Tag: 200-300

Synthesis and conformational study of stereoisomeric 3-benzylperhydro-1,2,3-benzoxathiazine and -benzoxathiazole 2-oxides was written by Viljanen, Tapio;Pihlaja, Kalevi;Fulop, Ferenc. And the article was included in Acta Chemica Scandinavica in 1996.Safety of Trans-2-(benzylamino)cyclohexanol This article mentions the following:

Cis- and trans-fused 3-benzyl-3,4,4a,5,6,7,8,8a-octahydro-1,2,3-benzoxathiazine 2-oxides and 3-benzyl-3H-3a,4,5,6,7,7a-hexahydro-1,2,3-benzoxathiazole 2-oxides have been prepared by means of cyclization of cis- and trans-N-benzyl-2-aminomethyl- and -2-amino-cyclohexanols with thionyl chloride and N-sulfinylamides. Depending on the ring-closure reagent, different ratios of the diastereomers were found. Configurational and conformational assignments were based on the anal. of ¹H and ¹³C NMR spectra. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Safety of Trans-2-(benzylamino)cyclohexanol).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.Safety of Trans-2-(benzylamino)cyclohexanol

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

A family of immobilizable chiral bis(pinenebipyridine) ligands was written by Pollnitz, Alpar;Skupienski, Radek;Stoeckli-Evans, Helen;Crochet, Aurelien;Silvestru, Anca;Fromm, Katharina M.;Mamula, Olimpia. And the article was included in Synlett in 2013.Reference of 49669-14-9 This article mentions the following:

New enantiopure ligands I [RR¹ = O(CH₂)₂O; RR¹ = O; R = H, R¹ = OH] containing 2 (-)-5,6-pinenebipyridine units connected by a bridge situated in position 6′ of the bipyridines were prepared The chem. addressable groups of the bridge (hydroxyl or keto) can be covalently bound to various supports in order to heterogenize the ligand. In the experiment, the researchers used many compounds, for example, 2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9Reference of 49669-14-9).

2-Bromo-6-(2-methyl-1,3-dioxolan-2-yl)pyridine (cas: 49669-14-9) belongs to alcohols. Alkyl halides are often synthesized from alcohols, in effect substituting a halogen atom for the hydroxyl group. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Reference of 49669-14-9

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synergistic effect of GO/SrFe₁₂O₁₉ as magnetic hybrid nanocatalyst for regioselective ring-opening of epoxides with amines under eco-friendly conditions was written by Laayati, Mouhsine;Mekkaoui, Ayoub Abdelkader;Fkhar, Lahcen;Ait Ali, Mustapha;Anane, Hafid;Bahsis, Lahoucine;El Firdoussi, Larbi;El Houssame, Soufiane. And the article was included in RSC Advances in 2022.Electric Literature of C13H19NO This article mentions the following:

Herein, a highly efficient magnetically separable hybrid GO/SrFe₁₂O₁₉ nanocomposite was synthesized via dispersing M-type strontium hexaferrite (SrFe₁₂O₁₉) on graphene oxide (GO) sheets. First, SrFe₁₂O₁₉ nanoparticles (NPs) and GO sheets were prepared via chem. coprecipitation and chem. oxidation of graphite powder, resp. Chem. reduced GO (rGO) and rGO/SrFe₁₂O₁₉ were also prepared for comparison purposes. Thereafter, the prepared nanostructured materials were explored by XRD, FTIR, FESEM-EDX, BET, and Zetasizer analyses. All the characterizations confirmed the nanoscale and the high stability structures of the prepared materials. The prepared hybrid magnetic nanocomposite GO/SrFe₁₂O₁₉ exhibited a high surface area value resulting in a high catalytic activity and selectivity for the epoxide ring-opening with amines in neat water. The use of hybrid GO/SrFe₁₂O₁₉ compared with pure SrFe₁₂O₁₉ and GO sheets was of great interest for using environmentally benign heterogeneous nanocatalysts, for the synthesis of β-amino alcs., with excellent recyclability under eco-friendly conditions. Moreover, a mechanistic study was performed through d. functional theory (DFT) calculations and Parr functions to explain the observed reactivity and selectivity of SrFe-GO catalyst in the epoxide ring-opening reactions. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Electric Literature of C13H19NO).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Electric Literature of C13H19NO

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cu-Catalyzed Silylation and Borylation of Vinylidene Cyclopropanes was written by Chen, Jichao;Gao, Shang;Chen, Ming. And the article was included in Organic Letters in 2019.Recommanded Product: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine This article mentions the following:

A Cu-catalyzed addition of silicon or boron nucleophiles, pinB-SiMe₂Ph and pinB-Bdan, resp., to vinylidene cyclopropanes, di-R 2-(R²CH:C:)-3-R¹-1,1-cyclopropanedicarboxylates, giving propargylsilanes and boranes, (RO₂C)₂CHCH₂CCCH₂E (E = SiMePh₂, Bdan) is reported. The reactions generated propargylic silane or boron products by forming a C-Si or C-B bond at the terminal carbon of the allene moiety of vinylidene cyclopropanes. The obtained silicon and boron reagents are versatile intermediates that can undergo a variety of transformations to give synthetically useful products. Preliminary mechanistic studies indicated a copper enolate was involved in the reaction process. In the experiment, the researchers used many compounds, for example, 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6Recommanded Product: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine).

2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine (cas: 1214264-88-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-naphtho[1,8-de][1,3,2]diazaborinine

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Syntheses, structures and catalytic activities of low-coordinated rare-earth metal complexes containing 2,2′-pyridylpyrrolides was written by Du, Jun;Zhou, Shuangliu;Zhang, Xiuli;Zhang, Lijun;Cui, Peng;Huang, Zeming;Wei, Yun;Zhu, Xiancui;Wang, Shaowu. And the article was included in Applied Organometallic Chemistry in 2020.Application of 40571-86-6 This article mentions the following:

Reactions of the ligand precursors 2-(2′-pyridyl)-3,5-Me₂-pyrrole (L¹H) and 2-(2-pyridyl)-3,4,5-Me₃-pyrrole (L²H) with [(Me₃Si)₂N]₃RE(μ-Cl)Li(THF)₃ in toluene afforded low-coordinated rare-earth metal bis-amido complexes L¹RE[N(SiMe₃)₂]₂ [RE = Y(1a), Dy(1b), Er(1c), Yb(1d)] and L²RE[N(SiMe₃)₂]₂ [RE = Y(2a), Dy(2b), Er(2c), Yb(2d)]. With the ionic radius of rare-earth metal increasing, the reaction of L¹H and [(Me₃Si)₂N]₃RE(μ-Cl)Li(THF)₃ gave dinuclear (L¹)₂RE(μ-Cl)(μ-η⁵:η¹:η¹-L¹)RE(L¹)[N(SiMe₃)₂]₂ [RE = Sm(1e), Pr(1f)]; however, the reaction of L²H and [(Me₃Si)₂N]₃Sm(μ-Cl)Li(THF)₃ afforded (L²)₂Sm[N(SiMe₃)₂]₂ (2e). The ionic radius of rare-earth metal and subtle change in the ligands have substantial effects on the structure and bonding mode of complexes. The complexes showed a high catalytic activity for the ring-opening reaction of cyclohexene oxide with amines to afford various β-aminoalcs. under mild solvent-free conditions. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Application of 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Application of 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Food phytochemicals, epigallocatechin gallate and myricetin, covalently bind to the active site of the coronavirus main protease in vitro was written by Kato, Yoji;Higashiyama, Akari;Takaoka, Emi;Nishikawa, Miyu;Ikushiro, Shinichi. And the article was included in Advances in Redox Research in 2021.Related Products of 10083-24-6 This article mentions the following:

SARS-CoV-2 main protease is a possible target for protection against viral infection. This study examined the inhibitory effect of food phytochems. on the main protease of SARS-CoV-2 by determining a cleaved product after chromatog. separation First, 37 phytochems., including glycosides and metabolites, were screened at 20μM; epigallocatechin gallate, myricetin, theaflavin, herbacetin, piceatannol, myricitrin, and isothiocyanates inhibited the enzyme in varying degrees. The IC50 values were estimated from 0.4 to 33.3μM against the 0.5-μM enzyme. The dose-dependent adduction of epigallocatechin gallate and myricetin was confirmed by quinone staining of protein blotted onto a membrane. The enzyme activity was decreased by increasing the concentration of the two phytochems., accompanied by increasing the resp. adducted mol. estimated by intact mass spectrometry. Reduced glutathione canceled the formation of conjugate and the inhibitory effect of epigallocatechin gallate or myricetin on the enzyme, suggesting that the formation of the quinone moiety in the phytochems. is critical for the inhibition. The covalent binding of epigallocatechin gallate or myricetin to the cysteine residue at the active site was confirmed by analyzing peptides from the chymotrypsin-digested main protease. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Related Products of 10083-24-6).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Secondary alcohols are easily oxidized without breaking carbon-carbon bonds only as far as the ketone stage. No further oxidation is seen except under very stringent conditions.Related Products of 10083-24-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Orthogonal Stability and Reactivity of Aryl Germanes Enables Rapid and Selective (Multi)Halogenations was written by Fricke, Christoph;Deckers, Kristina;Schoenebeck, Franziska. And the article was included in Angewandte Chemie, International Edition in 2020.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

While halogenation is of key importance in synthesis and radio-imaging, the currently available repertoire is largely designed to introduce a single halogen per mol. This report makes the selective introduction of several different halogens accessible. Showcased here is the privileged stability of nontoxic aryl germanes under harsh fluorination conditions (that allow selective fluorination in their presence), while displaying superior reactivity and functional-group tolerance in electrophilic iodinations and brominations, out-competing silanes or boronic esters under rapid and additive-free conditions. Mechanistic experiments and computational studies suggest a concerted electrophilic aromatic substitution as the underlying mechanism. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Recommanded Product: 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Branched poly (trimethylphosphonium ethylacrylate-co-PEGA) by RAFT: alternative to cationic polyammoniums for nucleic acid complexation was written by Cook, Alexander B.;Peltier, Raoul;Barlow, Tammie R.;Tanaka, Joji;Burns, James A.;Perrier, Sebastien. And the article was included in Journal of Interdisciplinary Nanomedicine in 2018.SDS of cas: 4074-88-8 This article mentions the following:

Cationic and highly branched poly (trimethylphosphonium ethylacrylate-co-poly (ethylene glycol) acrylate) (p (TMPEA-co-PEGA)), and its ammonium equivalent, have been synthesized from post-polymerization modification of a poly (bromo ethylacrylate-co-poly (ethylene glycol) acrylate) (p (BEA-co-PEGA)) precursor polymer produced using reversible addition fragmentation chain transfer (RAFT) polymerization The cationic polymers were evaluated for their ability to complex nucleic acids, their in vitro cytotoxicity and their GFP pDNA transfection efficiency. The results show RAFT copolymerization of BEA and PEGA is a simple route to polyphosphoniums showing reduced cytotoxicities and higher transfection efficiencies than their polyammonium alternatives. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8SDS of cas: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Under appropriate conditions, inorganic acids also react with alcohols to form esters. To form these esters, a wide variety of specialized reagents and conditions can be used. A multistep synthesis may use Grignard-like reactions to form an alcohol with the desired carbon structure, followed by reactions to convert the hydroxyl group of the alcohol to the desired functionality.SDS of cas: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Roles of the molecular weight of n-ethylene glycol diacrylates and UV irradiance on the mechanical properties at the gel point of acrylic acid based hydrogels was written by Magami, Saminu M.;Williams, Rhodri L.. And the article was included in Journal of Applied Polymer Science in 2019.Electric Literature of C10H14O5 This article mentions the following:

We investigated sol-gel transitions in acrylic acid based hydrogels with real time in situ photocrosslinking and Fourier transform mech. spectroscopy. Crosslinkable n-ethylene glycol diacrylate (EGDA) compounds with mol. weights (MWs) in the range 171-575 g/mol were used in standard solutions of known polyacrylamide. The mutation number (N_mu) was monitored in all of the experiments, such that N_mu was 0.3 or lower at all of the exptl. frequencies. During gelation, a frequency independence of tan δ was observed in all cases, such that the storage and loss moduli were scaled as about ωⁿ; this indicated the establishment of a sample spanning network in the hydrogels with the Winter-Chambon criteria. The relaxation exponents (ns) ranged from 0.35 to 0.81 when they were affected by both the MWs of the EGDAs and the UV irradiance. The stiffness of the critical gels steadily increased with increases in both the MWs of the EGDAs and the UV irradiance. The fractal dimensions decreased at the gel point with increasing MWs of the EGDAs, whereas it increased with an increase in the UV irradiance. An optimization tool (Design-Expert) was used to compare the effects and interactions of the reaction parameters on the gel-time characteristics of the critical gels and those of the fully formed hydrogels. A map (description) of the reaction parameters that can be used in the design of specific networks, particularly with values of n that are close to or equal to 0.5, is proposed. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47606. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Electric Literature of C10H14O5).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C10H14O5

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Blue laser diode-initiated photosensitive resins for 3D printing was written by Cui, Ke-Jian;Zhu, Cai-Zhen;Zhang, Huan;Xuan, Qin;Zou, Wei-Zhi;Zhang, Zhi-Yan;Lin, Xue-Chun;Zhao, Ning;Xu, Jian. And the article was included in Journal of Materials Chemistry C: Materials for Optical and Electronic Devices in 2017.HPLC of Formula: 4074-88-8 This article mentions the following:

Herein, a promising application of blue LD-initiated photosensitive resins in 3D printing is developed. Compared with traditional UV 3D printing, a safer and inexpensive light source, higher polymerization efficiency, and more available precursors are presented. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8HPLC of Formula: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.HPLC of Formula: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts