Tag: M.W=100-150

Jukic, Ivo published the artcileUniversal features in the lifetime distribution of clusters in hydrogen-bonding liquids, Related Products of alcohols-buliding-blocks, the main research area is universal lifetime distribution hierarchy cluster liquid hydrogen bond.

Hydrogen-bonding liquids, typically water and alcs., are known to form labile structures (network, chains, etc.); hence, the lifetime of these structures is an important microscopic parameter, which can be calculated via computer simulations. Since these cluster entities are mostly statistical in nature, one would expect that, in the short-timescale regime, their lifetime distribution would be a broad Gaussian-like function of time, with a single maximum representing their mean lifetime, and be weakly dependent on criteria such as the bonding distance and angle, much similar to non-hydrogen-bonding simple liquids, while the long-timescale regime is known to have some power law dependence. Unexpectedly, all the hydrogen-bonding liquids studied herein, namely water and alcs., display three highly hierarchical specific lifetimes, in the sub-picosecond range 0-0.5 ps. The dominant lifetime depends very strongly on the bonding-distance criterion and is related to hydrogen-bonded pairs. This mode is absent in non-H-bonding simple liquids The secondary and tertiary mean lifetimes are related to clusters and are nearly independent of the bonding criterion. Of these two lifetimes, only the first one can be related to that of simple liquids, which poses the question of the nature of the third lifetime. The study of alcs. reveals that this third lifetime is related to the topol. of the H-bonded clusters and that its distribution may also be affected by the alkyl tail surrounding the “”bath””. This study shows that hydrogen-bonding liquids have a universal hierarchy of hydrogen-bonding lifetimes with a timescale regularity across very different types, and which depend on the topol. of the cluster structures.

Physical Chemistry Chemical Physics published new progress about Aliphatic alcohols, C1-8 Role: PEP (Physical, Engineering or Chemical Process), PRP (Properties), PROC (Process). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Hwa-Jin published the artcileMechanism for Transition of Reverse Cylindrical Micelles to Spherical Micelles Induced by Diverse Alcohols, HPLC of Formula: 111-87-5, the main research area is reverse micelle lecithin calcium chloride propanol pentanol hexanol octanol.

Herein, the effects of various alcs. on lecithin/CaCl2 organogels are investigated. Mixtures of lecithin and CaCl2 form reverse cylindrical micelles, resulting in optically transparent organogels. The addition of various alcs. to a mixture of lecithin and CaCl2 induces a decrease in viscosity through which reverse cylindrical micelles are transformed into spherical micelles (or short cylindrical micelles). Long-hydrocarbon-chain alcs. decrease the viscosity of lecithin/CaCl2 mixtures more efficiently. Hydrogen bonding and hydrocarbon chain interactions between lecithin and alc. play important roles in the morphol. transition. More importantly, isothermal titration calorimetry was conducted to obtain thermodn. variables such as the enthalpy, equilibrium constant, Gibbs free energy, entropy, and stoichiometry of the associated mols. observed in the transition. It was found that the transition is an entropically driven process, in which the endothermic and exothermic behaviors were observed depending on the hydrocarbon chain length in the alc. In addition, the enthalpy for the association of the alc. with lecithin showed a linear relationship depending on the hydrocarbon chain length, in which the magnitude of hydrogen bonding and hydrocarbon chain interactions was obtained quant. To the best of our knowledge, this is the first study reporting the thermodn. properties of the morphol. transition observed in a reverse self-assembly process.

Langmuir published new progress about Enthalpy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miklas, Jason W. published the artcileAmino acid primed mTOR activity is essential for heart regeneration, Product Details of C4H6O5, the main research area is heart disease regeneration mTOR amino acid; Biological sciences; Cell biology; Tissue Engineering.

Heart disease is the leading cause of death with no method to repair damaged myocardium due to the limited proliferative capacity of adult cardiomyocytes. Curiously, mouse neonates and zebrafish can regenerate their hearts via cardiomyocyte de-differentiation and proliferation. However, a mol. mechanism of why these cardiomyocytes can re-enter cell cycle is poorly understood. Here, we identify a unique metabolic state that primes adult zebrafish and neonatal mouse ventricular cardiomyocytes to proliferate. Zebrafish and neonatal mouse hearts display elevated glutamine levels, predisposing them to amino-acid-driven activation of TOR, and that TOR activation is required for zebrafish cardiomyocyte regeneration in vivo. Through a multi-omics approach with cellular validation we identify metabolic and mitochondrial changes during the first week of regeneration. These data suggest that regeneration of zebrafish myocardium is driven by metabolic remodeling and reveals a unique metabolic regulator, TOR-primed state, in which zebrafish and mammalian cardiomyocytes are regeneration competent.

iScience published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pichaud, Nicolas published the artcileAdjustments of cardiac mitochondrial phenotype in a warmer thermal habitat is associated with oxidative stress in European perch, Perca fluviatilis, Quality Control of 97-67-6, the main research area is pyruvate malate mitochondria climate change oxidative stress Perca.

Mitochondria are playing key roles in setting the thermal limits of fish, but how these organelles participate in selection mechanisms during extreme thermal events associated with climate warming in natural populations is unclear. Here, we investigated the thermal effects on mitochondrial metabolism, oxidative stress, and mitochondrial gene expression in cardiac tissues of European perch (Perca fluviatilis) collected from an artificially heated ecosystem, the “”Biotest enclosure””, and an adjacent reference area in the Baltic sea with normal temperatures (∼ 23°C and ∼ 16°C, resp., at the time of capture in summer). Fish were sampled one month after a heat wave that caused the Biotest temperatures to peak at ∼ 31.5°C, causing significant mortality. When assayed at 23°C, Biotest perch maintained high mitochondrial capacities, while reference perch displayed depressed mitochondrial functions relative to measurements at 16°C. Moreover, mitochondrial gene expression of nd4 (mitochondrial subunit of complex I) was higher in Biotest fish, likely explaining the increased respiration rates observed in this population. Nonetheless, cardiac tissue from Biotest perch displayed higher levels of oxidative damage, which may have resulted from their chronically warm habitat, as well as the extreme temperatures encountered during the preceding summer heat wave. We conclude that eurythermal fish such as perch are able to adjust and maintain mitochondrial capacities of highly aerobic organs such as the heart when exposed to a warming environment as predicted with climate change. However, this might come at the expense of exacerbated oxidative stress, potentially threatening performance in nature.

Scientific Reports published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (cytb). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gao, Xindi published the artcileCryptococcal Hsf3 controls intramitochondrial ROS homeostasis by regulating the respiratory process, HPLC of Formula: 97-67-6, the main research area is Hsf3 ROS unfolded protein response electron transfer Cryptococcus.

Mitochondrial quality control prevents accumulation of intramitochondrial-derived reactive oxygen species (mtROS), thereby protecting cells against DNA damage, genome instability, and programmed cell death. However, underlying mechanisms are incompletely understood, particularly in fungal species. Here, we show that Cryptococcus neoformans heat shock factor 3 (CnHsf3) exhibits an atypical function in regulating mtROS independent of the unfolded protein response. CnHsf3 acts in nuclei and mitochondria, and nuclear- and mitochondrial-targeting signals are required for its organelle-specific functions. It represses the expression of genes involved in the tricarboxylic acid cycle while promoting expression of genes involved in electron transfer chain. In addition, CnHsf3 responds to multiple intramitochondrial stresses; this response is mediated by oxidation of the cysteine residue on its DNA binding domain, which enhances DNA binding. Our results reveal a function of HSF proteins in regulating mtROS homeostasis that is independent of the unfolded protein response.

Nature Communications published new progress about Animal gene, SOD1 Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Evans, Heather M. published the artcileRestraint of fumarate accrual by HIF-1α preserves miR-27a-mediated limitation of interleukin 10 during infection of macrophages by Histoplasma capsulatum, Product Details of C4H6O5, the main research area is HIF1alpha mir27a IL10 macrophages Histoplasma; Histoplasma; hypoxia inducible factor 1; innate immunity; lung; mitochondrial metabolism.

Hypoxia-inducible factor 1α (HIF-1α) regulates the immunometabolic phenotype of macrophages, including the orchestration of inflammatory and antimicrobial processes. Macrophages deficient in HIF-1α produce excessive quantities of the anti-inflammatory cytokine interleukin 10 (IL-10) during infection with the intracellular fungal pathogen Histoplasma capsulatum. Thus, the macrophage fails to become activated in response to proinflammatory cytokines and remains the intracellular niche of the pathogen. Here, we identify the tricarboxylic acid (TCA) cycle metabolite fumarate as the driver of IL-10 during macrophage infection with H. capsulatum in the absence of HIF-1α. Accumulation of fumarate reduced expression of a HIF-1α-dependent microRNA (miRNA), miR-27a, known to mediate decay of Il10 mRNA. Inhibition of fumarate accrual in vivo limited IL-10 and fungal growth. Our data demonstrate the critical role of HIF-1α in shaping appropriate TCA cycle activity in response to infection and highlight the consequences of a dysregulated immunometabolic response.

mBio published new progress about Glucose transporter 1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zengin, Hilal published the artcileSynthesis and characterization of novel 2-{[2-(dimethylamino)ethyl](methyl)amino}ethoxy-substituted metallophthalocyanines, Quality Control of 2212-32-0, the main research area is metallophthalocyanine transition metal aminoethylaminoethoxy substituted preparation quaternized derivative.

The synthesis of novel, sym., tetra-substituted metallophthalocyanines (Co, Zn, and Cu) bearing four 2-{[2-(dimethylamino)ethyl](methyl)amino}ethoxy units is reported. The dinitrile derivative was converted into the water-soluble quaternized product by its reaction with MeI. The quaternized Zn phthalocyanine was obtained from the reaction of the water-soluble dinitrile derivative with zinc acetate. The structures of the newly synthesized mols. are proposed according to elemental anal., 1H NMR, FTIR, and UV-visible spectral data.

Turkish Journal of Chemistry published new progress about Microwave irradiation. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Quality Control of 2212-32-0.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Yao published the artcileEffects of spontaneous fermentation on the microorganisms diversity and volatile compounds during ‘Marselan’ from grape to wine, Product Details of C4H10OS, the main research area is spontaneous fermentation volatile compound marselan grape wine.

‘Marselan is a promising wine grapevine with unique qualities, studies on its introduction and characteristics have never stopped. However, little is known about the fermentation process of ‘Marselan wine. In this study, we compared industrial-scale spontaneous (SMF) and inoculated (IMF) fermentation processes on the succession of microbial community and the change in volatile compounds and predicted their correlations. SMF could ferment ‘Marselan to dry red wine with alc. content of 13.37% ± 0.76% (volume/volume) in 10 days and enhance the total concentration and odor activity values (OAVs) of volatile compounds Et caprylate, Et caprate, Et caproate and citronellol (OAVs > 1.0) were important volatile compounds in SMF and IMF wines. Compared with IMF, SMF was more outstanding in initial non-Saccharomyces diversity, including Hanseniaspora, Metschnikowia and Issatchenkia. In addition, Spearmans correlation (|ρ| > 0.7) and bidirectional orthogonal partial least squares (O2PLS, VIP > 1.0) anal. showed that some indigenous microorganisms in grape were closely related to the formation of volatile compounds, such as lactic acid bacteria, non-Saccharomyces and Saccharomyces cerevisiae. Overall, results showed that SMF could strengthen the flavor of ‘Marselan’ wine, and the possibility of consideration screening indigenous aroma-producing microorganisms as starter to improve the unique characteristics of ‘Marselan wine.

LWT–Food Science and Technology published new progress about Alcohols Role: PAC (Pharmacological Activity), THU (Therapeutic Use), BIOL (Biological Study), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Product Details of C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kikuchi-Taura, Akie published the artcileGap junction-mediated cell-cell interaction between transplanted mesenchymal stem cells and vascular endothelium in stroke, HPLC of Formula: 111-87-5, the main research area is cell gap junction communication stemcell transplantation vascular endothelium stroke; COVID-19; cell therapy; gap junction; immunosuppression; mesenchymal stem cell.

We have shown previously that transplanted bone marrow mononuclear cells (BM-MNC), which are a cell fraction rich in hematopoietic stem cells, can activate cerebral endothelial cells via gap junction-mediated cell-cell interaction. In the present study, we investigated such cell-cell interaction between mesenchymal stem cells (MSC) and cerebral endothelial cells. In contrast to BM-MNC, for MSC we observed suppression of vascular endothelial growth factor uptake into endothelial cells and transfer of glucose from endothelial cells to MSC in vitro. The transfer of such a small mol. from MSC to vascular endothelium was subsequently confirmed in vivo and was followed by suppressed activation of macrophage/microglia in stroke mice. The suppressive effect was absent by blockade of gap junction at MSC. Furthermore, gap junction-mediated cell-cell interaction was observed between circulating white blood cells and MSC. Our findings indicate that gap junction-mediated cell-cell interaction is one of the major pathways for MSC-mediated suppression of inflammation in the brain following stroke and provides a novel strategy to maintain the blood-brain barrier in injured brain. Furthermore, our current results have the potential to provide a novel insight for other ongoing clin. trials that make use of MSC transplantation aiming to suppress excess inflammation, as well as other diseases such as COVID-19 (coronavirus disease 2019).

Stem Cells (Durham, NC, United States) published new progress about Adhesion G protein-coupled receptor E1 Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, HPLC of Formula: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Puzakova, L. V. published the artcileTissue Specificity of the AqE Gene Activity in the Yellow Croaker Larimichthys crocea, HPLC of Formula: 97-67-6, the main research area is sulfolactate dehydrogenase AqE Larimichthys transcriptional activity.

Abstract: The study of the diversity of metabolic pathways is an important aspect for understanding the evolutionary relationships between metabolic pathways and their biochem. precursors. Recently, researchers described a sulfolactate dehydrogenase-like protein encoded in eukaryotes by the AqE gene, which remains highly conserved in teleosts. However, the metabolic role of this enzyme is still unknown. In the present work, we studied the transcriptional activity of the AqE gene, as well as other genes associated with energy exchange in the large yellow croaker Larimichthys crocea. The quant. anal. of expression showed the tissue specificity of the AqE gene activity in the yellow croaker. The gene is active in the liver, skin, and gills. The anal. of gene expression in various organs and under the influence of stressful conditions suggests that the enzyme encoded by the AqE gene is involved in the malate-aspartate shuttle or in the excretion of the final metabolites (sulfolactate) from the organism.

Russian Journal of Genetics published new progress about Gill. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts