Tag: M.W=100-150

da Silva, Marliane Cassia Soares published the artcileProcessing techniques and microbial fermentation on microbial profile and chemical and sensory quality of the coffee beverage, Computed Properties of 97-67-6, the main research area is coffee beverage chem sensory quality microbial fermentation.

Post-harvest processing and microbial fermentation of coffee fruits play an essential role in the metabolites formation that influence the nutritional and sensory quality of the beverage. Thus, the objective of this study was to analyze the effect of coffee cherries processing and fermentation conditions on the microbial communities and the chem. and sensory quality of the beverage. Induced fermentation changed in the bacteria and fungi communities (Treatments: T1, T3, and T7). Klebsiella sp. inoculation (T1) allowed an increase in richness of bacteria and 81 points in the sensory score over the fermentation time. However, there was a reduction in richness of microbial community in treatments with Saccharomyces cerevisiae (T3 and T7). An increase in the indexes of microbial diversity was observed in 72 h in treatment with coffee pulp (T2). In treatment with coffee cherries and spontaneous fermentation (T4) had a higher sensory score than other treatments, indicating a sensory gain from 36 to 72 h. Coffee cherries with superficial disinfection (T5) had a reduction in microbial profile, but did not change the final score of the beverage over the 72 h. In T6 (floaters fruits) was observed an alteration in the fungal community (36-72 h) and the lowest sensory score. The impact of adding water on coffee fermentation was dependent on time (T3 and T7). Furthermore, 5-hydroxymethylfurfural has a pos. correlation with the final score of the beverage. Thus, microbial profile and sensory score of beverages are dependent of conditions of processing of coffee fruits and fermentation

European Food Research and Technology published new progress about Coffee beverages. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Computed Properties of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cipullo, Miriam published the artcileHuman GTPBP5 is involved in the late stage of mitoribosome large subunit assembly, Synthetic Route of 97-67-6, the main research area is GTPBP5 FASTKD4 mitoribosome large subunit assembly.

Human mitoribosomes are macromol. complexes essential for translation of 11 mitochondrial mRNAs. The large and the small mitoribosomal subunits undergo a multistep maturation process that requires the involvement of several factors. Among these factors, GTP-binding proteins (GTPBPs) play an important role as GTP hydrolysis can provide energy throughout the assembly stages. In bacteria, many GTPBPs are needed for the maturation of ribosome subunits and, of particular interest for this study, ObgE has been shown to assist in the 50S subunit assembly. Here, we characterize the role of a related human Obg-family member, GTPBP5. We show that GTPBP5 interacts specifically with the large mitoribosomal subunit (mt-LSU) proteins and several late-stage mitoribosome assembly factors, including MTERF4:NSUN4 complex, MRM2 methyltransferase, MALSU1 and MTG1. Interestingly, we find that interaction of GTPBP5 with the mt-LSU is compromised in the presence of a non-hydrolysable analog of GTP, implying a different mechanism of action of this protein in contrast to that of other Obg-family GTPBPs. GTPBP5 ablation leads to severe impairment in the oxidative phosphorylation system, concurrent with a decrease in mitochondrial translation and reduced monosome formation. Overall, our data indicate an important role of GTPBP5 in mitochondrial function and suggest its involvement in the late-stage of mt-LSU maturation.

Nucleic Acids Research published new progress about Computer program. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sun, Weixiao published the artcileEffective Control of Particle Size and Electron Density of Pd/C and Sn-Pd/C Nanocatalysts for Vanillin Production via Base-Free Oxidation, Formula: C8H18O, the main research area is nanocatalyst palladium carbon tin vanillyl alc oxidation vanillin preparation.

The effective control of particle size and electron d. of metal active sites is challenging yet important for supported nanoparticles, as size effects and promoter effects play vital roles in heterogeneous catalysis on the nanoscale. In this work, we report Pd/C and Sn-Pd/C nanocatalysts for the base-free aerobic oxidation of vanillyl alc. to vanillin, a challenging reaction not only in the fundamental research of selective oxidation of alcs. but also for the practical transformation of bio-based alcs. to value-added chems. We effectively tuned the mean size of Pd nanoparticles from 1.8 to 6.7 nm by varying the temperature used for catalyst preparation and further modified the electron d. of the Pd/C catalyst by adding a SnO2 promoter with different loadings. TEM, HAADF-STEM, XPS, CO chemisorption, and in situ DRIFT-IR of CO adsorption characterizations allowed us to get insight into the unique catalytic properties of Pd nanocatalysts. It was conjectured that the base-free aerobic oxidation of vanillyl alc. to vanillin over the Pd/C catalyst can be a structure-sensitive reaction and the Pd particle size was decisive for the dispersion of Pd, the proportion of catalytically active Pd0 sites, and the intrinsic turnover frequency (iTOF). The 1 weight % Pd/C (1.8 nm) catalyst showed an iTOF value of 268 h-1 and 100% yield to vanillin at 120°C, 5 bar of O2, and 20 mg of the catalyst within 9 h. We further demonstrated that Sn4+ ions in SnO2 as an electronic promoter can promote Pd/C activity by the formation of highly active, electron-sufficient Pd0 sites which significantly lowered the apparent activation energy of reaction. The 0.1Sn-Pd/C catalyst showed a higher iTOF value of 458 h-1 and a yield of 100% to vanillin at 120°C, 3 bar of O2 and 15 mg of the catalyst within 6 h. Moreover, we verified a satisfying reusability and an adequate substrate scope over the 0.1Sn-Pd/C catalyst.

ACS Catalysis published new progress about Electron density. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Roulet, Julia published the artcileModification of PapA5 acyltransferase substrate selectivity for optimization of short-chain alcohol-derived multimethyl-branched ester production in Escherichia coli, COA of Formula: C8H18O, the main research area is acyltransferase Mycobacterium tuberculosis Escherichia coli; Acyltransferase; Mutant variants; Polyketide-associated protein; Substrate selectivity.

Abstract: Plant waxes are interesting substitutes of fossil-derived compounds; however, their limited sources and narrow structural diversity prompted the development of microbial platforms to produce esters with novel chem. structures and properties. One successful strategy was the heterologous expression of the mycocerosic polyketide synthase-based biosynthetic pathway (MAS-PKS, PapA5 and FadD28 enzymes) from Mycobacterium tuberculosis in Escherichia coli. This recombinant strain has the ability to produce a broad spectrum of multimethyl-branched long-chain esters (MBE) with novel chem. structures and high oxidation stability. However, one limitation of this microbial platform was the low yields obtained for MBE derived of short-chain alcs. In an attempt to improve the titers of the short-chain alc.-derived MBE, we focused on the PapA5 acyltransferase-enzyme that catalyzes the ester formation reaction. Specific amino acid residues located in the two-substrate recognition channels of this enzyme were identified, rationally mutated, and the corresponding mutants characterized both in vivo and in vitro. The phenylalanine located at 331 position in PapA5 (F331) was found to be a key residue that when substituted by other bulky and aromatic or bulky and polar amino acid residues (F331W, F331Y or F331H), gave rise to PapA5 mutants with improved bioconversion efficiency; showing in average, 2.5 higher yields of short-chain alc.-derived MBE compared with the wild-type enzyme. Furthermore, two alternative pathways for synthesizing ethanol were engineered into the MBE producer microorganism, allowing de novo production of ethanol-derived MBE at levels comparable with those obtained by the external supply of this alc. Key points: • Mutation in channel 2 changes PapA5 acyltransferase bioconversion efficiency. • Improved production of short-chain alc. derived multimethyl-branched esters. • Establishing ethanologenic pathways for de novo production of ethanol derived MBE. • Characterization of a novel phenylethanol-derived MBE.

Applied Microbiology and Biotechnology published new progress about Escherichia coli. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sprakel, Lisette M. J. published the artcileImproving understanding of solvent effects on intermolecular interactions in reactive liquid-liquid extraction with Isothermal Titration Calorimetry and molecular modeling, Category: alcohols-buliding-blocks, the main research area is trioctylamine acetic acid solvent effect intermol interaction liquid extraction.

Isothermal Titration Calorimetry (ITC) and mol. modeling (MM) were combined with liquid-liquid equilibrium data to obtain better understanding of solvent effects on complexation in reactive liquid-liquid extraction Two examples with ample extraction literature available were studied, acetic acid extraction and phenol extraction Interactions with binary solvents were studied. Based on the insight and quantification of complexation with MM and ITC, models describing the liquid-liquid equilibrium (LLE) were formulated and validated with experiments, showing that ITC can predict LLE. ITC together with MM indeed can yield addnl. insight in complexation behavior in reactive liquid-liquid extraction and may guide solvent selection procedures.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about Binary solutions. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Gray, Geoffrey M. published the artcileSecondary structure of peptides mimicking the Gly-rich regions of major ampullate spidroin protein 1 and 2, Synthetic Route of 111-87-5, the main research area is spider silk dope secondary structure helix simulation; 3(1)-helices; Dope; Secondary structure; Simulation; Spider silk.

Spider dragline silk has highly desirable material properties, possessing high extensibility, strength, and biocompatibility. Before it is spun, the constituent proteins are stored in a concentrated dope that is void of fibrils. To investigate the structural properties of the amorphous fiber regions in the dope, computer simulations were performed on model peptides representing the N. clavipes Gly-rich regions. Anal. of the secondary structure found predominantly turns, bends and coils; a small 31-helical population decreased with increasing concentration Interestingly, the population of 31-helixes saw a large increase in octanol. These results indicate that the unusual 31-helical secondary structure of the Gly-rich region of the fiber is a consequence of the spinning process, and that the low dielec. environment of the fiber may assist in favoring this structure.

Biophysical Chemistry published new progress about Biocompatibility. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Qiu, Yaxin published the artcileSelectively Sensing Capacities of Biocompatible Shape Memory Materials Based on Cross-Linked Poly(L-malic acid): Visual Discrimination of the Solvents with Similar Structures, HPLC of Formula: 97-67-6, the main research area is sensor biocompatibility shape memory crosslinking polymalic acid solvent discrimination.

A biomass-derived and biocompatible poly(L-malic acid) (PMA) based material with shape memory effect (SME) was developed in this work. 1,8-Octanediol was used as the crosslinker to construct crosslinking networks with hydrophilic backbone chain of PMA, tuning the d. of networks and their swelling capacities by controlling -COOH/-OH ratios. The solvent-induced SME of as-obtained crosslinked PMAs was activated under mild conditions in this way. Using the shape recovery levels of U-shaped samples as the probes, the mixed methanol/ethanol/water systems with various ratios could be easily discriminated because the crosslinked PMAs show different sensing capacities to different components. The mechanisms were then studied in terms of the solvent mol.-polymer interactions. This work provides an interesting approach of visible discrimination of the solvents with similar structures, or their mixtures with various ratios, and also opens applications of biocompatible shape memory polymers in biomedical and chem. industries.

ACS Applied Polymer Materials published new progress about Biocompatibility. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, HPLC of Formula: 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Vieira, Nicole S. M. published the artcileHuman cytotoxicity and octanol/water partition coefficients of fluorinated ionic liquids, Name: n-Octanol, the main research area is fluorinated ionic liquid cytotoxicity octanol water partition coefficient; 1-Octanol/water partition coefficient; Cytotoxicity; Fluorinated ionic liquids; Hydrophilic/lipophilic balance.

The use of fluorinated ionic liquids (FILs) as novel materials in biol. and pharmaceutical applications is an emerging research field. The knowledge of their cytotoxicity and that of 1-octanol/water partition coefficients are essential to assess their environmental risks, to estimate their toxicity and activity, or the hydrophilic/lipophilic balance, as well as to explore their properties as solvents in extraction processes or for successful drug design. The study of the cytotoxicity in four different human cell lines and the exptl. measurement of the partition coefficient between 1-octanol and water (Po/w), using the slow-stirring method, were carried out for several FILs. In both studies, the effect of the cation ([C2C1Im]+, [C2C1py]+, [C4C1pyr]+, [N1112(OH)]+, or [N4444]+), the cationic alkyl side-chain length ([CnC1Im]+, with n = 2, 6, 8 or 12), and the anionic fluorinated chain length/anionic fluorinated domain size ([C4F9SO3] ̅, [C8F17SO3] ̅, or [N(C4F9SO3)2] ̅) were analyzed. The results reveal that both toxicity and partition properties are mainly influenced by the size of the cationic hydrogenated alkyl side-chain and that of the anionic fluorinated domain. The intrinsic tuneability of the FILs allows for their selection according to the lipophilic or hydrophilic character of the target biol. system under consideration. The toxicity studies corroborate the biocompatible nature of some FILs tested in this work. Along, for all the FILs under study Po/w < 1.00. Accordingly, a decadic logarithm of the bioconcentration factor in fish of 0.5 would be estimated, which is below the regulatory endpoint used by regulatory agencies. Chemosphere published new progress about Biocompatibility. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bermejo, Jesus F. published the artcileWater-soluble carbosilane dendrimers: synthesis, biocompatibility and complexation with oligonucleotides; evaluation for medical applications, Related Products of alcohols-buliding-blocks, the main research area is carbosilane dendrimer biocompatibility oligonucleotide plasmid gene delivery.

Novel amine- or ammonium-terminated carbosilane dendrimers of type nG-[Si{OCH2(C6H3)-3,5-(OCH2CH2NMe2)2}]x, nG-[Si{O(CH2)2N(Me)(CH2)2NMe2}], and nG-[Si{(CH2)3NH2}]x or nG-[Si{OCH2(C6H3)-3,5-(OCH2CHNMe3+I-)2}]x, nG-[Si{O(CH2)2N(Me)(CH2)2NMe3+I-}]x, and nG-[Si{(CH2)3NH3+Cl-}]x have been synthesized and characterized up to the third generation by two strategies: (1) alcoholysis of Si-Cl bonds with amino alcs. and subsequent quaternization with MeI, and (2) hydrosilylation of allylamine with Si-H bonds of the dendritic systems and subsequent quaternization with HCL. Quaternized carbosilane dendrimers are soluble in water, although degradation is apparent due to hydrolysis of Si-O bonds. However, dendrimers containing Si-C bonds are water-stable. The biocompatibility of the second-generation dendrimers in primary cell cultures of peripheral blood mononuclear cells (PBMCs) and erythrocytes have been analyzed, and they show good toxicity profiles over extended periods. In addition, we describe a study on the interactions between the different carbosilane dendrimers and DNA oligodeoxynucleotides (ODNs) and plasmids along with a comparative anal. of their toxicity. They can form complexes with DNA ODNs and plasmids at biocompatible doses via electrostatic interaction. Also a preliminary transfection assay has been accomplished. These results demonstrate that the new ammonium-terminated carbosilane dendrimers are good base mols. to be considered for biomedical applications.

Chemistry – A European Journal published new progress about Biocompatibility. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Han published the artcileDesign of 2,5-furandicarboxylic based polyesters degraded in different environmental conditions: Comprehensive experimental and theoretical study, Recommanded Product: 2,2′-Oxydiacetic acid, the main research area is furandicarboxylic acid polyester seawater biodegradability mol dynamic simulation; Catalytic mechanism; Degradable polyesters; Enzymatic degradation; Hydrolytic reaction; MD simulation.

Nowadays, the promotion and application of aliphatic-aromatic copolyesters, such as poly (butylene adipate-co-terephthalate) (PBAT), are growing into a general trend. Although the structures of diacids exerted substantial impacts on degradation behavior, the underlying mechanisms have rarely been studied. In this work, 2,5-Furandicarboxylic acid was combined with succinic acid (PBSF), adipic acid (PBAF) and diglycolic acid (PBDF) to prepare three kinds of copolyesters. They showed unique degradation behaviors in buffer, enzyme environment and artificial seawater. These characteristics are closely related to the structural compositions of diacids. PBAFs displayed impressive biodegradability when catalyzed by Candida antarctica lipase B (CALB), while the more hydrophilic PBDFs exhibited faster hydrolysis in both buffer and artificial seawater. PBSFs, with hydrophobic and short segments, obtained a relatively slower rate of hydrolysis and enzymic degradation The reactivity sites and hydrolytic pathway were revealed by the combination of DFT calculation and Fukui function anal. MD simulations, QM/MM optimizations and theozyme calculations showed that PBAF-CALB was prone to form a pre-reaction state, leading to the reduced energy barrier in the acylation process. This work revealed the effects of different structural features of diacids on polymer degradation and paved a way to design target biodegradable polymers in different degradation conditions.

Journal of Hazardous Materials published new progress about Biodegradability. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2′-Oxydiacetic acid, and the molecular formula is C4H6O5, Recommanded Product: 2,2′-Oxydiacetic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts