Tag: M.W=100-150

Kamran, Muhammad published the artcileRole of TaALMT1 malate-GABA transporter in alkaline pH tolerance of wheat, SDS of cas: 97-67-6, the main research area is ALMT1 GABA transporter alk pH tolerance wheat; Hordeum vulgare; Triticum aestivum; aluminate; aluminum; barley; gama-aminobutyric acid; proton efflux; rhizosphere acidification.

Malate exudation through wheat (Triticum aestivum L) aluminum-activated malate transporter 1 (TaALMT1) confers Al3+ tolerance at low pH, but is also activated by alk. pH, and is regulated by and facilitates significant transport of gamma-aminobutyric acid (GABA, a zwitterionic buffer). Therefore, TaALMT1 may facilitate acidification of an alk. rhizosphere by promoting exudation of both malate and GABA. Here, the performance of wheat near isogenic lines ET8 (Al+3-tolerant, high TaALMT1 expression) and ES8 (Al+3-sensitive, low TaALMT1 expression) are compared. Root growth (at 5 wk) was higher for ET8 than ES8 at pH 9. ET8 roots exuded more malate and GABA at high pH and acidified the rhizosphere more rapidly. GABA and malate exudation was enhanced at high pH by the addition of aluminate in both ET8 and transgenic barley expressing TaALMT1. Xenopus laevis oocytes expressing TaALMT1 acidified an alk. media more rapidly than controls corresponding to higher GABA efflux. TaALMT1 expression did not change under alk. conditions but key genes involved in GABA turnover changed in accordance with a high rate of GABA synthesis. We propose that TaALMT1 plays a role in alk. tolerance by exuding malate and GABA, possibly coupled to proton efflux.

Plant, Cell & Environment published new progress about Chlorophylls Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, SDS of cas: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Laurent, Jitka published the artcileThe Potential of Kluyveromyces marxianus to Produce Low-FODMAP Straight-Dough and Sourdough Bread: a Pilot-Scale Study, HPLC of Formula: 505-10-2, the main research area is Kluyveromyces Saccharomyces sourdough bread glucose microbial growth.

Diets low in fermentable oligo-, di-, and monosaccharides and polyols (FODMAPs) can help reduce symptoms in 50 to 80% of patients suffering from irritable bowel syndrome. Patients are, therefore, often advised to avoid products contributing to FODMAP intake, such as cereal grain products. However, these products are nutritious staple foods and avoiding their consumption may result in nutritional deficiencies. The development of low-FODMAP, high-fiber cereal grain products is therefore desirable. This pilot-scale study shows that Kluyveromyces marxianus CBS6014 (K. marxianus) results in more fructan hydrolysis and a significantly lower final fructan level in white and whole-grain toast bread as well as in rye sourdough bread compared to a com. Saccharomyces cerevisiae baking strain. Moreover, combined fructan and fructose levels in white and whole-grain bread prepared with K. marxianus remained well below the threshold concentration for low-FODMAP products. In addition to reducing fructan levels, K. marxianus in rye sourdough bread also pos. impacted bread height. Whereas further follow-up studies are needed to assess the potential of K. marxianus for bread production fully, our study suggests that this yeast species may open exciting novel routes for the production of low-FODMAP, high-fiber products.

Food and Bioprocess Technology published new progress about Disaccharides Role: FFD (Food or Feed Use), BIOL (Biological Study), USES (Uses). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, HPLC of Formula: 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gonzalez-Alvarez, Rafael Jesus published the artcileA handling-free methodology for rapid determination of Cu species in seawater based on direct solid micro-samplers analysis by high-resolution continuum source graphite furnace atomic absorption spectrometry, Related Products of alcohols-buliding-blocks, the main research area is rapid copper species seawater solid microsampler; resolution continuum source graphite furnace atomic absorption spectrometry; Continuum source solid sampling graphite furnace atomic absorption spectrometry; Copper speciation; Direct determination; Seawater; Solvent bar.

A simple, sensible and advanced new methodol. for the determination of copper species in seawater was developed. The method consisted of two steps: first a separation/preconcentration of copper species by using liquid phase microextraction-based solvent bars followed by the direct anal. of these solid polymeric micro-samplers in an at. absorption spectrometer provided with a device for direct anal. For liquid microextraction, di-2-pyridylketone benzoylhydrazone (dPKBH) dissolved in octan-1-ol was selected as the extracting agent due to its ability to transport inorganic Cu species from seawater samples. The optimum chem. and phys. conditions for copper micro-extraction were sample pH 8, a dPKBH concentration of 0.010 mol L-1, a stirring speed of 800 rpm and an extraction time of 10 min. A graphite furnace temperature program was optimized to assure the complete elimination of the solvent bar matrix, and the atomization step took place at 2200°. The method exhibited a limit of detection of 0.026 μg L-1 of copper and a linear range up to 1.50 μg L-1, showing great repeatability and reproducibility (4.07% and 4.43%, resp.). Suitability of the method was confirmed by analyzing a certified reference material (CASS-4) under optimum conditions, being the first time ever that a direct solid anal.-based method was used for the determination of total dissolved copper concentration in seawater. Furthermore, the method was applied to the determination of the operationally defined transportable Cu fraction in seawater samples at natural conditions and the results were compared with theor. data provided by Visual MINTEQ 3.1 software. A math. model that permits to estimate total dissolved copper concentration was obtained, and the non-transportable copper fraction was calculated by difference.

Talanta published new progress about High-resolution continuum source graphite furnace atomic absorption spectroscopy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Yuan published the artcileThe metabolic origins of non-photorespiratory CO2 release during photosynthesis: a metabolic flux analysis, Name: (S)-2-hydroxysuccinic acid, the main research area is Camelina sativa carbon dioxide photosynthesis metabolic flux analysis.

Respiration in the light (RL) releases CO2 in photosynthesizing leaves and is a phenomenon that occurs independently from photorespiration. Since RL lowers net carbon fixation, understanding RL could help improve plant carbon-use efficiency and models of crop photosynthesis. Although RL was identified more than 75 years ago, its biochem. mechanisms remain unclear. To identify reactions contributing to RL, we mapped metabolic fluxes in photosynthesizing source leaves of the oilseed crop and model plant camelina (Camelina sativa). We performed a flux anal. using isotopic labeling patterns of central metabolites during 13CO2 labeling time course, gas exchange, and carbohydrate production rate experiments To quantify the contributions of multiple potential CO2 sources with statistical and biol. confidence, we increased the number of metabolites measured and reduced biol. and tech. heterogeneity by using single mature source leaves and quickly quenching metabolism by directly injecting liquid N2; we then compared the goodness-of-fit between these data and data from models with alternative metabolic network structures and constraints. Our anal. predicted that RL releases 5.2 μmol CO2 g-1 FW h-1 of CO2, which is relatively consistent with a value of 9.3μmol CO2 g-1 FW h-1 measured by CO2 gas exchange. The results indicated that ≤10% of RL results from TCA cycle reactions, which are widely considered to dominate RL. Further anal. of the results indicated that oxidation of glucose-6-phosphate to pentose phosphate via 6-phosphogluconate (the G6P/OPP shunt) can account for >93% of CO2 released by RL.

Plant Physiology published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

de Avila Silva, Lucas published the artcileSpecific leaf area is modulated by nitrogen via changes in primary metabolism and parenchymal thickness in pepper, Safety of (S)-2-hydroxysuccinic acid, the main research area is pepper parenchymal thickness nitrogen primary metabolism specific leaf area; Capsicum; Chili pepper; Leaf morphology and anatomy; Shade; Tissue density.

Nitrogen promotes changes in SLA through metabolism and anatomical traits in Capsicum plants. Specific leaf area (SLA) is a key trait influencing light interception and light use efficiency that often impacts plant growth and production SLA is a key trait explaining growth variations of plant species under different environments. Both light and nitrogen (N) supply are important determinants of SLA. To better understand the effect of irradiance level and N on SLA in Capsicum chinense, we evaluated primary metabolites and morphol. traits of two com. cultivars (Biquinho and Habanero) in response to changes in both parameters. Both genotypes showed increased SLA with shading, and a decrease in SLA in response to increased N supply, however, with Habanero showing a stable SLA in the range of N deficiency to sufficient N doses. Correlation analyses indicated that decreased SLA in response to higher N supply was mediated by altered amino acids, protein, and starch levels, influencing leaf d. Moreover, in the range of moderate N deficiency to N sufficiency, both genotypes exhibited differences in SLA response, with Biquinho and Habanero displaying alterations on palisade and spongy parenchyma, resp. Altogether, the results suggest that SLA responses to N supply are modulated by the balance between certain metabolites content and genotype-dependent changes in the parenchyma cells influencing leaf thickness and d.

Planta published new progress about Amino acids Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mestre, Maria Victoria published the artcileImpact on Sensory and Aromatic Profile of Low Ethanol Malbec Wines Fermented by Sequential Culture of Hanseniaspora uvarum and Saccharomyces cerevisiae Native Yeasts, Formula: C4H10OS, the main research area is Hanseniaspora Saccharomyces ethanol wine sensory profile.

It is well known that high ethanol levels in wines adversely affect the perception of new wine consumers. Moreover, numerous issues, such as civil restrictions, health risk and trade barriers, are associated with high ethanol concentrations Several strategies have been proposed to produce wines with lower alc. content, one simple and inexpensive approach being the use of new wine native yeasts with less efficiency in sugar to ethanol conversion. Nevertheless, it is also necessary that these yeasts do not impair the quality of wine. In this work, we tested the effect of sequential culture between Hanseniaspora uvarum BHu9 and Saccharomyces cerevisiae BSc114 on ethanol production Then, the wines produced were analyzed by GC-MS and tested by a sensorial panel. Co-culture had a pos. impact on ethanol reduction and sensory profile when compared to the S. cerevisiae monoculture. Wines with lower alc. content were related to fruity aroma; moreover, color intensity was associated The wines obtained with S. cerevisiae BSc114 in pure conditions were described by parameters linked with high ethanol levels, such as hotness and astringency. Moreover, floral profile was related to this treatment. Based on these findings, this work provides a contribution to answer the current consumers’ preferences and addresses the main challenges faced by the enol. industry.

Fermentation published new progress about Carbohydrates Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cheng, Gang published the artcilePotent inhibition of tumour cell proliferation and immunoregulatory function by mitochondria-targeted atovaquone, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is cancer cell mitochondrial complex III atovaquone antiproliferative triphenylphosphonium.

Abstract: The FDA-approved prophylactic antimalarial drug atovaquone (ATO) recently was repurposed as an antitumor drug. Studies show that ATO exerts a profound antiproliferative effect in several cancer cells, including breast, ovarian, and glioma. Analogous to the mechanism of action proposed in parasites, ATO inhibits mitochondrial complex III and cell respiration. To enhance the chemotherapeutic efficacy and oxidative phosphorylation inhibition, we developed a mitochondria-targeted triphenylphosphonium-conjugated ATO with varying alkyl side chains (Mito4-ATO, Mito10-ATO, Mito12-ATO, and Mito16-ATO). Results show, for the first time, that triphenylphosphonium-conjugated ATO potently enhanced the antiproliferative effect of ATO in cancer cells and, depending upon the alkyl chain length, the mol. target of inhibition changes from mitochondrial complex III to complex I. Mito4-ATO and Mito10-ATO inhibit both pyruvate/malate-dependent complex I and duroquinol-dependent complex III-induced oxygen consumption whereas Mito12-ATO and Mito16-ATO inhibit only complex I-induced oxygen consumption. Mitochondrial target shifting may have immunoregulatory implications.

Scientific Reports published new progress about CD25 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Spera, Iolanda published the artcileThe J2-Immortalized Murine Macrophage Cell Line Displays Phenotypical and Metabolic Features of Primary BMDMs in Their M1 and M2 Polarization State, COA of Formula: C4H6O5, the main research area is inflammation BMDM macrophage polarization phenotype metabolism; cell line; immortalized macrophages; immune model; inflammation; macrophage; metabolism.

Macrophages are immune cells that are important for the development of the defensive front line of the innate immune system. Following signal recognition, macrophages undergo activation toward specific functional states, consisting not only in the acquisition of specific features but also of peculiar metabolic programs associated with each function. For these reasons, macrophages are often isolated from mice to perform cellular assays to study the mechanisms mediating immune cell activation. This requires expensive and time-consuming breeding and housing of mice strains. To overcome this issue, we analyzed an inhouse J2-generated immortalized macrophage cell line from BMDMs, both from a functional and metabolic point of view. By assaying the intracellular and extracellular metabolism coupled with the phenotypic features of immortalized vs. primary BMDMs, we concluded that classically and alternatively immortalized macrophages display similar phenotypical, metabolic and functional features compared to primary cells polarized in the same way. Our study validates the use of this immortalized cell line as a suitable model with which to evaluate in vitro how perturbations can influence the phenotypical and functional features of murine macrophages.

Cancers published new progress about CD38 antigens Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ozyagci, Bensu published the artcileEsterification of 1-Octanol on Clinoptilolite-Supported TiO2 Catalysts, Safety of n-Octanol, the main research area is octanol clinoptilolite supported titanium oxide catalyst esterification.

In this study, a natural type of zeolite, Clinoptilolite (CLI), is used as a support for TiO2. First, TiO2-supported heterogeneous catalysts originated from the high temperature calcination of TiCl4 groups, which were thermally immobilized on clinoptilolite, were obtained. Powder-XRD and EDX analyzes showed that the oxide form of Ti-immobilized on dealuminated clinoptilolite were formed in the anatase phase, and the zeolite structure was preserved. As seen in TGA/DTA analyzes, this catalyst could be efficient and have high stability for many reactions. Second, the esterification reaction of 1-octanol with acetic acid is used as a reference reaction for this catalyst.

Silicon published new progress about Clinoptilolite-type zeolites Role: CAT (Catalyst Use), USES (Uses) (dealuminated). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tan, Sze Chieh published the artcileA metal-organic framework of type MIL-101(Cr) for emulsification-assisted micro-solid-phase extraction prior to UHPLC-MS/MS analysis of polar estrogens, Recommanded Product: n-Octanol, the main research area is polar estrogen UHPLC MS micro solid phase extraction review; Endocrine disrupting compounds; Environmental water; Hormones; Liquid chromatography-tandem mass spectrometry; Membrane-protected; Microextraction; Porous material; Sample preparation.

A seamless two-step extraction procedure integrating ultrasound-assisted emulsification microextraction (USAEME) and vortex-assisted micro-solid-phase extraction (μ-SPE) was developed. A highly porous metal-organic framework of type MIL-101(Cr) is used as the sorbent, and ultra-high-performance liquid chromatog. in combination with tandem mass spectrometry is used for detection. The steroid hormones estrone 17β-estradiol, estriol, and 17α-ethynylestradiol were extracted from water samples by using this method. These steroids are polar and do not pass through the polypropylene membrane that is conventionally used in μ-SPE. In the method presented here, 1-octanol is used in USAEME to extract and pre-concentrate the steroids. This facilitates the transfer to the MIL-101(Cr) phase retained by the membrane in the subsequent μ-SPE step. MIL-101(Cr) was characterized by various methods, and the parameters affecting the overall extraction efficiency were optimized. Under the most favorable conditions, the limits of detection are between 0.95 and 23 ng L-1. Good intra-day and inter-day precisions were obtained, with relative standard deviations of ≤ 9.9%. Enrichment factors are between 34 and 52. The method was applied to genuine environmental water samples in which estrone was detected. Relative recoveries ranged between 85.4% and 120.8%. [Figure not available: see fulltext.].

Microchimica Acta published new progress about Activated charcoal Role: TEM (Technical or Engineered Material Use), USES (Uses). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts