Tag: M.W=100-150

Park, Hea Jung published the artcileNew blue phosphorescent heteroleptic Ir(III) complexes with imidazole- and N-methylimidazole carboxylates as ancillary ligands, Computed Properties of 22483-09-6, the main research area is spirocyclic phenylpyridinyl iridacycle imidazolecarboxylate preparation electrochem OLED phosphorescence; crystal structure spirocyclic phenylpyridinyl iridacycle imidazolecarboxylate; mol structure spirocyclic phenylpyridinyl iridacycle imidazolecarboxylate.

Imidazole- and N-methylimidazole carboxylate were introduced to serve as ancillary ligands in heteroleptic Ir(III) complexes containing 2-phenylpyridine-based main ligands, with consideration of the frontier orbital energy levels. Complexes Ir1-Ir4 were synthesized and found to have LUMO levels higher than that of the corresponding Ir(III) complex containing pyridyl carboxylate. All the synthesized Ir(III) complexes exhibited blue phosphorescence emission maxima at 465-467 nm at room temperature Phosphorescent quantum efficiencies were increased by a factor of 1.8-6.7 by blocking the intermol. H bonding between the imidazole carboxylate ligands of neighboring Ir(III) complexes, which was achieved by N-methylation of the imidazole carboxylate ancillary ligand. The organic light-emitting diodes fabricated using Ir3 and Ir4 as dopant materials in the emissive layers emit blue emission with peaks at 469 and 471 nm and maximum external quantum efficiencies of 20.0 and 22.4%, resp. Also, all the fabricated devices with Ir3 and Ir4 exhibited low efficiency roll-off, indicating excellent stability of the materials.

Journal of Materials Chemistry C: Materials for Optical and Electronic Devices published new progress about Carboxylic esters Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), SPN (Synthetic Preparation), PROC (Process), PREP (Preparation) (spirocyclic iridacycle imidazolecarboxylates). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Computed Properties of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Genyi published the artcileModular click chemistry libraries for functional screens using a diazotizing reagent, Application of 2,2-Dimethoxyethanamine, the main research area is alkyl aryl azide triazole chemoselective preparation; fluorosulfonyl azide generation chemoselective diazotization primary amine; combinatorial generation library alkyl aryl azide cycloaddition alkyne; functional screen click chem azide generated in situ.

Alkyl and aryl azides were prepared from the corresponding primary alkyl and aryl amines by reaction with fluorosulfonyl azide generated in situ from a fluorosulfonylimidazolium triflate and sodium azide, expanding access to azides and both to the 1,2,3-triazoles derived from them and to functional screens employing them. The method allowed the preparation of a library of >1000 azides from the corresponding amines; the azide library underwent copper-catalyzed azide-alkyne cycloaddition reactions to yield a library of >1000 1,2,3-triazoles.

Nature (London, United Kingdom) published new progress about Aromatic amines Role: CMB (Combinatorial Study), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation) (primary). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Application of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Long, Christopher P. published the artcileHigh-resolution 13C metabolic flux analysis, Synthetic Route of 97-67-6, the main research area is Escherichia 13C metabolic flux analysis glycogen glucose ribose.

Precise quantification of metabolic pathway fluxes in biol. systems is of major importance in guiding efforts in metabolic engineering, biotechnol., microbiol., human health, and cell culture. 13C metabolic flux anal. (13C-MFA) is the predominant technique used for determining intracellular fluxes. Here, we present a protocol for 13C-MFA that incorporates recent advances in parallel labeling experiments, isotopic labeling measurements, and statistical anal., as well as best practices developed through decades of experience. The protocol is based on growing microbes in two (or more) parallel cultures with 13C-labeled glucose tracers, followed by gas chromatog.-mass spectrometry measurements of isotopic labeling of protein-bound amino acids, glycogen-bound glucose, and RNA-bound ribose. Fluxes are then estimated using software for 13C-MFA, such as Metran, followed by comprehensive statistical anal. to determine the goodness of fit and calculate confidence intervals of fluxes. The presented protocol can be completed in 4 d and quantifies metabolic fluxes with a standard deviation of =2%, a substantial improvement over previous implementations. The presented protocol is exemplified using an Escherichia coli ΔtpiA case study with full supporting data, providing a hands-on opportunity to step through a complex troubleshooting scenario. This protocol can be easily adjusted for application to eukaryotic organisms.

Nature Protocols published new progress about Computer program (Metran). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adebomi, Victor published the artcileMetal-free selective modification of secondary amides: Application in late-stage diversification of peptides, Formula: C4H11NO2, the main research area is peptide solid phase synthesis twisted amide diversification metal free; carbon nitrogen bond activation DFT ground state rotational energy; transamidation esterification thiocarbonyl insertion reaction thiocarbonylation solid support; mol structure twisted amino acid.

Here we solve a long-standing challenge of the site-selective modification of secondary amides and present a simple two-step, metal-free approach to selectively modify a particular secondary amide in mols. containing multiple primary and secondary amides. D. functional theory (DFT) provides insight into the activation of C-N bonds. This study encompasses distinct chem. advances for late-stage modification of peptides thus harnessing the amides for the incorporation of various functional groups into natural and synthetic mols.

Organic Letters published new progress about Amino acids Role: PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zheng, Yuzhu published the artcileDirect activation of alcohols via perrhenate ester formation for an intramolecular dehydrative Friedel-Crafts reaction, Related Products of alcohols-buliding-blocks, the main research area is silica supported rhenium oxide preparation; tetrahydronaphthalene derivative preparation; aryl alc intramol dehydrative Friedel Crafts rhenium oxide catalyst.

A general method for synthesis of tetrahydronaphthalene derivatives I [R = Ph, 4-MeC6H4, 2-BrC6H4, etc.; R1 = H, Me; R2 = H, 5-Me, 7-Br, etc.; X = CH2, O, NTs; Y = CH2, O, NTs] via Re2O7 catalyzed intramol. dehydrative Friedel-Crafts reaction of alcs. in hexafluoroisopropanol (HFIP) was reported. The potential application of this methodol. was exemplified by the formal or total synthesis of several com. available drugs or biol. relevant mols., including sertraline, nafenopin, etc. DFT calculations showed the preference for the activation of hydroxyl groups by Re2O7 via perrhenate ester formation followed by heterolytic C-O bond cleavage over Bronsted acid-catalyzed dehydration.

Organic Chemistry Frontiers published new progress about Free energy. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ji, Xiaoliang published the artcilePalladium-Catalyzed Cross Haloalkynylation of Haloalkynes, Quality Control of 107-54-0, the main research area is dihaloalkenyne preparation regioselective chemoselective diastereoselective; haloalkynol haloalkyne cross haloalkynylation palladium catalyst.

A robust Pd-catalyzed haloalkynylation of haloalkynes for the synthesis of dihaloalkenyne derivatives R1R2C(OH)C≡CC(R3)=C(R4)R5 [R1 = Me, Et, n-Bu, i-Bu, 3-ClC6H4CH2; R2 = Me, Et, n-Bu, i-Bu; R3 = Br, Cl; R4 = Br, Cl; R5 = hexyl, Ph, 4-MeC6H4, etc.; R1R2 = (CH2)4, (CH2)5, (CH2)7, etc.] was developed. This cross-haloalkynylation reaction proceeded in a highly chemo- and regioselective manner under mild conditions in the presence of two slightly structurally different haloalkynes and showed strong functional group tolerance under ligand- and base-free conditions.

Organic Letters published new progress about Alkynyl alcohols Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Quality Control of 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Jianheng published the artcileDesign, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFRL858R/T790M inhibitors, Application In Synthesis of 505-10-2, the main research area is cyclopropylindolyl anilinopyrimidine preparation EGFR inhibitor structure activity; pyrimidine antitumor EGFR inhibition SAR docking apoptosis induction pharmacokinetic; Anti-proliferation; Anti-tumor efficacy in vivo; Epidermal growth factor receptor; L858R/T790M double mutants; Non-small cell lung cancer (NSCLC).

A new series of 2,4-diarylpyrimidine derivatives containing a cyclopropyl moiety, I [R = N(Me)(CH2)2OH, thiomorpholino, O(CH2)3SMe, etc., X = H; R = S(CH2)2NMe2, S(O)(CH2)2NMe2, X = Cl], were designed, synthesized and evaluated as novel selective EGFRL858R/T790M inhibitors. The most promising compound, I [R = S(:O)CH2CH2NMe2] (II), demonstrated excellent kinase inhibitory activity against EGFR double mutation with IC50 value of 0.26 nM. Moreover, II provided strong activity against H1975 cells with IC50 value of 0.008μM and exhibited little toxicity toward four non-tumorigenic cell lines. Furthermore, II showed potent antitumor efficacy in a murine EGFRL858R/T790M-driven H1975 xenograft model. These results indicated that II may be a promising drug candidate for further study.

European Journal of Medicinal Chemistry published new progress about Aminopyrimidines Role: ADV (Adverse Effect, Including Toxicity), PAC (Pharmacological Activity), PKT (Pharmacokinetics), PRP (Properties), RCT (Reactant), SPN (Synthetic Preparation), THU (Therapeutic Use), BIOL (Biological Study), RACT (Reactant or Reagent), PREP (Preparation), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application In Synthesis of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preethi, P. C. published the artcileSynthesis of oxydiacetate functionalized strontium coordination polymer through gel diffusion technique: A new dual luminescent chemosensor for the detection of Copper(II) ions and Cr(VI) oxyanions in aqueous medium, SDS of cas: 110-99-6, the main research area is gel diffusion preparation oxydiacetate functionalized strontium coordination polymer; crystal structure oxydiacetate functionalized strontium coordination polymer; thermal decomposition oxydiacetate functionalized strontium coordination polymer; luminescence chemosensor oxydiacetate functionalized strontium coordination polymer.

The current scenario shows the wide applicability of coordination polymers (CPs) in various fields due to their structural topol. and tunable properties. The development of these mols. with potential application can be obtained by incorporating active metals with highly functionalized ligands under different synthetic conditions. Here in the authors report a newly synthesized dual luminescent chemosensor based on oxydiacetate functionalized strontium [Sr(C4H4O5)(H2O)3]n·nH2O by one of the simplest gel diffusion technique at room temperature The grown crystal was characterized by elemental anal., FTIR, UV-Visible Spectroscopy, Single Crystal x-ray Diffraction and TG/DTA measurements. Single Crystal x-ray diffraction studies of the synthesized CP revealed a monoclinic crystal system with space group P21/c. The luminescent properties of the synthesized analyte were analyzed from photoluminescence (PL) spectrum. The coordination polymer displayed an emission of 371 nm upon excitation of 313 nm. The luminescence titration experiments showed that the synthesized coordination polymer dispersed in water, can selectively sense Cu(II) metal ions as well as the Cr(VI) oxyanions [CrO42-/Cr2O72-] from the aqueous media with a detection limit of 0.2536μM and 0.1060μM, resp. The grown strontium based CP can thus be used as an effective dual luminescent chemosensor for the detection and probing of both Cu2+ and Cr(VI) oxyanions (CrO42-/Cr2O72-) in aqueous medium. The study further suggests the possibility of fabrication of strontium based luminescent chemosensors for the detection of Cu(II) cations and CrO42-/Cr2O72- anions in aqueous medium with high selectivity and sensitivity.

Polyhedron published new progress about Crystal structure. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, SDS of cas: 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kohlmeyer, Corinna published the artcileFormamide-Catalyzed Nucleophilic Substitutions: Mechanistic Insight and Rationalization of Catalytic Activity, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is formamide catalyzed nucleophilic substitution mechanism.

Herein, detailed mechanistic investigations into formamide-catalyzed nucleophilic substitution (SN) of alcs. are reported. Alkoxyiminium chlorides and hexafluorophosphates were synthesized and characterized as a key intermediate of the catalytic cycle. The determination of reaction orders and control experiments indicated that the nucleophilic attack of the formamide catalyst onto the reagent BzCl is the rate-determining step. Linear free energy relationship revealed a correlation between the quantified Lewis basicity strength of formamides by means of 11B NMR spectroscopy and their catalytic activity in SN-transformations. The observed difference in catalytic ability was attributed to the natural bond order charge, dipole moment, and Sterimol parameter B5. Importantly, this rationalization enables the prediction of the capacity of formamides to promote SN-type transformations in general.

ACS Catalysis published new progress about Allylic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kuduk, Scott D. published the artcileDevelopment of Orally Bioavailable and CNS Penetrant Biphenylaminocyclopropane Carboxamide Bradykinin B₁ Receptor Antagonists, Product Details of C6H13BO3, the publication is Journal of Medicinal Chemistry (2007), 50(2), 272-282, database is CAplus and MEDLINE.

A series of biphenylaminocyclopropane carboxamide based bradykinin B₁ receptor antagonists has been developed that possesses good pharmacokinetic properties and is CNS penetrant. Discovery that the replacement of the trifluoropropionamide in the lead structure with polyhaloacetamides, particularly a trifluoroacetamide, significantly reduced P-glycoprotein mediated efflux for the series proved essential. One of these novel bradykinin B₁ antagonists (13b) also exhibited suitable pharmacokinetic properties and efficient ex vivo receptor occupancy for further development as a novel approach for the treatment of pain and inflammation.

Journal of Medicinal Chemistry published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Product Details of C6H13BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts