Tag: M.W=100-150

Lee, Richard G. published the artcileCardiolipin is required for membrane docking of mitochondrial ribosomes and protein synthesis, Application of (S)-2-hydroxysuccinic acid, the main research area is cardiolipin mitochondrial ribosome protein synthesis membrane docking; Cardiolipin; Mitochondrial membrane; Mitochondrial ribosomes; Protein synthesis.

The mitochondrial inner membrane contains a unique phospholipid known as cardiolipin (CL), which stabilizes the protein complexes embedded in the membrane and supports its overall structure. Recent evidence indicates that the mitochondrial ribosome may associate with the inner membrane to facilitate co-translational insertion of the hydrophobic oxidative phosphorylation (OXPHOS) proteins into the inner membrane. We generated three mutant knockout cell lines for the CL biosynthesis gene Crls1 to investigate the effects of CL loss on mitochondrial protein synthesis. Reduced CL levels caused altered mitochondrial morphol. and transcriptome-wide changes that were accompanied by uncoordinated mitochondrial translation rates and impaired respiratory chain supercomplex formation. Aberrant protein synthesis was caused by impaired formation and distribution of mitochondrial ribosomes. Reduction or loss of CL resulted in divergent mitochondrial and endoplasmic reticulum stress responses. We show that CL is required to stabilize the interaction of the mitochondrial ribosome with the membrane via its association with OXA1 (also known as OXA1L) during active translation. This interaction facilitates insertion of newly synthesized mitochondrial proteins into the inner membrane and stabilizes the respiratory supercomplexes.

Journal of Cell Science published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Agpat5). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ravi, Archna published the artcilePI5P4Ks drive metabolic homeostasis through peroxisome-mitochondria interplay, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is PIPK metabolic homeostasis peroxisome mitochondria interplay; PI-4,5-P(2); PI-5-P; PI5P4Ks; cancer; fatty acid; lipid; lipid droplet; metabolism; mitochondria; peroxisome; phosphoinositide; phosphoinositide kinase; sarcoma; β-oxidation.

PI5P4Ks are a class of phosphoinositide kinases that phosphorylate PI-5-P to PI-4,5-P2. Distinct localization of phosphoinositides is fundamental for a multitude of cellular functions. Here, we identify a role for peroxisomal PI-4,5-P2 generated by the PI5P4Ks in maintaining energy balance. We demonstrate that PI-4,5-P2 regulates peroxisomal fatty acid oxidation by mediating trafficking of lipid droplets to peroxisomes, which is essential for sustaining mitochondrial metabolism Using fluorescent-tagged lipids and metabolite tracing, we show that loss of the PI5P4Ks significantly impairs lipid uptake and b-oxidation in the mitochondria. Further, loss of PI5P4Ks results in dramatic alterations in mitochondrial structural and functional integrity, which under nutrient deprivation is further exacerbated, causing cell death. Notably, inhibition of the PI5P4Ks in cancer cells and mouse tumor models leads to decreased cell viability and tumor growth, resp. Together, these studies reveal an unexplored role for PI5P4Ks in preserving metabolic homeostasis, which is necessary for tumorigenesis.

Developmental Cell published new progress about Cell death. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Smolobochkin, A. V. published the artcileAcid-catalyzed reaction of 1-(2,2-dimethoxyethyl)ureas with phenols as an effective approach to diarylethanes and dibenzoxanthenes, Application of 2,2-Dimethoxyethanamine, the main research area is dimethoxyethyl urea preparation aryl alc trifluoroacetic acid catalyst; hydroxyarylethyl urea preparation; naphthol urea phenol trifluoroacetic acid catalyst; dibenzoxanthenemethyl urea preparation.

A one-pot synthesis of urea-substituted diarylethanes and dibenzoxanthenes starting from 1-(2,2-dimethoxyethyl)ureas and phenols was developed. The approach used readily available reagents and catalysts, requires mild reaction conditions and provides the target compounds in good to high yields.

ARKIVOC (Gainesville, FL, United States) published new progress about Alkylarenes Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Application of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kuznetsova, E. A. published the artcileDiastereoselective intramolecular cyclization/Povarov reaction cascade for the one-pot synthesis of polycyclic quinolines, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is diimidazoquinoline diimidazolone preparation one pot regioselective diastereoselective; aryl urea intramol cyclization Povarov reaction imidazolone oxoimidazolium.

The method for the synthesis of complex alkaloid-like aza-heterocycles has been developed through the Povarov reaction of in situ generated 2-oxoimidazolium cations. The reaction leads to the formation of 2 C-N, 2 C-C bonds and three stereocenters, and features excellent regio- and diastereoselectivity. Based on the controlled experiments and quantum chem. data, the mechanism of the reaction cyclization was proposed and diastereoselectivity origins were rationalized. Addnl., a straightforward synthesis of hardly accessible 4,4′-bi(imidazol-2-one) derivatives has been achieved using the same methodol.

Organic & Biomolecular Chemistry published new progress about Cyclization, stereoselective. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Fu-Dong published the artcilePhotoinduced C-O bond cleavage for copper-catalyzed allenyl radical cyanation, Related Products of alcohols-buliding-blocks, the main research area is allenyl nitrile chemoselective preparation; alkyl alkynyl benzoate photoinduced CO bond cleavage copper catalyst.

In this work, allenyl radicals were generated by the photoinduced cleavage of carbon-oxygen bonds, and participated in the copper catalytic cycle, affording structurally diverse and highly significant allenyl nitriles R(CN)C=C=CR1R2 [R = H, n-Bu; R1 = t-Bu, Ph, 3-thienyl, etc.; R2 = H, Me, n-Pr, etc.]. Both 1,3-disubstituted allenyl nitriles and trisubstituted allenyl nitriles could be assembled with moderate to good yields (24 examples, 65-95% yields) and high chemoselectivity. To prove the utility of this new methodol., an allene nitrile was converted into other valuable synthetic blocks including an allyl nitrile, alkyl nitrile and α-cyano cyclic ketone.

Organic Chemistry Frontiers published new progress about Allenes Role: SPN (Synthetic Preparation), PREP (Preparation). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Singh, Sangh Priya published the artcileRegioselective Synthesis of Functionalized Pyrrolo[1,2-a]pyrazine-3,6(2H,4H)-diones via Tandem Post-Ugi Cyclization and Gold(I)-Catalyzed Annulation, Recommanded Product: 2,2-Dimethoxyethanamine, the main research area is pyrrolopyrazine dione preparation regioselective; dihydropyrazinone preparation cyclization gold catalyst; Ugi alkynamide cyclization.

A convenient synthesis of less explored pyrrolo[1,2-a]pyrazine-3,6(2H,4H)-diones I (R = H, Me; R1 = H, i-Pr, cyclopropyl, thiophen-2-yl, etc.; RR1 = -(CH2)3-, -(CH2)4-; R2 = H, Me, Ph, 4-fluorophenyl, etc.; R3 = Cy, Bn, Ph, C(O)OEt;) and II is described in two steps from Ugi adducts RNHC(O)CH(R1)N(C(O)CCR2)CH2CH(OCH3)2. The method involves acid-mediated cyclization of Ugi adducts to form dihydropyrazinones II followed by gold(I)-catalyzed regioselective annulation. The generality of the transformation was established by reacting a variety of substituted dihydropyrazinones II under the optimized reaction conditions to form densely functionalized pyrrolo[1,2-a]pyrazine-3,6(2H,4H)-diones I in good-to-excellent yields. It was also observed That some of the acetone-derived Ugi adducts furnish 7-acyl-pyrroloimidazolones III as a byproduct during TFA-mediated cyclization via alkyne-carbonyl metathesis and condensation.

Journal of Organic Chemistry published new progress about Amides Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Recommanded Product: 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Islam, Sk. Safikul published the artcileGreen Synthesized AgNPs Embedded in COF: An Efficient Catalyst for the Synthesis of 2-Oxazolidinones and α-Alkylidene Cyclic Carbonates via CO2 Fixation, Application of 3,5-Dimethylhex-1-yn-3-ol, the main research area is porous covalent organic framework silver nanocatalyst preparation; terminal propargyl amine carboxylative cyclization; propargyl alc carboxylative cyclization; aryl oxazolidinone green preparation; cyclic carbonate green preparation.

The synthesis of silver nanoparticles (AgNPs) by an eco-friendly method and incorporation of the particles into a covalent organic framework obtained a sustainable heterogeneous catalyst, AgN@COF was demonstrated. The catalyst was characterized in detail by FT-IR,UV-Vis. spectroscopy, FE-SEM, TEM, EDAX, XPS, PXRD, ICP-AES, TG-DTA and N2 absorption-desorption studies. The synthesized catalyst was able to fix CO2 to terminal propargylic amine and propargylic alc. for the production of 2-oxazolidinones and α-alkylidene cyclic carbonates, resp., through two different catalytic pathways. In both catalytic protocols, one atm. carbon dioxide was used. Production of α-alkylidene cyclic carbonates occurred at room temperature and solvent-free condition, and 2-oxazolidinones were obtained under mild reaction conditions. Moreover, the catalyst was recyclable and reusable. Its catalytic efficacy was preserved even after the use of six consecutive catalytic cycles.

ChemNanoMat published new progress about Amines Role: RCT (Reactant), RACT (Reactant or Reagent). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Application of 3,5-Dimethylhex-1-yn-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Feng, Xi published the artcileCopper(II)-Catalyzed Tandem Reaction: Synthesis of Furo[3,2-c]coumarin Derivatives and Evaluation for Photophysical Properties, Synthetic Route of 107-54-0, the main research area is methylene dihydro furochromenone preparation fluorescence; hydroxycoumarin propargyl carbonate tandem Claisen allyl rearrangement catalyst copper.

An efficient protocol for synthesizing furo[3,2-c]coumarin derivatives I [R1 = H, 8-Cl, 9-MeO, etc.; R2 = Me; R3 = Me, Et, iso-Bu, Ph, hexyl; R2R3 = (CH2)2] was described. The novel reaction could afforded the desired furocoumarins I with good to excellent yields in a mild and rapid manner. Large substrate scope screening and scale-up preparation had also been accomplished, and selected compounds I [R1 = 7-N(Me)2; R2 = R3 = Me] and II were evaluated for their photophys. properties.

Journal of Organic Chemistry published new progress about Aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Synthetic Route of 107-54-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Yirong published the artcileA rhodium catalyzed cycloisomerization and tandem Diels-Alder reaction for facile access to diverse bicyclic and tricyclic heterocycles, Related Products of alcohols-buliding-blocks, the main research area is exocyclic diene preparation regioselective chemoselective; allenene cycloisomerization tandem Diels Alder rhodium catalyst; cyclic heterocyclic preparation regioselective chemoselective; dienophile allenene cycloisomerization tandem Diels Alder rhodium catalyst.

A regioselective distal cycloisomerization of 1,6-allenenes e.g., N-allyl-N-tosylbuta-2,3-dien-1-amine was successfully developed to afford six-membered ring exocyclic 1,3-dienes e.g., 3,4-dimethylene-1-tosylpiperidine employing a rhodium/diphosphine catalyst system. Deuterium labeling experiments and DFT calculations were performed to provide insights into the reaction mechanism of this unprecedented transformation. In addition, one-pot tandem Diels-Alder reactions with various dienophiles e.g., N-Ph maleimide could readily construct diverse bicyclic and tricyclic nitrogen heterocycles e.g., I, which are ubiquitous core scaffolds for a variety of natural products and bioactives. High efficiency and exclusive chemo and regioselectivities for a broad substrate scope were achieved under mild conditions using a low catalyst loading of 0.5 mol%.

Chemical Science published new progress about Chemoselectivity. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Molteni, Raffaella published the artcileOncogene-induced maladaptive activation of trained immunity in the pathogenesis and treatment of Erdheim-Chester disease, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is oncogene trained immunity erdheim chester disease.

Trained immunity (TI) is a proinflammatory program induced in monocyte/macrophages upon sensing of specific pathogens and is characterized by immunometabolic and epigenetic changes that enhance cytokine production Maladaptive activation of TI (ie, in the absence of infection) may result in detrimental inflammation and development of disease; however, the exact role and extent of inappropriate activation of TI in the pathogenesis of human diseases is undetermined In this study, we uncovered the oncogene-induced, maladaptive induction of TI in the pathogenesis of a human inflammatory myeloid neoplasm (Erdheim-Chester disease, [ECD]), characterized by the BRAFV600E oncogenic mutation in monocyte/macrophages and excess cytokine production Mechanistically, myeloid cells expressing BRAFV600E exhibit all mol. features of TI: activation of the AKT/mammalian target of rapamycin signaling axis; increased glycolysis, glutaminolysis, and cholesterol synthesis; epigenetic changes on promoters of genes encoding cytokines; and enhanced cytokine production leading to hyperinflammatory responses. In patients with ECD, effective therapeutic strategies combat this maladaptive TI phenotype; in addition, pharmacol. inhibition of immunometabolic changes underlying TI (ie, glycolysis) effectively dampens cytokine production by myeloid cells. This study revealed the deleterious potential of inappropriate activation of TI in the pathogenesis of human inflammatory myeloid neoplasms and the opportunity for inhibition of TI in conditions characterized by maladaptive myeloid-driven inflammation.

Blood published new progress about Cell differentiation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts