Tag: 200-300

Versatility in acyltransferase activity completes chicoric acid biosynthesis in purple coneflower was written by Fu, Rao;Zhang, Pingyu;Jin, Ge;Wang, Lianglei;Qi, Shiqian;Cao, Yang;Martin, Cathie;Zhang, Yang. And the article was included in Nature Communications in 2021.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

Purple coneflower (Echinacea purpurea (L.) Moench) is a popular native North American herbal plant. Its major bioactive compound, chicoric acid, is reported to have various potential physiol. functions, but little is known about its biosynthesis. Here, taking an activity-guided approach, we identify two cytosolic BAHD acyltransferases that form two intermediates, caftaric acid and chlorogenic acid. Surprisingly, a unique serine carboxypeptidase-like acyltransferase uses chlorogenic acid as its acyl donor and caftaric acid as its acyl acceptor to produce chicoric acid in vacuoles, which has evolved its acyl donor specificity from the better-known 1-O-β-D-glucose esters typical for this specific type of acyltransferase to chlorogenic acid. This unusual pathway seems unique to Echinacea species suggesting convergent evolution of chicoric acid biosynthesis. Using these identified acyltransferases, we have reconstituted chicoric acid biosynthesis in tobacco. Our results emphasize the flexibility of acyltransferases and their roles in the evolution of specialized metabolism in plants. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Genetic and bioprocess engineering for the selective and high-level production of geranyl acetate in Escherichia coli was written by Wang, Xun;Zhang, Xinyi;Zhang, Jia;Xiao, Longjie;Zhou, Yujunjie;Zhang, Yu;Wang, Fei;Li, Xun. And the article was included in ACS Sustainable Chemistry & Engineering in 2022.Related Products of 367-93-1 The following contents are mentioned in the article:

Geranyl acetate is, as one of the monoterpenoids, a natural constituent of more than 60 essential oils. Production of such an ester fragrance compound by plant extracts is limited by low yield and high processing costs but plausible by microbial synthesis. We report a microbial cell factory that realizes selective and high-level geranyl acetate production in Escherichia coli. For this purpose, co-expression of geraniol synthase and alc. acetyltransferase was initially used to increase production yield, but a considerable quantity of precursor geraniol was also produced. Further, introducing an extra AAT gene copy and controlling the substrate glycerol supply enabled a drastically higher selective geranyl acetate production Eventually, the highest reported titer of 52.78 mM (equivalent to 10.36 g/L) geranyl acetate, accounting for 98.5% of total products, was achieved under a controlled fermentation system. Such selective and high-level geranyl acetate production by combining genetic and bioprocess engineering is also a promising strategy for other monoterpene esters in E. coli. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Related Products of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Related Products of 367-93-1

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Experimental and Computational Investigations of 4-((E)-(2-Amino-5- Nitrophenylimino)Methyl)-5- (Hydroxymethyl)-2-Methylpyridin-3-Ol Schiff Base Derived from Vitamin B₆ was written by Beyramabadi, S. A.;Khashi, M.;Morsali, A.;Gharib, A.;Chegini, H.. And the article was included in Journal of Structural Chemistry in 2018.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

An unsym. tridentate Schiff base 4-((E)-(2-amino-5-nitrophenylimino)methyl)-5-(hydroxymethyl)- 2-methylpyridin-3-ol is newly synthesized and characterized exptl. Its geometrical parameters, the assignment of IR bands and NMR chem. shifts are also computed by the d. functional theory method. In addition, the atoms in mols. (AIM) anal. is employed to investigate its geometry. Only one of the diamine-NH₂ groups undergoes the condensation reaction. In the structure of the synthesized Schiff base, the remaining amino group lies in the para position with respect to the nitro group (isomer 1). In both gas and solution phases, isomer 1 is more stable than isomer 2 with the meta orientation of the amino and nitro groups. The NMR chem. shifts and the AIM anal. show that isomer 1 is a more favorite structure for the synthesized Schiff base. It has no planar structure. The phenolic proton is engaged in the intramol. hydrogen bond with the azomethine nitrogen atom. The exptl. results are in good agreement with the theor. ones, confirming the validity of the optimized geometry. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Development of a ligand for in vivo imaging of mutant huntingtin in Huntington’s disease was written by Bertoglio, Daniele;Bard, Jonathan;Hessmann, Manuela;Liu, Longbin;Gartner, Annette;De Lombaerde, Stef;Huscher, Britta;Zajicek, Franziska;Miranda, Alan;Peters, Finn;Herrmann, Frank;Schaertl, Sabine;Vasilkovska, Tamara;Brown, Christopher J.;Johnson, Peter D.;Prime, Michael E.;Mills, Matthew R.;Van der Linden, Annemie;Mrzljak, Ladislav;Khetarpal, Vinod;Wang, Yuchuan;Marchionini, Deanna M.;Skinbjerg, Mette;Verhaeghe, Jeroen;Dominguez, Celia;Staelens, Steven;Munoz-Sanjuan, Ignacio. And the article was included in Science Translational Medicine in 2022.COA of Formula: C9H18O5S The following contents are mentioned in the article:

Huntington’s disease (HD) is a dominantly inherited neurodegenerative disorder caused by a CAG trinucleotide expansion in the huntingtin (HTT) gene that encodes the pathol. mutant HTT (mHTT) protein with an expanded polyglutamine (polyQ) tract. Whereas several therapeutic programs targeting mHTT expression have advanced to clin. evaluation, methods to visualize mHTT protein species in the living brain are lacking. Here, we demonstrate the development and characterization of a positron emission tomog. (PET) imaging radioligand with high affinity and selectivity for mHTT aggregates. This small mol. radiolabeled with 11C ([11C]CHDI-180R) allowed noninvasive monitoring of mHTT pathol. in the brain and could track region- and time-dependent suppression of mHTT in response to therapeutic interventions targeting mHTT expression in a rodent model. We further showed that in these animals, therapeutic agents that lowered mHTT in the striatum had a functional restorative effect that could be measured by preservation of striatal imaging markers, enabling a translational path to assess the functional effect of mHTT lowering. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1COA of Formula: C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.COA of Formula: C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Pyridoxal-based low molecular weight progelator as a new chemosensor for the recognition of Ag⁺ and Hg²⁺ under different conditions was written by Roy, Saswati Ghosh;Kumar, Abhishek;Misra, Neeraj;Ghosh, Kumaresh. And the article was included in Materials Advances in 2022.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Pyridoxal-based low mol. weight progelator 1 has been designed and synthesized for the selective visual detection of Ag⁺ ions through sol-to-gel conversion. Compound 1 shows excellent gelation property with desired gel stiffness only in the presence of Ag⁺ ions over a series of other metal ions in 1 : 1 (volume/volume) aqueous solvent system miscible with organic solvents such as DMSO, DMF, and dioxane, and validates the visual detection of Ag⁺ ions. The gel properties were studied by FTIR, UV-Vis, SEM (SEM), and rheol. measurements. Min. gelation concentration was found to be 3 mg mL^-1. While Ag⁺-induced metallogel in DMSO/H₂O is thermally reversible, it is irreversible in the DMF/H₂O system. The model compound 2, devoid of hydroxyl groups, did not show gelation under identical conditions and established the role of pyridoxal moiety in 1. In addition, compound 1 exhibits the selective sensing of Hg²⁺ ions over a series of metal ions in the solution phase, as established by UV-Vis, fluorescence, and ¹H NMR studies. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

The NMR structure of the engineered halophilic DnaE intein for segmental isotopic labeling using conditional protein splicing was written by Heikkinen, Harri A.;Aranko, A. Sesilja;Iwai, Hideo. And the article was included in Journal of Magnetic Resonance in 2022.Formula: C9H18O5S The following contents are mentioned in the article:

Protein trans-splicing catalyzed by split inteins has been used for segmental isotopic labeling of proteins for alleviating the complexity of NMR signals. Whereas inteins spontaneously trigger protein splicing upon protein folding, inteins from extremely halophilic organisms require a high salinity condition to induce protein splicing. We designed and created a salt-inducible intein from the widely used DnaE intein from Nostoc punctiforme by introducing 29 mutations, which required a lower salt concentration than naturally occurring halo-obligate inteins. We determined the NMR solution structure of the engineered salt-inducible DnaE intein in 2 M NaCl, showing the essentially identical three-dimensional structure to the original one, albeit it unfolds without salts. The NMR structure of a halo-obligate intein under high salinity suggests that the stabilization of the active folded conformation is not a mere result of various intramol. interactions but the subtle energy balance from the complex interactions, including the solvation energy, which involve waters, ions, co-solutes, and protein polypeptide chains. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Formula: C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Formula: C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lewis Acid-Promoted Typical Friedel-Crafts Reactions Using DMSO as a Carbon Source was written by Vodnala, Nagaraju;Singh, Sanjay;Hazra, Chinmoy Kumar. And the article was included in Journal of Organic Chemistry in 2022.Quality Control of 4,4′-Methylenediphenol The following contents are mentioned in the article:

A mild and efficient synthetic protocol for the synthesis of sym. and unsym. diarylmethanes (DAMs) R¹CH₂R² (R¹ = 4-methoxyphenyl, 2,4,6-trimethylphenyl, 1H-indol-3-yl, 4-hydroxy-2-oxo-2H-chromen-3-yl, etc.; R² = 4-hydroxy-3,5-dimethylphenyl, 5-methylfuran-2-yl, 4-amino-3,5-bis(propan-2-yl)phenyl, etc.) was reported. Using DMSO as the C₁ source and TMSOTf as the Lewis acid promoter, a series of functionalized sym. and unsym. DAMs was synthesized in high yields. Gratifyingly, DMSO plays a dual role as a solvent and a C₁ source and can also be replaced with its deuterated counterpart, DMSO-d₆, enabling the incorporation of the -CD₂ moiety into the diarylmethane skeleton. The developed approach has been applied to a wide range of substrates having various functional groups, and this protocol has also been extended to the synthesis of an anti-breast cancer agent and an anticoagulant agent using common feedstock compounds In addition, the postulated mechanism has been explicitly demonstrated via control experiments This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Quality Control of 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Quality Control of 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis, x-ray crystal structures, spectroscopic and electrochemical studies of Zn(II), Cd(II), Ni(II) and Mn(II) complexes of N¹,N⁴-bis(pyridoxylidene)triethylenetetramine was written by Mondal, Satyajit;Adak, Piyali;Das, Chandrima;Naskar, Sumita;Pakhira, Bholanath;Rheingold, Arnold L.;Sinn, Ekkehard;Eribal, Carla Sue;Chattopadhyay, Shyamal Kumar. And the article was included in Polyhedron in 2014.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

Zn(II), Cd(II), Ni(II) and Mn(II) complexes of a new hexadentate ligand N¹,N⁴-bis(pyridoxylidene)triethylenetetramine were synthesized. X-ray crystal structures show that in all the complexes the metal:ligand stoichiometry is 1:1 and the ligand coordinates in a di-deprotonated hexadentate manner through two phenolate oxygens, two imine nitrogens and two secondary amine N atoms. Fluorescence spectroscopy shows that the ligand centered emission undergoes 3-fold enhancement of intensity on complexation with Zn(II) ion, whereas it is quenched or remains unaffected in presence of various biol. relevant divalent metal ions. The Zn(II) specific fluorescence enhancement indicates that the ligand may be used as a fluorogenic sensor for Zn(II) in biol. systems, with a sensitivity of detection of 10^-8 M. The electronic structures of the ligand as well as the complexes and their UV-visible absorption spectra are explained on the basis of DFT and TD-DFT calculations, resp. Covalence of the metal ligand bond follows the order Ni(II) >>> Mn(II) > Zn(II) ≈ Cd(II). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Safety of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transiently gene-modulated cell reporter for ultrasensitive detection of estrogen-like compounds in tap water was written by Ren, Yun;Zheng, Jing;Wang, Hailin. And the article was included in Chemosphere in 2022.Name: 4,4′-Methylenediphenol The following contents are mentioned in the article:

Abnormal elevation of indispensable steroid hormone estrogens and exposure to exogenous estrogen-like compounds pose adverse health effects to aquatic animals and human alike. These compounds generally display functionally important estrogenic activity even at extremely low picomolar concentrations In this study we identified one critical but lethal gene (TAF1) that remarkably represses estrogenic activity. This gene is selected as a candidate for genetically modulating an estrogen-responding cell line. To overcome its lethality, instead of adopting a gene knockout strategy, we developed a transient TAF1 depletion strategy using a designed small interfering RNA. By the transient knockdown of TAF1 in the estrogen-responding reporter cell line, the maximum induction signals for endogenous estrogen 17β-estradiol (E2) and environmental estrogens 17α-ethynyl estradiol (EE2) and bisphenol compounds were enhanced by 4.8-13.3 folds. The limit of detection for EE2 is about 8 x 10-15 mol/L. Moreover, by the established method, trace estrogenic activity (14.7-24.2 pg E2 equiv (E2Eq)/L) can be detected in a portion of Tap water samples. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Name: 4,4′-Methylenediphenol).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: 4,4′-Methylenediphenol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cellular Computational Logic Using Toehold Switches was written by Choi, Seungdo;Lee, Geonhu;Kim, Jongmin. And the article was included in International Journal of Molecular Sciences in 2022.Electric Literature of C9H18O5S The following contents are mentioned in the article:

The development of computational logic that carries programmable and predictable features is one of the key requirements for next-generation synthetic biol. devices. Despite considerable progress, the construction of synthetic biol. arithmetic logic units presents numerous challenges. In this paper, utilizing the unique advantages of RNA mols. in building complex logic circuits in the cellular environment, we demonstrate the RNA-only bitwise logical operation of XOR gates and basic arithmetic operations, including a half adder, a half subtractor, and a Feynman gate, in Escherichia coli. Specifically, de-novo-designed riboregulators, known as toehold switches, were concatenated to enhance the functionality of an OR gate, and a previously utilized antisense RNA strategy was further optimized to construct orthogonal NIMPLY gates. These optimized synthetic logic gates were able to be seamlessly integrated to achieve final arithmetic operations on small mol. inputs in cells. Toehold-switch-based ribocomputing devices may provide a fundamental basis for synthetic RNA-based arithmetic logic units or higher-order systems in cells. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Electric Literature of C9H18O5S).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Electric Literature of C9H18O5S

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts