Tag: M.W=100-150

Pandey, Bedraj; Xu, Shi; Ding, Keying published the artcile< Switchable β-alkylation of Secondary Alcohols with Primary Alcohols by a Well-Defined Cobalt Catalyst>, Electric Literature of 403-41-8, the main research area is alkylation primary secondary alc preparation cobalt triphosphine pyridine catalyst; switchable ketone secondary alc preparation alkylation benzenemethanol cobalt catalyst.

β-Alkylation of secondary alcs. R1CH(OH)Me with primary alcs. R2CH2OH catalyzed by cobalt(I) triphosphine-pyridine complex in the presence of KOtBu selectively generate either alcs. R1CH(OH)CH2CH2R2 or ketones R1COCH2CH2R2 in dependence of catalyst and base loadings and hydrogen presence or removal. Remarkably, a low catalyst loading of 0.7 mol% can be employed for the reaction. More significantly, this study represents the first Co-catalyzed switchable alc./ketone synthesis by simply manipulating the reaction parameters. In addition, the transformation is environmentally friendly, with water as the only byproduct.

Organometallics published new progress about Alkylation. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Electric Literature of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Poly, Sharmin Sultana; Hashiguchi, Yuta; Sultana, Asima; Nakamura, Isao; Shimizu, Ken-ichi; Yasumura, Shunsaku; Fujitani, Tadahiro published the artcile< Flow reactor approach for the facile and continuous synthesis of efficient Pd@Pt core-shell nanoparticles for acceptorless dehydrogenative synthesis of pyrimidines from alcohols and amidines>, Related Products of 403-41-8, the main research area is palladium platinum core shell nanoparticle dehydrogenative pyrimidine alc amidine.

Carbon supported Pd@Pt core-shell nanoparticles catalyst was prepared in a flow reactor toachieve enhanced catalytic activities with low Pt loading for the acceptorless dehydrogenative synthesis of pyrimidines. Spectroscopic (XAS anal.) and microscopic (HAADF-STEM) techniques reveled that the core-shell structure was formed by the applied preparation method. The Pd@Pt/PVP (polyvinylpyrrolidone)/C catalyst showed the activity for the three component one pot synthesis of pyrimidines through a series of consecutive reactions including oxidation of alcs., C-C, and C-N coupling, followed by heterocyclization and dehydrogenation employing various primary alcs., secondary alcs., and amidines. The reaction mechanism on Pd@Pt/PVP/C catalyst was explored by comparison with the control experiments

Applied Catalysis, A: General published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Related Products of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wakayama, Takanari; Ito, Yuki; Miyake, Mio; Nomasa, Karin; Sakai, Kiyoshi; Oya, Naoko; Sato, Hirotaka; Ohno, Hiroyuki; Kamijima, Michihiro published the artcile< Inhalation exposure to 2-ethyl-1-hexanol causes hepatomegaly and transient lipid accumulation without induction of peroxisome proliferator-activated receptor alpha in mice.>, SDS of cas: 104-76-7, the main research area is 2-Ethyl-1-hexanol; Hepatic enlargement; Inhalation exposure; Lipid droplet; Peroxisome proliferator-activated receptor alpha (PPARα); Volatile organic compound (VOC).

2-Ethyl-1-hexanol (2EH) is a volatile organic compound known to cause sick building syndrome. However, 2EH-induced hepatotoxicity has been mainly evaluated in experiments orally administering 2EH as a metabolite of di(2-ethylhexyl) phthalate. To evaluate the hepatotoxicity risk of 2EH as an indoor air pollutant, we exposed 10-wk-old male ICR mice to 2EH by inhalation for 8 h/d, 5 d/wk for 3 months (0, 20, 60, or 150 ppm) or 6 months (0, 0.5, 10, or 100 ppm). In both experiments, relative liver weights significantly increased in the highest exposure groups. The 3-month exposure increased histopathological lipid droplets in the liver in a dose-dependent manner, hepatic triglyceride at all exposure levels, hepatic phospholipid at 150 ppm, and microsomal triglyceride transfer protein at 60 and 150 ppm; however, these changes were not observed following the 6-month of exposure. Following the 3-month exposure, alanine transaminase and peroxisomal bifunctional proteins, known markers of liver injury and peroxisome proliferation, respectively, remained unaltered. Therefore, in the present study, the inhalation concentration range of 2EH induced a toxic hypertrophic change, revealing a limited role of peroxisome proliferator-activated receptor alpha (PPARα). The liver weights may have presumably increased via a mechanism independent of PPARα activation.

Industrial health published new progress about 104-76-7. 104-76-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H18O, SDS of cas: 104-76-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hamdi, Naceur.; Slimani, Ichraf; Mansour, Lamjed; Alresheedi, Faisal; Ozdemir, Ismail; Gurbuz, Nevin published the artcile< Rhodium(I) complexes with N-heterocyclic carbene ligands: synthesis, biological properties and catalytic activity in the hydrosilylation of aromatic ketones>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is rhodium NHC benzimidazolylidene cyclooctadiene complex preparation antibacterial antitumor agent; ketone hydrosilylation catalyst rhodium NHC benzimidazolylidene cyclooctadiene complex; crystal mol structure buried volume rhodium NHC benzimidazolylidene complex.

New rhodium(I) N-heterocyclic carbene (NHC) complexes were synthesized in good yields by the reactions of rhodium dimer [Rh(OMe)(cycloocta-1,5-diene:COD)]2 with benzimidazolium salts in THF. All the complexes were characterized by IR, 1H-NMR, and 13C-NMR spectroscopy, DART-TOF mass spectrometry and elemental anal. All complexes were used as catalysts in the hydrosilylation of acetophenone derivatives with triethylsilane at 80°C for 1 h. These Rh(I) NHC showed good catalytic performance for the hydrosilylation of acetophenone derivatives by using 1 mol % of the rhodium complexes. In addition the new rhodium(I) NHC complexes were tested against MCF7 and MDA-MB-231 cancer cells, Micrococcus luteus LB 14110, Listeria monocytogenes ATCC 19117, Salmonella Typhimurium ATCC 14028, Staphylococcus aureus ATCC 6538, Pseudomonas aeruginosa and Candida albicans microorganisms. The synthesized rhodium(I) NHC complex was found the most active against MCF7 cancer cells (half-growth inhibition concentration (IC50) = 0.3μg mL-1), as well as the most potent antimicrobial against L. monocytogenes ATCC 19117 (inhibition zone (IZ) = 29 mm). Moreover, the antioxidant activity determination of these complexes was studied with the DPPH (2,2-diphenyl-1-picryl-hydrazyl-hydrate) and compared with gallic acid and butylated hydroxytoluene.

Journal of Coordination Chemistry published new progress about Antibacterial agents. 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Laiqiang; Hou, Zhong-Wei; Li, Pinhua; Wang, Lei published the artcile< Electrochemical Dearomatizing Spirocyclization of Alkynes with Dimethyl 2-Benzylmalonates to Spiro[4.5]deca-trienones>, Formula: C9H8O, the main research area is alkene dimethyl benzylmalonate ferrocene catalyst electrochem dearomatizing spirocyclization; spiro decatrienone preparation green chem.

An electrochem. dearomatizing spirocyclization of alkynes with di-Me 2-benzylmalonates for the preparation of spiro[4.5]deca-trienones had been developed. This approach adopted ferrocene (Cp2Fe) as an electrocatalyst to produce carbon-centered radical intermediates from C-H-based malonates, which obviated the forthputting of noble-metal reagents, sacrificial chem. oxidants and 2-bromomalonates. A wide variety of spiro compounds were efficiently prepared with satisfactory results under mild conditions.

Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 10602-04-7 belongs to class alcohols-buliding-blocks, and the molecular formula is C9H8O, Formula: C9H8O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Shanshan; Wang, Zheng; Cao, Qianrong; Yue, Erlin; Liu, Qingbin; Ma, Yanping; Liang, Tongling; Sun, Wen-Hua published the artcile< Aza-crown compounds synthesised by the self-condensation of 2-amino-benzyl alcohol over a pincer ruthenium catalyst and applied in the transfer hydrogenation of ketones>, HPLC of Formula: 403-41-8, the main research area is aminobenzyl alc pincer ruthenium catalyst self condensation; aza crown compound preparation; alkyl aryl ketone transfer hydrogenation iron catalyst; aralkyl alc preparation.

A well-defined PNN-Ru catalyst was revisited to self-condense 2-aminobenzyl alc. formed a series of novel aza-crown compounds All aza-crown compounds were separated and determined by NMR, IR, and ESI-MS spectroscopy as well as X-ray crystallog., indicated the saddle structure of aza-12-crown-3 and the twisted 1,3-alternate conformation structure of aza-20-crown-5. These aza-crown compounds was explored to study ferric initiation of transfer hydrogenation (TH) of ketones into their corresponding secondary alcs. in the presence of 2-propanol with a basic t-BuOK solution, achieving a high conversion (up to 95%) by a ferric complex with aza-16-crown-4 in a low loading (0.05 mol%).

Dalton Transactions published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, HPLC of Formula: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kishore, Jugal; Thiyagarajan, Subramanian; Gunanathan, Chidambaram published the artcile< Ruthenium(II)-catalyzed direct synthesis of ketazines using secondary alcohols>, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol, the main research area is ketazine preparation diastereoselective; secondary alc hydrazine hydrate oxygen hydrogen bond activation; ruthenium pincer complex catalyst.

Direct one-pot synthesis of ketazines (E,E)-R1R2C:NN:CR1R2 (R1 = Me, Et, Pr, etc.; R2 = C6H5, 4-MeC6H4, 2-MeOC6H4, etc.) from secondary alcs. R1R2CH(OH) and hydrazine hydrate catalyzed by a ruthenium pincer complex is reported, which proceeds through O-H bond activation of secondary alcs. via amine-amide metal-ligand cooperation in the catalyst. Remarkably, liberated mol. hydrogen and water are the only byproducts.

Chemical Communications (Cambridge, United Kingdom) published new progress about Azines Role: SPN (Synthetic Preparation), PREP (Preparation) (ketazines). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Recommanded Product: 1-(4-Fluorophenyl)ethyl Alcohol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Buhaibeh, Ruqaya; Filippov, Oleg A.; Bruneau-Voisine, Antoine; Willot, Jeremy; Duhayon, Carine; Valyaev, Dmitry A.; Lugan, Noel; Canac, Yves; Sortais, Jean-Baptiste published the artcile< Phosphine-NHC Manganese Hydrogenation Catalyst Exhibiting a Non-Classical Metal-Ligand Cooperative H2 Activation Mode>, Application In Synthesis of 403-41-8, the main research area is manganese NHC phosphine complex hydrogenation catalyst cooperative hydrogen activation; DFT calculations; N-heterocyclic carbenes; manganese; metal-ligand cooperation; phosphonium ylides.

Deprotonation of the MnI NHC-phosphine complex fac-[MnBr(CO)3(κ2P,C-Ph2PCH2NHC)] (2, II) under a H2 atmosphere readily gives the hydride fac-[MnH(CO)3(κ2P,C-Ph2PCH2NHC)] (3, III) via the intermediacy of the highly reactive 18-e NHC-phosphinomethanide complex fac-[Mn(CO)3(κ3P,C,C-Ph2PCHNHC)] (6a, VI). DFT calculations revealed that the preferred reaction mechanism involves the unsaturated 16-e mangana-substituted phosphonium ylide complex fac-[Mn(CO)3(κ2P,C-Ph2P=CHNHC)] (6 b) as key intermediate able to activate H2 via a non-classical mode of metal-ligand cooperation implying a formal λ5-P-λ3-P phosphorus valence change. Complex 2 is shown to be one of the most efficient pre-catalysts for ketone hydrogenation in the MnI series reported to date (TON up to 6200).

Angewandte Chemie, International Edition published new progress about Carbene complexes, N-heterocyclic, transition metal complexes Role: CAT (Catalyst Use), PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), USES (Uses), PROC (Process), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Application In Synthesis of 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ganguli, Kasturi; Shee, Sujan; Panja, Dibyajyoti; Kundu, Sabuj published the artcile< Cooperative Mn(I)-complex catalyzed transfer hydrogenation of ketones and imines>, Formula: C8H9FO, the main research area is alc preparation chemoselective; ketone transfer hydrogenation manganese catalyst; aryl aldehyde transfer hydrogenation manganese catalyst; imine transfer hydrogenation manganese catalyst.

The synthesis and reactivity of Mn(I) complexes bearing bifunctional ligands comprising both the amine N-H and benzimidazole fragments I and II (R = H, Me; R1 = H, Me, phenyl; R2 = H, Me) are reported. Among the various ligands, the N-((1H-benzimidazol-2-yl)methyl)aniline ligand containing Mn(I) complex II (R = R2 = H; R1 = Ph) presented higher reactivity in the transfer hydrogenation (TH) of ketones R3C(O)R4 (R3 = Ph, thiophen-2-yl, cyclopropyl, etc.; R4 = Me, propan-2-yl, tert-Bu, etc.; R3R4 = 9H-fluoren-9-yl, 1,2,3,4-tetrahydronaphthalen-1-yl, cyclohexyl) in 2-propanol. Exptl., it was established that both the benzimidazole and amine N-H proton played a vital role in the enhancement of the catalytic activity. Utilizing this system, a wide range of ketones R3C(O)R4 and aldehydes R5CHO (R5 = 4-CH3C6H4, thiophen-2-yl, pentyl, etc.) was reduced efficiently. Notably, the TH of several imines R6R7C=NR8 (R6 = 4-OCH3C6H4, thiophen-2-yl, naphthalen-2-yl, etc.; R7 = H, Me, Et; R8 = C6H5, 4-OCH3C6H4, CH3(CH2)3, etc.), as well as chemoselective reduction of unsaturated ketones, was achieved in the presence of this catalyst. DFT calculations were carried out to understand the plausible reaction mechanism which disclosed that the transfer hydrogenation reaction followed a concerted outer-sphere mechanism.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, Formula: C8H9FO.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Zheng; Liu, Yahuan; Han, Mingyang; Ma, Ning; Lyu, Quanming; Liu, Qingbin; Sun, Wen-Hua published the artcile< Efficient transfer hydrogenation of ketones using molybdenum complexes by comprehensively verifying the auxiliary ligands>, SDS of cas: 403-41-8, the main research area is ketone hydrogenation molybdenum complex catalyst.

Molybdenum complexes ligated with N1,N1-dialkyl-N2-(5,6,7,8-tetrahydroquinolin-8-yl)ethane-1,2-diamines and auxiliary ligands, providing various structural features, were developed: [NNH/NNHN]Mo(CO)4/3, [NNHN]Mo(CO)2Br, [NNH]Mo(CO)(η3-C3H5)Br and [NNHN/S]Mo(CO)(PPh3)2. All the complexes were highly active in the transfer hydrogenation (TH) of a model substrate (acetophenone), providing excellent yields of 1-phenylethanol. The structural variation in the ligand framework had a modest effect on the catalyst performance as compared to the changes in the auxiliary ligands Br, PPh3 and CO. This structural evolution provided the complex [Mo(NNH)(η3-C3H5)(CO)2Br] as the most effective catalyst not only for the transfer hydrogenation of acetophenone but also for a wide range of diverse ketones (up to 43 examples). Moreover, easy purification of the products by only removing the acetone byproduct is another noteworthy feature of this environmentally friendly route.

Dalton Transactions published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 403-41-8 belongs to class alcohols-buliding-blocks, and the molecular formula is C8H9FO, SDS of cas: 403-41-8.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts