Tag: M.W=100-150

Saric, Ankica published the artcileSolvothermal synthesis of zinc oxide nanoparticles: A combined experimental and theoretical study, Safety of n-Octanol, the main research area is zinc oxide nanoparticle solvothermal synthesis.

Zinc oxide particles were synthesized from zinc acetylacetonate in the presence of triethanolamine (TEA) and various alc. solvent, ethanol or octanol, at 170°. The structural, optical, and morphol. characteristics of ZnO particles were monitored using X-ray powder diffraction (XRD), UV-Vis and FT-IR spectroscopies, and field emission SEM (FE-SEM). The exptl. findings were confirmed by means of DFT calculations which were obtained in nonpolar alc. 1-octanol, as a follow up to our previous study in polar ethanol. The nucleation and formation mechanism of ZnO nanoparticles is proposed considering the results obtained from a computational study of Gibbs free energies of ZnO-TEA mol. interactions (ΔG*INT) in various solvent system. The calculations revealed different binding affinities which initiated the nucleation processes of ZnO nanoparticles in the presence of alcs. of different size and polarity. The high chelating efficiency of TEA towards zinc with tetrahedral geometry is observed The results of X-ray diffraction size-strain anal. indicate the presence of size anisotropy as well as a reduction in the ZnO crystallite size with the change of solvent from ethanol to 1-octanol (<10 nm). Journal of Molecular Structure published new progress about Bond length. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Safety of n-Octanol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cilloni, Daniela published the artcileIron overload alters the energy metabolism in patients with myelodysplastic syndromes: results from the multicenter FISM BIOFER study, Recommanded Product: (S)-2-hydroxysuccinic acid, the main research area is myelodysplastic syndrome iron metabolism.

Abstract: Myelodysplastic syndromes (MDS) are hematol. malignancies characterized by ineffective hematopoiesis and increased apoptosis in the bone marrow, which cause peripheral cytopenia. Although the energy metabolism could represent an attractive therapeutic target, it was poorly investigated in MDS. The purpose of the study was to analyze how the presence of myelodysplastic hematopoiesis, iron overload and chelation impact on mitochondrial metabolism We compared energy balance, OxPhos activity and efficiency, lactic dehydrogenase activity and lipid peroxidation in mononuclear cells (MNCs), isolated from 38 MDS patients and 79 healthy controls. Our data show that ATP/AMP ratio is reduced during aging and even more in MDS due to a decreased OxPhos activity associated with an increment of lipid peroxidation Moreover, the lactate fermentation enhancement was observed in MDS and elderly subjects, probably as an attempt to restore the energy balance. The biochem. alterations of MNCs from MDS patients have been partially restored by the in vitro iron chelation, while only slight effects were observed in the age-matched control samples. By contrast, the addition of iron chelators on MNCs from young healthy subjects determined a decrement in the OxPhos efficiency and an increment of lactate fermentation and lipid peroxidation In summary, MDS-MNCs display an altered energy metabolism associated with increased oxidative stress, due to iron accumulation. This condition could be partially restored by iron chelation.

Scientific Reports published new progress about Bone marrow. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Recommanded Product: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sa’adiyah, Devy Setiorini published the artcileSpatial Evolution of CO2-Contaminated Water Bubble Flows in a Vertical Pipe, COA of Formula: C8H18O, the main research area is carbon dioxide contaminated water bubble flow vertical pipe.

Experiments on CO2-water bubble flows in a vertical pipe were carried out for clean water, an aqueous NaCl solution, and an aqueous NaCl solution with 1-octanol to obtain databases of spatial evolutions of the flows with the impurities. Mass transfer correlations for bubbles in these liquids were implemented into a one-way bubble tracking method. Numerical predictions of the spatial evolution, e.g., transition from a bubbly to a slug flow, depending on the impurities agreed well with the experiments

Chemie Ingenieur Technik published new progress about Bubble flow. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, COA of Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hippmann, Anna A. published the artcileProteomic analysis of metabolic pathways supports chloroplast-mitochondria cross-talk in a Cu-limited diatom, Application of (S)-2-hydroxysuccinic acid, the main research area is proteome copper metabolism signaling mitochondria chloroplast oxidative stress Thalassiosira; Cu limitation; copper; cross‐talk; diatom; proteomics.

Diatoms are one of the most successful phytoplankton groups in our oceans, being responsible for over 20% of the Earth’s photosynthetic productivity. Their chimeric genomes have genes derived from red algae, green algae, bacteria, and heterotrophs, resulting in multiple isoenzymes targeted to different cellular compartments with the potential for differential regulation under nutrient limitation. The resulting interactions between metabolic pathways are not yet fully understood. We previously showed how acclimation to Cu limitation enhanced susceptibility to overredn. of the photosynthetic electron transport chain and its reorganization to favor photoprotection over light harvesting in the oceanic diatom Thalassiosira oceanica (Hippmann et al., 2017, 10.1371/journal.pone.0181753). In order to gain a better understanding of the overall metabolic changes that help alleviate the stress of Cu limitation, we have further analyzed the comprehensive proteomic datasets generated in that study to identify differentially expressed proteins involved in carbon, nitrogen, and oxidative stress-related metabolic pathways. Metabolic pathway anal. showed integrated responses to Cu limitation. The upregulation of ferredoxin (Fdx) was correlated with upregulation of plastidial Fdx-dependent isoenzymes involved in nitrogen assimilation as well as enzymes involved in glutathione synthesis, thus suggesting an integration of nitrogen uptake and metabolism with photosynthesis and oxidative stress resistance. The differential expression of glycolytic isoenzymes located in the chloroplast and mitochondria may enable them to channel both excess electrons and/or ATP between these compartments. An addnl. support for chloroplast-mitochondrial cross-talk is the increased expression of chloroplast and mitochondrial proteins involved in the proposed malate shunt under Cu limitation.

Plant Direct published new progress about Chloroplast. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Application of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Igamberdiev, Abir U. published the artcileCitrate valve integrates mitochondria into photosynthetic metabolism, Product Details of C4H6O5, the main research area is review citrate mitochondria photosynthetic metabolism; Citrate hemicycle; Citrate valve; Isocitrate dehydrogenase; Malate valve; Plant mitochondria; Redox regulation; Thermodynamic buffering.

While in heterotrophic cells and in darkness mitochondria serve as main producers of energy, during photosynthesis this function is transferred to chloroplasts and the main role of mitochondria in bioenergetics turns to be the balance of the level of phosphorylation of adenylates and of reduction of pyridine nucleotides to avoid over-energization of the cell and optimize major metabolic fluxes. This is achieved via the establishment and regulation of local equilibrium of the tricarboxylic acid (TCA) cycle enzymes malate dehydrogenase and fumarase in one branch and aconitase and isocitrate dehydrogenase in another branch. In the conditions of elevation of redox level, the TCA cycle is transformed into a non-cyclic open structure (hemicycle) leading to the export of the tricarboxylic acid (citrate) to the cytosol and to the accumulation of the dicarboxylic acids (malate and fumarate). While the buildup of NADPH in chloroplasts provides operation of the malate valve leading to establishment of NADH/NAD+ ratios in different cell compartments, the production of NADH by mitochondria drives citrate export by establishing conditions for the operation of the citrate valve. The latter regulates the intercompartmental NADPH/NADP+ ratio and contributes to the biosynthesis of amino acids and other metabolic products during photosynthesis.

Mitochondrion published new progress about Chloroplast. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Andrade, Brenda published the artcileNonionic Surfactant Properties of Amphiphilic Hyperbranched Polyglycerols, Category: alcohols-buliding-blocks, the main research area is nonionic surfactant amphiphilic hyperbranched polyglycerol.

The surfactant properties of amphiphilic hyperbranched polyglycerols (HPGs) were investigated. The HPGs were prepared by ring-opening multibranching polymerization of glycidol using hydrophobic initiators of varying size and structure. The cloud points for all HPG surfactants were found to be >80 °C in deionized water with >1 wt % NaCl. The HPG surfactants with hydrophilic-lipophilic balance values between 16 and 18 were found to form stable octanol/water (o/w) emulsions within a 24 h period. Several surface properties, including critical micelle concentration (CMC), efficiency of surface tension reduction (pC20), effectiveness of surface tension reduction (γCMC), surface excess concentration at the CMC (Γmax), min. area/mol. at the interface (Amin), and the CMC/C20 ratio of the HPG surfactants were measured in deionized water at 22.6 °C. In general, increasing HPG size was marked by an increase in min. surface area per mol. (Amin) at the aqueous liquid/air interface. This increase in size also led to lower CMC and greater pC20 values of HPG surfactants prepared with Tergitol 15-S-7 initiator (HPG 5a-5d), a com. available ethylene glycol oligomer with a branched hydrophobic tail.

Langmuir published new progress about Cloud point. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sibirtsev, Stephan published the artcileAutomation of a Procedure for the Experimental Investigation of Liquid-Liquid Phase Separation, Formula: C8H18O, the main research area is octanol water liquid phase separation automation process.

Optimal design of a liquid-liquid settler requires exptl. investigation on phase separation behavior of the used material system under the same operating conditions as in the tech. application. Performing these experiments and evaluating the obtained data is highly time-consuming. To reduce manual effort, the procedure was largely automated. In this work, the exptl. setup, the automated procedure, and its validation results at various operating temperatures are presented. The results show the suitability of the automated procedure and the influence of temperature on phase separation behavior of the liquid-liquid system 1-octanol/water.

Chemie Ingenieur Technik published new progress about Coalescence. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Formula: C8H18O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wong, Shaio Wen published the artcileCatalysis in competing isocyanate reactions, COA of Formula: C7H18N2O, the main research area is phenyl isocyanate butanol esterification kinetics; dipropylenetriamine catalyst isocyanate butanol esterification; organotin catalyst isocyanate butanol esterification; amine catalyst isocyanate butanol esterification.

The effects of various organotin and tertiary amine catalysts on the product distributions in the esterification of Ph isocyanate (I) [103-71-9] with n-BuOH (II) [71-36-3] as model reaction for the preparation of polyurethanes were determined The esterification in the presence of N,N,N’,N’,N”-pentamethyldipropylenetriamine (III) [66537-05-1] catalyst in MeCN at 50° was first order with respect to I and III concentrations and half order with respect to II concentration with an apparent activation energy of 22.9 kcal/mol. Tri-Ph isocyanurate (IV) [1785-02-0], Bu phenylcarbamate  [1538-74-5], and Bu α,γ-diphenylallophanate  [21367-12-4] were formed by the reaction with IV being the major reaction product. The presence of H2O delayed the reaction rate and inhibited the formation of IV.

Polimeri (Zagreb, Croatia) published new progress about Cyclization. 2212-32-0 belongs to class alcohols-buliding-blocks, name is N2-(2-Hydroxyethyl)-N1,N1,N2-trimethyl-1,2-ethylenediamine, and the molecular formula is C7H18N2O, COA of Formula: C7H18N2O.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Mackay, Amy D. published the artcileExercise, but Not Metformin Prevents Loss of Muscle Function Due to Doxorubicin in Mice Using an In Situ Method, Formula: C4H6O5, the main research area is doxorubicin metformin chemotherapy skeletal muscle function mitochondria; chemotherapy; exercise; metformin; mitochondria; muscle contractions; skeletal muscle.

Though effective in treating various types of cancer, the chemotherapeutic doxorubicin (DOX) is associated with skeletal muscle wasting and fatigue. The purpose of this study was to assess muscle function in situ following DOX administration in mice. Furthermore, pre-treatments with exercise (EX) or metformin (MET) were used in an attempt to preserve muscle function following DOX. Mice were assigned to the following groups: control, DOX, DOX + EX, or DOX + MET, and were given a single injection of DOX (15 mg/kg) or saline 3 days prior to sacrifice. Preceding the DOX injection, DOX + EX mice performed 60 min/day of running for 5 days, while DOX + MET mice received 5 daily oral doses of 500 mg/kg MET. Gastrocnemius-plantaris-soleus complex function was assessed in situ via direct stimulation of the sciatic nerve. DOX treatment increased time to half-relaxation following contractions, indicating impaired recovery (p < 0.05). Interestingly, EX prevented any increase in half-relaxation time, while MET did not. An impaired relaxation rate was associated with a reduction in SERCA1 protein content (p = 0.07) and AMPK phosphorylation (p < 0.05). There were no differences between groups in force production or mitochondrial respiration. These results suggest that EX, but not MET may be an effective strategy for the prevention of muscle fatigue following DOX administration in mice. International Journal of Molecular Sciences published new progress about Body weight. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lee, Pearl published the artcileTargeting glutamine metabolism slows soft tissue sarcoma growth, COA of Formula: C4H6O5, the main research area is soft tissue sarcoma glutamine metabolomics sarcomagenesis glutaminase 1.

Abstract: Tumor cells frequently utilize glutamine to meet bioenergetic and biosynthetic demands of rapid cell growth. However, glutamine dependence can be highly variable between in vitro and in vivo settings, based on surrounding microenvironments and complex adaptive responses to glutamine deprivation. Soft tissue sarcomas (STSs) are mesenchymal tumors where cytotoxic chemotherapy remains the primary approach for metastatic or unresectable disease. Therefore, it is critical to identify alternate therapies to improve patient outcomes. Using autochthonous STS murine models and unbiased metabolomics, we demonstrate that glutamine metabolism supports sarcomagenesis. STS subtypes expressing elevated glutaminase (GLS) levels are highly sensitive to glutamine starvation. In contrast to previous studies, treatment of autochthonous tumor-bearing animals with Telaglenastat (CB-839), an orally bioavailable GLS inhibitor, successfully inhibits undifferentiated pleomorphic sarcoma (UPS) tumor growth. We reveal glutamine metabolism as critical for sarcomagenesis, with CB-839 exhibiting potent therapeutic potential.

Nature Communications published new progress about Body weight. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, COA of Formula: C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts