Tag: M.W=0-100

Adding a certain compound to certain chemical reactions, such as: 124-68-5, 2-Amino-2-methyl-1-propanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, category: alcohols-buliding-blocks, blongs to alcohols-buliding-blocks compound. category: alcohols-buliding-blocks

To a stirred solution of 2, 4-dichloro-5-methoxypyrimidine (5 g, 27.93 mmol) in 1, 4-dioxane (50 mL) under argon atmosphere were added diisopropylethylamine (7.2 g,55.86 mmol) and 2-amino-2-methylpropan-1-ol (2.4 g, 27.93 mmol) at RT. The reaction mixture was stirred at 130 C for 48 h. After consumption of the starting materials (monitored by TLC), the volatile components were evaporated in vacuo.The residue was diluted with a saturated sodium bicarbonate solution (50 mL) and extracted with EtOAc (2 x 50 mL). The combined organic extracts were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified by column chromatography using 10% EtOAc:hexanes to afford 2-((2-chloro-5 -methoxypyrimidin-4-yl) amino)-2-methylpropan- 1 -ol (5.5 g, 84%) as a white solid. ?H-NMR(DMSO-d6, 500 MHz): oe 7.69 (s, 1H), 6.19 (s, 1H), 6.11 (t, 1H), 3.82 (s, 3H), 3.45 (d, 2H), 1.33 (s, 6H); TLC: 50% EtOAc:hexanes (Rf 0.3).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,124-68-5, 2-Amino-2-methyl-1-propanol, and friends who are interested can also refer to it.

Reference:
Patent; FORUM PHARMACEUTICALS INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66696; (2015); A1;,
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Related Products of 616-29-5, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 616-29-5 as follows.

To a solution of l,3-diaminopropan-2-ol (5 g, 55.48 mmol) in MeOH (50 mL) was added TEA (16.84 g, 166.44 mmol, 23.17 mL) and Boc20 (31.48 g, 144.25 mmol, 33.14 mL) at 15 C. The mixture was stirred at 45C for 12 h under N2atmosphere. The reaction mixture was concentrated under reduced pressure. The residue was purified by column chromatography (silica gel, Petroleum ether/Ethyl acetate=20/l to 0: 1) to give /er/-butyl N-[3-(/er/- butoxycarbonylamino)-2-hydroxy-propyl] carbamate (15.47 g, 96.04% yield) as a white solid.1H NMR (400 MHz, CDCl3): d 5.03 (brs, 2H), 4.08-4.02 (m, 2H), 4.27 (s, 2H), 3.22-3.06 (m, 4H), 1.37 (s, 18H).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,616-29-5, its application will become more common.

Reference:
Patent; ARBUTUS BIOPHARMA, INC.; BI, Yingzhi; DORSEY, Bruce D.; FAN, Yi; MOORE, Christopher Brooks; NGUYEN, Duyan; (169 pag.)WO2019/191624; (2019); A1;,
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Electric Literature of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

A 50-L jacket vessel was charged with DCM (20 L) (KF 34 ppm), and cyclobutylmethyl alcohol (5.0 kg, 58.0 mol) followed by TEA (8850 mL, 63.5 mol). The reaction mixture was cooled to approximately -10C, and MsCl (4735 mL, 60.8 mol) was added via an addition funnel dropwise over approximately 3 hours, while the temperature was maintained below -5C. The reaction resulted in a yellow slurry after 70 minutes of aging. H20 (8 L) was added to give a clear solution, which was agitated for 15 minutes. Then, the organic layer was separated. H20 (8 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. Brine (10% solution, 4 L) was charged to the organic layer. The mixture was agitated for 20 minutes, and then the organic layer was separated. The organic phase was concentrated by vacuum distillation at approximately 30C to 40C and 28 inches Hg, resulting in a light brown residue (10.0 kg crude, approximately 9.5 kg product assumed, 58.0 mol, approximately 100% yield). A portion of the material was purified by distillation for characterization.1H NMR (CDC13, 400 MHz): ? 4.18 (d, J = 6.8 Hz, 2H), 3.00 (s, 3H), 2.71 (m, 1H), 2.11 (m, 2H), 2.00-1.80 (m, 4H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; MERCK SHARP & DOHME CORP.; WU, George, G.; ITOH, Tetsuji; MCLAUGHLIN, Mark; LIU, Zhijian; QIAN, Gang; WO2013/66734; (2013); A1;,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 2867-59-6, name is 3-Aminobutan-1-ol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Formula: C4H11NO

A mixture of 4-chloro-1-methyl-6-nitroquinolin-2(1/-/)-one (Intermediate F1 ; 250 mg, 1.05 mmol) and 3-aminobutan-1-ol (280 mg, 3.14 mmol) and DIPEA (0.36 mL, 2.10 mmol) in NMP (1.9 mL) was stirred at 160 C for 20h. The reaction mixture was allowed to cool to rt. The reaction mixture was diluted with water and extracted with EtOAc. The organic extracts were combined, washed with water and brine, dried (Na2S04) and concentrated in vacuo. Purification by flash chromatography (50 g KP-sil; 0% to 10% MeOH in CH2CI2, afforded 4- ((4-hydroxybutan-2-yl)amino)-1-methyl-6-nitroquinolin-2(1/-/)-one (200 mg, 66%). 1H NMR (500 MHz, CDCb) d 8.48 (d, J = 2.5 Hz, 1 H), 8.36 (dd, J = 9.3, 2.5 Hz, 1 H), 7.38 (d, J = 9.3 Hz, 1 H), 6.05 (d, J = 6.6 Hz, 1 H), 5.80 (s, 1 H), 4.10 – 3.97 (m, 1 H), 3.96 – 3.82 (m, 2H), 3.68 (s, 3H), 2.08 – 1.95 (m, 2H), 1.89 (dtd, J = 14.8, 6.3, 3.5 Hz, 1 H), 1.35 (d, J = 6.4 Hz, 3H). LCMS (Method T2) RT 1.21 min, m/z 292.13 [M+H]+.

With the rapid development of chemical substances, we look forward to future research findings about 2867-59-6.

Reference:
Patent; CANCER RESEARCH TECHNOLOGY LIMITED; THE INSTITUTE OF CANCER RESEARCH: ROYAL CANCER HOSPITAL; BELLENIE, Benjamin Richard; CHEUNG, Kwai Ming Jack; DAVIS, Owen Alexander; HOELDER, Swen; HUCKVALE, Rosemary; COLLIE, Gavin; MENICONI, Mirco; BRENNAN, Alfie; LLOYD, Matthew Garth; (222 pag.)WO2019/197842; (2019); A1;,
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Adding a certain compound to certain chemical reactions, such as: 16545-68-9, Cyclopropanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Safety of Cyclopropanol, blongs to alcohols-buliding-blocks compound. Safety of Cyclopropanol

Step 6: N-methyl-7-cyclopropoxy-6-nitro-1,2,3,4-tetrahydroisoquinoline N-methyl-7-fluoro-6-nitro-1,2,3,4-tetrahydroisoquinoline (150mg, 0.72mmol), sodium tert-butoxide (83mg, 0.86mmol) and N, N-dimethylformamide (5mL) were added to a 25ml reaction flask under nitrogen protection. The reaction was stirred for 10 minutes at 0C, and added with cyclopropanol (54mg, 0.93mmol) in N, N-dimethylformamide (5mL) solution. The reaction was stirred and reacted for 1 hour at 0C. After completion of the reaction, ethyl acetate and water were added to the reaction solution, and the reaction solution was extracted with ethyl acetate twice additionally. The combined organic phase was washed with saturated brine, dried and concentrated. The obtained crude product was separated and purified by column chromatography (silica gel column, eluent: ethyl acetate/petroleum ether, gradient: 0?50%) to obtain the title compound (140mg, 79%). (MS: [M+1] 249.1)

The synthetic route of 16545-68-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Beijing Pearl Biotechnology Limited Liability Company; DONG, Jiaqiang; ZHONG, Boyu; YUAN, Hongbin; SHI, Quan; CHU, Shaosong; ZHANG, Deyi; ZHANG, Ruihao; (219 pag.)EP3150592; (2017); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.2566-44-1, name is 2-Cyclopropylethanol, molecular formula is C5H10O, molecular weight is 86.13, as common compound, the synthetic route is as follows.Safety of 2-Cyclopropylethanol

EXAMPLE 172; 2-[9-(2-cyclopropylethoxy)-6-(2-hydroxy-2-methylpropyl)-leta-phenanthro[9,10-d]imidazol-2-yl]-5- fluoroisophthalonitrile; Step 1; 3-bromo-6-(2-cyclopropylethoxy)phenanthrene; To a mixture of 6-bromophenanthren-3-ol (3 g, 11 mmol) from Step 1 of Route A of Example 168, 2-cyclopropylethanol (2.85 g, 33 mmol) and triphenylphosphine (5.78 g, 22 mmol) in THF (50 mL) was added di-tert-butylazodicarboxylate (5.08 g, 22 mmol). The reaction mixture was stirred at room temperature overnight, then quenched with water. The aqueous layer was extracted with ethyl acetate. The combined organic layer was washed with brine, dried over MgSO4, filtered and concentrated. The material was purified by flash chromatography on silica (100% hexanes) to afford 3- bromo-6-(2-cyclopropylethoxy)phenanthrene.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,2566-44-1, 2-Cyclopropylethanol, and friends who are interested can also refer to it.

Reference:
Patent; MERCK FROSST CANADA LTD.; WO2007/59610; (2007); A1;,
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Reference of 4415-82-1, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 4415-82-1, name is Cyclobutylmethanol. This compound has unique chemical properties. The synthetic route is as follows.

4-Cyclobutylmethoxy-1H-indole-2-carboxylic acid (83) DEAD (2.1 ml, 13.65 mmol) is slowly added to a solution of 4-hydroxy-1 H-indole-2-carboxylic acid ethyl ester 79 (2 g, 9.75 mmol), triphenylphosphine (3.58 g, 13.65 mmol) and cyclobutyl-methanol (1.25 ml, 12.26 mmol) in 20 ml of THF, so that the temperature always remained below 30 OC. Stirring is continued for 2 hours and the solvent is then evaporated. The crude residue is purified by chromatography (cyclohexane : EtOAc/95: 5). Yield : 1. 86 g (70%). MS (ESI) : 274.2 [M+H] +, 1 H-NMR (CDC13) : 5 (ppm) 8.83 (s, 1 H), 7.35 (s, 1H), 7.21 (t, 1H), 6.98 (d, 1H), 6.49 (d, 1H), 4.4 (q, 2H), 4.07 (d, 2H), 2.85 (m, 1H), 2.17 (m, 2H), 1.95 (m, 4H), 1.42 (t, 3H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4415-82-1, Cyclobutylmethanol.

Reference:
Patent; NOVARTIS AG; NOVARTIS PHARMA GmbH; WO2005/77932; (2005); A2;,
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Reference of 110-73-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 110-73-6, name is 2-(Ethylamino)ethanol, molecular formula is C4H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: To a solution of 2-(chloromethyl)-4-(cyclohexylmethoxy)-1Hbenzo[d]imidazole 7 (0.72 mmol) in DMF (5 mL), K2CO3(0.79 mmol) and appropriate amine 8 or 9 or 10 (0.79 mmol) wereadded. The resulting solution was stirred at 60 C for 3 h. Themixture was cooled, diluted with water, and then extracted withEtOAc. The combined organic extracts were washed with water,brine solution, dried over anhydrous Na2SO4 and then concentratedunder reduced pressure. The crude mixture was subjected to flashsilica gel (230-400 mesh) column chromatography (eluting with0e2% MeOH in dichloromethane) to afford the title compounds 5.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 110-73-6, 2-(Ethylamino)ethanol.

Reference:
Article; Boggu, Pulla Reddy; Kim, Youngsoo; Jung, Sang-Hun; European Journal of Medicinal Chemistry; vol. 181; (2019);,
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Related Products of 534-03-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 534-03-2, name is 2-Aminopropane-1,3-diol, molecular formula is C3H9NO2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A stirred solution of 2-amino-1,3-propanediol (serinol) 4 (1 eq) and triethylamine (TEA) inMeOH (10 mL) was cooled at -20 C (carbon dioxide snow) and added dropwise a solutionof the corresponding acyl chloride (1.1 eq) in THF (5 mL). The reaction mixture was allowed towarm to room temperature and stirred overnight. Then it was poured into brine and extractedwith dichloromethane (3 10 mL). The combined organic phases were washed with brine, driedover MgSO4 and concentrated under reduced pressure. The residue was purified by flash columnchromatography on silica gel using as eluent EtOAc/MeOH (20:1 to 7:1) to provide the correspondingN-acyl serinol derivatives. 4.1.4. N-octanoyl Serinol (5)According to the general procedure serinol 4 (150 mg, 1.64 mmol) was treated with octyl chloride(1.81 mmol, 0.3 mL) and TEA (0.4 mL) to give 267 mg (75%) of 5 as an amorphous white solid.

According to the analysis of related databases, 534-03-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Jimenez, Aranza; Garcia, Pablo; De La Puente, Sofia; Madrona, Andres; Camarasa, Maria Jose; Perez-Perez, Maria-Jesus; Quintela, Jose-Carlos; Garcia-del Portillo, Francisco; San-Felix, Ana; Molecules; vol. 23; 7; (2018);,
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Application of 110-73-6, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 110-73-6, name is 2-(Ethylamino)ethanol. This compound has unique chemical properties. The synthetic route is as follows.

Potassium carbonate (10.4 g, 75.4 mmol) and 2-(ethylamino)ethanol (6.72 g, 75.4 mmol) were added to a solution of 2-bromo-1-phenylethanone (5.00 g, 25.1 mmol) in acetonitrile (150 ml), and the mixture was stirred at RT overnight. The solids were then removed by filtration, and the filtrate was concentrated under reduced pressure to afford the crude title compound which was used in the next step without further purification. Yield: 5.00 g (85% purity, 82% yield). LC/MS [Method 3]: Rt = 0.44 min; MS (ESIpos): m/z = 208 [M+H]+. 1H-NMR (400 MHz, DMSO-d6): d [ppm] = 7.55-7.48 (m, 2H), 7.37-7.23 (m, 3H), 4.11-4.03 (m, 1H), 3.67-3.59 (m, 1H), 3.48-3.36 (m, 1H), 2.76-2.67 (m, 2H), 2.36-2.26 (m, 1H), 2.16-2.06 (m, 1H), 2.01 (d, 1H), 0.99 (t, 3H).

According to the analysis of related databases, 110-73-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; BAYER AKTIENGESELLSCHAFT; BAYER PHARMA AKTIENGESELLSCHAFT; MUeLLER, Steffen; SCHOHE-LOOP, Rudolf; ORTEGA, HERNANDEZ, Nuria; SUeSSMEIER, Frank; JIMENEZ NUNEZ, Eloisa; BRUMBY, Thomas; LINDNER, Niels; GERDES, Christoph; POOK, Elisabeth; BUCHMUeLLER, Anja; GAUGAZ, Fabienne, Zdenka; LANG, Dieter; ZIMMERMANN, Stefanie; EHRMANN, Alexander, Helmut, Michael; GERISCH, Michael; LEHMANN, Lutz; TIMMERMANN, Andreas; SCHAeFER, Martina; SCHMIDT, Georg; SCHLEMMER, Karl-Heinz; FOLLMANN, Markus; KERSTEN, Elisabeth; WANG, Vivian; GAO, Xiang; WANG, Yafeng; (801 pag.)WO2019/219517; (2019); A1;,
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