Tag: M.W=100-150

Cheng, Zhi-Qiang published the artcileMolecular-docking-guided design and synthesis of new IAA-tacrine hybrids as multifunctional AChE/BChE inhibitors, Product Details of C4H11NO2, the main research area is indoleacetic acid tacrine synthesis antiAlzheimer pharmacokinetics acetylcholinesterase butyrylcholinesterase; Alzheimer’s disease; Dual AChE/BChE inhibitor; IAA-tacrine hybrids; Molecular docking; Neural network electrical activity.

A series of new indole-3-acetic acid (IAA)-tacrine hybrids as dual acetylcholinesterase (AChE)/butyrylcholinesterase (BChE) inhibitors were designed and prepared based on the mol. docking mode of AChE with an IAA derivative (1a), a moderate AChE inhibitor identified by screening our compound library for anti-Alzheimer’s disease (AD) drug leads. The enzyme assay results revealed that some hybrids, e.g. 5d and 5e, displayed potent dual in vitro inhibitory activities against AChE/BChE with IC50 values in low nanomolar range. Mol. modeling studies in tandem with kinetic anal. suggest that these hybrids target both catalytic active site and peripheral anionic site of cholinesterase (ChE). Mol. dynamic simulations and Mol. Mechanics/Poisson-Boltzmann Surface Area (MM-PBSA) calculations indicate that 5e has more potent binding affinity than hit 1a, which may explain the stronger inhibitory effect of 5e on AChE. Furthermore, their predicted pharmacokinetic properties and in vitro influences on mouse brain neural network elec. activity were discussed. Taken together, compound 5e can be highlighted as a lead compound worthy of further optimization for designing new anti-AD drugs.

Bioorganic Chemistry published new progress about Alzheimer disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Product Details of C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Tosatti, Jessica Abdo Goncalves published the artcileEffects of Resveratrol Supplementation on the Cognitive Function of Patients with Alzheimer’s Disease: A Systematic Review of Randomized Controlled Trials, Related Products of alcohols-buliding-blocks, the main research area is review resveratrol neuroprotective agent Alzheimers disease.

Alzheimers disease (AD) comprises 60-70% of diagnosed dementia cases, and is characterized by the deposition of β-amyloid peptide and the formation of neurofibrillary tangles of tau protein. Resveratrol is a neuroprotective agent acting in the prevention of redox impairment in addition to exerting anti-apoptotic actions on brain cells. An ability to reduce neuronal damage in patients with AD has been suggested by preclin. studies. Objectives: The aim of this systematic review was to investigate the evidence in the published literature from studies that evaluated the effects of supplementation with resveratrol, alone or in a solution with glucose and malate (RGM), on the functional and cognitive performance of patients with AD, as assessed by validated instruments. A systematic literature search was performed in MEDLINE, CENTRAL, Embase, CINAHL, Web of Science, and Scopus databases including articles published up to August 2021. Randomized, placebo-controlled, clin. trials that reported cognitive and functional performance, as measured by the Alzheimer’s Disease Assessment Scale-Cognitive Subscale (ADAS-cog), Cooperative Study of Alzheimers Disease-Activities of Daily Living (ADCS-ADL), or the Mini Mental State Examination (MMSE), in AD patients treated with resveratrol, alone or as RGM, were included. After 1855 studies were identified, 24 RCTs underwent full-text review, with 20 studies excluded because they did not meet the inclusion criteria. Thus, four RCTs were included in the qual. analyses. The findings demonstrate that there are still few studies in humans, but they showed that this polyphenol acts in the delay of cognitive impairment in patients with AD, when administered alone or in combination with glucose and malate. Supplementation with resveratrol seems to influence the progressive cognitive and functional decline in AD patients, when compared with a placebo group.

Drugs & Aging published new progress about Alzheimer disease. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Wenwen published the artcileHonokiol Restores Microglial Phagocytosis by Reversing Metabolic Reprogramming, Category: alcohols-buliding-blocks, the main research area is honokiol restores microglial phagocytosis metabolic reprogramming; Honokiol; metabolic reprogramming; microglial phagocytosis; mitochondria.

Dysfunction of microglia has been increasingly recognized as a causative factor in Alzheimerprimes disease (AD); thus, developing medicines capable of restoring microglial functions is critically important and constitutes a promising therapeutic strategy. Honokiol is a natural neuroprotective compound extracted from Magnolia officinalis, which may play roles in AD therapy. This study aimed to evaluate the role and the underlying mechanisms of honokiol in microglial phagocytosis. MTT and flow cytometry were used to assess the cell viability and apoptosis, resp. Phagocytic capacity, mitochondrial reactive oxygen species production, and membrane potential were evaluated using fluorescence microscopy. Seahorse XF24 extracellular flux analyzer was for cell glycolysis and oxidative phosphorylation detection. Mass spectrometry was applied for metabolites measurement. Quant. real-time polymerase chain reaction and western blotting were performed to detect the mRNA and protein level of PPARgamma and PGC1alpha, resp. Honokiol alleviated Abeta42-induced BV2 neurotoxicity. Honokiol promoted phagocytic efficiency of BV2 cells through reversing a metabolic switch from oxidative phosphorylation to anaerobic glycolysis and enhancing ATP production Meanwhile, honokiol reduced mitochondrial reactive oxygen species production and elevated mitochondrial membrane potential. Moreover, honokiol increased the expression of PPARgamma and PGC1alpha, which might play pos. roles in energy metabolism and microglial phagocytosis. In this study, honokiol was identified as an effect natural product capable of enhancing mitochondrial function thus promoting microglial phagocytic function.

Journal of Alzheimer’s Disease published new progress about Alzheimer disease. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hoang, Van-Hai published the artcileDiscovery of Conformationally Restricted Human Glutaminyl Cyclase Inhibitors as Potent Anti-Alzheimer’s Agents by Structure-Based Design, Formula: C4H11NO2, the main research area is Alzheimer’s disease glutaminyl cyclase SAR conformational analysis.

Alzheimer’s disease (AD) is an incurable, progressive neurodegenerative disease whose pathogenesis cannot be defined by one single element but consists of various factors; thus, there is a call for alternative approaches to tackle the multifaceted aspects of AD. Among the potential alternative targets, we aim to focus on glutaminyl cyclase (QC), which reduces the toxic pyroform of β-amyloid in the brains of AD patients. On the basis of a putative active conformation of the prototype inhibitor 1, a series of N-substituted thiourea, urea, and α-substituted amide derivatives were developed. The structure-activity relationship analyses indicated that conformationally restrained inhibitors demonstrated much improved QC inhibition in vitro compared to nonrestricted analogs, and several selected compounds demonstrated desirable therapeutic activity in an AD mouse model. The conformational anal. of a representative inhibitor indicated that the inhibitor appeared to maintain the Z-E conformation at the active site, as it is critical for its potent activity.

Journal of Medicinal Chemistry published new progress about Alzheimer disease. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lu, Yao published the artcileEffect of 1-octanol on the stabilization of crude oil emulsions with hydrophobically modified polyacrylamide, Recommanded Product: n-Octanol, the main research area is octanol stabilization petroleum emulsion hydrophobically modified polyacrylamide.

The formation of a stable crude oil emulsion is of great significance for enhancing oil recovery in oilfield development. The effect of 1-octanol (C8OH) on the emulsifying properties of hydrophobically modified polyacrylamide (HMP) was studied based on a novel multiple light scattering method. The emulsions stabilized by different polymer systems were evaluated in terms of stability and rheol. properties. The obtained results show that the combined system of HMP + C8OH gives more stable emulsion with smaller droplet size compared to individual HMP. There is a strong bulk and interface interaction between HMP and C8OH for stabilizing emulsions, while such effect was observed neither between partially hydrolyzed polyacrylamide and 1-octanol nor between HMP and 1-octane. In the bulk phase of aqueous solution, the C8OH can be solubilized in the micro-domains of HMP, enhancing the intermol. association structure and slowing down the creaming rate of the corresponding emulsions. The adsorption at the oil-water interface of HMP can be enhanced and tighter interfacial film can be formed due to the formation of the hydrogen bond between HMP and C8OH. The obtained results are of obvious importance for designing the amphiphilic polymer-containing emulsion more suitable to improve oil recovery as well as for better understanding the self-assembling mechanism of amphiphilic polymers and fatty alcs.

Fuel published new progress about Emulsion stability. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Xiaoying published the artcileSolubility Determination and Thermodynamic Modeling of Buprofezin in Different Solvents and Mixing Properties of Solutions, Computed Properties of 111-87-5, the main research area is solubility thermodn model buprofezin solvent property solution.

In this work, the equilibrium solubility of buprofezin in different pure solvents was determined The mole solubility of buprofezin in these studied pure solvents increased with increasing temperature The solubility data decreased according to the following order: toluene > Et acetate > DMF > acetone > 1-octanol > 1-butanol > n-propanol > acetonitrile > isopropanol > ethanol > methanol > water. The results were correlated with four thermodn. models (the modified Apelblat equation, λh equation, NRTL model, and Wilson model), and the values of root-mean-square deviation (RMSD) and relative average deviation (RAD) are no >27.26 × 10-4 and 2.76%, resp. Due to the maximum values of RAD and RMSD were 1.58% and 3.77 × 10-4 in modified Apelblat equation, which indicate that it is a suitable model to describe the results. Besides, the mixing Gibbs energy, mixing enthalpy, and mixing entropy were computed. The values of ΔmixG are neg. in this experiment; therefore, the dissolution process is a spontaneous and favorable process, and the ΔmixS are all pos., which indicate the dissolving process is entropy favorable as well.

Journal of Chemical & Engineering Data published new progress about Excess free energy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Katagiri, Mayu published the artcileMagneto-Plasmonic Co@Pt@Au Nanocrystals for Biosensing and Therapeutics, Name: n-Octanol, the main research area is magnetism plasmon resonance cobalt platinum gold nanocrystal biosensor therapeutic.

Multifunctional nanoparticles (NPs) exhibiting high magnetic property and plasmonic resonance are expected to be advanced nanomaterials which enable therapy, detection, and diagnosis simultaneously for medical applications. To achieve the practical performance of the multifunctional NPs, the precise design and synthesis are both required. In this work, considering the chem. stability and controllability, Co-Pt@Au core-shell NPs, which exhibit high magnetic property and plasmonic resonance, were theor. designed based on calculation and then exptl. synthesized using an alc. reduction method. Co-Pt NPs were uniformly synthesized using a technique which enables reduction control of Pt through the formation of a Pt-oleylamine complex. Moreover, depending on the Co/Pt ratio, the distribution of Co and Pt in a nanoparticle was precisely controlled, and as a result, Co-Pt alloy and Co@Pt core-shell NPs were individually prepared In particular, Co@Pt NPs exhibit a high magnetic property and are suitable for Au coating due to a small lattice mismatch. In fact, Au coating onto Co@Pt NPs was successfully performed via inhomogeneous nucleation, which results in Co@Pt@Au NPs exhibiting plasmonic response of Au with high magnetic property and being dispersed in water by ligand exchange for in vivo use. The developed synthetic method enables designed synthesis of complicated multicomponent nanoparticles through tunable reduction reaction and provides highly potential NPs for transport and sensing applications.

ACS Applied Nano Materials published new progress about Magnetic materials. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Man published the artcileMixtures of octanol and an ionic liquid: Structure and transport, Recommanded Product: n-Octanol, the main research area is structure transport mixture octanol ionic liquid.

Ionic liquids (ILs) with long alkyl substituents are amphiphilic, which leads to a bicontinuous liquid structure. The strongly interacting anionic and cationic head groups form a long range charge network, with the hydrocarbon tails forming a nonpolar domain. Such nonpolar domains have been shown to dissolve a variety of neutral organic solvents. In mixtures of ILs with solvents the neutral organic mols. residing in the nonpolar domains experience different environments and friction from the charged cations and anions. Thus, the neutral mols. diffuse much faster than predicted by hydrodynamic scaling using the average viscosity of the mixture In this work, we report studies on the structure and transport properties of mixtures of 1-octanol with the IL trihexyltetradecylphosphonium bis(trifluoromethylsulfonyl)imide (P6,6,6,14+/NTf2-). The majority of the atom fraction in the P6,6,6,14+ cation comprises four hydrocarbon substituents. The unique amphiphilic nature of ILs with the P6,6,6,14+ cation makes 1-octanol fully miscible with the IL at ambient temperatures X-ray scattering experiments show that the IL structure persists in the mixtures for 1-octanol mole fractions as large as xoct = 0.90. The self-diffusion coefficients of the three mol. species in the mixtures were measured by NMR experiments The self-diffusion of the P6,6,6,14+ cation is well described by the Stokes-Einstein equation, while the diffusivity of the NTf2- anion is slightly lower than the hydrodynamic prediction. The measured diffusivities of octanol in these mixtures are 1.3-4 times higher than the hydrodynamic predictions. (c) 2020 American Institute of Physics.

Journal of Chemical Physics published new progress about Activation energy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Xiaorong published the artcileStudy on stable mass transfer and enrichment of phenol by 1-octanol/kerosene/polyvinyl chloride polymer inclusion membrane, SDS of cas: 111-87-5, the main research area is octanol polyvinyl chloride kerosene liquid paraffin phenol mass transfer; 1-Octanol; Mass transfer; Phenol; Polymer inclusion membrane; Stability.

A polymer inclusion membrane (PIM) that contains a polyvinyl chloride (PVC) polymer matrix and 1-octanol (OCT) as specific carrier (PO-PIM) was prepared to investigate the mass transfer behavior of phenol in aqueous solutions Results showed that the mass transfer behavior of the PO-PIM for phenol conformed to the first-order kinetics. In addition, the mass transfer efficiency for phenol reached the maximum when the OCT content was 82.8 wt%. The mass transfer activation energy (Ea) was 14.46 kJ mol-1, which indicated that intramembranous diffusion was the main controlling factor in the mass transfer process. The introduction of hydrophobic additives, such as kerosene, liquid paraffin and vegetable oil, into the PO-PIM could remarkably improve its stability. In an aqueous solutions of phenol ranging from 0 mg L-1 to 9000 mg L-1, the initial flux (J0) of kerosene/PVC/OCT-PIM (KPO-PIM) was pos. correlated with the initial concentration of phenol. For a stripping solution with a feed solution pH of 2.0 and a sodium hydroxide concentration of 0.1 mol L-1, the maximum permeability coefficient during stable mass transfer reached 12.55μm s-1. At a mass transfer area of 3.14 cm2, an enrichment factor (EF) of 3.5 for 200 mg L-1 of phenolic aqueous solution was achieved within 48 h through KPO-PIM.

Environmental Pollution (Oxford, United Kingdom) published new progress about Activation energy. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maghsoudi, Majid published the artcileDevelopment of electrically assisted solvent bar microextraction followed by high performance liquid chromatography for the extraction and quantification of basic drugs in biological samples, SDS of cas: 111-87-5, the main research area is solvent bar microextraction high performance liquid chromatog extraction; Basic drugs; Biological sample; Electrically assisted solvent bar microextraction; Plasma; Urine.

In this study, a new extraction procedure is introduced based on elec. assisted solvent bar microextraction In the first step, the analytes are transferred from sample solution to the hollow fiber supported organic solvent. After that, with the aid of an elec. field, the analytes migrated into the aqueous extractant. The proposed approach was used to extract the three basic drugs (including lidocaine, diltiazem, and propranolol) from the plasma and urine samples. Under the optimized condition, (the supported organic solvent: 1-octanol, stirring rate: 300 rpm, pH of sample solution: 12.0, salt concentration: 2.0% (w/v), extraction time: 15 min, aqueous extractant: (30μL, 100 mM HCl), back-extraction time: 2 min, back-extraction voltage: 100 V), the proposed procedure presented wide linearities with coefficients of determination more than 0.992 over a concentration range of 5.0-1000 ng mL-1. The limit of detection was also determined in the range of 0.5 to 5.0 ng mL-1, repeatability (intra-day) was between 3.3 and 11.1% (n = 4), and reproducibility (inter-day) was between 4.3 and 14.6% (n = 4 days). It was indicated that the proposed approach could effectively extract the analytes from the plasma and urine samples, and the relative recoveries were between 90.2 and 105.6%, indicating the validity of this method.

Journal of Chromatography A published new progress about Biological samples. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, SDS of cas: 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts