Tag: M.W=100-150

AL-Hashimi, Nabil N. published the artcileCetyl-alcohol-reinforced hollow fiber solid/liquid-phase microextraction and HPLC-DAD analysis of ezetimibe and simvastatin in human plasma and urine, Synthetic Route of 111-87-5, the main research area is ezetimibe simvastatin cetyl alc hollow fiber SLPME HPLC DAD; HPLC-DAD; cetyl alcohol; ezetimibe and simvastatin; plasma; reinforced solid/liquid microextraction; urine.

A new cetyl-alc.-reinforced hollow fiber solid/liquid-phase microextraction (CA-HF-SLPME) followed by high-performance liquid chromatog.-diode array detection (HPLC-DAD) method was developed for simultaneous determination of ezetimibe and simvastatin in human plasma and urine samples. To prepare the CA-HF-SLPME device, the cetyl-alc. was immobilized into the pores of a 2.5 cm hollow fiber micro-tube and the lumen of the micro-tube was filled with 1-octanol with the two ends sealed. Afterwards, the prepared device was introduced into 10 mL of the sample solution containing the analytes with agitation. Under optimized conditions, calibration curves plotted in spiked plasma and urine samples were linear in the ranges of 0.363-25/0.49-25 μg L-1 for ezetimibe/simvastatin and 0.193-25/0.312-25 μg L-1 for ezetimibe/simvastatin in plasma and urine samples, resp. The limit of detection was 0.109/0.174 μg L-1 for ezetimibe/simvastatin in plasma and 0.058/0.093 μg L-1 for ezetimibe/simvastatin in urine. As a potential application, the proposed method was applied to determine the concentration of selected analytes in patient plasma and urine samples after medication and satisfactory results were achieved. In comparison with reference methods, the CA-HF-SLPME-HPLC-DAD method demonstrates considerable potential in the biopharmaceutical anal. of selected drugs.

Biomedical Chromatography published new progress about Biopharmaceuticals. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhang, Lijie published the artcileEffects of Tetragenococcus halophilus and Candida versatilis on the production of aroma-active and umami-taste compounds during soy sauce fermentation, Related Products of alcohols-buliding-blocks, the main research area is Tetragenococcus Candida soy sauce fermentation umami taste; Candida versatilis; Tetragenococcus halophilus; aroma-active; soy sauce; umami-taste compounds.

BACKGROUND : Soy sauce is a well-known condiment worldwide. High salt soy sauce usually has the better quality (aroma and taste) than low salt. Tetragenococcus halophilus and Candida versatilis are important starters for soy sauce fermentation It is of urgent need to explore what the effect of these two strains on the aroma- and taste-attributes of soy sauce to achieve high quality fermentation with low salt. RESULTS : In this study, aroma-active and taste compounds in soy sauce were reviewed and listed. Then, soy sauce fermentation inoculated with different combinations of T. halophilus (at different inoculated time) and C. versatilis were completed. Aroma-active and taste compounds in different samples were quantified. Multivariate anal. was used to analyze these data. The aroma-active compounds which were highly related to the inoculation of T. halophilus and C. versatilis were found. Meanwhile, the addition time of T. halophilus could also be highly related to the production of aroma-active compounds More importantly, T. halophilus was highly correlated with the production of umami-taste compounds in soy sauce, including aspartic acid, glutamic acid, alanine and N-succinyl-glutamic acid. CONCLUSION : These results will provide a better understanding of the effects of T. halophilus and C. versatilis on the formation of significant aroma-active and umami-taste constituents in soy sauce. Furthermore, it will be helpful to realize fermentative control of soy sauce with high quality at low salt.

Journal of the Science of Food and Agriculture published new progress about Candida versatilis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reeves, Benjamin M. published the artcileTransition-Metal-Free Reductive Hydroxymethylation of Isoquinolines, Safety of 2,2-Dimethoxyethanamine, the main research area is isoquinolinium iodide paraformaldehyde reductive hydroxymethylation Cannizzaro Evans Tishchenko; hydroxymethylated tetrahydroisoquinoline preparation; potassium methoxide isoquinolinium iodide paraformaldehyde methylation hydroxymethylation tandem; tetrahydroisoquinoline one pot preparation; formaldehyde; reductive-functionalization; tandem reaction; tetrahydroisoquinoline; transition-metal-free synthesis.

A transition-metal-free reductive hydroxymethylation reaction has been developed, enabling the preparation of tetrahydroisoquinolines, e.g., I, bearing C4-quaternary centers from the corresponding isoquinolines. Deuterium labeling studies and control experiments enable a potential mechanism to be elucidated which features a key Cannizzaro-type reduction followed by an Evans-Tishchenko reaction. When isoquinolines featuring a proton at the 4-position are used, a tandem methylation-hydroxymethylation occurs, leading to the formation of II with 2 new C-C bonds in one pot.

Angewandte Chemie, International Edition published new progress about C-C bond formation. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Safety of 2,2-Dimethoxyethanamine.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vitvitsky, Victor published the artcileThe mitochondrial NADH pool is involved in hydrogen sulfide signaling and stimulation of aerobic glycolysis, Computed Properties of 97-67-6, the main research area is mitochondrial NADH hydrogen sulfide signaling aerobic glycolysis; aerobic glycolysis; electron transport chain; hydrogen sulfide; sulfide quinone oxidoreductase.

Hydrogen sulfide is synthesized by enzymes involved in sulfur metabolism and oxidized via a dedicated mitochondrial pathway that intersects with the electron transport chain at the level of complex III. Studies with H2S are challenging since it is volatile and also reacts with oxidized thiols in the culture medium, forming sulfane sulfur species. The half-life of exogenously added H2S to cultured cells is unknown. In this study, we first examined the half-life of exogenously added H2S to human colonic epithelial cells. In plate cultures, H2S disappeared with a t1/2 of 3 to 4 min at 37 °C with a small fraction being trapped as sulfane sulfur species. In suspension cultures, the rate of abiotic loss of H2S was slower, and we demonstrated that sulfide stimulated aerobic glycolysis, which was sensitive to the mitochondrial but not the cytoplasmic NADH pool. Oxidation of mitochondrial NADH using the genetically encoded mito-LbNOX tool blunted the cellular sensitivity to sulfide-stimulated aerobic glycolysis and enhanced its oxidation to thiosulfate. In contrast, sulfide did not affect flux through the oxidative pentose phosphate pathway or the TCA cycle. Knockdown of sulfide quinone oxidoreductase, which commits H2S to oxidation, sensitized cells to sulfide-stimulated aerobic glycolysis. Finally, we observed that sulfide decreased ATP levels in cells. The dual potential of H2S to activate oxidative phosphorylation at low concentrations, but inhibit it at high concentrations, suggests that it might play a role in tuning electron flux and, therefore, cellular energy metabolism, particularly during cell proliferation.

Journal of Biological Chemistry published new progress about Cell proliferation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, La published the artcileMetformin attenuates hepatoma cell proliferation by decreasing glycolytic flux through the HIF-1α/PFKFB3/PFK1 pathway, Related Products of alcohols-buliding-blocks, the main research area is hepatoma cell metformin glycolytic flux HIF1 alpha PFKFB3 PFK1; Glycolytic flux; Hepatocellular carcinoma; Metformin; PFK1.

Enhanced aerobic glycolysis is an essential hallmark of malignant cancer. Blocking the glycolytic pathway has been suggested as a therapeutic strategy to impair the proliferation of tumor cells. Metformin, a widely used anti-diabetes drug, exhibits anti-tumor properties. Stable isotope tracing technol. and gas chromatog.-mass spectrometry method were utilized to analyze the effect of metformin on glycolytic flux in HCC cells. Western blot and immunohistochem. were utilized to analyze the expression of phosphofructokinase-1 and 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 in HCC cells or xenograft tumor tissues. Lactate measurement and glucose uptake assay were used to analyze the level of lactate and glucose in the presence of frucose-2,6-diphosphate in HCC cells treated with metformin. We found that metformin significantly impaired hepatoma cell proliferation by inhibiting the glycolytic flux via PFK1 blockade. Interestingly, activation of PFK1 by F2,6BP reverses the inhibitory effect of metformin on hepatoma cell proliferation and glycolysis. Mechanistically, PFKFB3,a potent allosteric activator of PFK1, was markedly suppressed through inhibiting hypoxia-induced factor 1 accumulation mediated by metformin. Taken together these data indicate that HIF-1α/PFKFB3/PFK1 regulatory axis is a vital determinant of glucose metabolic reprogramming in hepatocellular carcinoma, which gives new insights into the action of metformin in combating liver cancer.

Life Sciences published new progress about Cell proliferation. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Frymark, Justyna published the artcileExcess of polyamine as a factor influencing the mode of coordination in the Eu(III)/α-hydroxy acid/spermine system, Computed Properties of 97-67-6, the main research area is europium complexation hydroxy acid spermine excess polyamine spectroscopy.

The complexes of europium(III) ions in binary and ternary systems with α-hydroxy acids and biogenic amine – spermine were investigated. Studies have been performed in aqueous solution using the potentiometric method with computer anal. of the data. Anal. of the equilibrium constants of the reactions and spectroscopic data have allowed us to determine the type of coordination and effectiveness of the carboxyl groups in the process of complex formation in the systems studied. Furthermore, the results confirmed the occurrence of non-covalent interactions of protonated spermine with coordinated α-hydroxy acid. The effect of biogenic polyamine concentration was clearly confirmed, and their influence on the stability and coordination mode of ternary complexes was found.

Polyhedron published new progress about Circular dichroism. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Du, Weichao published the artcileSynthesis of cyclohexanone-alcohol hemiketals and evaluation as flow improver for waxy crude oil, Quality Control of 111-87-5, the main research area is cyclohexanone alc hemiketal waxy crude oil flow improver.

In this paper, four novel cyclohexanone-alc. hemiketals (KL-1, KL-2, KL-3, KL-4) as waxy crude oil flow improver have been prepared by cyclohexanone and 1-pentanol, 1-Hexanol, 1-heptanol, 1-octanol. Evaluation results demonstrate the hemiketal compounds have obvious effect on the viscosity and pour point of Henan crude oil. DSC anal. showed that waxing point and waxing peak decreased to a certain degree in 0.05% hemiketal solutions Wax crystal morphol. anal. indicated the four hemiketals played a role of nucleation in the process of waxy crude oil decoagulation, and in that way acts as waxy crude oil flow improver.

Petroleum Science and Technology published new progress about Crystal morphology. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Quality Control of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gu, Jianhong published the artcileSolubility and Model Correlation of Amprolium Hydrochloride in Pure Solvent at the Temperature Range of 273.15-313.15 K, Safety of n-Octanol, the main research area is solubility model correlation amprolium hydrochloride pure solvent.

The solubility data of amprolium hydrochloride in 12 pure solvents including methanol, ethanol, n-propanol, isopropanol, n-butanol, i-butanol, n-octanol, acetone, Et acetate, 1,4-dioxane, acetonitrile, and cyclohexanone was determined at temperature range from T = 273.15 to 313.15 K. The maximum value was obtained in methanol (x = 12.99 × 10-4 at T = 313.15 K, in mole fraction) and the min. data in n-octanol (x = 2.0 × 10-6 at T = 273.15 K, in mole fraction). As expected, it increased with rising temperature in all of the selected solvents. The values from high to low obeyed the following sequence: methanol > acetone > cyclohexanone > ethanol > 1,4-dioxane > n-propanol > Et acetate > n-butanol > isopropanol > i-butanol > acetonitrile > n-octanol. Moreover, the results of IR spectrogram indicated that there was no polymorph transformation or solvate formation during the determination process. The modified Apelblat equation and λh equation were applied to correlate the solubility data. The maximum values of the root mean square deviation (RMSD) and relative average deviation (RAD) were 4.02 × 10-5 (in methanol) and 4.77% (in ethanol), resp. Moreover, two statistical values selected in modified Apelblat equation are significantly smaller than those in λh equation. Therefore, modified Apelblat equation is more suitable to correlate the solute solubility in selected solvents. More importantly, the solubility data will be significant to the engineers and researchers before recrystallization

Journal of Chemical & Engineering Data published new progress about Crystal polymorphs. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pfeiffer, Peter published the artcileCopolymers of pyrrole and N-(hydroxypropyl)pyrrole: properties and interaction with DNA, Name: 3-(1H-Pyrrol-1-yl)propan-1-ol, the main research area is pyrrole hydroxypropy pyrrole copolymer elec conductivity chronoamperometry cyclic voltammetry; conducting polymer polypyrrole plasmid DNA complex lithium perchlorate dopant.

Copolymers derived from mixtures of pyrrole and N-(hydroxypropyl)pyrrole have been prepared electrochem. using various concentration ratios. Copolymers were generated on stainless electrodes by chronoamperometry and cyclic voltammetry in a LiClO4 acetonitrile solution Relevant phys. (d. and doping level) and electrochem. (electroactivity and electrostability) properties of the copolymers have been examined and compared with those of the two corresponding homopolymers, which were prepared using the same electrochem. procedures. Results show that the copolymer obtained using the 25:75 N-(hydroxypropyl)pyrrole:pyrrole molar ratio presents an interesting behavior. Finally, the ability of the latter copolymer to form specific interactions with plasmid DNA has been compared with that of polypyrrole.

Journal of Polymer Research published new progress about Cyclic voltammetry. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Name: 3-(1H-Pyrrol-1-yl)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Trombach, N. published the artcileSynthesis and electropolymerization of pyrrol-1-yl substituted phthalocyanines, HPLC of Formula: 50966-69-3, the main research area is pyrrolyl alkoxy phthalocyanine monomer preparation cyclotrimerization substitution; polypyrrole phthalocyanine preparation oxidative polymerization isolated electroactive group; redox potential electrochromism polypyrrole phthalocyanine conducting polymer.

Metal-free and Zn, Co, Ni – 2,9,16,23-Tetrakis(2-pyrrol-1-yl-alkoxy)phthalocyanines, in which the phthalocyanine is connected via an alkylene spacer to a pyrrole substituent, were prepared via three step reaction sequence to obtain monomers with groups for electropolymerization electronically isolated from the phthalocyanine. The synthesis sequence involves cyclotrimerization, substitution of NO2 groups with OH groups, then conversion to the phthalocyanine ring by the Li pentanolate method. Electrochem. oxidative polymerizations were carried out either under potentiodynamic conditions by scanning between 0.1 and 1.4 V vs. SCE at scan rate of 10 mV s-1 or at a fixed potential of 1.4 V vs. SCE. Polypyrrole films of thickness up to 5 μm were obtained on ITO electrodes. The UV/Vis spectra show the presence of phthalocyanine and polypyrrole structural units in the polymers. The charge-discharge redox process of the conducting polymers is accompanied by a reversible electrochromic color change. The polypyrrole-phthalocyanine films exhibit specific elec. conductivity of ∼10-5 S-cm-1.

Journal of Materials Chemistry published new progress about Cyclotrimerization. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, HPLC of Formula: 50966-69-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts