Tag: M.W=100-150

Maman, Manju P. published the artcileReversible polymorphic structural transition of crown-like nickel nanoclusters and its effect on conductivity, Name: 2-Phenylethanethiol, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(23), 2935-2938, database is CAplus and MEDLINE.

The reversible polymorphic phase transition of [Ni₆(PET)₁₂] (PET = phenylethanethiol) and its effect on the conductivity are reported. This cluster′s self-assembly leads to 2 polymorphic structures with distinct conductivity, caused by variation of the noncovalent S···S interactions. These results enlighten the effect of noncovalent interactions on conductivity

Chemical Communications (Cambridge, United Kingdom) published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brimble, Margaret A. published the artcileSynthesis of a dimeric pyranonaphthoquinone via a novel double furofuran annulation strategy, Related Products of alcohols-buliding-blocks, the publication is Tetrahedron Letters (1998), 39(31), 5647-5650, database is CAplus.

The first synthesis of a dimeric pyranonaphthoquinone (I) which is related to the naturally occurring dimeric pyranonaphthoquinones, e.g. actinorhodin and crisamycin, is described. The key biaryl (II) is prepared by means of a Suzuki coupling reaction, utilizing the Miyaura reagent to generate the organoboron coupling partner. The first example of a double annulation of a bisquinone with 2-trimethylsilyloxyfuran to afford a bisfuronaphthofuran (III) and subsequent double oxidative rearrangement to a dimeric pyranonaphthoquinone is described.

Tetrahedron Letters published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gnanakumar, Edwin S. published the artcilePlasma-Assisted Synthesis of Monodispersed and Robust Ruthenium Ultrafine Nanocatalysts for Organosilane Oxidation and Oxygen Evolution Reactions, Application of Triethylsilanol, the publication is ChemCatChem (2017), 9(22), 4159-4163, database is CAplus and MEDLINE.

A facile and general approach for preparing ultrafine Ru nanocatalysts by using a plasma-assisted synthesis at <100° is reported. The resulting Ru nanoparticles are monodispersed (typical size 2 nm) and remain that way upon loading onto C and TiO₂ supports. This gives robust catalysts with excellent activities in both organosilane oxidation and the O evolution reaction.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Application of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hoang, Van-Hai published the artcileDiscovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design, Recommanded Product: 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2019), 62(17), 8011-8027, database is CAplus and MEDLINE.

Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor 1, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogs, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational anal. of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Meng, Charles Q. published the artcileCarboxylated, Heteroaryl-Substituted Chalcones as Inhibitors of Vascular Cell Adhesion Molecule-1 Expression for Use in Chronic Inflammatory Diseases, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2007), 50(6), 1304-1315, database is CAplus and MEDLINE.

Starting from a simple chalcone template, structure-activity relationship (SAR) studies led to a series of carboxylated, heteroaryl-substituted chalcone derivatives as novel, potent inhibitors of vascular cell adhesion mol.-1 (VCAM-1) expression. Correlations between lipophilicity determined by calculated logP values and inhibitory efficacy were observed among structurally similar compounds of the series. Various substituents were found to be tolerated at several positions of the chalcone backbone as long as the compounds fell into the right range of lipophilicity. The chalcone α,β-unsaturated ketone moiety seemed to be the pharmacophore required for inhibition of VCAM-1 expression. Compound 19 (I) showed significant antiinflammatory effects in a mouse model of allergic inflammation, indicating that this series of compounds might have therapeutic value for human asthma and other inflammatory disorders.

Journal of Medicinal Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEnhanced mechanical, crystallisation and thermal properties of graphene flake-filled polyurethane nanocomposites: the impact of thermal treatment on the resulting microphase-separated structure, Quality Control of 111-29-5, the publication is Journal of Polymer Research (2021), 28(8), 302, database is CAplus.

The present work investigates the combined effect of the addition of graphite nanoplatelets (xGNPs) to polyurethane copolymer (PUC) and thermal treatment was employed. The PUC reinforced by xGNP were synthesized by in-situ polymerization, which leads to an effective performance of the PUC/xGNP system. Meanwhile, X-ray diffraction and Raman spectroscopy tests displayed the inter-spacing planar quality of xGNP nanofillers. The thermal stability of PUC was seen to increase with addition of xGNP. Addnl., the dynamic storage modulus (E’) showed better performance after thermal treatment than in the untreated samples. However, a relationship between the microphase-separated morphol. of PUC induced by thermal treatment and the addition of xGNP has been observed Consequently, the crystallinity percentage increased after thermal treatment @ 80 C for 4 days, presuming a re-ordering of amorphous hard segments during the heating in a packed microphase conformation. On the other hand, better dispersion and interaction of xGNP can play a crucial role in enhancing the thermal and mech. properties, and thus a significant reinforcement for PUC. The tensile properties such as modulus and tensile strength showed significant enhancement with xGNP incorporation, while the elongation steeply dropped. On the contrary, a deterioration in modulus and tensile strength resulted from thermal treatment, likely due to the restacking of xGNP during segmental movement and thus increasing the amorphous phase rather than the crystalline phase. A modified Halpin-Tsai model was utilized to predict the mismatch between the empirical and theor. results. Consequently, the findings displayed the divergence of the nanocomposite modulus of PUC with greater amounts of xGNP nanofillers.

Journal of Polymer Research published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEffect of OMMT reinforcement on morphology and rheology properties of polyurethane copolymer nanocomposites, Related Products of alcohols-buliding-blocks, the publication is Journal of Elastomers & Plastics (2021), 53(8), 992-1014, database is CAplus.

The remarkable structural features of organic modified montmorillonite particles (OMMT) enable them to complete their important role in enhancing different properties of polyurethane copolymer with 75 weight% hard segments (PUC/75). Based on the melt intercalation approach, various amounts of OMMT were incorporated into PUC/75 solution followed by the injection molding process. It is essential to mention that the synthesized PUC/75 in this work relied on using 1,5-Pentanediol as a chain extender in order to produce a long-term and thermal-stable PUC successfully. The effect of incorporating various loading of OMMT on rheol. properties of neat PUC/75 and its nanocomposites was investigated. The structure of PUC/OMMT was studied using X-ray diffraction (XRD) and SEM. Addnl., differential scanning calorimetry (DSC) thermograms were utilized to investigate OMMT effect on the thermal transitions and crystallinity of resultant PUC nanocomposites. Interestingly, the dynamic rheol. anal. exhibited a remarkable increase in melt rheol. behavior with increasing OMMT loading compared to neat PUC/75. This could imply a good interaction between the functional group on the surface of OMMT and PUC/75 domains; particularly hard domains, herein the DSC results showed moderate improvement in melt temperature (T_m) of PUC/OMMT nanocomposite. However, a decline in crystalline temperature (T_c) was also seen due to aggregation of OMMT, especially at higher OMMT loading. While XRD results exhibited a slight shifting in crystalline peaks of PUC nanocomposites relative to neat PUC/75.

Journal of Elastomers & Plastics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileStudy on the effect of tailoring the hard copolymer polyurethane on the thermal, mechanical and electrical properties of hard copolymer polyurethane/multi-walled carbon nanotubes nanocomposites, SDS of cas: 111-29-5, the publication is Journal of Composite Materials (2022), 56(10), 1467-1480, database is CAplus.

This study focusses on the effect of the addition of multi-walled carbon nanotubes (MWCNTs) on the morphol. and thermal, rheol. and elec. properties of hard copolymer polyurethane (HCPU) using 1,5 pentane-diols as a chain extender, containing 85% of hard segment blocks. Step-growth polymerization was used to synthesize a HCPU polymer matrix, followed by melt compounding to prepare the nanocomposites. SEM investigation of the neat HCPU structure and its nanocomposites indicated the uniform dispersion of MWCNTs within the polymer matrix; further TEM morphol. investigation showed some agglomeration regions, attributed to the high MWCNT content (2 wt%). An XRD test confirmed a homogeneous distribution of MWCNTs by observing the remaining location of the highest peaks of MWCNTs and amorphous peaks of the HCPU matrix. Anal. of the melt rheol. test results showed an improvement in complex viscosity combined with an increase in the G’ and G” of nanocomposites from those of pure HCPU due to the presence of MWCNTs. Finally, elec. conductivity of nanocomposites demonstrated a significant improvement in its value at high loading of MWCNTs from that of pure HCPU matrix.

Journal of Composite Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, SDS of cas: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Albozahid, Muayad published the artcileEffect of dispersion methods on the performance of novel rigid copolymer polyurethane nanocomposites based on graphene nanofillers, Application In Synthesis of 111-29-5, the publication is Polymer-Plastics Technology and Materials (2022), 61(4), 426-440, database is CAplus.

The Rigid Copolymer Polyurethanes (RCPUs) as nanocomposites were synthesized by in-situ polymerization (ISP), melt compounding (MC), and solution mixing (SM) with wide range of weight ratios of graphite nanoplatelets (GNP). The blending process was utilized to obtain well- dispersed of GNP and thus strong interaction, leading to an effective performance of the RCPU/GNP nanocomposites. The structure of RCPU/GNP nanocomposites was studied using FTIR test. The thermal stability of RCPU nanocomposites was seen by TGA anal., showing an increase with addition of GNP nanofillers. Rheol. anal. revealed network formation with well-dispersed GNP regarding different dispersion approaches. Thermal and elec. tests were also conducted, approving that dispersion and interaction of GNP can play a crucial role for enhancing the thermal and elec. properties. Such a significant improvement in RCPU matrix performance could lead to the use of this material for different application.

Polymer-Plastics Technology and Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kanda, Yuzuru published the artcileTwo-Phase Synthesis of Taxol, Related Products of alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2020), 142(23), 10526-10533, database is CAplus and MEDLINE.

Taxol is widely regarded as amongst the most famed natural isolates ever discovered, and has been the subject of innumerable studies in both basic and applied science. Its documented success as an anticancer agent, coupled with early concerns over supply, stimulated a furious worldwide effort from chemists to provide a solution for its preparation through total synthesis. Those pioneering studies proved the feasibility of retrosynthetically-guided access to synthetic Taxol, albeit in minute quantities and with enormous effort. In practice, all medicinal chem. efforts and eventual commercialization have relied upon natural-(plant material) or biosynthetically-derived (synthetic biol.) supplies. Here we show how a complementary divergent synthetic approach that is holistically patterned off of biosynthetic machinery for terpene synthesis can be used to arrive at Taxol.

Journal of the American Chemical Society published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts