Tag: 200-300

A pyridoxal-based chemosensor for visual detection of copper ion and its application in bioimaging was written by Yin, Cai-Xia;Qu, Li-Jun;Huo, Fang-Jun. And the article was included in Chinese Chemical Letters in 2014.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A pyridoxal-based chemosensor (I) was synthesized by reacting hydrazine hydrate and pyridoxal hydrochloride in ethanol and characterized by NMR and ESI-MS. The optical properties of the compound were studied in a methanol: HEPES solution The compound displayed selectivity for Cu²⁺, as evidenced by a colorless to yellow color change, which was characterized using UV-visible spectroscopy. The fluorescence of the compound can be quenched only by Cu²⁺, accompanying by a color change from blue to colorless. Furthermore, it can be used in bioimaging. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reaction of Pyridoxal with Hydrophosphoryl Compounds was written by Kibardina, Lyudmila K.;Trifonov, Alexey V.;Dobrynin, Alexey B.;Pudovik, Michael A.;Burilov, Alexander R.;Sinyashin, Oleg G.. And the article was included in Heteroatom Chemistry in 2016.Related Products of 65-22-5 The following contents are mentioned in the article:

The products of carbonyl phosphonylation of pyridoxal with dialkylphosphinous acid, alkylphosphinic acid Et esters, and phosphorous acid dialkyl (or diphenyl) esters have been obtained for the first time. In some cases, the products of addition are hydrolytically unstable and stabilized by forming internal betaine structures. The reaction of pyridoxal with phosphorous acid in alc. solutions gives alkoxyfuropyridines possessing the iminium nitrogen atom. The structure and composition of the prepared compounds have been established by ³¹P and ¹H NMR spectroscopy, mass spectrometry (MALDI-TOF), and X-ray anal. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Transition metal complexes with thiosemicarbazide-based ligands. Part 60. Reactions of copper(II) bromide with pyridoxal S-methylisothiosemicarbazone (PLITSC). Crystal structure of [Cu(PLITSC-H)H₂O]Br·H₂O was written by Leovac, Vukadin M.;Vojinovic-Jesic, Ljiljana S.;Ivkovic, Sonja A.;Rodic, Marko V.;Jovanovic, Ljiljana S.;Hollo, Berta;Szecsenyi, Katalin Meszaros. And the article was included in Journal of the Serbian Chemical Society in 2014.COA of Formula: C8H10ClNO3 The following contents are mentioned in the article:

The synthesis and structural characterization of a square-planar copper(II) complex with pyridoxal S-methylisothiosemicarbazone (PLITSC) of the formula [Cu(PLITSC-H)H₂O]Br·H₂O (1) as the first Cu(II) complex with a monoanionic form of this ligand were described. Complex 1 together with two previously synthesized complexes [Cu(PLITSC)Br₂] (2) and [Cu(PLITSC)Br(MeOH)]Br (3) were characterized by elemental anal., IR and electronic spectroscopy and by the methods of thermal anal., conductometry and magnetic susceptibility. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5COA of Formula: C8H10ClNO3).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.COA of Formula: C8H10ClNO3

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kinetics of DNA looping by Anabaena sensory rhodopsin transducer (ASRT) by using DNA cyclization assay was written by Lee, Jae Jin;Kim, Sung Hyun;Lee, Keon Ah;Chuon, Kimleng;Jung, Kwang-Hwan;Kim, Doseok. And the article was included in Scientific Reports in 2021.Reference of 367-93-1 The following contents are mentioned in the article:

DNA cyclization assay together with single-mol. FRET was employed to monitor protein-mediated bending of a short dsDNA (∼ 100 bp). This method provides a simple and easy way to monitor the structural change of DNA in real-time without necessitating prior knowledge of the mol. structures for the optimal dye-labeling. This assay was applied to study how Anabaena sensory rhodopsin transducer (ASRT) facilitates loop formation of DNA as a possible mechanism for gene regulation. The ASRT-induced DNA looping was maximized at 50 mM of Na⁺, while Mg²⁺ also played an essential role in the loop formation. This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Reference of 367-93-1).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 367-93-1

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Alcohol – Wikipedia,
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A Bioisosteric and Scaffold Hopping Approach for the Design and Synthesis of Double Ring Replacement Analogues of 4-Aryl-4H-Chromenes and in silico Tubulin Inhibitor Studies was written by Kottha, Thirumalaswamy S.;Gnanasambandam, Vasuki. And the article was included in ChemistrySelect in 2018.Related Products of 65-22-5 The following contents are mentioned in the article:

An eco-friendly reaction protocol was developed for the synthesis of heterocyclic hybrid scaffolds through bioisosteric replacement and scaffold hopping approach. The isosteric analogs of salicylaldehyde were designed, identified/synthesized and employed in a three component reaction to afford bioisosteric analogs of 4-aryl-4H-chromenes. Thus central core swapping of benzene-pyridine/pyrazole ring on 4-aryl-4H-chromenes was achieved under simple one-pot reaction conditions and easy work-up. Docking studies show that almost all the compounds possess good binding affinities at the colchicine binding site of tubulin. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Selective Oxidation of Alkylarenes to the Aromatic Ketones or Benzaldehydes with Water was written by Zhang, Jin;Du, Jihong;Zhang, Chenyang;Liu, Kun;Yu, Feifei;Yuan, Yongkun;Duan, Baogen;Liu, Renhua. And the article was included in Organic Letters in 2022.Reference of 620-92-8 The following contents are mentioned in the article:

Here a palladium-catalyzed oxidation method for converting alkylarenes into the aromatic ketones or benzaldehydes ArC(O)R¹ [Ar = Ph, 4-MeC₆H₄, 4-HOC₆H₄, etc.; R¹ = H, Ph, 4-ClC₆H₄, etc.] with water as the only oxygen donor was reported. This C-H bond oxidation functionalization did not require other oxidants and hydrogen acceptors, and H₂ was the only byproduct. The oxygen atom introduced into the products was confirmed to be from water by the MS anal. on the product of the ¹⁸O-labeled water reaction. This study involved multiple reactions and reactants, such as 4,4′-Methylenediphenol (cas: 620-92-8Reference of 620-92-8).

4,4′-Methylenediphenol (cas: 620-92-8) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Reference of 620-92-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reaction of Pyridoxal with Phenols: Synthesis of Novel 1-Aryl-Substituted Furopyridines was written by Kibardina, Ludmila K.;Chumakova, Ludmila V.;Gazizov, Almir S.;Burilov, Alexander R.;Pudovik, Michail A.. And the article was included in Synthesis in 2015.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A new method based on the acid-catalyzed reaction of pyridoxal with polyfunctional phenols was developed for the synthesis of potentially biol. active 1-aryl-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ols. Advantages of this method include a good yield of the target furopyridines and the use of readily available hydrochloric acid as a catalyst. The possibility of extending the proposed approach to nucleophiles other than phenols was demonstrated by the synthesis of the known biol. active compound 1-(5-hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)-6-methyl-1,3-dihydrofuro[3,4-c]pyridin-7-ol hydrochloride (TM2002). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Name: 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A Domino Reaction for the Synthesis of Novel 1,3-Dihydrofuro[3,4-c]pyridines from Pyridoxal and Ketones was written by Casadia, Izamara;Daher, Thalita O.;Moura, Sidnei;Back, Davi F.;Faoro, Eliandro;Schwalm, Cristiane S.;Casagrande, Gleison A.;Paveglio, Guilherme C.;Pizzuti, Lucas. And the article was included in Synthesis in 2021.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride The following contents are mentioned in the article:

A convenient domino route for the synthesis of novel 1,3-dihydrofuro[3,4- c]pyridines from pyridoxal and alkyl, aryl or heteroaryl ketones under basic conditions is reported. A series of nine derivatives is obtained in 53-90% yields after stirring reactants for 48 h at room temperature Most products are easily isolated by filtration followed by recrystallization from ethanol. All products were fully characterized by FTIR, HRMS, and ¹H and ¹³C NMR spectroscopy. The X-ray crystal structure of a representative example of the 1,3-dihydrofuro[3,4- c]pyridine series is also presented. This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Application In Synthesis of 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chemical synthesis of 5′-β-glycoconjugates of vitamin B₆ was written by Bachmann, Thomas;Schnurr, Christian;Zainer, Laura;Rychlik, Michael. And the article was included in Carbohydrate Research in 2020.Related Products of 65-22-5 The following contents are mentioned in the article:

Various 5′-β-saccharides of pyridoxine, namely the mannoside, galactoside, arabinoside, maltoside, cellobioside and glucuronide, were synthesized chem. according to Koenigs-Knorr conditions using α4,3-O-isopropylidene pyridoxine and the resp. acetobromo glycosyl donors with AgOTf (3.0 equivalent) and NIS (3.0 equivalent) as promoters at 0°C. Furthermore, 5′-β-[¹³C₆]-labeled pyridoxine glucoside (PNG) was prepared starting from [¹³C₆]-glucose and pyridoxine. Addnl., two strategies were examined for the synthesis of 5′-β-pyridoxal glucoside (PLG). This study involved multiple reactions and reactants, such as 3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5Related Products of 65-22-5).

3-Hydroxy-5-(hydroxymethyl)-2-methylisonicotinaldehyde hydrochloride (cas: 65-22-5) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Related Products of 65-22-5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A light-controlled biocatalytic system for precise regulation of enzymatic decarboxylation was written by Cheng, Feng;Wu, Dong-Yang;Liang, Xi-Hang;Wang, Cheng-Jiao;Weng, Jia-Qi;Zou, Shu-Ping;Xu, Jian-Miao;Xue, Ya-Ping;Zheng, Yu-Guo. And the article was included in Catalysis Science & Technology in 2022.Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol The following contents are mentioned in the article:

Precise control of a biocatalytic system is highly important but remains a major challenge. Herein, we developed a light-controlled enzyme production-biocatalysis one-pot system by combination of photocatalysis and photogenetic-regulated enzyme production As proof-of-principle, a photoenzyme in an Escherichia coli-based biocatalyst was produced and restored by gene expression in the dark for decarboxylation under illumination. The kinetic resolution of racemic phosphinothricin with an intermittent illumination model displayed higher conversion (49%) and excellent stereoselectivity (ee = 98%), compared to a continuous illumination model (conv. = 44%; ee = 71%). This study involved multiple reactions and reactants, such as (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol).

(2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol (cas: 367-93-1) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Application In Synthesis of (2R,3R,4S,5R,6S)-2-(Hydroxymethyl)-6-(isopropylthio)tetrahydro-2H-pyran-3,4,5-triol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts