Tag: M.W=100-150

Fanfoni, Lidia published the artcileEfficient synthesis of new fluorinated building blocks by means of hydroformylation, Quality Control of 83706-94-9, the publication is Chimia (2014), 68(6), 371-377, database is CAplus and MEDLINE.

The hydroformylation reactions of fluorinated olefins were reviewed and added new results from the research group. The particular attention is paid to the remarkable influence of organofluorine substituents on catalyst activity, regio- and stereoselectivity of the hydroformylation reaction.

Chimia published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Quality Control of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paioti, Paulo H. S. published the artcileCatalytic Enantioselective Boryl and Silyl Substitution with Trifluoromethyl Alkenes: Scope, Utility, and Mechanistic Nuances of Cu-F β-Elimination, Application In Synthesis of 83706-94-9, the publication is Journal of the American Chemical Society (2019), 141(50), 19917-19934, database is CAplus and MEDLINE.

Catalytic enantioselective methods are introduced that allow access to a variety of allyl boronates and silanes that contain a difluoroalkene unit; the resulting products may be used for the preparation of organofluorine compounds in high enantiomeric purity. Also, a number of key mechanistic aspects of the transformations were studied and analyzed. Thus, 1st, an NHC-Cu-catalyzed method for boryl substitution with F₃C-substituted alkenes is introduced. These processes, unlike the previously reported strategies, are applicable to alkyl as well as aryl substituted substrates, afford allyl boronates bearing a difluoroalkene moiety (up to 98% yield and 95:5 er). Second, the corresponding silyl substitutions, the 1st reported cases of their kind, are presented (up to 94% yield and 97:3 er). Third, exptl. and computational (DFT) studies are described that shed light on key mechanistic aspects of the catalytic processes. Evidence (x-ray structures of Cu-alkyl intermediates and kinetic studies) is put forth illustrating that the initial Cu-boryl and Cu-silyl addition is significantly faster than the ensuing Cu-F elimination, and that the latter step can be facilitated by either a mild Lewis acid (e.g., a Li or Na cation) or a nucleophilic promoter (e.g., an alkoxide). These findings together with DFT studies demonstrate that Cu-F β-elimination probably proceeds with anti-stereochem. Representative cases of ways through which the new mechanistic understanding may be used to rationalize previously disclosed findings, significantly improve a transformation, or develop new diastereo- and enantioselective catalytic methods are provided. For example, an explanation is provided regarding why bisphosphine-Cu complexes do not efficiently promote boryl substitutions with aryl-substituted substrates, but the corresponding silyl substitutions are facile, and how the size of a ligand can impact regioselectivity and efficiency.

Journal of the American Chemical Society published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Application In Synthesis of 83706-94-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Youyi published the artcileNanoporous gold film: fabrication and role as a catalytic reactor, Application In Synthesis of 597-52-4, the publication is Dalton Transactions (2015), 44(26), 11929-11934, database is CAplus and MEDLINE.

Nanoporous gold (NPG) is attractive due to its high catalytic activity. From an applied and economical point of view, fabricating thin NPG films is recognized to be an ideal approach. Herein, we report an interesting finding that a thin NPG film with a thickness of 90 nm can be prepared on various substrates conveniently by using seed-mediated growth. The film has a nanoporous character with 30-60 nm and 10-30 nm of ligament and pore size, resp. The high cost-efficiency, adjustable substrates, easy and convenient operation make this film reactor a good candidate for catalyzing both oxidative and hydrogenation reactions.

Dalton Transactions published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C2H8Cl2N4S2, Application In Synthesis of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Denisov, E. T. published the artcileKinetic parameters for the forward and reverse reactions of the tert-butoxyl radical with phenols, Computed Properties of 14703-69-6, the publication is Kinetika i Kataliz (1993), 34(3), 424-9, database is CAplus.

Parameters of the parabolic transition state model (2 intersecting unperturbed potential energy curves) for H-abstraction reaction of Me₃CO^• with phenols were evaluated from exptl. kinetic data reported in the literature. Constancy of the br_e parameter for classes of sterically hindered and nonhindered phenols permitted calculation of forward and reverse rate constants of 99 phenols with Me₃CO^• at 333 K.

Kinetika i Kataliz published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Computed Properties of 14703-69-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mullenix, John B. published the artcileElectronic decay through non-linear carbon chains, Synthetic Route of 2240-88-2, the publication is Journal of Physics B: Atomic, Molecular and Optical Physics (2020), 53(18), 184006, database is CAplus.

A multielectron wave-packet propagation method was used to calculate the electronic decay of oxygen and fluorine 2s vacancies for a group of trifluoroalkyl alcs., HOC_nH_(2n-1)F₃, with n between 1 and 5. Whether ionizing O2s or F2s orbitals, it is shown that an electron can be emitted non-locally from the opposite terminus of the mol. The decay of the O(2s^-1) state is found to be about 2-3 times faster than that of the F(2s^-1), but in both cases the process takes only a few femtoseconds, demonstrating a highly efficient energy transfer through the carbon bridge. A comparison to the previously reported non-local decay in linear difluorocumulenone systems shows that the non-linearity of the trifluoroalkyl alcs. does not appear to dramatically influence the decay efficiency. These results shed light onto the nature of the scaling of electron correlation and open the door to the potential design of mols. that take advantage of this mechanism.

Journal of Physics B: Atomic, Molecular and Optical Physics published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hemelaere, Remy published the artcileIntroduction of the 4,4,4-Trifluorobut-2-ene Chain Exploiting a Regioselective Tsuji-Trost Reaction Catalyzed by Palladium Nanoparticles, Application of (E)-4,4,4-Trifluorobut-2-en-1-ol, the publication is Organic Letters (2015), 17(7), 1770-1773, database is CAplus and MEDLINE.

A palladium-nanoparticle-catalyzed Tsuji-Trost reaction of 4,4,4-trifluorobut-2-en-1-yl acetate and ethyl(4,4,4-trifluorobut-2-en-1-yl)carbonate was accomplished with various nucleophiles including phenols, amines, and malonates. In the case of the phenols, isomerization of the double bond in the product (up to 20%) was observed as a side reaction [e.g., reaction of carbonate I with PhOH using in situ generated Pd NPs afforded II (62%) along with isomerization byproduct III (II:III = 90:10)]. Further synthetic transformations including hydrogenation, the Diels-Alder reaction, and asym. dihydroxylation of a product were also examined

Organic Letters published new progress about 83706-94-9. 83706-94-9 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethylated Building Blocks, name is (E)-4,4,4-Trifluorobut-2-en-1-ol, and the molecular formula is C4H5F3O, Application of (E)-4,4,4-Trifluorobut-2-en-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Eswaramoorthy, Senthil Kumar published the artcileAtomically Precise Palladium Nanoclusters with 21 and 38 Pd Atoms Protected by Phenylethanethiol, Application In Synthesis of 4410-99-5, the publication is Journal of Physical Chemistry C (2022), 126(1), 444-450, database is CAplus.

Monolayer thiolate-protected nanoclusters (MPCs) are extensively studied due to their distinctive properties. The at. precision in MPCs, especially in gold MPCs, is determined through mass spectrometry, which leads to the accurate identification of metal-ligand composition The total structure determination of gold and silver MPCs using ScXRD revolutionized the field by providing insights into the structural arrangement at an at. level. The synthesis of atomically precise MPCs using other metals like palladium (Pd) to study and compare properties is tedious and complex. In one end, larger size monodisperse Pd nanoparticles (NPs) were synthesized and studied for various catalytic properties. Meanwhile, on the other end, a small-mol. tiara-like Pd-thiolate complex was reported. However, at. precise Pd MPCs in the middle and its detailed studies are not yet explored. Here, we report the synthesis and identification of atomically precise phenylethanethiol-protected Pd₂₁(SCH₂CH₂Ph)₁₈ and Pd₃₈(SCH₂CH₂Ph)₂₁S₂ Pd nanoclusters. The size distribution is confirmed using matrix-assisted laser desorption ionization mass spectra (MALDI-MS), and electrospray ionization mass spectrometry (ESI-MS) confirms the composition through the isotopically resolved peak. The XPS spectra elucidate the cluster formation in smaller size.

Journal of Physical Chemistry C published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Application In Synthesis of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Lizi published the artcileStructure-Affinity Relationships and Structure-Kinetic Relationships of 1,2-Diarylimidazol-4-carboxamide Derivatives as Human Cannabinoid 1 Receptor Antagonists, Product Details of C3H5F3O, the publication is Journal of Medicinal Chemistry (2017), 60(23), 9545-9564, database is CAplus and MEDLINE.

