Tag: M.W=100-150

Pichon, Maeva M. published the artcileTight-binding inhibition of jack bean α-mannosidase by glycoimidazole clusters, Quality Control of 22483-09-6, the main research area is tight binding jack bean mannosidase glycoimidazole cluster inhibition.

The best multivalent effects observed in glycosidase inhibition have been achieved so far with jack bean α-mannosidase (JBα-man) using iminosugar clusters based on weakly binding mismatching active-site-directed inhibiting epitopes (inhitopes) in the D-gluco series. Here, we synthesize and evaluate as JBα-man inhibitors a series of mono- to 14-valent glycoimidazoles with inhitopes displaying inhibition values up to the range of hundreds of nMs to study the impact of inhitope affinity on the multivalent effect. The most potent inhibitor of the series, a 14-valent mannoimidazole derivative, inhibits JBα-man with a nanomolar Ki value (2 ± 0.5 nM) and binding enhancements observed are, at best, relatively small (up to 25-fold on a valency-corrected basis). The results of this study support the fact that JBα-man-inhitope affinity and the strength of the inhibitory multivalent effect evolve in the opposite direction. The major impact of the glycoimidazole-based inhitope is found on the binding scenario; most of the synthesized mannoimidazole clusters as well as a 14-valent glucoimidazole derivative prove to be tight binding inhibitors of JBα-man.

Organic & Biomolecular Chemistry published new progress about Canavalia. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Quality Control of 22483-09-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Li, Zhengxin published the artcileGrowth Rates of Hydrogen Microbubbles in Reacting Femtoliter Droplets, Computed Properties of 111-87-5, the main research area is growth rate hydrogen microbubble reaction femtoliter droplet.

Chem. reactions in small droplets are extensively explored to accelerate the discovery of new materials and increase the efficiency and specificity in catalytic biphasic conversion and high-throughput analytics. In this work, we investigate the local rate of the gas-evolution reaction within femtoliter droplets immobilized on a solid surface. The growth rate of hydrogen microbubbles (≥500 nm in radius) produced from the reaction was measured online with high-resolution confocal microscopic images. The growth rate of bubbles was faster in smaller droplets and near the droplet rim in the same droplet. The results were consistent for both pure and binary reacting droplets and on substrates of different wettability. Our theor. anal. based on diffusion, chem. reaction, and bubble growth predicted that the concentration of the reactant depended on the droplet size and the bubble location inside the droplet, in good agreement with exptl. results. Our results reveal that the reaction rate may be spatially nonuniform in the reacting microdroplets. The findings may have implications for formulating the chem. properties and uses of these droplets.

Langmuir published new progress about Catalysis. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Computed Properties of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Karanjit, Sangita published the artcileA heterogeneous bifunctional silica-supported Ag2O/Im+Cl- catalyst for efficient CO2 conversion, Name: 3,5-Dimethylhex-1-yn-3-ol, the main research area is silica silver oxide imidazolium salt catalyst carbon dioxide conversion.

A silica-supported bifunctional heterogeneous catalytic system was developed based on imidazolium salt (Im+Cl-@SiO2) as an activator. The Im+Cl-@SiO2 activated both the Ag-catalyst and substrate for the carboxylative cyclization reaction of alcs. by the efficient utilization of CO2 under ambient conditions. The catalyst is quite stable and versatile and could be stored without the need of a protective atm. We also confirmed the reusability of the catalyst up to five cycles. Our catalytic system performed very well not only for the two-component reaction of propargyl alcs./amines with CO2, but also for the three-component reaction of propargyl alcs., CO2, and other alcs./amines with excellent yields of the corresponding carbonates and carbamates under mild reaction conditions. This system secures the advantages of both homogeneous and heterogeneous catalysis of ammonium salts with good activity, as well as easy isolation of the product and easy recovery of the catalyst.

Catalysis Science & Technology published new progress about Catalysts. 107-54-0 belongs to class alcohols-buliding-blocks, name is 3,5-Dimethylhex-1-yn-3-ol, and the molecular formula is C8H14O, Name: 3,5-Dimethylhex-1-yn-3-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Khorasani, Reza published the artcileHydrogen production from dairy wastewater using catalytic supercritical water gasification: Mechanism and reaction pathway, Formula: C4H10OS, the main research area is hydrogen production dairy wastewater catalytic supercritical water gasification.

The supercritical water gasification (SCWG) of real dairy wastewater (cheese-based or whey) was performed in a batch reactor in presence of two catalysts (MnO2, MgO) and one additive (formic acid). The operational conditions of this work were at a temperature range of 350-400 C and the residence time of 30-60 min. The catalysts and formic acid were applied in 1 wt%, 3 wt%, and 5 wt% to determine their effect on hydrogen production The concentrations of catalysts and formic acid were calculated based on the weight of feedstock without ash. The results showed that increased temperature and prolonged residence time contributed to the hydrogen production (HP) and gasification efficiency (GE). The gas yield of hydrogen in the optimum condition (400 C and 60 min) was achieved as 1.36 mmol/gr DAF (dry ash free). Formic acid addition was favored towards enhancing hydrogen content while the addition of metal oxides (MnO2 and MgO) had an apex in their hydrogen production and they reached the highest hydrogen in 1 wt% concentration then ebbed. Moreover, GE was increased by the addition of the catalysts and formic acid concentrations The highest hydrogen content (35.4%) was obtained in 1 wt% MnO2 and the highest GE (32.22%) was attained in the 5 wt% formic acid concentration A reaction pathway was proposed based on the GC-MS data of feedstock and produced liquid phase at different condition as well as similar studies.

International Journal of Hydrogen Energy published new progress about Catalysts. 505-10-2 belongs to class alcohols-buliding-blocks, name is 3-(Methylthio)propan-1-ol, and the molecular formula is C4H10OS, Formula: C4H10OS.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Hu, Yan published the artcileGossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton, Product Details of C4H6O5, the main research area is Gossypium allotetraploidy whole genome evolution.

Allotetraploid cotton is an economically important natural-fiber-producing crop worldwide. After polyploidization, Gossypium hirsutum L. evolved to produce a higher fiber yield and to better survive harsh environments than Gossypium barbadense, which produces superior-quality fibers. The global genetic and mol. bases for these interspecies divergences were unknown. Here we report high-quality de novo-assembled genomes for these two cultivated allotetraploid species with pronounced improvement in repetitive-DNA-enriched centromeric regions. Whole-genome comparative analyses revealed that species-specific alterations in gene expression, structural variations and expanded gene families were responsible for speciation and the evolutionary history of these species. These findings help to elucidate the evolution of cotton genomes and their domestication history. The information generated not only should enable breeders to improve fiber quality and resilience to ever-changing environmental conditions but also can be translated to other crops for better understanding of their domestication history and use in improvement.

Nature Genetics published new progress about Cell wall. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Torres, Maria J. published the artcileIntracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury, Product Details of C4H6O5, the main research area is ischemia reperfusion injury intracardiac ephrinA1 mitochondrial bioenergetics; Cardioprotection; Mitochondrial bioenergetics; Myocardial infarction; ephrinA1.

Herein, 10 wk-old B6129SF2/J male mice were exposed to acute ischemia/reperfusion injury immediately followed by intracardiac injection of either EphrinA1-Fc or IgG-Fc. After 24 h of reperfusion, sections of the infarct margin in the left ventricle were imaged via transmission electron microscopy, and mitochondrial function was assessed in both permeabilized fibers and isolated mitochondria, to examine mitochondrial structure, function, and energetics in the early stages of repair. At a structural level, EphrinA1-Fc administration prevented the I/R-induced loss of sarcomere alignment and mitochondrial organization along the Z disks, as well as disorganization of the cristae and loss of inter-mitochondrial junctions. Preservation of cardiac bioenergetics was not due to changes in mitochondrial JH2O2 emitting potential, membrane potential, ADP affinity, efficiency of ATP production, or activity of the main dehydrogenase enzymes, suggesting that EphrinA1-Fc indirectly maintains respiratory function via preservation of the mitochondrial network. Moreover, these protective effects were lost in isolated mitochondria, further emphasizing the importance of the intact cardiomyocyte ultrastructure in mitochondrial energetics. Collectively, these data suggest that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.

Life Sciences published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yang, Nanmu published the artcileHBXIP drives metabolic reprogramming in hepatocellular carcinoma cells via METTL3-mediated m6A modification of HIF-1α, Synthetic Route of 97-67-6, the main research area is hepatocellular carcinoma HBXIP METTL3 m6A HIF1alpha hepatocyte prognosis; HBXIP; HIF-1α; METTL3; N6-methyladenosine methylation; hepatocellular carcinoma.

Cancer cells sustain high levels of glycolysis and glutaminolysis via reprogramming of intracellular metabolism, which represents a driver of hepatocellular carcinoma (HCC) progression. Understanding the mechanisms of cell metabolic reprogramming may present a new basis for liver cancer treatment. Herein, we collected HCC tissues and noncancerous liver tissues and found hepatitis B virus X-interacting protein (HBXIP) was found to be upregulated in HCC tissues and associated with poor prognosis. The N6-methyladenosine (m6A) level of hypoxia-inducible factor-1α (HIF-1α) in HCC cells was evaluated after the intervention of METTL3. The possible m6A site of HIF-1α was queried and the binding relationship between METTL3 and HIF-1α was verified. The interference of HBXIP suppressed HCC malignant behaviors and inhibited the Warburg effect in HCC cells. METTL3 was upregulated in HCC tissues and pos. regulated by HBXIP. Overexpression of METTL3 restored cell metabolic reprogramming in HCC cells with partial loss of HBXIP. HBXIP mediated METTL3 to promote the metabolic reprogramming and malignant biol. behaviors of HCC cells. The levels of total m6A in HCC cells and m6A in HIF-1α were increased. METTL3 had a binding relationship with HIF-1α and mediated the m6A modification of HIF-1α. In conclusion, HBXIP drives metabolic reprogramming in HCC cells via METTL3-mediated m6A modification of HIF-1α.

Journal of Cellular Physiology published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Synthetic Route of 97-67-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

He, Nianzhe published the artcileDiscovery of selective Mcl-1 inhibitors via structure-based design and structure-activity relationship analysis, Product Details of C4H11NO2, the main research area is cervical cancer Mcl1 Bcl2 anticancer apoptosis structure activity relationship; Apoptosis; Cancer; Mcl-1; Protein–protein interaction.

Based on Nap-1, a Mcl-1/Bcl-2 dual inhibitor reported by our group, we carried out a structure-guided mol. design and structure-activity relationship (SAR) anal. to study structural features contributing to Mcl-1 binding selectivity and affinity. A series of derivatives of Nap-1 with various pharmacophores were synthesized and among them a dual Mcl-1/Bcl-2 inhibitor A4 with enhanced affinities (IC50 = 0.15 μM for Mcl-1, 0.43 μM for Bcl-2) and a selective Mcl-1 inhibitor B9 with a 20-fold selectivity over Bcl-2 (IC50 = 0.51 μM vs 9.46 μM) were obtained by enzyme linked immunosorbent assay (ELISA). The SAR data and binding modes of A4 and B9 investigated by 2D-NMR derived docking study illustrated that p2 pockets exhibiting different geometry and binding features between Mcl-1 and Bcl-2 contribute to specific binding properties of Mcl-1. In addition, apoptosis-inducing potencies of A4 and B9 were consistent with their binding selectivity determined in vitro.

Biochemical and Biophysical Research Communications published new progress about Apoptosis. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Product Details of C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Garcia-Caballero, Melissa published the artcileRole and therapeutic potential of dietary ketone bodies in lymph vessel growth, Safety of (S)-2-hydroxysuccinic acid, the main research area is dietary ketone body lymph vessel growth therapeutics.

Abstract: Lymphatic vessels (LVs), lined by lymphatic endothelial cells (LECs), are indispensable for life1. However, the role of metabolism in LECs has been incompletely elucidated. In the present study, it is reported that LEC-specific loss of OXCT1, a key enzyme of ketone body oxidation2, reduces LEC proliferation, migration and vessel sprouting in vitro and impairs lymphangiogenesis in development and disease in Prox1ΔOXCT1 mice. Mechanistically, OXCT1 silencing lowers acetyl-CoA levels, tricarboxylic acid cycle metabolite pools, and nucleotide precursor and deoxynucleotide triphosphate levels required for LEC proliferation. Ketone body supplementation to LECs induces the opposite effects. Notably, elevation of lymph ketone body levels by a high-fat, low-carbohydrate ketogenic diet or by administration of the ketone body β-hydroxybutyrate increases lymphangiogenesis after corneal injury and myocardial infarction. Intriguingly, in a mouse model of microsurgical ablation of LVs in the tail, which repeats features of acquired lymphoedema in humans, the ketogenic diet improves LV function and growth, reduces infiltration of anti-lymphangiogenic immune cells and decreases edema, suggesting a novel dietary therapeutic opportunity.

Nature Metabolism published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Miniero, Daniela Valeria published the artcileThe Interaction of Hemin, a Porphyrin Derivative, with the Purified Rat Brain 2-Oxoglutarate Carrier, Product Details of C4H6O5, the main research area is hemin porphyrin derivative rat brain oxoglutarate carrier; induced-fit molecular docking; inhibition; kinetic study; mitochondrial carrier; porphyrin derivatives; single binding centre gated pore mechanism.

The mitochondrial 2-oxoglutarate carrier (OGC), isolated and purified from rat brain mitochondria, was reconstituted into proteoliposomes to study the interaction with hemin, a porphyrin derivative, which may result from the breakdown of heme-containing proteins and plays a key role in several metabolic pathways. By kinetic approaches, on the basis of the single binding center gated pore mechanism, we analyzed the effect of hemin on the transport rate of OGC in uptake and efflux experiments in proteoliposomes reconstituted in the presence of the substrate 2-oxoglutarate. Overall, our exptl. data fit the hypothesis that hemin operates a competitive inhibition in the 0.5-10 μM concentration range. As a consequence of the OGC inhibition, the malate/aspartate shuttle might be impaired, causing an alteration of mitochondrial function. Hence, considering that the metabolism of porphyrins implies both cytoplasmic and mitochondrial processes, OGC may participate in the regulation of porphyrin derivatives availability and the related metabolic pathways that depend on them (such as oxidative phosphorylation and apoptosis). For the sake of clarity, a simplified model based on induced-fit mol. docking supported the in vitro transport assays findings that hemin was as good as 2-oxoglutarate to bind the carrier by engaging specific ionic hydrogen bond interactions with a number of key residues known for participating in the similarly located mitochondrial carrier substrate binding site.

Biomolecules published new progress about Apoptosis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Product Details of C4H6O5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts