Tag: M.W=100-150

Huang, Sai published the artcileSystematic synthesis of REVO4 micro/nano crystals with selective exposure of high energy {001} facets and luminescence (RE = Lanthanide and Y0.95Eu0.05), Related Products of alcohols-buliding-blocks, the main research area is lanthanide micro crystals luminescence.

Systematic synthesis of REVO4 nano/microcrystals (RE = La-Lu lanthanides) was performed via hydrothermal reaction under 200°C and pH = 12 for 30 h, and the effects of malate (Mal2-) chelate and lanthanide contraction on phase structure and crystal morphol. were revealed. With RE = Y0.95Eu0.05 as representative, the influence of solution pH, reaction temperature/duration and VO3-4 concentration was also systematically investigated. Mal2- was demonstrated to promote crystallization of phase-pure REVO4 through suppressing RE3+ hydrolysis to form hydroxyl nitrate impurity. The t-REVO4 crystals were identified to be single-crystalline quasi-squares significantly exposed with high energy {001} facets (∼80% coverage for t-LuVO4) owing to the capping effect of Mal2-, and the lateral size of the crystals gradually increased from ∼20 to 850 nm with decreasing RE3+ size from Ce3+ to Lu3+. Aside from structure details and IR response of the full series of REVO4, photoluminescence features were analyzed for RE = Y0.95Eu0.05, Eu, Dy, Er and Tm, and the 600°C calcined (Y0.95Eu0.05).

Journal of Materials Research and Technology published new progress about Hydrolysis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Liu, Kai published the artcileUncovering abnormal changes in logP after fluorination using molecular dynamics simulations, Recommanded Product: n-Octanol, the main research area is mol dynamics simulations; Fluorination; Molecular dynamics; Solvation free energy calculation; logP.

The fluorination-induced changes in the logP (1-octanol/water partition coefficient) of ligands were examined by mol. dynamics simulations. The protocol and force field parameters were first evaluated by calculating the logP values for n-alkanes, and their monofluorinated and monochlorinated analogs. Then, the logP values of several test sets (1-butanol, 3-propyl-1H-indole, and analogs fluorinated at the terminal Me group) were calculated The calculated results agree well with experiment, and the root mean square error values are 0.61 and 0.68 log units for the GAFF and GAFF2 force fields, resp. Finally, the logP estimation was extended to a drug mol., TAK-438, for which fluorination-induced abnormal logP reduction has been observed exptl. This abnormal change was qual. reproduced by the mol. dynamics simulations. We found that the abnormal logP reduction can be mainly attributed to the effect of fluorination-induced dipole change. Our results suggest that mol. simulation is a useful strategy to predict the fluorination-induced change in logP for drug discovery applications.

Journal of Computer-Aided Molecular Design published new progress about Dipole. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cao, Jingsong published the artcilemRNA Therapy Improves Metabolic and Behavioral Abnormalities in a Murine Model of Citrin Deficiency, COA of Formula: C4H6O5, the main research area is metabolic behavioral abnormality citrin deficiency mRNA lipid nanoparticle.

Citrin deficiency is an autosomal recessive disorder caused by loss-of-function mutations in SLC25A13, encoding the liver-specific mitochondrial aspartate/glutamate transporter. It has a broad spectrum of clin. phenotypes, including life-threatening neurol. complications. Conventional protein replacement therapy is not an option for these patients because of drug delivery hurdles, and current gene therapy approaches (e.g., AAV) have been hampered by immunogenicity and genotoxicity. Although dietary approaches have shown some benefits in managing citrin deficiency, the only curative treatment option for these patients is liver transplantation, which is high-risk and associated with long-term complications because of chronic immunosuppression. To develop a new class of therapy for citrin deficiency, codon-optimized mRNA encoding human citrin (hCitrin) was encapsulated in lipid nanoparticles (LNPs). We demonstrate the efficacy of hCitrin-mRNA-LNP therapy in cultured human cells and in a murine model of citrin deficiency that resembles the human condition. Of note, i.v. (i.v.) administration of the hCitrin-mRNA resulted in a significant reduction in (1) hepatic citrulline and blood ammonia levels following oral sucrose challenge and (2) sucrose aversion, hallmarks of hCitrin deficiency. In conclusion, mRNA-LNP therapy could have a significant therapeutic effect on the treatment of citrin deficiency and other mitochondrial enzymopathies with limited treatment options.

Molecular Therapy published new progress about Body weight. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhou, Cuiyan published the artcileMalate-aspartate shuttle plays an important role in LPS-induced neuroinflammation of mice due to its effect on STAT3 phosphorylation, Application of (S)-2-hydroxysuccinic acid, the main research area is malate aspartate shuttle STAT3 phosphorylation neuroinflammation; aminooxyacetic acid; malate-aspartate shuttle; neuroinflammation; pyruvate; stat3.

Neuroinflammation is a key pathol. factor in numerous neurol. disorders. Cumulating evidence has indicated critical roles of NAD+/NADH metabolism in multiple major diseases, while the role of malate-aspartate shuttle (MAS) – a major NADH shuttle – in inflammation has remained unclear. In this study we investigated the roles of MAS in LPS-induced neuroinflammation both in vivo and in vitro. Immunofluorescence staining, Western blot assay and Real-time PCR assays were conducted to determine the activation of Iba-1, the protein levels of iNOS and COX2 and the mRNA levels of IL-1β, IL-6, and TNF-α in vivo, showing that both pre-treatment and post-treatment of aminooxyacetic acid (AOAA) – an MAS inhibitor – profoundly decreased the LPS-induced neuroinflammation in mice. BV2 microglia was also used as a cellular model to investigate the mechanisms of this finding, in which such assays as Western blot assay and nitrite assay. Our study further indicated that AOAA produced its effects on LPS-induced microglial activation by its effects on MAS: Pyruvate treatment reversed the effects of AOAA on the cytosolic NAD+/NADH ratio, which also restored the LPS-induced activation of the AOAA-treated microglia. Moreover, the lactate dehydrogenase (LDH) inhibitor GSK2837808A blocked the effects of pyruvate on the AOAA-produced decreases in both the cytosolic NAD+/NADH ratio and LPS-induced microglial activation. Our study has further suggested that AOAA produced inhibition of LPS-induced microglial activation at least partially by decreasing STAT3 phosphorylation. Collectively, our findings have indicated AOAA as a new and effective drug for inhibiting LPS-induced neuroinflammation. Our study has also indicated that MAS is a novel mediator of LPS-induced neuroinflammation due to its capacity to modulate LPS-induced STAT3 phosphorylation, which has further highlighted a critical role of NAD+/ NADH metabolism in inflammation.

Frontiers in Molecular Biosciences published new progress about Brain dentate gyrus. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

John, Gerald F. published the artcileEnhanced effectiveness of oil dispersants in destabilizing water-in-oil emulsions, SDS of cas: 111-87-5, the main research area is water oil emulsion stability dispersant.

Oil impacting the northern Gulf of Mexico shoreline from the 2010 Deepwater Horizon accident was predominantly in the form of water-in-oil emulsions (WOE), a chem. weathered, highly viscous, neutrally buoyant material. Once formed, WOE are extremely difficult to destabilize. Com.-available oil dispersants are largely ineffective de-emulsifiers as a result of the inability of dispersant surfactants to displace asphaltenes stabilizing the oil-water interface. This study investigated the effectiveness of the com.-available dispersant Corexit 9500A, modified to enhance its polar fraction, in destabilizing WOE. Results suggest that Corexit modified to include between 20-60% fractional amount of either polar additive (1-octanol or hexylamine) will produce a modest increase in WOE instability, with a Corexit to hexylamine ratio of approx. 80/20 providing the most effective enhanced destabilization. Results support the hypothesis that modifying the fraction of polar constituents in com. dispersants will increase asphaltene solubility, decrease oil-water interface stability, and enhance WOE instability.

PLoS One published new progress about Coalescence. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kononenko, Veno published the artcileGrouping of poorly soluble low (cyto)toxic particles: example with 15 selected nanoparticles and A549 human lung cells, Safety of (S)-2-hydroxysuccinic acid, the main research area is lung cell soluble cytotoxic nanoparticle; alveolar type II cells; biopersistent particles; endo-lysosomal organelles; fast screening tools; poorly soluble low toxicity particles (PSLTs).

Poorly soluble, low (cyto)toxic particles (PSLTs) are often regarded as one group, but it is important that these particles can be further differentiated based on their bioactivity. Currently, there are no biol. endpoint based groupings for inhaled nanoparticles (NPs) that would allow us to subgroup PSLTs based on their mode of action. The aim of this study was to group NPs based on their cytotoxicity and by using the in vitro response of the endo-lysosomal system as a biol. endpoint. The endo-lysosomal system is a main cellular loading site for NPs. An impaired endo-lysosomal system in alveolar type II cells may have serious adverse effects on the maintenance of pulmonary surfactant homeostasis. The 15 different NPs were tested with human lung adenocarcinoma (A549) cells. The highly soluble NPs were most cytotoxic. With respect to PSLTs, only three NPs increased the cellular load of acid and phospholipid rich organelles indicating particle biopersistence. All the rest PSLTs could be regarded as low hazardous. The presented in vitro test system could serve as a fast screening tool to group particles according to their ability to interfere with lung surfactant metabolism We discuss the applicability of the suggested test system for bringing together substances with similar modes-of-action on lung epithelium. In addition, we discuss this approach as a benchmark test for the comparative assessment of biopersistence of PSLTs.

Nanomaterials published new progress about Carboxyl group. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Colombo Dugoni, Greta published the artcileDeep eutectic solvents: promising co-solvents to improve the extraction kinetics of CyMe4-BTBP, Application of 2,2′-Oxydiacetic acid, the main research area is deep eutectic solvent cosolvent extraction SANEX fuel reprocessing actinide.

In this communication, the authors report on the use of deep eutectic solvents (DESs) for processing nuclear waste, with a view to selectively recovering minor actinides (MA) from highly active raffinate solutions DESs are an interesting new class of green and eco-sustainable solvents. Here, a representative family of DES was tested as a co-solvent for MA/lanthanides partitioning based on Selective ActiNide Extraction (SANEX)-like hydrometallurgical processes. The reference system exploits the CyMe4-BTBP lipophilic extractant for selective MA recovery, but the slow kinetics is the main limitation toward the industrial implementation. A selection of hydrophilic DESs has been proposed as a phase transfer catalyst and tested to improve the process performances. In this work, the radiochem. stability and the extraction behavior of these DESs have been ascertained. Moreover, a preliminary optimization of system composition has been achieved. This study underlines a catalytic effect of DES that can be proficiently exploited to enhance CyMe4-BTBP extraction and selectivity.

ACS Omega published new progress about Chemical stability (radiochem.). 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Application of 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Aravamudhan, Sriram published the artcilePhosphoproteomics of the developing heart identifies PERM1 – An outer mitochondrial membrane protein, Quality Control of 97-67-6, the main research area is heart phosphoproteomics mitochondrial membrane protein; Heart development; Lipid metabolism; Mitochondria; PERM1; Phosphoproteomics; SILAC.

Heart development relies on PTMs that control cardiomyocyte proliferation, differentiation and cardiac morphogenesis. We generated a map of phosphorylation sites during the early stages of cardiac postnatal development in mice; we quantified over 10,000 phosphorylation sites and 5000 proteins that were assigned to different pathways. Anal. of mitochondrial proteins led to the identification of PGC-1- and ERR-induced regulator in muscle 1 (PERM1), which is specifically expressed in skeletal muscle and heart tissue and associates with the outer mitochondrial membrane. We demonstrate PERM1 is subject to rapid changes mediated by the UPS through phosphorylation of its PEST motif by casein kinase 2. Ablation of Perm1 in mice results in reduced protein expression of lipin-1 accompanied by accumulation of specific phospholipid species. Isolation of Perm1-deficient mitochondria revealed significant downregulation of mitochondrial transport proteins for amino acids and carnitines, including SLC25A12/13/29/34 and CPT2. Consistently, we observed altered levels of various lipid species, amino acids, and acylcarnitines in Perm1-/- mitochondria. We conclude that the outer mitochondrial membrane protein PERM1 regulates homeostasis of lipid and amino acid metabolites in mitochondria.

Journal of Molecular and Cellular Cardiology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Nakamura, Shinji published the artcileDiscovery of phenylpyrrolidine derivatives as a novel class of retinol binding protein 4 (RBP4) reducers, Category: alcohols-buliding-blocks, the main research area is trifluoromethyl phenyl oxazolyl propanoic acid preparation RBP4 reducer SAR; pyrrolidinyloxy acetic acid trifluoromethyl phenyl preparation RBP4 reducer SAR; Age-related macular degeneration (AMD); Diabetes; Protein–protein interaction (PPI); Retinol-binding protein 4 (RBP4); Transthyretin (TTR).

Retinol-binding protein 4 (RBP4) is a potential drug target for metabolic and ophthalmol. diseases. A high-throughput screening of compound library has identified a small-mol. RBP4 reducer compound I, as a hit compound Aiming to provide a suitable tool for investigating the pharmacol. effects of RBP4 reducers, we conducted a structure-activity relationship study of compound I. Exploration of the aryl head, oxazole core, and propanoic acid tail of compound I resulted in the discovery of novel, potent, and orally available phenylpyrrolidine derivatives ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid and ({(3R)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid. Compound ({(3S)-1-[3,5-bis(trifluoromethyl)phenyl]pyrrolidin-3-yl}oxy)acetic acid had a potent and long-lasting blood RBP4-level-reducing effect when orally administered to mice at a dose as low as 0.3 mg/kg.

Bioorganic & Medicinal Chemistry published new progress about Eye disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fall, Fanta published the artcileMetabolic reprograming of LPS-stimulated human lung macrophages involves tryptophan metabolism and the aspartate-arginosuccinate shunt, Category: alcohols-buliding-blocks, the main research area is LM tryptophan metabolism lipopolysaccharide aspartate arginosuccinate metabolic reprogramming.

The objective of the present work was to characterize the metabolic alterations occurring during the exptl. M1 LM polarization. Human LM were obtained from resected lungs and cultured for 24 h in medium alone or with 10 ng.mL-1 lipopolysaccharide. Cells and culture supernatants were subjected to extraction for metabolomic anal. with high-resolution LC-MS (HILIC and reverse phase -RP- chromatog. in both neg. and pos. ionization modes) and GC-MS. The data were analyzed with R and the Worklow4Metabolomics and MetaboAnalyst online infrastructures. A total of 8,741 and 4,356 features were detected in the intracellular and extracellular content, resp., after the filtering steps. Pathway anal. showed involvement of arachidonic acid metabolism, tryptophan metabolism and Krebs cycle in the response of LM to LPS, which was confirmed by the specific quantitation of selected compounds This refined anal. highlighted a regulation of the kynurenin pathway as well as the serotonin biosynthesis pathway, and an involvement of aspartate-arginosuccinate shunt in the malate production Macrophages M1 polarization is accompanied by changes in the cell metabolome, with the differential expression of metabolites involved in the promotion and regulation of inflammation and antimicrobial activity. The anal. of this macrophage immunometabolome may be of interest for the understanding of the pathophysiol. of lung inflammatory disesases.

PLoS One published new progress about Homo sapiens. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts