Tag: M.W=100-150

Lagerspets, Emi published the artcileSchiff base Cu(I) catalyst for aerobic oxidation of primary alcohols, Application of n-Octanol, the main research area is copper Schiff base complex catalyst preparation; aldehyde preparation; alc aerobic oxidation copper Schiff base complex catalyst.

New copper(I)-Schiff base complexes were reported for the selective aerobic oxidation of primary alcs. to aldehydes RCHO [R = (CH2)6, Ph, (CH2)2Ph, etc.] under ambient conditions. Particularly, the copper(I) complex bearing N-(4-fluorophenyl)-1-(furan-2-yl)methanimine showed high activity in the series and gave near- quant. yields in the oxidations of benzyl alc. (99% yield in 1 h) and 1-octanol (96% yield in 24 h). Based on the X-ray structure determination, the complex had a square pyramidal coordination accomplished by two N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands and bromide as a counter anion. The oxidation reactions were monitored with UV-vis and in situ ATR-IR spectroscopy to study the changes in the catalytic structure and to elucidate the catalytic properties and the mechanistic details. Accordingly, detachment of one of the N-(4-fluorophenyl)-1-(furan-2-yl)methanimine ligands from the complexes was related to the oxidation activity.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Application of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Srinivasachary, K. published the artcilePractical and Efficient Route to Dolutegravir Sodium via One-Pot Synthesis of Key Intermediate with Controlled Formation of Impurities, COA of Formula: C4H11NO2, the main research area is dolutegravir sodium preparation green chem.

An efficient, cost effective and com. viable synthesis of dolutegravir sodium has been developed from com. available I as the key intermediate. The key features of the synthesis are lower number of synthetic steps and the use of eco-friendly and inexpensive reagents. The process has been demonstrated to meet ICH requirements on scaling up.

Russian Journal of Organic Chemistry published new progress about Aralkyl amines Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Yiwei published the artcilePrognostic effects of glycometabolism changes in lung adenocarcinoma: a prospective observational study, Quality Control of 97-67-6, the main research area is human lung adenocarcinoma glycometabolism prognostic effect; Lung adenocarcinoma; Warburg effect; clinicopathological characteristics; glycometabolism changes; prognosis.

Changes in glycometabolism of cancer cells provides cancer cells with growth advantages, which are also of great value in the prognosis prediction of the patients with lung adenocarcinoma. However, currently available studies are controversial. We successively collected 100 paired surgical specimens from patients with lung adenocarcinoma. The content of glycometabolic intermediates in tissues was tested by liquid chromatog.-mass spectrometry. Follow-up was conducted every 6 mo for patients enrolled in this study. There were significant differences in the contents of six intermediates, including glucose (P<0.0001), pyruvate (P = 0.0009), lactate (P<0.0001), citrate (P = 0.0001), α-ketoglutarate (P = 0.0002), and fumarate (P = 0.0096). For different TNM stages, the pyruvate content (P<0.001) and lactate content (P<0.001) in the II/III/IV stage cancer tissues were significantly higher than those in the stage I cancer tissues. The overall survival (OS) of patients with high levels of glucose (P = 0.0034), pyruvate (P<0.0001), lactate (P = 0.049), and citrate (P = 0.024) in cancer tissues was significantly worse than that of patients with low levels. N stage (P<0.001) and the contents of pyruvate (P = 0.033) were independent prognostic factors for the OS. The contents of glucose, pyruvate, lactate, and citrate in cancer tissues are higher than that in para-carcinoma tissues, and the long-term survival decrease in patients with higher glucose, pyruvate, lactate, and citrate. Translational Lung Cancer Research published new progress about Carbohydrate metabolism disorders Role: BIOL (Biological Study). 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Quality Control of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Wenjun published the artcileBasic Promotors Impact Thermodynamics and Catalyst Speciation in Homogeneous Carbonyl Hydrogenation, Recommanded Product: n-Octanol, the main research area is promotor thermodn homogeneous catalyst carbonyl hydrogenation.

Homogeneously catalyzed reactions often make use of additives and promotors that affect reactivity patterns and improve catalytic performance. While the role of reaction promotors is often discussed in view of their chem. reactivity, we demonstrate that they can be involved in catalysis indirectly. In particular, we demonstrate that promotors can adjust the thermodn. of key transformations in homogeneous hydrogenation catalysis and enable reactions that would be unfavorable otherwise. We identified this phenomenon in a set of well-established and new Mn pincer catalysts that suffer from persistent product inhibition in ester hydrogenation. Although alkoxide base additives do not directly participate in inhibitory transformations, they can affect the equilibrium constants of these processes. Exptl., we confirm that by varying the base promotor concentration one can control catalyst speciation and inflict substantial changes to the standard free energies of the key steps in the catalytic cycle. Despite the fact that the latter are universally assumed to be constant, we demonstrate that reaction thermodn. and catalyst state are subject to external control. These results suggest that reaction promotors can be viewed as an integral component of the reaction medium, on its own capable of improving the catalytic performance and reshaping the seemingly rigid thermodn. landscape of the catalytic transformation.

Journal of the American Chemical Society published new progress about Alcohols Role: SPN (Synthetic Preparation), PREP (Preparation). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Xiaochun published the artcileSynthesis of Unsymmetrical N-Heterocyclic Carbene-Nitrogen-Phosphine Chelated Ruthenium(II) Complexes and Their Reactivity in Acceptorless Dehydrogenative Coupling of Alcohols to Esters, Formula: C8H18O, the main research area is tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle preparation catalyst dehydrogenative coupling alc; crystal structure tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle; mol structure tridentate phosphinophenyliminoimidazolylidene chelated ruthenacycle; ester preparation.

Two novel Ru complexes RuH(CO)Cl(PPh3)(κ2-CP) (1) and [fac-RuH(CO)(PPh3)(κ3-CNP)]Cl (2) bearing unsym. N-heterocyclic carbene-N-phosphine (CNP) were synthesized and characterized with 1H NMR, 31P NMR, and HRMS. The structure of complex 2 was further confirmed by single-crystal x-ray diffraction. An anion exchange experiment proved that complex 2 could transform into complex 1 in solution The two complexes exhibited a highly catalytic performance in acceptorless dehydrogenative coupling of alcs. to esters, and the excellent isolated yields of esters were given in a catalyst loading of 1% for para- and meta-substituted benzyl alcs. and long-chain primary alcs. Although some ortho-substituted benzyl alcs. displayed a relatively low reactivity due to the steric hindrance and the coordination of electron donor with the Ru center, the good product yields were still obtained by prolonging the reaction time. Especially, this system successfully realized the dehydrogenative cross-coupling to esters between two different primary alcs.

Organometallics published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ghandi, Mehdi published the artcileA combined multicomponent-acid catalyzed cyclization reaction as an efficient route to novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives, SDS of cas: 22483-09-6, the main research area is tricyclic pyrroloisoquinoline preparation; polysubstituted pyrrole preparation heterocyclization sulfuric acid catalyst; arylglyoxal cyclic dicarbonyl dimethoxyethanamine keto ester four component Knoevenagel.

A simple, new two-step procedure for the synthesis of novel tricyclic pyrrolo[2,1-a]isoquinoline derivatives I (R = H, Me, Cl, Ph; R1 = 2-hydroxy-4,4-dimethyl-6-oxocyclohex-1-en-1-yl, 2-hydroxy-6-oxocyclohex-1-en-1-yl, 4-hydroxy-2-oxo-2H-chromen-3-yl; R2 = Me, Et) is described. The initially prepared polysubstituted pyrroles II via the four-component condensation of arylglyoxals 4-RC6H4C(O)CHO, cyclic 1,3-dicarbonyls such as 1,3-cyclohexanedione, 5,5-dimethyl-1,3-cyclohexanedione, 4-hydroxy-2H-chromen-2-one, aminoacetaldehyde di-Me acetal and β-keto esters R2OC(O)CH2C(O)CH3 subsequently underwent intramol. acid-catalyzed cyclization to give the desired products in moderate to good yields I.

Journal of Heterocyclic Chemistry published new progress about Cyclic diketones Role: RCT (Reactant), RACT (Reactant or Reagent). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, SDS of cas: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Guan, Zhipeng published the artcileElectrochemical Oxidative Carbon-Atom Difunctionalization: Towards Multisubstituted Imino Sulfide Ethers, COA of Formula: C4H10OS, the main research area is electrochem oxidative difunctionalization isocyanide imino sulfide ether stereoselective synthesis; electrochemistry; ethers; isocyanides; radicals; synthetic methods.

Ethers (C-O/S) are ubiquitously found in a wide array of functional mols. and natural products. Nonetheless, the synthesis of imino sulfide ethers, containing an N(sp2)=C(sp2)-O/S fragment, still remains a challenge because of its sensitivity to acid. Developed here in is an unprecedented electrochem. oxidative carbon-atom difunctionalization of isocyanides, providing a series of novel multisubstituted imino sulfide ethers. Under metal-free and external oxidant-free conditions, isocyanides react smoothly with simple and readily available mercaptans and alcs. [e.g., 4-fluorobenzenethiol + Et isocyanoacetate + methanol �(Z)-I (80% isolated)]. Importantly, the procedure exhibited high stereoselectivities, excellent functional-group tolerance, and good efficiency on large-scale synthesis, as well as further derivatization of the products.

Angewandte Chemie, International Edition published new progress about Aromatic thiols Role: RCT (Reactant), RACT (Reactant or Reagent). 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, COA of Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wang, Yuanze published the artcileDiverse Isoquinoline Scaffolds by Ugi/Pomeranz-Fritsch and Ugi/Schlittler-Mueller Reactions, Quality Control of 22483-09-6, the main research area is isoquinoline scaffold preparation Ugi Pomeranz Fritsch Schlittler Mueller.

The Pomeranz-Fritsch reaction and its Schlittler-Mueller modification were successfully applied in the Ugi postcyclization strategy by using orthogonally protected aminoacetaldehyde di-Et acetal and complementary electron rich building blocks. Several scaffolds, including isoquinolines, carboline, alkaloid-like tetrazole-fused tetracyclic compounds, and benzo[d]azepinone scaffolds, were synthesized in generally moderate to good yield. All the authors’ syntheses provide a short MCR-based sequence to novel or otherwise difficult to access scaffolds. Hence, the authors foresee multiple applications of these synthesis technologies.

Organic Letters published new progress about Carbolines Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hang, Zhaojun published the artcileA practical method for N-cyanation of secondary amines and sulfonamides, HPLC of Formula: 22483-09-6, the main research area is cyanamide preparation; secondary amine sulfonamide CBX cyanation alk condition.

Cyanamides are an important class of mols. This work describes a facile synthesis of disubstituted cyanamides. Here, readily accessible 1-cyano-1,2-benziodoxol-3-(1H)-one (CBX) was applied as a stable electrophilic cyanation reagent. Diverse secondary amines were effectively cyanated. Moreover, secondary sulfonamides proved to be suitable substrates and were readily converted to N-alkyl(aryl)-N-arylsulfonyl-cyanamides, as the significant building blocks of the organic transformation.

Tetrahedron Letters published new progress about Cyanamides Role: SPN (Synthetic Preparation), PREP (Preparation). 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, HPLC of Formula: 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Fang, L. published the artcileNanoceria-promoted low Pd-Ni catalyst for the synthesis of secondary amines from aliphatic alcohols and ammonia, Synthetic Route of 111-87-5, the main research area is nanoceria palladium nickel catalyst secondary amine aliphatic alc ammonia.

This paper describes the preparation of bimetallic Pd-Ni catalysts supported over nanoceria with very low Ni and Pd loading (<0.5%) for the direct amination of aliphatic alcs. with NH3. Different metal impregnation methods were used for engineering the interaction between Pd, Ni and nanoceria. The as-prepared catalysts were characterized in detail by combining XRD, H2-TPR, H2-TPD, STEM-EDS-SDD and XPS. The sequence of impregnation of both metals and the Pd loading affected to an important extent the catalytic activity by conditioning the crystallite size and the Pd and Ni speciation, as well as the reducibility and reversible H2 storage properties. By optimizing the preparation protocols, a 0.5% Pd-0.5% Ni-Pd/CeO2 formulation prepared by sequential impregnation of the Ni and Pd precursors afforded 80% yield of dioctylamine at almost full conversion [TON = 1160 mmol per mmol (Ni + Pd)surface] in the direct amination reaction of 1-octanol with NH3 at 180° for 2 h. Metal leaching during the reaction could be completely avoided. The high catalytic performance of Pd-Ni induced by nanoceria places this catalyst among the best ever reported catalysts for the synthesis of secondary amines. Catalysis Science & Technology published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts