Tag: M.W=100-150

Mao, Di published the artcileA Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures, Recommanded Product: 3-(Methylamino)phenol, the publication is Angewandte Chemie, International Edition (2017), 56(7), 1765-1770, database is CAplus and MEDLINE.

A major hurdle in stem cell therapy is the tumorigenic risk of residual undifferentiated stem cells. This report describes the design and evaluation of synthetic hybrid mols. that efficiently reduce the number of human induced pluripotent stem cells (hiPSCs) in cell mixtures The design takes advantage of Kyoto probe 1 (KP-1), a fluorescent chem. probe for hiPSCs, and clin. used anticancer drugs. Among the KP-1-drug conjugates we synthesized, we found an exceptionally selective, chem. tractable mol. that induced the death of hiPSCs. Mechanistic anal. suggested that the high selectivity originates from the synergistic combination of transporter-mediated efflux and the cytotoxicity mode of action. The present study offers a chem. and mechanistic rationale for designing selective, safe, and simple reagents for the preparation of non-tumorigenic clin. samples.

Angewandte Chemie, International Edition published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Recommanded Product: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jimenez, Elena published the artcileAtmospheric lifetimes and global warming potentials of CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH, HPLC of Formula: 2240-88-2, the publication is ChemPhysChem (2010), 11(18), 4079-4087, database is CAplus and MEDLINE.

A comprehensive study of several atm. degradation routes for two hydrofluoroalcs., CF₃(CH₂)_x=1,2CH₂OH, is presented. The gas-phase kinetics of their reactions with hydroxyl radicals (OH) and chlorine (Cl) atoms are investigated by absolute and relative techniques, resp. The room-temperature rate coefficients (±σ, in cm³ mol.^-1 s^-1) k_OH and k_Cl, are resp. (9.7 ± 1.1) × 10^-13 and (1.60 ± 0.45) × 10^-11 for CF₃CH₂CH₂OH, and (2.62 ± 0.32) × 10^-12 and (8.71 ± 0.24) × 10^-11 for CF₃(CH₂)₂CH₂OH. Average lifetimes of CF₃CH₂CH₂OH and CF₃(CH₂)₂CH₂OH due to the OH and Cl reactions are estimated to be 12 and 4 days, and greater than 20 and 4 years, resp. Also, the IR and UV absorption cross sections of CF₃(CH₂)_x=1,2CH₂OH are determined in the spectral ranges of 500-4000 cm^-1 and 200-310 nm. Photolysis of CF₃(CH₂)_x=1,2CH₂OH in the actinic region (λ ≥ 290 nm) is negligible compared to their homogeneous removal. Addnl., computational IR spectra are consistent with the exptl. ones, thus giving high confidence in the obtained results. The lifetimes of CF₃(CH₂)_x=1,2CH₂OH and IR spectra reported herein allow the calculation of the direct global warming potential of these hydrofluoroalcs. The contribution of CF₃(CH₂)_xCH₂OH to radiative forcing of climate change will be negligible.

ChemPhysChem published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, HPLC of Formula: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brandi, Francesco published the artcileControlled lignosulfonate depolymerization via solvothermal fragmentation coupled with catalytic hydrogenolysis/hydrogenation in a continuous flow reactor, Synthetic Route of 645-56-7, the publication is Green Chemistry (2021), 23(24), 9894-9905, database is CAplus.

Sodium lignosulfonate (LS) was valorized to low mol. weight (M_w) fractions by combining solvothermal (SF) and catalytic hydrogenolysis/hydrogenation fragmentation (SHF) in a continuous flow system. This was achieved in either alc./H₂O (EtOH/H₂O or MeOH/H₂O) or H₂O as a solvent and Ni on nitrogen-doped carbon as a catalyst. The tunability according to the temperature of both SF and catalytic SHF of LS has been sep. investigated at 150°C, 200°C, and 250°C. In SF, the minimal M_w was 2994 g mol^-1 at 250°C with a dispersity (D) of 5.3 using MeOH/H₂O. In catalytic SHF using MeOH/H₂O, extremely low M_w was found (433 mg gLS^-1) with a D of 1.2 combined with 34 mg gLS^-1. The monomer yield was improved to 42 mg gLS^-1 using dual catalytic beds. These results provide direct evidence that lignin is an unstable polymer at elevated temperatures and could be efficiently deconstructed under hydrothermal conditions with and without a catalyst.

Green Chemistry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Synthetic Route of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shubhashish, Shubhashish published the artcileSynthesis of Highly Porous Metal Oxide Nanoparticles for Adsorption Applications, HPLC of Formula: 111-29-5, the publication is ACS Applied Nano Materials (2022), 5(5), 7078-7091, database is CAplus.

Herein, we report a general and straightforward synthesis method for large-pore highly mesoporous metal oxide nanoparticles via a modified inverse micelle formation. The role of diols as solvents has been demonstrated and extended to other metal oxides using ethylene glycol. After scanning most of the metals from the periodic table, magnesium and calcium from the s-block; tin from the p-block; vanadium, nickel, zinc, zirconium, and hafnium from the d-block; and lanthanum and cerium from the f-block elements, all these have been successfully synthesized as large-pore-diameter metal oxides. Because of thermodn. stability of chelate formation, ethylene glycol, 1,3-propanediol, 1,4-butanediol, and 1,5-pentanediol give a higher pore diameter, whereas a further increase in the diol carbon chain (1,6-hexanediol and 1,12-dodecanediol) leads to pore contraction. By varying the synthesis temperature, the effect of viscosity on the pore diameter has also been demonstrated. Potential applications of oxides of magnesium have been tested for carbon dioxide capture and adsorption of macromols. such as proteins and lipids and small mols. such as curcumin, dopamine, and sucrose. As predicted, larger-pore-diameter and higher-pore-volume mesoporous magnesium oxide shows higher carbon dioxide capture and adsorption compared to com. magnesium oxide. A mechanism for the higher pore diameters of mesoporous metal oxide nanomaterials has been proposed based on the results and previous reported literature studies.

ACS Applied Nano Materials published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C10H6F17N, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gershonov, Eytan published the artcileRegio- and chemoselectivity in S- and O- difluoromethylation reactions using diethyl (bromodifluoromethyl)phosphonate, Related Products of alcohols-buliding-blocks, the publication is Journal of Fluorine Chemistry (2021), 109867, database is CAplus.

The effective difluoromethylations of various S- and O- based- nucleophiles, presenting a wide range of pKa values, using diethyl(bromodifluoromethyl)phosphonate under basic conditions was described. These reactions, which rely on the quant. generation of difluorocarbene formed through the hydrolysis of phosphonate, were found to be effective only once the starting materials had pKa values of less than ca. 11. Importantly, in cases in which the substrates held two or three nucleophilic centers this feature was successfully implemented to achieve a high chemo- or regioselective difluoromethylation of the center exhibiting the lowest pKa value and the highest polarizability.

Journal of Fluorine Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Henley, Zoe A. published the artcileOptimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target, Name: 2-Morpholinoethanol, the publication is Journal of Medicinal Chemistry (2020), 63(2), 638-655, database is CAplus and MEDLINE.

Optimization of a lead series of PI3Kδ inhibitors based on a dihydroisobenzofuran core led to the identification of potent, orally bioavailable compound 19. Selectivity profiling of compound 19 showed similar potency for class III PI3K, Vps34, and PI3Kδ, and compound 19 was not well-tolerated in a 7-day rat toxicity study. Structure-based design led to an improvement in selectivity for PI3Kδ over Vps34 and, a focus on oral phramacokinetics properties resulted in the discovery of compound 41, which showed improved toxicol. outcomes at similar exposure levels to compound 19.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Name: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Niu-niu published the artcileSynthesis, evaluation, and mechanism study of new tepotinib derivatives as antiproliferative agents, Recommanded Product: 2-Morpholinoethanol, the publication is Molecules (2019), 24(6), 1173/1-1173/16, database is CAplus and MEDLINE.

Inspired by the potent inhibition activity of the c-Met (mesenchymal-epithelial transition factor) inhibitor Tepotinib, a series of new Tepotinib derivatives were synthesized and evaluated for their ability to act as antiproliferative agents to find the leading compounds with good activity and limited side effects. Among them, compound 31e exhibited potent antiproliferative activity (IC50 (50% inhibitory concentration) = 0.026μM) against hepatic carcinoma 97H (human liver cancer cell) cells and, importantly, had very low inhibitory activity against normal cells. A mechanism study demonstrated that 31e induced G1 phase (First growth phase or G indicating gap) arrest, inhibited the phosphorylation of c-Met and its downstream signaling component, Akt (Protein Kinase B), and also inhibited the migration of hepatic carcinoma 97H cells.

Molecules published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C7H13BrSi, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Zhiyong published the artcileCatalytic activity of nickel and cobalt for amination of ethylene glycol: Which is better?, Synthetic Route of 111-29-5, the publication is Molecular Catalysis (2022), 112243, database is CAplus.

Metal Ni and Co are widely used in the catalytic amination of alcs. and Ni is more favored due to its better catalytic performance. Here we compared their catalytic performance for the amination of ethylene glycol and unexpectedly found that Co is more active than Ni. DFT calculation results showed that the energy barriers for the dissociation of O-H and C-H bond in an ethylene glycol mol. are smaller on Co (0001) plane, accounting for higher ethylene glycol conversion and primary amine yield on metal Co catalyst. The C-C bond dissociation in a glycolaldehyde (dehydrogenation intermediate of ethylene glycol) mol. has significantly lower energy barrier on Ni (111) plane, being consistent with lower selectivity of primary amine on metal Ni catalyst. We also compared their catalytic performance for the amination of other diols and the results showed that Co is more active when short-chain diols are used as the substrate.

Molecular Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C11H19N, Synthetic Route of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bansal, Kuldeep Kumar published the artcileEvaluation of solubilizing potential of functional poly(jasmine lactone) micelles for hydrophobic drugs: A comparison with commercially available polymers, Category: alcohols-buliding-blocks, the publication is International Journal of Polymeric Materials and Polymeric Biomaterials, database is CAplus.

Achieving high solubilization capacity with the aid of polymeric micelles (PM) is still a major challenge. To address this shortcoming, novel poly(jasmine lactone) (PJL)-based PM were developed and compared with Soluplus and poly(lactide) copolymer. The presence of “ene” groups on PJL′s backbone offers a unique opportunity to insert functional groups. We introduced -COOH and Ph groups onto the PJL copolymer and observed a ∼334-fold increment in aqueous solubility of clotrimazole with -COOH-terminated PJL copolymer compared to Soluplus. We thus successfully demonstrated that the presence of appropriate free functional groups on the polymer chain can facilitate the solubilization potential of PM.

International Journal of Polymeric Materials and Polymeric Biomaterials published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

de Gracia Lux, Caroline published the artcileControlled degradation and release of polymer based nanoparticles, Quality Control of 25240-59-9, the publication is PMSE Preprints (2012), No pp. given, database is CAplus.

Polymer based nano and microparticles have recently received much interest for their ability both to encapsulate a therapeutic and release a payload on demand, in response to stimuli such as removal of a protecting group, pH, light and oxidative conditions. Upon exposure to specific conditions, these materials undergo reactions which degrade them in a very controlled manner. This paper presents controlled degradation and release studies from two new polymeric nanoparticles. First we use oxidative conditions to trigger the degradation of H₂O₂ bioresponsive polymeric nanoparticles. Then, using another approach, we exploit light sensitive end-cap groups to trigger the disassembly of a linear self-immolative material. Encapsulation of drugs could provide improved pharmacokinetics as they would be protected from the physiol. environment. Selected release could also allow lower drug loading through effective site delivery.

PMSE Preprints published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Quality Control of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts