Tag: 200-300

Iridium and rhodium complexes bearing a silyl-bipyridine pincer ligand: synthesis, structures and catalytic activity for C-H borylation of arenes was written by Komuro, Takashi;Mochizuki, Daiki;Hashimoto, Hisako;Tobita, Hiromi. And the article was included in Dalton Transactions in 2022.Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Unsaturated 16-electron iridium and rhodium complexes bearing a silyl-bipyridine-based SiNN-pincer ligand (Bpy^SiNN) were synthesized and characterized by x-ray crystallog. and NMR spectroscopy. The iridium-Bpy^SiNN complex facilitated the catalytic C(sp²)-H borylation of arenes to give arylboronate esters in high yields (≥93%) under mild conditions (∼40°). In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Application In Synthesis of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Alcohol – Wikipedia,
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Modified Montmorillonite clay catalyzed regioselective ring opening of epoxide with amines and alcohols under solvent free conditions was written by Bhuyan, Diganta;Saikia, Lakshi;Dutta, Dipak Kumar. And the article was included in Applied Catalysis, A: General in 2014.Recommanded Product: Trans-2-(benzylamino)cyclohexanol This article mentions the following:

Modification of Montmorillonite by acid treatment depletes the layered structure and generates micro- and mesopores. The catalytic activity of naturally occurring Montmorillonite clay modified by acid treatment is reported for the reactions of epoxides with nucleophiles such as amines and alcs. at ambient temperature and solvent-free condition. The solid acid catalyst of the present study is reusable and exhibits significantly higher catalytic activities than known catalysts for the opening of the oxirane ring with nitrogen (aromatic as well as aliphatic amines) and oxygen (aromatic as well as aliphatic alcs.). A wide range of β-amino alcs. and β-alkoxy alcs. are synthesized with high epoxide conversion of excellent regioselectivity. The modified catalyst is recycled up to five times without significant loss in conversion and selectivity. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Recommanded Product: Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Recommanded Product: Trans-2-(benzylamino)cyclohexanol

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Alcohol – Wikipedia,
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Scandium triflate as an efficient and useful catalyst for the synthesis of β-amino alcohols by regioselective ring opening of epoxides with amines under solvent-free conditions was written by Placzek, Andrew T.;Donelson, James L.;Trivedi, Rushi;Gibbs, Richard A.;De, Surya K.. And the article was included in Tetrahedron Letters in 2005.Name: Trans-2-(benzylamino)cyclohexanol This article mentions the following:

A simple and efficient method was developed for the synthesis of β-amino alcs. by ring opening of epoxides in the presence of a catalytic amount of Sc(O₃SCF₃)₃ at room temperature under solvent-free conditions. The reaction works well with both aromatic and aliphatic amines. High regio- and diastereoselectivity can be considered as a noteworthy advantage of this method. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Name: Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: Trans-2-(benzylamino)cyclohexanol

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Alcohol – Wikipedia,
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Rh-Catalyzed Base-Free Decarbonylative Borylation of Twisted Amides was written by Bie, Fusheng;Liu, Xuejing;Shi, Yijun;Cao, Han;Han, Ying;Szostak, Michal;Liu, Chengwei. And the article was included in Journal of Organic Chemistry in 2020.COA of Formula: C12H16BBrO2 This article mentions the following:

We report the rhodium-catalyzed base-free decarbonylative borylation of twisted amides. The synthesis of versatile arylboronate esters from aryl twisted amides is achieved via decarbonylative rhodium(I) catalysis and highly selective N-C(O) insertion. The method is notable for a very practical, additive-free Rh(I) catalyst system. The method shows broad functional group tolerance and excellent substrate scope, including site-selective decarbonylative borylation/Heck cross-coupling via divergent N-C/C-Br cleavage and late-stage pharmaceutical borylation. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4COA of Formula: C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.COA of Formula: C12H16BBrO2

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Alcohol – Wikipedia,
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Pressurized-liquid extraction as an efficient method for valorization of Thymus serpyllum herbal dust towards sustainable production of antioxidants was written by Mrkonjic, Zivan;Rakic, Dusan;Kaplan, Muammer;Teslic, Nemanja;Zekovic, Zoran;Pavlic, Branimir. And the article was included in Molecules in 2021.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol This article mentions the following:

The aim of this study was to valorize Thymus serpyllum herbal dust, a particular fraction distinguished as an industrial waste from filter-tea production Pressurized liquid extraction (PLE) was used with the aim of overcoming certain obstacles of conventional extraction techniques in terms of shortening extraction time, reducing solvent consumption and energy costs, using green solvents and obtaining high yield and quality products. In order to optimize PLE of T. serpyllum herbal dust, the preliminary screening of the independent variables in order to define the most influential parameters and their domain was done first. After the screening, the optimization study using the face-centered central composite exptl. design (CCD) with response surface methodol. (RSM) was implemented. Addnl., taking into account the high awareness of the pos. influence of antioxidants on the human health and associating it with high content of polyphenolic compounds in various members of Lamiaceae family, PLE has proven to be a great approach for antioxidants recovery from T. serpyllum herbal dust. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Similar to water, an alcohol can be pictured as having an sp3 hybridized tetrahedral oxygen atom with nonbonding pairs of electrons occupying two of the four sp3 hybrid orbitals. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol

Referemce:
Alcohol – Wikipedia,
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Fast microwave-promoted palladium-catalyzed synthesis of phthalides from bromobenzyl alcohols utilizing DMF and Mo(CO)₆ as carbon monoxide sources was written by Wu, Xiongyu;Mahalingam, A. K.;Wan, Yiqian;Alterman, Mathias. And the article was included in Tetrahedron Letters in 2004.Recommanded Product: 60666-70-8 This article mentions the following:

A fast method utilizing in situ generated CO for the synthesis of phthalides was developed. DMF and Mo(CO)₆ were applied as two alternative CO-sources in these microwave promoted carbonylation-lactone formation reactions. Mo(CO)₆ was found to be the more generally applicable CO-source and provided phthalides as well as dihydroisocoumarin, 1-isoindolinone, and phthalimide from the corresponding aryl bromide via an efficient CO insertion within a 1 h reaction time. In the experiment, the researchers used many compounds, for example, (2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8Recommanded Product: 60666-70-8).

(2-Bromo-5-chlorophenyl)methanol (cas: 60666-70-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Recommanded Product: 60666-70-8

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Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A multi-residue method by supercritical fluid chromatography coupled with tandem mass spectrometry method for the analysis of chiral and non-chiral chemicals of emerging concern in environmental samples was written by Rice, Jack;Lubben, Anneke;Kasprzyk-Hordern, Barbara. And the article was included in Analytical and Bioanalytical Chemistry in 2020.Formula: C16H16O3 This article mentions the following:

Abstract: This manuscript presents the development, validation and application of a multi-residue supercritical fluid chromatog. coupled with tandem mass spectrometry method for the anal. of 140 chiral and non-chiral chems. of emerging concern in environmental samples, with 81 compounds being fully quant., 14 semi-quant. and 45 qual., validated according to European Medicine Agency (EMA) guidelines (European Medicines Agency 2019). One unified LC-MS method was used to analyze all analytes, which were split into three injection methods to ensure sufficient peak resolution The unified method provided an average of 113% accuracy and 4.5% precision across the analyte range. Limits of detection were in the range of 35 pg L^-1-0.7 μg L^-1, in both river water and wastewater, with an average LOD of 33 ng L^-1. The method was combined with solid-phase extraction and applied in environmental samples, showing very good accuracy and precision, as well as excellent chromatog. resolution of a range of chiral enantiomers including beta-blockers, benzodiazepines and antidepressants. The method resulted in quantification of 75% of analytes in at least two matrixes, and 56% in the trio of environmental matrixes of river water, effluent wastewater and influent wastewater, enabling its use in monitoring compounds of environmental concern, from their sources of origin through to their discharge into the environment. In the experiment, the researchers used many compounds, for example, 2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6Formula: C16H16O3).

2-(3-(Hydroxy(phenyl)methyl)phenyl)propanoic acid (cas: 59960-32-6) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C16H16O3

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Alcohol – Wikipedia,
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Visible-Light-Driven Reductive Carboarylation of Styrenes with CO₂ and Aryl Halides was written by Wang, Hao;Gao, Yuzhen;Zhou, Chunlin;Li, Gang. And the article was included in Journal of the American Chemical Society in 2020.COA of Formula: C12H16BBrO2 This article mentions the following:

The first example of visible-light-driven reductive carboarylation of styrenes with CO₂ and aryl halides in a regioselective manner has been achieved. A broad range of aryl iodides and bromides were compatible with this reaction. Moreover, pyridyl halides, alkyl halides, and even aryl chlorides were also viable with this method. These findings may stimulate the exploration of novel visible-light-driven Meerwein arylation-addition reactions with user-friendly aryl halides as the radical sources and the photocatalytic utilization of CO₂. Thus, e.g., reaction of 1,1-diphenylethylene with PhI and CO₂ under blue light in presence of [Ir(ppy)₂(dtbbpy)]PF₆ photocatalyst and hydrogen atom transfer catalyst DABCO with HCO₂K as terminal reductant and K₂CO₃ as base in DMSO followed by methylation afforded I (82%, 78% isolated). In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4COA of Formula: C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.COA of Formula: C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Bioactive-guided isolation and identification of oligostilbenes as anti-rheumatoid arthritis constituents from the roots of Caragana stenophylla was written by Pan, Lan;Zhang, Tao;Yu, Meng;Shi, Minghui;Jia, Xinyue;Jia, Xiaoguang;Zou, Zhongmei. And the article was included in Journal of Ethnopharmacology in 2021.Computed Properties of C14H12O4 This article mentions the following:

The roots of Caragana stenophylla have been used as folk medicine due to the functions of activating blood, diuresis, analgesic and tonicity, especially in treating rheumatoid arthritis and hypertension. However, the anti-rheumatoid arthritis mechanisms and bioactive ingredients have not previously been fully investigated. The aim of this study was to assess the anti-rheumatoid arthritis effects of the roots of Caragana stenophylla ethanol extract (EC), elucidate its mechanism of action and identify its active substances. Anti-rheumatoid arthritis activity of EC was assessed using type II-collagen induced arthritis in rats. Arthritis severity was evaluated by foot paw volume, arthritis index, joint swelling degree and histopathol. The serum inflammatory cytokines and matrix metalloproteinases (MMPs) were also detected by immunohistochem. anal. In addition, the protein expression of IκB, p-IκB, iNOS and COX-2 was analyzed by western blot. RAW 264.7 macrophage cells were employed to assess the anti-inflammatory effects of fractions and compounds in vitro. UPLC-Q-TOF-MS was adopted to appraise the ingredients of the active fraction of the roots of C. stenophylla. Furthermore, various chromatog. techniques and spectroscopic methods were used for isolation and structure elucidation of compounds The results showed that EC could reduce type II collagen-induced rheumatoid arthritis model arthritic score and histopathol. markedly at dose of 240 mg/kg. Besides, EC could suppress the levels of pro-inflammatory cytokines (IL-1β, IL-6, IL-8, IL-17, and TNF-α) and matrix metalloproteinases (MMP-3, MMP-9), and the expression levels of COX-2, p-IκB and iNOS also were declined. While, the levels of IL-10 and IκB were increased. The Et acetate fraction exhibited potent inhibitory effects against nitric oxide production in RAW 264.7 macrophage cells. Eleven main components including 1 flavonoid and 10 oligostilbenes from active fraction were isolated by mass directed chromatog. techniques. Their structures were determined on the basis of various spectroscopic methods and by comparison with the published NMR data.The roots of C. stenophylla attenuated arthritis severity, restored serum cytokine imbalances by regulating NF-κB signaling pathway in type II collagen-induced rheumatoid arthritis model. Oligostilbenes were essential ingredients in Et acetate extract of C. stenophylla roots. Stilbenes and flavonoids should be responsible for its anti-rheumatoid arthritis activities. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Computed Properties of C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Computed Properties of C14H12O4

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Alcohol – Wikipedia,
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Synthesis of a CGRP Receptor Antagonist via an Asymmetric Synthesis of 3-Fluoro-4-aminopiperidine was written by Molinaro, Carmela;Phillips, Eric M.;Xiang, Bangping;Milczek, Erika;Shevlin, Michael;Balsells, Jaume;Ceglia, Scott;Chen, Jiahui;Chen, Lu;Chen, Qinghao;Fei, Zhongbo;Hoerrner, Scott;Qi, Ji;de Lera Ruiz, Manuel;Tan, Lushi;Wan, Baoqiang;Yin, Jingjun. And the article was included in Journal of Organic Chemistry in 2019.Formula: C12H16BBrO2 This article mentions the following:

A practical and efficient enantioselective synthesis of the calcitonin gene-related peptide receptor antagonist I has been developed. The key structural component of the active pharmaceutical ingredient is a syn-1,2-amino-fluoropiperidine II•2HCl. Two approaches were developed to synthesize this important pharmacophore. Initially, Ru-catalyzed asym. hydrogenation of fluoride-substituted enamide III enabled the synthesis of sufficient quantities of compound I to support early preclin. studies. Subsequently, cost-effective route to this intermediate was developed utilizing a dynamic kinetic asym. transamination of tert-Bu 3-fluoro-4-oxopiperidine-1-carboxylate. This synthesis also features a robust Ullmann coupling to install a bis-aryl ether using a soluble Cu(I) catalyst. Finally, an enzymic desymmetrization of meso-dimethyl 3-methylglutarate was exploited for the construction of the γ-lactam moiety in I. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Formula: C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Formula: C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts