Tag: M.W=100-150

Zsabka, Peter published the artcileSelective extraction of trivalent actinides using CyMe4BTPhen in the ionic liquid Aliquat-336 nitrate, Name: n-Octanol, the main research area is trivalent actinide ionic liquid aliquat336 nitrate phase transfer catalyst.

The extraction of Am(III), Cm(III) and Eu(III) by 2,9-bis(5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-1,2,4-benzotriazin-3-yl)-1,10-phenanthroline (CyMe4BTPhen) from nitric acid solution was studied using the ionic liquid Aliquat-336 nitrate ([A336][NO3]) as diluent. Results show a high selectivity of the solvent for Am(III) and Cm(III) over Eu(III), but rather slow extraction kinetics. The kinetics of CyMe4BTPhen were largely improved by the addition of 0.005 mol L-1N,N,N’,N’-tetra-n-octyl-diglycolamide (TODGA) as a phase transfer reagent and by the use of 1-octanol as co-diluent. The addition of the phase transfer catalyst and co-diluent did not compromise the selectivity towards the actinide/lanthanide separation and thus this four-component system can be successfully applied to sep. Am(III) and Cm(III) from the lanthanides.

RSC Advances published new progress about Ionic liquids. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Name: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Duss, Markus published the artcileA new simplified tray efficiency model with improved accuracy for sieve trays, Product Details of C8H18O, the main research area is sieve tray efficiency ammonia styrene acetic acid.

Engineers rarely use modern tray efficiency models due to the high effort required implementing them and due to their lack of accuracy. The more rigorous traditional models require many input parameters; newer mechanistic models increase the complexity even further. In sharp contrast, O’Connell’s empirical but simple correlation is widely applied despite its shortcomings.We will present a simplified model based on the traditional approach that allows a process engineer to estimate the tray efficiency during the hydraulic design phase, when an equilibrium stage simulation is available. Despite the simplifications, the new model achieves improved accuracy at predicting the section efficiencies when compared to both the O’Connell method and to more rigorous (and complicated) modern methods.

Chemical Engineering Research and Design published new progress about Mass transfer. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Product Details of C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Naeem, Mohammad published the artcileEffective performance of CeO2 based silica for preparation of octanal, Related Products of alcohols-buliding-blocks, the main research area is octanal ceria silica nanoparticle oxidation catalyst property.

Alcs. are naturally occurring substances that are mainly used to prepare aldehydes through oxidation/dehydrogenation processes (such as coupling transfer dehydrogenation reactions), where unsaturated organic compounds are used as an oxidants. In the industrial field, various homogeneous and heterogeneous catalysts are used for the oxidation of alcs. and the formation of aldehydes in a short period of time, greater chem. conversion, high yields and higher selectivity. In this work, silica and ceria nanoparticles have been synthesized by sol-gel and co-precipitation methods, where silica is used as a support material for catalytically active nano-sized ceria. Catalyst calcined at 600°C and characterized by FT-IR, TEM, SEM and XRD was used for liquid-phase oxidation of primary alcs. Maximum percentage conversion with high selectivity of octanol to octanal was obtained at 60°C in 1 h with respect to 0.5 g catalytic dose. In the presence of a heterogeneous catalyst, the percentage conversion and selectivity of octanol to octanal was found to increase over time.

Journal of Porous Materials published new progress about Nanoparticles. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Price, Paige M. published the artcileClustering of Iron Oxide Nanoparticles with Amphiphilic Invertible Polymer Enhances Uptake and Release of Drugs and MRI Properties, Recommanded Product: n-Octanol, the main research area is iron oxide nanoparticles polymers.

A functionalization of iron oxide nanoparticles (NPs) of different diameters by the amphiphilic invertible polymer, (PEG600-alt-PTHF650)k (PEG and PTHF stand for poly(ethylene glycol) and poly(tetrahydrofuran), resp.), leads to different NP/polymer architectures for dye/drug uptake and release, as is reported here for the first time. It is demonstrated that 18.6 ± 1.4 and 11.9 ± 0.6 nm NPs are individually coated by this polymer, while 5.9 ± 0.6 nm NPs form nanoparticle clusters (NPCs) which could be isolated by either ultracentrifugation or magnetic separation This phenomenon is most likely due to the character of the (PEG600-alt-PTHF650)k macromol. with alternating hydrophilic and hydrophobic fragments and its dimensions sufficient to cause NP clustering. Utilizing Rhodamine B base (RBB) and doxorubicin (DOX), the data on uptake upon mixing and further release via inversion into octanol (mimicking the penetration of the cell biomembrane) are presented. The magnetic NPCs display enhanced uptake and release of both RBB and DOX most likely due to the higher retained polymer amount The NPCs also display exceptional magnetic resonance imaging properties. This and the high uptake/release efficiency of the NPCs combined with easy magnetic separation make them promising for theranostic probes for magnetically targeted drug delivery.

Particle & Particle Systems Characterization published new progress about Nanoparticles. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Recommanded Product: n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Parpinello, Giuseppina Paola published the artcileComparison of Sangiovese wines obtained from stabilized organic and biodynamic vineyard management systems, Synthetic Route of 505-10-2, the main research area is Sangiovese wine organic biodynamic vineyard management; Bioactive compounds; Biodynamic; Organic; Sensory evaluation; Volatiles compounds; Wine sustainability.

Sangiovese red wines produced from organic (ORG) and biodynamic (BDN) vineyards over two consecutive vintages (2011 and 2012) were compared for chem. and sensory parameters to investigate a sustainable approach to grape production The effects of management practice, vintage, and their interaction were investigated. The ORG wines showed higher total acidity and lower volatile acidity and pH. Although trained panelists highlighted some differences in astringency and odor complexity between ORG and BDN wines, consumers had no preference. The concentrations of anthocyanins, phenolic and cinnamic acids, and flavonols, as well as color components, did not differ-contrary to results from the conversion period from ORG to BDN (2009 and 2010) in the same vineyard (Parpinello, Rombola,́ Simoni, & Versari, 2015). Together, these two studies demonstrate that ORG and BDN wine characteristics tend to be similar after the first year of conversion, indicating that the BDN method can produce high-quality Sangiovese wine.

Food Chemistry published new progress about Wine analysis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Synthetic Route of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lan, Yi-Bin published the artcileCharacterization and differentiation of key odor-active compounds of ‘Beibinghong’ icewine and dry wine by gas chromatography-olfactometry and aroma reconstitution, Application In Synthesis of 505-10-2, the main research area is icewine aroma gas chromatog olfactometry; Aroma reconstitution; GC-O; Icewine; PLSR; Quantitative descriptive analysis; ‘Beibinghong’.

Freezing-thawing events contribute to the unique aroma profile of icewines. Differences in key odor-active volatile compounds between ‘Beibinghong’ (Vitis amurensis × V. vinifera) icewines and dry wines were investigated by gas chromatog.-olfactometry and gas chromatog.-mass spectrometry. Acceptable agreement between the olfactometric and quant. results was obtained. ‘Beibinghong’ icewine was characterized by high concentrations of volatile phenols, lactones, (E)-β-damascenone, and phenylacetaldehyde, which were associated with on-vine freezing-thawing events in grape. Low concentrations of higher alc. acetates and Et esters of fatty acids were attributed to hyperosmotic stress during fermentation The overall aroma of icewine could be mimicked by reconstitution containing 44 identified volatiles. Partial least squares regression anal. demonstrated that the concentrations of these volatile compounds determined the distinct sensory profiles of icewines, which have higher intensities of honey/sweet, smoky, caramel, dried fruit, apricot/peach, and floral aromas, and lower intensities of fresh fruity and herbaceous notes in comparison with dry wines.

Food Chemistry published new progress about Wine analysis. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Application In Synthesis of 505-10-2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Davidov, Tzila published the artcilePorcine arterial ECM hydrogel: Designing an in vitro angiogenesis model for long-term high-throughput research, Synthetic Route of 97-67-6, the main research area is angiogenesis porcine arterial ECM hydrogel; ECM hydrogel; angiogenesis; arterial ECM; in vitro model.

The field of angiogenesis research provides deep understanding regarding this important process, which plays fundamental roles in tissue development and different abnormalities. In vitro models offer the advantages of low-cost high-throughput research of angiogenesis while sparing animal lives, and enabling the use of human cells. Nevertheless, prevailing in vitro models lack stability and are limited to a few days’ assays. This study, therefore, examines the hypothesis that closely mimicking the vascular microenvironment can more reliably support longer angiogenesis processes in vitro. To this end, porcine arterial extracellular matrix (paECM)- a key component of blood vessels-was isolated and processed into a thermally induced hydrogel and characterized in terms of composition, structure, and mech. properties, thus confirming the preservation of important characteristics of arterial extracellular matrix. This unique hydrogel was further tailored into a three-dimensional model of angiogenesis using endothelial cells and supporting cells, in a configuration that allows high-throughput quant. anal. of cell viability and proliferation, cell migration, and apoptosis, thus revealing the advantages of paECM over frequently used biomaterials. Markedly, when applied with well-known effectors of angiogenesis, the model measures reflected the expected response, hence validating its efficacy and establishing its potential as a promising tool for the research of angiogenesis.

FASEB Journal published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Meng, Ning published the artcileDesign and semisynthesis of oleanolic acid derivatives as VEGF inhibitors: Inhibition of VEGF-induced proliferation, angiogenesis, and VEGFR2 activation in HUVECs, Product Details of C4H11NO2, the main research area is semisynthesis oleanolic acid derivative VEGF inhibitor VEGFR2 angiogenesis; Angiogenesis; Oleanolic acid; Structural modification; VEGF inhibitor; VEGFR2.

Angiogenesis inhibitors targeting the VEGF signaling pathway are developed into drugs for the treatment of vaious diseases, such as cancer, rheumatoid arthritis, and age-related macular degeneration. Recent studies have revealed that oleanolic acid (OA), a natural pentacyclic triterpenoid, inhibited the VEGF/VEGFR2 signaling pathway and angiogenesis in HUVECs, which may represent an attractive VEGF inhibitor. In this paper, rational structural modification towards OA was performed in order to improve its inhibitory effects aganist VEGF and anti-angiogenesis potential. As a result, a series of novel OA derivatives, possessing α,β-unsaturated ketone system in ring A and amide functional group at C-28, were prepared and evaluated for cytotoxicity and their ability to inhibit VEGF-induced abnormal proliferation of HUVECs. The results showed that two promising derivatives, OA-1 and OA-16, exhibited no in vitro cytotoxicity against HUVECs but showed more potent inhibitory activity against VEGF-induced proliferation and angiogenesis in HUVECs, compared with OA. The results of Western blot indicated that OA-1 and OA-16 inhibited VEGF-induced VEGFR2 activation. Furthermore, small interfering RNA experiments were performed to confirm that both compounds inhibited VEGF-induced angiogenesis via VEGFR2. Thus, the present study resulted in the discovery of new promising OA-inspired VEGF inhibitors, which can serve as potential lead compounds for the treatment of angiogenesis-related diseases.

Chinese Journal of Natural Medicines (Amsterdam, Netherlands) published new progress about Angiogenesis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Product Details of C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Schiffmann, L. M. published the artcileMitochondrial respiration controls neoangiogenesis during wound healing and tumour growth, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is mitochondrial respiration neoangiogenesis wound healing lung carcinoma melanoma.

Abstract: The vasculature represents a highly plastic compartment, capable of switching from a quiescent to an active proliferative state during angiogenesis. Metabolic reprogramming in endothelial cells (ECs) thereby is crucial to cover the increasing cellular energy demand under growth conditions. Here we assess the impact of mitochondrial bioenergetics on neovascularisation, by deleting cox10 gene encoding an assembly factor of cytochrome c oxidase (COX) specifically in mouse ECs, providing a model for vasculature-restricted respiratory deficiency. We show that EC-specific cox10 ablation results in deficient vascular development causing embryonic lethality. In adult mice induction of EC-specific cox10 gene deletion produces no overt phenotype. However, the angiogenic capacity of COX-deficient ECs is severely compromised under energetically demanding conditions, as revealed by significantly delayed wound-healing and impaired tumor growth. We provide genetic evidence for a requirement of mitochondrial respiration in vascular endothelial cells for neoangiogenesis during development, tissue repair and cancer.

Nature Communications published new progress about Angiogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Ferreira de Lima, Nayana published the artcileIn vitro metabolic stress induced by nitazoxanide and flubendazole combination in Taenia crassiceps cysticerci, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is Taenia crassiceps nitazoxanide flubendazole antiparasitic cysticercosis; Experimental cysticercosis; Flubendazole; Metabolism; Nitazoxanide.

Taenia crassiceps is often used as exptl. model for T. solium cysticercosis studies. Currently cysticercosis antiparasitic treatment is based on albendazole and praziquantel which may present side effects and parasitic resistance. The search for other antiparasitic drugs is necessary. Nitazoxanide (NTZ) and flubendazole (FLB) are broad spectrum antiparasitic drugs that present anti-cysticercosis effect. Metabolic analyses help to determine the impact of these drugs on parasites. The aim of this study was to determine the impact on the production and excretion of organic metabolites in T. crassiceps cysticerci after in vitro exposure to NTZ and FLB, isolated or in combination. T. crassiceps cysticerci were culture in RPMI medium and exposed to 10μg/mL of NTZ, 10μg/mL of FLB or 10μg/mL of NTZ +10μg/mL of FLB. 24 h after exposure, the parasites were chromatog. analyzed to determine the impact of these drugs on glycolysis, homolactic fermentation, tricarboxylic acid cycle, fatty acids oxidation and proteins catabolism. It was possible to determine that the drugs combination induced greater metabolic impact on cysticerci in comparison to the isolated drugs exposure. The drugs combination induced gluconeogenesis, metabolic acidosis, increase in tricarboxylic acid cycle and in proteins catabolism. While the NTZ isolated exposure induced metabolic acidosis and protein catabolism and the FLB isolate exposure induced gluconeogenesis and protein catabolism. These results show that the combination of drugs with different modes of action increase the antiparasitic effect and may be indicated as alternative cysticercosis treatments.

Experimental Parasitology published new progress about Cysticercosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts