Tag: M.W=100-150

Roberts, Dean D. published the artcileRegioselective Synthesis of Multifunctional Allylic Amines; Access to Ambiphilic Aziridine Scaffolds, SDS of cas: 107-54-0, the main research area is allylic amine ambiphilic aziridine preparation regioselective; propargylic amine dimethylphenylsilane hydrosilylation platinum chloride XantPhos catalyst.

A highly regioselective hydrosilylation of propargylic amines has been described here for the first time. The reaction utilizes a PtCl2/XantPhos catalyst system to deliver hydrosilanes across the alkyne to afford multifunctional allylic amines in high yields. The reaction is tolerant to a wide variety of functional groups and provides high value intermediates with two distinct functional handles. The synthetic applicability of the reaction has been shown through the synthesis of diverse ambiphilic aziridines.

Organic Letters published new progress about Amines, propargyl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, SDS of cas: 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karlinskii, Bogdan Ya. published the artcileSynthesis of 2-Azidomethyl-5-ethynylfuran: A New Bio-Derived Self-Clickable Building Block, Computed Properties of 107-54-0, the main research area is azidomethylfurancarboxaldehyde preparation azide alkyne cycloaddition; triazolylmethylfurancarboxaldehyde preparation; azidomethylethynylfuran preparation polymerization copper catalyzed azide alkyne cycloaddition; biomass derived azide containing alkyne preparation polymerization; safety toxicity sodium azide.

Furanylmethyl azide I was prepared in three steps from D-fructose or cellulose; copper-catalyzed azide-alkyne cycloaddition of I with terminal alkynes and diynes yielded triazolylmethylfurancarboxaldehydes such as II [R = Me2C(OH), Ph, BuCH2, BuCH2CCCH2, MeO2C, NC(CH2)3, HO(CH2)4, BocNHCH2, HOCH2, 3-quinolinyl, MeOCH2, t-Bu, cyclopropyl, i-PrCH2CMe(OH), t-BuCMe(OH)]. 2-Azidomethyl-5-ethynylfuran III was prepared as a monomer; in the presence of CuBr and pentamethyldiethylenetriamine, it underwent polymerization to form oligomer with MN = 4100 g/mol. Sodium azide is toxic and should be handled with care.

Synthesis published new progress about Azide-alkyne 1,3-dipolar cycloaddition reaction. 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Computed Properties of 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Yulu published the artcilePhotocatalytic Sulfonylcarbocyclization of Alkynes Using SEt as a Traceless Directing Group: Access to Cyclopentenes and Indenes, HPLC of Formula: 107-54-0, the main research area is cyclopentene indene preparation regioselective; alkyne sodium sulfinate photocatalytic Sulfonylcarbocyclization; 5-endo-trig cyclization; C−H functionalization; alkyne; photocatalysis; radical.

Herein, a traceless directing group strategy was designed to reverse the regioselectivity of radical addition which enabled an unprecedented photocatalytic sulfonylcarbocyclization of terminal alkynes by forming C-C bond on inert C(sp3)-H bond. It offered a facile access to decorated cyclopentenes and indenes under mild conditions. The resultant products could be converted into a set of valuable mol. scaffolds, including a key intermediate of AM-6226. Mechanistic experiments suggested a radical cascade pathway comprising a Markovnikov-type sulfonylation, 1,5-hydrogen atom transfer, 5-endo-trig cyclization, and β-elimination. This study lays further groundwork for the use of anti-Baldwin 5-endo-trig radical cyclization in rapidly assembling five-membered carbocycles.

Angewandte Chemie, International Edition published new progress about Cyclization (sulfonylcarbocyclization). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, HPLC of Formula: 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pan, Mingzhang published the artcileImpact of carbon chain length of alcohols on the physicochemical properties and reactivity of exhaust soot, Synthetic Route of 111-87-5, the main research area is impact carbon chain alc physicochem property reactivity exhaust soot; Different alcohols-diesel fuels; Morphology; Nanostructure; Oxygenated functional groups.

Particle is the main pollutant in diesel engine exhaust, which seriously endangers human health and the atm. environment. The use of alc. fuels in diesel engines can effectively reduce particle emissions, but alc. fuels with different carbon chain lengths will affect the generation process of particles, which in turn changes the physicochem. properties and oxidation characteristics of the particles. Therefore, it is particularly important to study the properties of particle emitted by diesel engines fueling alc. fuels with different carbon chain lengths. The physicochem. properties of soot emitted from com. diesel engines were studied by thermogravimetric analyzer, HRTEM (high-resolution TEM), and XPS (XPS) in this paper, resp. The diesel engine used alc.-diesel blends of different carbon chain lengths with the same oxygen content as fuels, such as methanol/diesel blend (M10), n-butanol/diesel blend (NB25), and n-octanol/diesel blend (NO45), and pure diesel fuel was used as a reference The use of alcs. reduced the fractal dimension (Df) of particles, and the NB25 particles had the smallest Df. Moreover, the particles of blended fuels had smaller primary particle diameter (dp) compared to pure diesel. However, with the use of short-chain to long-chain alcs., an increasing tendency of dp was observed In terms of the nanostructure, as the use of short-chain to long-chain alcs., the La (fringe length) increased, both the d (fringe separation distance) and Tf (fringe tortuosity) reduced, which was not favorable for the oxidation of the particles. In addition, in terms of oxygenated surface functional groups (SFGs), the C=O group occupied a higher proportion in most working conditions relative to the groups of C-O and COO. Further anal. showed that the dp and nanostructure had more influence on the oxidation behavior of soot than Df and oxygenated SFGs.

Science of the Total Environment published new progress about Diesel exhaust gases. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Ye published the artcileEnantioselective Desymmetrization of Bisphenol Derivatives via Ir-Catalyzed Allylic Dearomatization, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is bisphenol iridium allylic dearomatization catalyst; spirocyclic hexadienone stereoselective preparation.

Spirocyclic hexadienones with multiple stereogenic centers are frequently found in natural products but remain challenging targets to synthesize. Herein, we report the enantioselective desymmetrization of bisphenol derivatives via Ir-catalyzed allylic dearomatization reactions, affording spirocyclic hexadienone derivatives with up to three contiguous stereogenic centers in good yields (up to 90%) and excellent enantioselectivity (up to 99% ee). The high efficiency of this reaction is exemplified by the short reaction time (30 min), low catalyst loading (down to 0.2 mol %), and ability to perform the reaction on a gram-scale. The total syntheses of (+)-tatanan B and (+)-tatanan C were also realized using this Ir-catalyzed allylic dearomatization reaction as a key step.

Journal of the American Chemical Society published new progress about Dearomatization (Allylic). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khvalbota, Liudmyla published the artcileSimultaneous distillation-solvent extraction gas chromatography-mass spectrometry analysis of Tokaj Muscat Yellow wines, SDS of cas: 505-10-2, the main research area is tokaj muscat yellow wine distillation solvent extraction GC MS.

In the present study, simultaneous distillation-solvent extraction conditions were optimized for the extraction of organic compounds from naturally sweet Tokaj wines. Solvent selection, optimization of phase ratio, time of extraction, and addition of modifier were studied. The volatile organic compounds profile of Slovak Tokaj Muscat Yellow wine was characterized using simultaneous distillation-solvent extraction gas chromatog.-mass spectrometry. Identified volatile organic compounds belonged to terpenes, esters, higher alcs., volatile acids, lactones, and furanoids. At optimized simultaneous distillation-solvent extraction conditions, anal. parameters such as linearity (R2 > 0.98), repeatability (from 3.33% to 10.39%), quantitation, and detection limits for selected compounds (Et hexanoate, geraniol, linalool oxide, α-terpineol, 1-octanol, geranyl acetate, nerol, benzyl alc., benzaldehyde, 1,2-dihydrolinalool, 4-terpineol, and di-Et succinate) were estimated

Separation Science plus published new progress about Botrytis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, SDS of cas: 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hayasaka, Kiyoshi published the artcileMetabolic basis and treatment of citrin deficiency, Name: (S)-2-hydroxysuccinic acid, the main research area is review citrin deficiency medium chain triglyceride supplement; adult-onset type II citrullinemia (CTLN2); citrin deficiency; failure to thrive and dyslipidemia by citrin deficiency (FTTDCD); medium-chain triglyceride (MCT); neonatal intrahepatic cholestasis by citrin deficiency (NICCD).

Citrin deficiency is a hereditary disorder caused by SLC25A13 mutations and manifests as neonatal intrahepatic cholestasis (NICCD), failure to thrive and dyslipidemia (FTTDCD), and adult-onset type II citrullinemia (CTLN2). Citrin is a component of the malate-aspartate NAD hydrogen (NADH) shuttle, an essential shuttle for hepatic glycolysis. Hepatic glycolysis and the coupled lipogenesis are impaired in citrin deficiency. Hepatic lipogenesis plays a significant role in fat supply during growth spurt periods: the fetal period, infancy, and puberty. Growth impairment in these periods is characteristic of citrin deficiency. Hepatocytes with citrin deficiency cannot use glucose and fatty acids as energy sources due to defects in the NADH shuttle and downregulation of peroxisome proliferator-activated receptor α (PPARα), resp. An energy deficit in hepatocytes is considered a fundamental pathogenesis of citrin deficiency. Medium-chain triglyceride (MCT) supplementation with a lactose-restricted formula and MCT supplementation under a low-carbohydrate diet are recommended for NICCD and CTLN2, resp. MCT supplementation therapy can provide energy to hepatocytes, promote lipogenesis, correct the cytosolic NAD+/NADH ratio via the malate-citrate shuttle and improve ammonia detoxification, and it is a reasonable therapy for citrin deficiency. It is very important to administer MCT at a dose equivalent to the liver’s energy requirements in divided doses with meals. MCT supplementation therapy is certainly promising for promoting growth spurts during infancy and adolescence and for preventing CTLN2 onset. I.v. administration of solutions containing fructose is contraindicated, and persistent hyperglycemia should be avoided due to glucose intoxication for patients receiving hyperalimentation or with complicating diabetes.

Journal of Inherited Metabolic Disease published new progress about Diabetes mellitus. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Jun published the artcileA new type of triptycene-based stationary phases with alkylated benzimidazolium cations for gas chromatographic separations, Computed Properties of 111-87-5, the main research area is triptycene benzimidazolium cation gas chromatog stationary phase separation.

Favorable physicochem. properties and unique mol. recognition capability endow triptycene-based materials with good potential as stationary phases for gas chromatog. (GC). This work reports a new type of triptycene-based materials functionalized by three benzimidazolium cations with different peripheral alkyl lengths (denoted as TP-3Bim-5C and TP-3Bim-12C) and their GC separation performance. As a result, they shared high resolving performance for the naphthalene isomers but differed for the benzene derivatives with varying polarity. Moreover, their capillary columns exhibited good repeatability and thermal stability. This work presents a facile strategy for tailoring the selectivity of the TP-based stationary phases and demonstrates their promising future for chromatog. anal.

Chinese Chemical Letters published new progress about Gas chromatographic capillary columns. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Fei published the artcileExploration of key aroma active compounds in strong flavor Baijiu during the distillation by modern instrument detection technology combined with multivariate statistical analysis methods, COA of Formula: C4H10OS, the main research area is hexyl hexanoate phenylacetaldehyde pentanoic acid ethyl linolenate.

Liquid-liquid microextraction (LLME) combined with gas chromatog.-mass spectrometry (GC-MS) and headspace-gas chromatog.-ion mobility spectrometry (HS-GC-IMS) were used to detect the variations in volatile compounds during the distillation process of strong flavor raw Baijiu. The 3D fingerprint spectrum clearly showed a variation in volatile compounds from different distillation stages, and most alc.-soluble and low mol. weight compounds showed a downward trend with the extension of distillation time, but water-soluble, high mol. weight and high boiling compounds showed the opposite result. Then, 50 aroma compounds were sniffed and identified by gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and multivariate statistical anal. including principal component anal. (PCA) and partial least squares discriminant anal. (PLS-DA) confirmed four aroma active markers related to classification. Finally, the receiver operating characteristic (ROC) curve was further used to verify that Et butanoate and Et hexanoate were the most effective difference marker to distinguish the head Baijiu samples and butanoic acid was the most effective difference marker for distinguishing the heart Baijiu samples from the tail Baijiu samples.

Journal of Food Composition and Analysis published new progress about Acids Role: ANT (Analyte), FFD (Food or Feed Use), ANST (Analytical Study), BIOL (Biological Study), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, COA of Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Lei published the artcileAroma enhancement in dry cured loins by the addition of nitrogen and sulfur precursors, Computed Properties of 505-10-2, the main research area is aroma dry cured loins nitrogen sulfur precursor; Aroma; Dry cured loins; Ornithine; Proline; Thiamine.

Dry cured loins containing nitrogen (proline and ornithine) and sulfur (thiamine) compounds as precursors of aroma compounds at two concentration levels were manufactured The effect of precursor addition on the microbiol. and chem. parameters of loins was studied together with the aroma study performed by olfactometry and Free Choice Profile sensory analyses. Addition of precursors did not affect the microbial and chem. parameters, while aroma was affected when precursors were added at the highest level. The dry loin aroma profile was mainly composed by compounds 3-methylbutanal, methional, Et 3-methylbutanoate, 3-methylbutanoic acid, 1-octen-3-ol, 2-acetyl-1-pyrroline and 2-acetylpyrrole that contribute to musty, cooked potatoes, fruity, cheesy, mushroom, roasted and meaty odor notes. Proline and ornithine supplementation modified the loins aroma profile producing toasted odors, while the effect of thiamine supplementation on the aroma was revealed by the presence of sulfur derived compounds (methional and 2-methyl-3-(methylthio)furan) that contribute to the ′cured meat odor′

Meat Science published new progress about Alcohols Role: ANT (Analyte), BSU (Biological Study, Unclassified), ANST (Analytical Study), BIOL (Biological Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Computed Properties of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts