a green solvent and reagent. I-IV are durable and robust homogeneous catalysts operating at temperatures of 100-160 degrees C for days without significant loss of catalytic activity. Likewise, I-IV selectively catalyze the conversion of 5-hydroxymethylfurfural (HMF) into 2,5-bis(isopropoxymethyl)furane (BPMF), a potentially high-performance fuel additive. Similar results were achieved by using a combination of M(OPri)(4) and ligand R-POSS(OH)(3) as a catalyst system demonstrating the potential of this in situ approach for applications in biomass transformations. A tentative reaction mechanism for the reductive etherification of aldehydes catalysed by I-IV is proposed.

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Authors Sun, ZL; Yang, XL; Yu, XF; Xia, LH; Peng, YH; Li, Z; Zhang, Y; Cheng, JB; Zhang, KS; Yu, JQ in ELSEVIER published article about in [Sun, Zhaoli; Yang, Xiaolong; Xia, Linhong; Peng, Yanhua; Li, Zhuo; Zhang, Yan; Yu, Jianqiang] Qingdao Univ, Coll Chem & Chem Engn, 308 Ning Xia Rd, Qingdao 266071, Peoples R China; [Yu, Xue-Fang; Cheng, Jianbo] Yantai Univ, Sch Chem & Chem Engn, Lab Theoret & Computat Chem, 32 Qingquan Rd, Yantai 264005, Peoples R China; [Zhang, Kaisheng] Chinese Acad Sci, HFIPS, Inst Solid State Phys, Environm Mat & Pollut Control Lab, Hefei 230031, Peoples R China in 2021, Cited 55. Application In Synthesis of (4-Methoxyphenyl)methanol. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

The recombination of photogenerated carriers seriously restricts their utilization efficiency in photocatalysis. Herein, surface oxygen vacancies (SOVs) were constructed in Pd-Bi2MoO6 interface to bridge ultra-low loading Pd cluster and Bi2MoO6 semiconductor (Pd/BMO-SOVs). It was found SOVs in Pd/Bi2MoO6-x serve as Electron Bridge to bridge ultra-low loading Pd cluster and Bi2MoO6-x, thus tremendously enhance utilization efficiency of photoexcited carriers and ultra-low loading Pd active sites for blue LED driven selective oxidation reaction. The Pd(0.05)/Bi2MoO6-SOVs exhibited 57.8 % conversion for selection oxidation of benzyl which are 6.5, 3.3 and 2.1 times higher than pristine Bi2MoO6, Bi2MoO6-x and Pd(0.05)/Bi2MoO6. Combined with theoretical calculations, SOVs was proposed as Electron Bridge to transfer photogenerated electrons from Bi2MoO6-x to ultra-low loading Pd clusters, thus greatly boosting separation and utilization efficiency of photogenerated electron-hole pairs.

Welcome to talk about 105-13-5, If you have any questions, you can contact Sun, ZL; Yang, XL; Yu, XF; Xia, LH; Peng, YH; Li, Z; Zhang, Y; Cheng, JB; Zhang, KS; Yu, JQ or send Email.. Application In Synthesis of (4-Methoxyphenyl)methanol

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In 2021 ORG LETT published article about CROSS-COUPLING REACTION; GRIGNARD REACTION; ARYL BROMIDES; VINYL HALIDES; SILANES; SILICON; ELECTROPHILES; CHLOROSILANES; PRECATALYST; METHYLATION in [Naganawa, Yuki; Sakamoto, Kei; Nakajima, Yumiko] Natl Inst Adv Ind Sci & Technol, Interdisciplinary Res Ctr Catalyt Chem IRC3, Tsukuba, Ibaraki 3058565, Japan in 2021, Cited 50. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5. HPLC of Formula: C8H10O2

Direct catalytic transformation of chlorosilanes into organosilicon compounds remains challenging due to difficulty in cleaving the strong Si-Cl bond(s). We herein report the palladium-catalyzed cross-coupling reaction of chlorosilanes with organoaluminum reagents. A combination of [Pd(C3H5)Cl](2) and DavePhos ligand catalyzed the selective methylation of various dichlorosilanes 1, trichlorosilanes 5, and tetrachlorosilane 6 to give the corresponding monochlorosilanes.

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An article Tungsten-Catalyzed Direct N-Alkylation of Anilines with Alcohols WOS:000605642300001 published article about BORROWING HYDROGEN; ALPHA-ALKYLATION; AROMATIC-AMINES; BOND FORMATION; COMPLEXES; EFFICIENT; KETONES; STRATEGY; LIGANDS; IMINES in [Lan, Xiao-Bing; Ye, Zongren; Yang, Chenhui; Li, Weikang; Liu, Jiahao; Huang, Ming; Ke, Zhuofeng] Sun Yat Sen Univ, Sch Mat Sci & Engn, PCFM Lab, Guangzhou 510275, Peoples R China; [Liu, Yan] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China; [Lan, Xiao-Bing] Xiangnan Univ, Sch Chem & Biol & Environm Engn, Hunan Prov Key Lab Xiangnan Rare Precious Met Cpd, Chenzhou 423000, Hunan, Peoples R China in 2021, Cited 63. Computed Properties of C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

The implementation of non-noble metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of non-noble metal catalysts. Herein, we report a tungsten-catalyzed N-alkylation reaction of anilines with primary alcohols via BH/HA. This phosphine-free W(phen)(CO)(4) (phen=1,10-phenthroline) system was demonstrated as a practical and easily accessible in-situ catalysis for a broad range of amines and alcohols (up to 49 examples, including 16 previously undisclosed products). Notably, this tungsten system can tolerate numerous functional groups, especially the challenging substrates with sterically hindered substituents, or heteroatoms. Mechanistic insights based on experimental and computational studies are also provided.

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Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ in [Peng, Da; Dai, Chengcheng; Wang, Zifan; Huang, Ziyi; Peng, Rui; Ma, Xuezhen] Qingdao Univ, Affiliated Qingdao Cent Hosp, Dept Oncol, 127 Siliunan Rd, Qingdao 266042, Shandong, Peoples R China; [Shan, Dongfeng] Qingdao Univ, Affiliated Hosp, Qingdao, Shandong, Peoples R China; [Li, Jie] Jiaozhou Cent Hosp, Dept Oncol, Jiaozhou, Peoples R China; [Zhao, Peng] Qingdao Univ, Affiliated Qingdao Cent Hosp, Biotherapy Ctr, Qingdao, Shandong, Peoples R China published Real-World Data on Osimertinib in Chinese Patients with Pretreated, EGFR T790M Mutation Positive, Advanced Non-Small Cell Lung Cancer: A Retrospective Study in 2021, Cited 25. HPLC of Formula: C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

Purpose: As a third-generation EGFR TKI has been taken orally, Osimertinib effectively inhibits mutant EGFR, including T790M EGFR resistance mutations. Here, we examined real-world efficacy and tolerability of Osimertinib among Chinese patients with advanced EGFR T790M-mutant NSCLC. Patients and Methods: A total of 106 advanced NSCLC patients who were taking Osimertinib following disease progression after EGFR-TKIs or other treatments were retro-spectively recruited in this study. The PFS and OS after Osimertinib treatment were analyzed as the primary endpoints. Results: Osimertinib was used as a second line and >= 3rd line treatment in 22.6% and 77.4% of the patients, respectively. DCR and ORR were 93.4% and 57.5%, respectively. Median PFS was 12.4 12 (95% CI, 10.5-13.5) months. The PFS was 11 (8.0, 14.0) and 12 (10.3,13.7) months (p = 0.373), in patients with and without CNS metastasis, respectively. PFS in 2nd and >= 3rd line treatment was 11 (9.0, 13.0) and 12.4 12 (8.9, 15.1) months (p = 0.799), respectively. In patients with EGFR exon 19 deletion and exon 21 L858 mutation, the median PFS was 11 (9.2, 12.8) and 12 (9.2, 14.8) months, respectively (p = 0.833). Median PFS in the monotherapy group and combined anti-angiogenesis group was 11 (9.9,12.1) and 14 (11.2,16.8) months, respectively. Median OS after Osimertinib initiation was 27 (19.6, 34.4) months: 15 (6.9, 23.1) and 27 (22, 32) months in patients with and without CNS metastasis (p=0.027), 27 (20.3,33.7) months and (undefined) as second line or >= 3rd line of treatment (p = 0.421), respectively. In patients with exon 19 deletion, the median OS was not reached, and in patients with exon 21 L858 mutations, the median OS was 23 (19.1,29.9) months (p=0.027). Median OS in the monotherapy group was 27 (21.7,32.3) months, and in combined anti-angiogenesis group was not reached (p=0.68). Conclusion: Osimertinib can effectively treat advanced NSCLC with T790M mutations independently of previous treatment lines.

HPLC of Formula: C8H10O2. Welcome to talk about 105-13-5, If you have any questions, you can contact Peng, D; Shan, DF; Dai, CC; Li, J; Wang, ZF; Huang, ZY; Peng, R; Zhao, P; Ma, XZ or send Email.

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Safety of (4-Methoxyphenyl)methanol. Authors Yang, SN; Liu, XY; Lu, SJ; Li, Z; Zhang, YM; Yu, SN; Song, J; Ding, CF; Yang, HY in WILEY-V C H VERLAG GMBH published article about in [Yang, Shouning; Yu, Shaoning; Yang, Huayan] Ningbo Univ, Sch Mat Sci & Chem Engn, Inst Mass Spectrometry, Zhejiang Prov Key Lab Adv Mass Spectrometry & Mol, Ningbo 315211, Zhejiang, Peoples R China; [Zhang, Yanmin; Song, Jian] Henan Normal Univ, Sch Phys, Xinxiang 453007, Henan, Peoples R China; [Yang, Shouning; Liu, Xiaoyang; Lu, Sijia; Li, Zhuo; Yang, Huayan] Henan Normal Univ, Collaborat Innovat Ctr Henan Prov Green Mfg Fine, Key Lab Green Chem Media & React, Minist Educ,Sch Chem & Chem Engn, Xinxiang 453007, Henan, Peoples R China in 2021, Cited 65. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

The development of eco-friendly and low cost catalysts is challenging. Here, heterostructures of Bi2S3 quantum dots (QDs) doped onto ultrathin BiOCl nanosheets were synthesized by a facile hydrothermal method to exploit efficient photosensitizers with appropriate electronic states to enhance the transfer of electrons. The obtained Bi2S3-BiOCl showed highly efficient photocatalytic ability for selective oxidation of aromatic alcohols to aldehydes. More oxygen vacancies are formed on the exposed 001 facet of the ultrathin BiOCl, which can effectively trap electrons and form O-.(2)- radicals. The cooperation between the BiOCl and the Bi2S3 QDs effectively separates photogenerated electron-hole pairs at the heterointerface and facilitates the cooperative actions of O-.(2)- radicals and holes, which brings about a desirable photocatalytic eciency for the selective oxidation of aromatic alcohols. This work highlights the synergistic effect of semiconductor QDs and two-dimensional materials on selective conversion processes and provides a new design paradigm using noble metal-free heteromaterials with high photocatalytic activity. This opens new possibilities for photocatalyst design using heteromaterials with high photocatalytic activity.

Safety of (4-Methoxyphenyl)methanol. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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Category: alcohols-buliding-blocks. Authors Cavallo, M; Arnodo, D; Mannu, A; Blangetti, M; Prandi, C; Baratta, W; Baldino, S in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Cavallo, Marzia; Arnodo, Davide; Mannu, Alberto; Blangetti, Marco; Prandi, Cristina; Baldino, Salvatore] Dipartimento Chim, Via P Giuria 7, I-10125 Turin, Italy; [Baratta, Walter] Univ Udine, Dipartimento DI4A, Via Cotonificio 108, I-33100 Udine, Italy in 2021, Cited 52. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

The employment of easily affordable ruthenium(II)-complexes as pre-catalysts in the transfer hydrogenation of carbonyl compounds in deep eutectic media is described for the first time. The eutectic mixture tetrabutylammonium bromide/formic acid = 1/1 (TBABr/HCOOH = 1/1) acts both as reaction medium and hydrogen source. The addition of a base is required for the process to occur. An extensive optimization of the reaction conditions has been carried out, in terms of catalyst loading, type of complexes, H-2-donors, reaction temperature and time. The combination of the dimeric complex [RuCl(p-cymene)-mu-Cl](2) (0.01-0.05 eq.) and the ligand dppf (1,10-ferrocenediyl-bis(diphenylphosphine)ferrocene) in 1/1 molar ratio has proven to be a suitable catalytic system for the reduction of several and diverse aldehydes and ketones to their corresponding alcohols under mild conditions (40-60 degrees C) in air, showing from moderate to excellent tolerability towards different functional groups (halogen, cyano, nitro, phenol). The reduction of imine compounds to their corresponding amine derivatives was also studied. In addition, the comparison between the results obtained in TBABr/HCOOH and in organic solvents suggests a non-innocent effect of the DES medium during the process. (C) 2021 Elsevier Ltd. All rights reserved.

Category: alcohols-buliding-blocks. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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An article Nickel-catalyzed C3-alkylation of indoles with alcohols via a borrowing hydrogen strategy WOS:000651900200001 published article about C BOND FORMATION; ALPHA-ALKYLATION; UNACTIVATED AMIDES; KETONES; METHYLATION; ESTERS; ARYLACETONITRILES; FUNCTIONALIZATION; COMPLEXES; METHANOL in [Hu, Miao; Jiang, Yong; Sun, Nan; Hu, Baoxiang; Shen, Zhenlu; Hu, Xinquan; Jin, Liqun] Zhejiang Univ Technol, Coll Chem Engn, Hangzhou 310032, Peoples R China; [Jin, Liqun] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China in 2021, Cited 65. COA of Formula: C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5

An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcohols as the alkylating reagents has been developed. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcohols and substituted indoles. Mechanistic studies suggested that the reaction proceeds through a borrowing hydrogen pathway.

Welcome to talk about 105-13-5, If you have any questions, you can contact Hu, M; Jiang, Y; Sun, N; Hu, BX; Shen, ZL; Hu, XQ; Jin, LQ or send Email.. COA of Formula: C8H10O2

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Cicek, M; Gurbuz, N; Ozdemir, N; Ozdemir, I; Ispir, E in [Cicek, Metin; Ispir, Esin] Kahramanmaras Sutcu Imam Univ, Dept Chem, Fac Sci & Arts, TR-46050 Kahramanmaras 9, Turkey; [Cicek, Metin; Gurbuz, Nevin; Ozdemir, Ismail] Inonu Univ, Catalysis Res & Applicat Ctr, TR-44280 Malatya, Turkey; [Gurbuz, Nevin; Ozdemir, Ismail] Inonu Univ, Dept Chem, Fac Sci & Art, TR-44280 Malatya, Turkey; [Ozdemir, Namik] Ondokuz Mayis Univ, Dept Math & Sci Educ, Fac Educ, TR-9055139 Samsun, Turkey published Half-sandwich Ru(II) arene complexes bearing benzimidazole ligands for the N-alkylation reaction of aniline with alcohols in a solvent-free medium in 2021, Cited 71. HPLC of Formula: C8H10O2. The Name is (4-Methoxyphenyl)methanol. Through research, I have a further understanding and discovery of 105-13-5.

In this article, the direct N-alkylation reactions of amines with alcohol derivatives using the borrowing hydrogen methodology have been investigated. For this purpose, a new series of half-sandwich ruthenium(II) complexes bearing N-coordinated benzimidazole complexes have been synthesized and fully characterized by FT-IR, H-1 NMR and C-13 NMR spectroscopies. Additionally, the structures of the complexes 2a-2e have been characterized by X-ray crystallography. ALL new complexes were investigated for their catalytic activities in the alkylation reaction of amines with alcohol derivatives. It was found that alkylation reactions in a solvent-free medium are efficient and selective.

HPLC of Formula: C8H10O2. Bye, fridends, I hope you can learn more about C8H10O2, If you have any questions, you can browse other blog as well. See you lster.

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