The synthesis and biol. evaluation of a series of 1,2-diarylimidazol-4-carboxamide derivatives, e.g. I, developed as CB₁ receptor antagonists is reported. These were evaluated in a radioligand displacement binding assay, a [³⁵S]GTPγS binding assay, and in a competition association assay that enables the relatively fast kinetic screening of multiple compounds The compounds show high affinities and a diverse range of kinetic profiles at the CB₁ receptor and their structure-kinetic relationships (SKRs) were established. Using the recently resolved hCB₁ receptor crystal structures, a modeling study was performed that sheds light on the crucial interactions for both the affinity and dissociation kinetics of this family of ligands. Evidence is provided that, next to affinity, addnl. knowledge of binding kinetics is useful for selecting new hCB₁ receptor antagonists in the early phases of drug discovery.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C10H14O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beattie, Deborah L. published the artcileRAFT aqueous dispersion polymerization of 4-hydroxybutyl acrylate: effect of end-group ionization on the formation and colloidal stability of sterically-stabilized diblock copolymer nanoparticles, Recommanded Product: 2-Phenylethanethiol, the publication is Polymer Chemistry (2022), 13(5), 655-667, database is CAplus.

A series of all-acrylic poly(2-hydroxyethyl acrylate)_x-poly(4-hydroxybutyl acrylate)_y (PHEA_x-PHBA_y) diblock copolymer nanoparticles were prepared via an efficient one-pot RAFT aqueous dispersion polymerization protocol using either a carboxylic acid-functionalized RAFT agent (HOOC-PHEA_x-PHBA_y) or a morpholine-functionalized RAFT agent (Mo-PHEA_x-PHBA_y). The pH-dependent colloidal stability of the resulting sterically-stabilized nanoparticles was assessed by dynamic light scattering and aqueous electrophoresis. The HOOC-PHEA₇₃-PHBA₂₁₇ nanoparticles exhibited reversible flocculation below pH 5.1, whereas the Mo-PHEA₇₆-PHBA₁₆₀ nanoparticles flocculated above pH 5. Moreover, the HOOC-PHEA₇₃-PHBA₂₁₇ nanoparticles proved to be sensitive to added salt, with incipient flocculation occurring in the presence of 20-60 mM KCl owing to charge screening. Thus, such nanoparticles require end-group ionization to confer colloidal stability via electrosteric stabilization. However, reducing the PHBA/PHEA molar ratio and/or increasing the PHEA_x stabilizer DP, leads to more efficient steric stabilization and hence enhanced colloidal stability. A series of HOOC-PHEA₇₃-PHBA_104-421 nano-objects prepared at pH 7 were characterized by visual inspection, DLS studies and shear-induced polarized light imaging. Discrepancies between these characterization techniques indicated that the worms and vesicles were unstable with respect to dilution TEM studies were conducted after covalent stabilization of the nano-objects using glutaraldehyde (GA). More specifically, TEM studies of GA-crosslinked HOOC-PHEA₇₃-PHBA₂₄₃ and HOOC-PHEA₇₃-PHBA₄₂₁ nano-objects indicated the presence of spheres in both cases when crosslinked at 0.1% weight/weight and either worms or vesicles resp., when crosslinked at 10-20% weight/weight Finally, HOOC-PHEA₇₃-PHBA₂₆₅ nano-objects were examined by variable temperature oscillatory rheol.; thermoreversible sphere/worm and worm/vesicle transitions were observed between 2 and 50°.

Polymer Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cincinelli, Raffaella published the artcileIntramolecular N-acyliminium ion versus Friedel-Crafts cyclization onto 3-indoles: synthesis of the novel rings pyrrolizino[2,1-b]indole and homologues, Quality Control of 4543-95-7, the publication is Tetrahedron (2009), 65(17), 3465-3472, database is CAplus.

Acid treatment of indole-2-carboxylic acid secondary δ-,ε-, and ζ-oxoamides cyclize to the novel heterocyclic ring systems pyrrolizino[2,1-b]indole (I, n = 1), indolizino[2,1-b]indole (I, n = II), and 9a,11-diaza-indeno[1,2-a]azulene (I, n = 3) with varying substitution. Tertiary amides cyclize through a simple Friedel-Crafts ring closure, thus allowing the synthesis of tricyclic ring systems containing larger rings, e.g., II.

Tetrahedron published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Quality Control of 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts