Tag: M.W=100-150

Neinast, Michael D. published the artcileQuantitative Analysis of the Whole-Body Metabolic Fate of Branched-Chain Amino Acids, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is cardiac skeletal muscle branched chain amino acid oxidation insulin; branched chain amino acids; insulin resistance; obesity; stable isotope tracing.

Elevations in branched-chain amino acids (BCAAs) associate with numerous systemic diseases, including cancer, diabetes, and heart failure. However, an integrated understanding of whole-body BCAA metabolism remains lacking. Here, we employ in vivo isotopic tracing to systemically quantify BCAA oxidation in healthy and insulin-resistant mice. We find that most tissues rapidly oxidize BCAAs into the tricarboxylic acid (TCA) cycle, with the greatest quantity occurring in muscle, brown fat, liver, kidneys, and heart. Notably, pancreas supplies 20% of its TCA carbons from BCAAs. Genetic and pharmacol. suppression of branched-chain alpha-ketoacid dehydrogenase kinase, a clin. targeted regulatory kinase, induces BCAA oxidation primarily in skeletal muscle of healthy mice. While insulin acutely increases BCAA oxidation in cardiac and skeletal muscle, chronically insulin-resistant mice show blunted BCAA oxidation in adipose tissues and liver, shifting BCAA oxidation toward muscle. Together, this work provides a quant. framework for understanding systemic BCAA oxidation in health and insulin resistance.

Cell Metabolism published new progress about Blood plasma. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wakasugi, Takayuki published the artcileRole of smooth muscle cell p53 in pulmonary arterial hypertension, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is smooth muscle cell pulmonary arterial hypertension p53.

Pulmonary arterial hypertension (PAH) is characterized by remodeling and narrowing of the pulmonary arteries, which lead to elevation of right ventricular pressure, heart failure, and death. Proliferation of pulmonary artery smooth muscle cells (PASMCs) is thought to be central to the pathogenesis of PAH, although the underlying mechanisms are still being explored. The protein p53 is involved in cell cycle coordination, DNA repair, apoptosis, and cellular senescence, but its role in pulmonary hypertension (PH) is not fully known. We developed a mouse model of hypoxia-induced pulmonary hypertension (PH) and found significant reduction of p53 expression in the lungs. Our in vitro experiments with metabolomic analyses and the Seahorse XF extracellular flux analyzer indicated that suppression of p53 expression in PASMCs led to upregulation of glycolysis and downregulation of mitochondrial respiration, suggesting a proliferative phenotype resembling that of cancer cells. It was previously shown that systemic genetic depletion of p53 in a murine PH model led to more severe lung manifestations. Lack of information about the role of cell-specific p53 signaling promoted us to investigate it in our mouse PH model with the inducible Cre-loxP system. We generated a mouse model with SMC-specific gain or loss of p53 function by crossing Myh11-Cre/ERT2 mice with floxed Mdm4 mice or floxed Trp53 mice. After these animals were exposed to hypoxia for 4 wk, we conducted hemodynamic and echocardiog. studies. Surprisingly, the severity of PH was similar in both groups of mice and there were no differences between the genotypes. Our findings in these mice indicate that activation or suppression of p53 signaling in SMCs has a minor role in the pathogenesis of PH and suggest that p53 signaling in other cells (endothelial cells, immune cells, or fibroblasts) may be involved in the progression of this condition.

PLoS One published new progress about Cardiovascular system. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cavicchioli, Valeria Quintana published the artcilePhysiological and molecular insights of bacteriocin production by Enterococcus hirae ST57ACC from Brazilian artisanal cheese, SDS of cas: 97-67-6, the main research area is Enterococcus hirae physiol bacteriocin production Brazilian artisanal cheese; ABC transporter; Enterococcus hirae; bacteriocin; cytotoxicity.

The bacteriocinogenic Enterococcus hirae ST57ACC recently isolated from a Brazilian artisanal cheese was subjected here to addnl. analyses in order to evaluate its bacteriocin production and the potential influence of ABC transporter system in its expression. Besides these physiol. and mol. aspects, the bacteriocin was evaluated for its cytotoxicity against HT-29. Differences in the inoculum size had no impact on the growth of E. hirae ST57ACC; however, the bacteriocin was only produced after 9 h of growth when the strain was inoculated at 5% or 10% (volume/volume), with similar levels of bacteriocin production obtained by both conventional growth and batch fermentation Furthermore, potential expression of ABC transporters corresponding to the bacteriocin transport and sugar metabolism was identified. In terms of adverse effects, when a semi-purified fraction of the bacteriocin and the cell-free supernatant were tested against HT-29, total cell viability was similar to observed on untreated cells, indicating the absence of cytotoxic effect. Based on the obtained results, E. hirae ST57ACC can produce its bacteriocin at industrial level by using bioreactors, its bacteriocin expression is potentially influenced by the ABC transporter system, and no cytotoxic effects were observed on HT-29 cells, indicating its potential use as a bio-preservative.

Brazilian Journal of Microbiology published new progress about Bacteriocins Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Charton, Lennart published the artcilePlant peroxisomal solute transporter proteins, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is review peroxisomal membrane ABC transporter.

Plant peroxisomes are unique subcellular organelles which play an indispensable role in several key metabolic pathways, including fatty acid β-oxidation, photorespiration, and degradation of reactive oxygen species. The compartmentalization of metabolic pathways into peroxisomes is a strategy for organizing the metabolic network and improving pathway efficiency. An important prerequisite, however, is the exchange of metabolites between peroxisomes and other cell compartments. Since the first studies in the 1970s scientists contributed to understanding how solutes enter or leave this organelle. This review gives an overview about our current knowledge of the solute permeability of peroxisomal membranes described in plants, yeast, mammals and other eukaryotes. In general, peroxisomes contain in their bilayer membrane specific transporters for hydrophobic fatty acids (ABC transporter) and large cofactor mols. (carrier for ATP, NAD and CoA). Smaller solutes with mol. masses below 300-400 Da, like the organic acids malate, oxaloacetate, and 2-oxoglutarate, are shuttled via non-selective channels across the peroxisomal membrane. In comparison to yeast, human, mammals and other eukaryotes, the function of these known peroxisomal transporters and channels in plants are discussed in this review.

Journal of Integrative Plant Biology published new progress about Homo sapiens. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schiffner, Julia A. published the artcileEnantioselective Fujiwara-Moritani Indole and Pyrrole Annulations Catalyzed by Chiral Palladium(II)-NicOx Complexes, SDS of cas: 50966-69-3, the main research area is pyridinecarboxylate oxazolinyl preparation chiral ligand Fujiwara Moritani annulation; indole pyrrole alkenyl preparation asym intramol Fujiwara Moritani cyclization.

The catalytic asym. Fujiwara-Moritani ring closures of several indole- and pyrrole-based cyclization precursors, e.g. I (R1 = H, R12 = benzo; X = CH2, CH2CH2; R2 = Me, Ph), are reported. These unprecedented oxidative palladium(II)-catalyzed annulations allow for the formation of a stereogenic quaternary carbon atom, and decent levels of enantiocontrol are seen in 5-exo-trig cyclizations (54% ee for an indole and 76% ee for a pyrrole) while 6-exo-trig ring closures afford essentially racemic material. Novel oxazoline ligands with a nicotine platform (NicOx) are pivotal for good catalytic turnover as conventional PyOx ligands failed to produce acceptable chem. yields. The preparation of these NicOx ligands II (R3 = i-Pr, t-Bu, PhCH2; R4 = Me, Et, F3CCH2) as well as the syntheses of the cyclization precursors, e.g. I, are described in detail.

European Journal of Organic Chemistry published new progress about Cyclization catalysts, stereoselective. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, SDS of cas: 50966-69-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bolle, Jennifer published the artcileIsomeric effects in structure formation and dielectric dynamics of different octanols, Related Products of alcohols-buliding-blocks, the main research area is octanol cluster aggregate hydrogen bond supramol structure.

The understanding of the microstructure of associated liquids promoted by hydrogen-bonding and constrained by steric hindrance is highly relevant in chem., physics, biol. and for many aspects of daily life. In this study we use a combination of X-ray diffraction, dielec. spectroscopy and mol. dynamics simulations to reveal temperature induced changes in the microstructure of different octanol isomers, i.e., linear 1-octanol and branched 2-, 3- and 4-octanol. In all octanols, the hydroxyl groups form the basis of chain-, cyclic- or loop-like bonded structures that are separated by outwardly directed alkyl chains. This clustering is analyzed through the scattering pre-peaks observed from X-ray scattering and simulations. The charge ordering which pilots OH aggregation can be linked to the strength of the Debye process observed in dielec. spectroscopy. Interestingly, all methods used here converge to the same interpretation: as one moves from 1-octanol to the branched octanols, the cluster structure evolves from loose large aggregates to a larger number of smaller, tighter aggregates. All alcs. exhibit a peculiar temperature dependence of both the pre-peak and Debye process, which can be understood as a change in microstructure promoted by chain association with increased chain length possibly assisted by ring-opening effects. All these results tend to support the intuitive picture of the entropic constraint provided by branching through the alkyl tails and highlight its capital entropic role in supramol. assembly.

Physical Chemistry Chemical Physics published new progress about Clusters. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khedri, Zohrab published the artcileThermodynamic Properties of 1-Hexyl-3-methylimidazolium Nitrate and 1-Alkanols Mixtures: PC-SAFT Model, Category: alcohols-buliding-blocks, the main research area is thermodn property PCSAFT hexylmethylimidazolium nitrate binary mixture alkanol.

To study the type, nature, and amount of interactions in binary systems including 1-hexyl-3-methylimidazolium nitrate ([Hmim][NO3]) ionic liquid and a homologous series of 1-alkanols (1-hexanol up to 1-decanol), some thermophys. properties via d. and viscosity measurements were calculated at temperatures of 293.15-323.15 K. Also, to study the behavior of systems with temperature, values of the thermal expansion coefficient, α, excess thermal expansion coefficient, αE, isothermal coefficient of excess molar enthalpy, (∂HEm/∂P)T,x, and partial molar volume, V̅i, for five binary mixtures at various temperatures were calculated Findings demonstrate that strong interactions between the mixture components occur and intermol. forces become weaker with the increase in the length of the alc. chain and temperature For a theor. study of mentioned mixtures, perturbed-chain statistical associating fluid theory was implemented. The d. and partial molar volume of mixtures were correlated and predicted by this theory, and the results show that outcomes are fairly consistent with the exptl. data.

Journal of Chemical & Engineering Data published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Almasi, Mohammad published the artcileKirkwood-Buff Integrals, Excess Volume, and Preferential Solvation in Pentanoic Acid/(C5-C10) 1-Alkanol Binary Mixtures, Product Details of C8H18O, the main research area is Kirkwood Buff integral excess volume solvation pentanoic acid alkanol.

In order to study the nature, type, and magnitude of interactions in the binary mixtures of pentanoic acid and a series of 1-alkanols from 1-pentanol up to 1-decanol, Kirkwood integrals along with the exptl. methods have been used and reported at T = 298.15 K. Neg. values of VEm, Gii, Gij, Δnii, Δnij, and δii and pos. values of Gij, Δnij, and δij indicate the fact that in the mixtures the tendency of the unlike mol. components to form the new interactions and stay together is much higher than the pure state. Investigating the changes in the calculated quantities for different mixtures shows that with the increase in the length of the alc. chain the tendency of the heterogeneous mols. to interact with each other decreases. Variations in the VEm values are in the same direction as the Kirkwood integrals, and mentioned data for binary systems are reported for the first time.

Journal of Chemical & Engineering Data published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Almasi, Mohammad published the artcileThermodynamic study of interactions between 1-alkanol and butanone, Formula: C8H18O, the main research area is thermodn Kirkwood Buff model alkanol butanone mixture solvation structure.

To obtain the new perspectives on the mol. interactions in the binary systems of butanone and a homologous series of 1-alkanol from 1-pentanol up to 1-decanol, these mixtures were studied using the Kirkwood-Buff (KB) formalism and preferential solvation anal. The results were confirmed using the exptl. excess molar volumes. KB integrals Gij, the excess or deficit number Δnij, and solvation coefficients δij are reported here. Anal. of obtained data regarding the KB formalism and preferential solvation reveals that interactions strength in mixtures depends on the butanone concentration and size of 1-alkanol. Also, interactions between similar mols. are remarkable and become stronger as the length of the alc. increases. Furthermore, mixtures structure was studied using the concentration-concentration structure factor, SCC(0). Results from application of this parameter show that the homo-coordination occurs in solutions Steric effects lead to the stronger orientations in the mentioned mixtures

Chemical Physics published new progress about Density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Rewcastle, Gordon W. published the artcileUnequivocal synthesis of substituted thiazolo[3,2-a]benzimidazoles, Related Products of alcohols-buliding-blocks, the main research area is thiazolobenzimidazole preparation.

An unequivocal route to individual substituted thiazolo[3,2-a]benzimidazole isomers I (R1 = H, Me; R2 = H, Me; R3 = H, OMe; R4 = CF3, OMe, NH2, etc.; R5 = H, OMe) has been developed, involving the acid-catalyzed intramol. condensation of dialkylacetals with the sulfur atom of benzimidazole-2-thiones II. Products I are isolated without isomerization, in contrast to several literature methods.

ARKIVOC (Gainesville, FL, United States) published new progress about Aromatic diamines Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts