Tag: M.W=100-150

Guan, Weixiang published the artcileHighly Dispersed Rh/NbO_x Invoking High Catalytic Performances for the Valorization of Lignin Monophenols and Lignin Oil into Aromatics, HPLC of Formula: 645-56-7, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(9), 3529-3541, database is CAplus.

As fossil fuels are constantly depleted, valorization of lignocellulosic biomass into valuable aromatic compounds is of great significance but exceedingly challenging. In this work, the structure and catalytic performance of various Rh/Nb₂O₅ catalysts were studied in detail via the catalytic hydrodeoxygenation of a representative lignin monophenol compound 2-methoxy-4-propylphenol. The best catalytic performance was obtained over Rh/Nb₂O₅-400 (Nb₂O₅ calcined at 400°C) with an exceptional 98% yield of propylbenzene under 0.5 MPa H₂, which was mainly due to the cooperation between highly dispersed Rh metals and NbO_x species, in which Rh was responsible for dissociation of H₂ and NbO_x for breaking of C-O bonds at the metal-support interface. Besides, the lignin oil obtained in depolymerization of raw pine wood was directly used as the substrate in the catalytic hydrodeoxygenation reaction over the Rh/Nb₂O₅-400 catalyst under 0.5 MPa H₂. Encouragingly, the liquid products were identified and found that lignin oil was completely converted into C₆-C₁₀ hydrocarbons (>99% selectivity) with an 80.1 mol % yield of aromatics The results achieved in this work highlighted that high-value utilization of lignocellulosic biomass feedstocks to produce aromatic chems. and liquid fuels could be achieved over Rh/Nb₂O₅ under a low hydrogen pressure.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, HPLC of Formula: 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tianhui published the artcileSynthesis of a phenylboronic ester-linked PEG-lipid conjugate for ROS-responsive drug delivery, Computed Properties of 25240-59-9, the publication is Polymer Chemistry (2017), 8(40), 6209-6216, database is CAplus.

Stimuli-responsive drug delivery systems (DDSs) offering spatial-temporal and dosage controlled transport of drugs in vivo have attracted much attention for anticancer drug delivery. In the present work, a kind of phenylboronic ester-linked PEG-lipid conjugate was designed and synthesized for H₂O₂-responsive drug delivery. Firstly, a chain-end alkynyl functionalized methoxy poly(ethylene glycol) with a phenylboronic pinacol ester linker was synthesized via a classical Passerini reaction of carboxyl functionalized methoxy poly(ethylene glycol)₂₀₀₀ (mPEG_2k-COOH), 4-formylphenylboronic pinacol ester and propargyl isocyanoacetamide. The obtained polymer was denoted as mPEG_2k-PBPE-alkynyl. Then, the oxidation-responsive cleavage of the phenylboronic pinacol ester linker between the mPEG_2k-COOH and alkynyl chain-end was verified by in situ¹H NMR and mass spectra characterization. Furthermore, the amphiphilic PEG-lipid conjugate was synthesized by the Cu(I)-catalyzed click reaction of mPEG_2k-PBPE-alkynyl and 3-azido-1,2-propanediol distearate (N₃-DSA). The resultant mPEG_2k-PBPE-DSA could self-assemble into stable micelles in aqueous media. Nile red was used as the model drug and was loaded into the micelles. The obtained drug loaded micelles exhibited a typical H₂O₂-responsive drug release behavior and could be effectively internalized by MCF-7 cells. In addition, the synthesized mPEG_2k-PBPE-DSA was tested to be nontoxic towards RAW264.7 cells. Therefore, this biocompatible mPEG_2k-PBPE-DSA conjugate would be promising for applications in ROS-responsive drug delivery.

Polymer Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C10H10O2, Computed Properties of 25240-59-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Xi published the artcileSynthesis of diosgenyl quaternary ammonium derivatives and their antitumor activity, Computed Properties of 622-40-2, the publication is Steroids (2021), 108774, database is CAplus and MEDLINE.

Giosgenin is a naturally steroidal saponin exhibiting a variety of biol. activities including antitumor ones. A series of novel diosgenyl quaternary ammonium derivatives were designed and synthesized to develop potential anti-tumor agents in our research. All novel derivatives were characterized by ¹H NMR, ¹³C NMR and HR-MS, and evaluated for their in vitro anti-proliferative activities using MTT assay. The human cancer cell lines were A549 (human lung cancer cell), H1975 (human lung adenocarcinoma cell), A431 (human skin squamous cell carcinoma), HCT-116 (human colorectal adenocarcinoma cell), Aspc-1 (human metastatic pancreatic cancer cell), Ramos (human B lymphoma cell), HBE (human bronchial epithelioid cell) and LO2 (human normal hepatocyte).

Steroids published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H13NO3, Computed Properties of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qiuyue published the artcileLow-Temperature Catalytic Hydrogenolysis of Guaiacol to Phenol over Al-Doped SBA-15 Supported Ni Catalysts, Computed Properties of 645-56-7, the publication is ChemCatChem (2020), 12(19), 4930-4938, database is CAplus.

Selective hydrogenolysis of aromatic carbon-oxygen (C_aryl-O) bonds is a key strategy for the generation of aromatic chems. from lignin. However, this process is usually operated at high temperatures and pressures over hydrogenation catalysts, resulting in a low selectivity for aromatics and an extra consumption of hydrogen. Here, a series of Al-doped SBA-15 mesoporous materials with different Si/Al molar ratios (Al-SBA-15) were prepared via a post-synthesis method using NaAlO₂ as the Al source, and then Al-SBA-15 supported Ni catalysts (Ni/Al-SBA-15) were prepared by a deposition-precipitation method using urea as the hydrolysis reagent. The prepared supports and catalysts were extensively characterized using various techniques such as XRD, N₂ adsorption/desorption, TEM, ²⁷Al NMR, NH₃-TPD, XPS, H₂-TPR, and pyridine-FT-IR, and the catalysts were evaluated in the hydrogenolysis of the C_aryl-O bond in guaiacol and lignin derived compounds under mild conditions. The effects of the Si/Al ratio in catalyst and reaction parameters on guaiacol conversion and product distribution were investigated in detail, associated with solvent effect. The incorporation of Al into the framework of SBA-15 can improve the Lewis acidity and the dispersion of the supported Ni particles and yet modulate the metal-support interactions, which are propitious to the hydrogenolysis of the C_aryl-O bond in guaiacol. The catalyst Ni/Al-SBA-15 with a Si/Al molar ratio of 10 shows the best performance with a guaiacol conversion of 87.4% and a phenol selectivity of 76.9% under the mild conditions conducted, because of its proper acidity, suitable metal-support interactions, and high dispersion of the active species. The present study would stimulate research and development in multi-functional catalysts for the generation of valuable chems. from biomass.

ChemCatChem published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C10H10O2, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Tsun-Ren published the artcileIridium/graphene nanostructured catalyst for the N-alkylation of amines to synthesize nitrogen-containing derivatives and heterocyclic compounds in a green process, Formula: C5H12O2, the publication is RSC Advances (2022), 12(8), 4760-4770, database is CAplus and MEDLINE.

A facile iridium/graphene-catalyzed methodol. providing an efficient synthetic route for C-N bond formation is reported. This catalyst can directly promote the formation of C-N bonds, without pre-activation steps, and without solvents, alkalis and other additives. This protocol provides a direct N-alkylation of amines using a variety of primary and secondary alcs. with good selectivity and excellent yields. Charmingly, the use of diols resulted in intermol. cyclization of amines, and such products are privileged structures in biol. active compounds Two examples illustrate the advantages of this catalyst in organic synthesis: the tandem catalysis to synthesize hydroxyzine, and the intermol. cyclization to synthesize cyclizine. Water is the only byproduct, which makes this catalytic process sustainable and environmentally friendly.

RSC Advances published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Ge published the artcileCatalytic depolymerization of Kraft lignin towards liquid fuels over bifunctional molybdenum oxide based supported catalyst, Formula: C9H12O, the publication is Fuel (2021), 121599, database is CAplus.

Catalytic depolymerization of Kraft lignin towards valuable liquid fuels and monomeric phenols has been a significant and extremely attractive target, but it remains a great challenge. Herein, we report a catalytic system consisted of bifunctional molybdenum oxide based supported catalyst for catalytic lignin hydroconversion into alkylated benzenes and phenols. In the meantime, the achieved yield of liquid product was 95% and petroleum ether extracted product was 65% at 300°C for 12 h over 20%MoO_x/ZIF-8@ZIF-67 catalyst. The calorific value was increased from 25.66 MJ/ Kg to 34.31 MJ/Kg. The characterization studies show the incorporation of MoOx species leads to the synergy between redox sites and acid sites. The product anal. and catalytic studies demonstrate its synergism to promote catalytic cleavage of C-O linkages via the coupled hydrodeoxygenation and alkylation reaction. The reasonable catalytic mechanism and redox cycle route of catalyst indicate that the cooperative catalytic system paves the way for high-efficiency waste lignin utilization.

Fuel published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brown, Herbert C. published the artcileMarkovnikov hydroboration of perfluoroalkylethylenes, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Angewandte Chemie, International Edition (1999), 38(13/14), 2052-2054, database is CAplus and MEDLINE.

Hydroboratation of (perfluoroalkyl)ethenes using dichloroborane and dibromoborane gave products with unprecedented Markovnikov regioselectivity. Thus, hydroboration of 3,3,3-trifluoro-1-propene gave 1,1,1-trifluoro-2-propanol.

Angewandte Chemie, International Edition published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jinping published the artcileBase-assisted activation of phenols in TiO₂ surface complex under visible light irradiation, Category: alcohols-buliding-blocks, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2022), 114005, database is CAplus.

Surface charge-transfer complex formed by TiO₂ and phenols has showed a great potential in visible-light photocatalysis. However, back electron transfer limits the charge transfer efficiency and the activation of phenols in surface complex. Herein, we disclosed the efficient activation of phenols in surface complex by introducing the base. Both homocoupling reactions and butylated hydroxytoluene-trapped experiments clearly demonstrated the generation of phenolic radicals from various lignin-derived substrates. The addition of base caused the blue-shifted absorption of surface complex, while increased the visible light-induced electron excitation from substrate to TiO₂. Vibrational spectra suggested that the interaction between phenolate and TiO₂ was stronger than the interaction between neutral phenol and TiO₂. This base-triggered strategy may be conducive to useful transformations or degradation of phenols via surface complex.

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H5FO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Qiumei published the artcileMorpholinyl dendrimer phthalocyanine: synthesis, photophysical properties and photoinduced intramolecular electron transfer, Quality Control of 622-40-2, the publication is Dalton Transactions (2018), 47(37), 13164-13170, database is CAplus and MEDLINE.

A novel series of morpholinyl dendrimer phthalocyanines were synthesized. Their structures were characterized by ¹H NMR, IR, elemental anal., ESI-MS as well as MALDI-TOF MS. The photophys. properties of these phthalocyanines were studied by UV/visible and fluorescence spectroscopic methods. The photophys. properties of these dendrimer phthalocyanines exhibited dependence on the number of morpholinyl groups and the central ion. The photoinduced intramol. electron transfer from the morpholinyl groups to the phthalocyanine ring was evidenced by the remarkably quenched fluorescence intensity and shortened lifetime of the silicon phthalocyanine. This difference in photoinduced intramol. electron transfer effect for axially and peripherally substituted morpholinyl dendrimer phthalocyanines was also studied. Besides, introduction of morpholinyl groups on the dendrimer structure could enhance water solubility as well as increase the singlet oxygen quantum yield.

Dalton Transactions published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bandarage, Upul K. published the artcileNitrosothiol esters of diclofenac: synthesis and pharmacological characterization as gastrointestinal-sparing prodrugs, Application of 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of Medicinal Chemistry (2000), 43(21), 4005-4016, database is CAplus and MEDLINE.

Despite its widespread use, diclofenac has gastrointestinal liabilities common to nonsteroidal antiinflammatory drugs (NSAIDs) that might be reduced by concomitant administration of a gastrointestinal cytoprotectant such as nitric oxide (NO). A series of novel diclofenac esters containing a nitrosothiol (-S-NO) moiety as a NO donor functionality has been synthesized and evaluated in vivo for bioavailability, pharmacol. activity, and gastric irritation. All S-NO-diclofenac derivatives acted as orally bioavailable prodrugs, producing significant levels of diclofenac in plasma within 15 min after oral administration to mice. At equimolar oral doses, S-NO-diclofenac derivatives I [R = R’ = Me, Et, RR’ = (CH₂)₅] and II (n = 2, 3) displayed rat antiinflammatory and analgesic activities comparable to those of diclofenac in the carrageenan-induced paw edema test and the mouse phenylbenzoquinone-induced writhing test, resp. All tested S-NO-diclofenac derivatives I and II were gastric-sparing in that they elicited markedly fewer stomach lesions as compared to the stomach lesions caused by a high equimolar dose of diclofenac in the rat. Nitrosothiol esters of diclofenac comprise a novel class of NO-donating compounds having therapeutic potential as nonsteroidal antiinflammatory agents with an enhanced gastric safety profile.

Journal of Medicinal Chemistry published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Application of 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts