Tag: 200-300

Active components from Cassia abbreviata prevent HIV-1 entry by distinct mechanisms of action was written by Zheng, Yue;Yang, Xian-Wen;Schols, Dominique;Mori, Mattia;Botta, Bruno;Chevigne, Andy;Mulinge, Martin;Steinmetz, Andre;Schmit, Jean-Claude;Seguin-Devaux, Carole. And the article was included in International Journal of Molecular Sciences in 2021.COA of Formula: C14H12O4 This article mentions the following:

Cassia abbreviata is widely used in Sub-Saharan Africa for treating many diseases, including HIV-1 infection. We have recently described the chem. structures of 28 compounds isolated from an alc. crude extract of barks and roots of C. abbreviata, and showed that six bioactive compounds inhibit HIV-1 infection. In the present study, we demonstrate that the six compounds block HIV-1 entry into cells: oleanolic acid, palmitic acid, taxifolin, piceatannol, guibourtinidol- (4α→8)-epiafzelechin, and a novel compound named as cassiabrevone. We report, for the first time, that guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone inhibit HIV-1 entry (IC⁵⁰ of 42.47 μM and 30.96 μM, resp.), as well as that piceatannol interacts with cellular membranes. Piceatannol inhibits HIV-1 infection in a dual-chamber assay mimicking the female genital tract, as well as HSV infection, emphasizing its potential as a microbicide. Structure-activity relationships (SAR) showed that pharmacophoric groups of piceatannol are strictly required to inhibit HIV-1 entry. By a ligand-based in silico study, we speculated that piceatannol and norartocarpetin may have a very similar mechanism of action and efficacy because of the highly comparable pharmacophoric and 3D space, while guibourtinidol-(4α→8)-epiafzelechin and cassiabrevone may display a different mechanism. We finally show that cassiabrevone plays a major role of the crude extract of CA by blocking the binding activity of HIV-1 gp120 and CD4. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6COA of Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.COA of Formula: C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Preparation and properties of UV-curable adhesives based on epoxy acrylate prepolymers was written by Chen, Yichi;He, Tao;Yang, Wei;Zhu, Liqun;Li, Weiping;Liu, Huicong. And the article was included in Advanced Materials Research (Durnten-Zurich, Switzerland) in 2012.Application In Synthesis of Diethyleneglycoldiacrylate This article mentions the following:

Three kinds of com. available epoxy acrylate reactive prepolymers with different mol. weight (MW) were used to formulate the UV-curable adhesives by addition of photo-initiator, reactive diluent, crosslinker and other additives as necessary. The MW of the said prepolymers were measured by gel permeation chromatog. (GPC), while the structural characterization of the prepolymers before and after UV-curing was made by FTIR. Thermal stability of two kinds of UV-cured prepolymers with distinct MW and MW distribution was detected by thermogravimetric (TG) anal. Lap shear strength of the adherents at different temperature were tested and compared with a known superior UV-curable adhesive (Loctite 3493). Adhesion strength of the adhesives at room temperature were all higher than 15 MPa which were more than the reported riveting intensity (10.3 MPa). In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Application In Synthesis of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Alcohols are among the most common organic compounds. They are used as sweeteners and in making perfumes, are valuable intermediates in the synthesis of other compounds, and are among the most abundantly produced organic chemicals in industry. Under carefully controlled conditions, simple alcohols can undergo intermolecular dehydration to give ethers. This reaction is effective only with methanol, ethanol, and other simple primary alcohols.Application In Synthesis of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cross-Coupling through Ag(I)/Ag(III) Redox Manifold was written by Demonti, Luca;Saffon-Merceron, Nathalie;Mezailles, Nicolas;Nebra, Noel. And the article was included in Chemistry – A European Journal in 2021.Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

Trifluoromethyl argentates(III) undergo reductive elimination with arylboronic acids, yielding trifluoromethylarenes. In ample variety of transformations, the presence of silver as an additive or co-catalyst is believed to be innocuous for the efficiency of the operating metal catalyst. Even though Ag additives are required often as coupling partners, oxidants or halide scavengers, its role as a catalytically competent species is widely neglected in cross-coupling reactions. Most likely, this is due to the erroneously assumed incapacity of Ag to undergo 2e^– redox steps. Definite proof is herein provided for the required elementary steps to accomplish the oxidative trifluoromethylation of arenes through Ag^I/Ag^III redox catalysis (i. e. CEL coupling), namely: (i) easy Ag^I/Ag^III 2e^– oxidation mediated by air; (ii) bpy/phen ligation to Ag^III; (iii) boron-to-Ag^III aryl transfer; and (iv) ulterior reductive elimination of benzotrifluorides from an [aryl-Ag^III-CF₃] fragment. More precisely, an ultimate entry and full characterization of organosilver(III) compounds [K]⁺[Ag^III(CF₃)₄]^– (K-1), [(bpy)Ag^III(CF₃)₃] (2) and [(phen)Ag^III(CF₃)₃] (3), is described. The utility of 3 in cross-coupling has been showcased unambiguously, and a large variety of arylboron compounds was trifluoromethylated via [Ag^III(aryl)(CF₃)₃]^– intermediates. This work breaks with old stereotypes and misconceptions regarding the inability of Ag to undergo cross-coupling by itself. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Quality Control of 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and self-assembly of pH and ROS dual responsive poly(β-thioester)s was written by Zhao, Wenjing;Qiao, Zengying;Duan, Zhongyu;Wang, Hao. And the article was included in Huaxue Xuebao in 2016.Safety of Diethyleneglycoldiacrylate This article mentions the following:

The Michael addition reaction, which was a mild reaction between activated olefins and nucleophiles, was widely used in synthesis of tailored macromol. architectures. We designed a copolymer nanoparticle to obtain the reactive oxygen species (ROS) and pH dual responsive capability. We synthesized the amphiphilic poly(β-thioester)s copolymers (D-D-P) composed of di(ethylene glycol) diacrylate (DEDA), DL-dithiothreitol (DTT), acryloyl chloride (AC) and hydrophilic mercaptopolyethylene glycol (PEG-SH) with average M_n = 2,000 g·mol^-1 via Michael addition reaction. The reactions were facile and controllable, and the structures of acquired copolymers were well characterized. The structures of the polymers were confirmed by ¹H NMR, and the number mol. weight and distribution of the copolymer D-D-P were measured by GPC (M_n = 50,400). D-D-P could self-assemble into nanoparticles with core-shell structures by dialysis method due to the composition of hydrophilic side chains and hydrophobic polymer backbones. After the preparation of ROS and pH dual responsive D-D-P nanoparticles in phosphate buffer solution, the morphol. and size of D-D-P nanoparticles were observed by transmission electron microscopy (TEM) and dynamic light scattering (DLS) showed that the number size distribution of nanoparticles was around 280 nm. Nile Red (NR) was a unique neutral hydrophobic mol., which showed very weak fluorescence in aqueous solution and could emit strong fluorescence in the hydrophobic environment. NR absorption and emission spectra were strongly dependent on environment polarity, which made it as a probe mol. that was widely used in the evaluation of microenvironment polarity. The disassembly behaviors of D-D-P nanoparticles were investigated by the change of the nanoparticle size and NR fluorescence spectra. The diameter of nanoparticle decreased under pH 5 and ROS environment conditions, and the NR fluorescence also became weak under pH 5 and ROS environment conditions, which could be attributed to the gradual dissolution of nanoparticles, proving the ROS and pH dual responsive properties of the poly(β-thioester)s. The release behaviors of the DOX encapsulated D-D-P nanoparticles in acidic and oxidative condition were studied by the UV absorption and were further proved in MCF-7 cells. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Safety of Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Safety of Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Single-Step Generation of Flexible, Free-Standing Arrays of Multimode Cylindrical Waveguides was written by Hudson, Alexander D.;Bacus, Czerysh;Whinton, Marlena;Brook, Michael A.;Saravanamuttu, Kalaichelvi. And the article was included in Advanced Engineering Materials in 2019.Name: Diethyleneglycoldiacrylate This article mentions the following:

Polymer matrixes patterned with 3-D waveguide circuitry are critical components of flexible photonics but cannot be fabricated through conventional, linear lithog. techniques. By exploiting the spontaneous filamentation and modulation instability (MI) of a uniform optical field in a range of silicone-acrylate-based photopolymerizable fluids, the authors report the generation of free-standing arrays of cylindrical, multimode waveguides with tunable flexibility in a single, room-temperature step. A broad, incandescent beam becomes unstable and spontaneously divides into a large population (≈10 000 cm^-2) of microscopic filaments; each filament becomes entrapped within a self-induced cylindrical waveguide and propagates through the medium without diverging. By spatially modulating the beam, it is possible to generate cylindrical waveguide arrays with square symmetry. By controlling the extent of crosslinking and the relative amount of silicone surfactant in the polymerized matrix, it is possible to tune the hardness of the arrays over an order of magnitude (Shore-OO 9 ± 5 to 94 ± 2). The authors show that flexible waveguide arrays that possess relatively low values of hardness can be reversibly compressed to up to 70% of their original lattice parameter while retaining waveguiding capacity; the arrays exhibit 100% recovery after multiple cycles of compression and decompression. In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Name: Diethyleneglycoldiacrylate).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Name: Diethyleneglycoldiacrylate

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Cobalt-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ was written by Wang, Yanwei;Jiang, Xiaomei;Wang, Baiquan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Product Details of 68716-49-4 This article mentions the following:

The transition-metal-catalyzed carboxylation of aryl and vinyl chlorides with CO₂ is rarely studied, and has been achieved only with a Ni catalyst or combination of palladium and photoredox. In this work, the cobalt-catalyzed carboxylation of aryl and vinyl chlorides and bromides with CO₂ has been developed. These transformations proceed under mild conditions and exhibit a broad substrate scope, affording the corresponding carboxylic acids in good to high yields. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Product Details of 68716-49-4).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. A strong base can deprotonate an alcohol to yield an alkoxide ion (R―O−). For example, sodamide (NaNH2), a very strong base, abstracts the hydrogen atom of an alcohol. The most common reactions of alcohols can be classified as oxidation, dehydration, substitution, esterification, and reactions of alkoxides.Product Details of 68716-49-4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthesis and basic properties of fluorinated core-shell acrylic latexes containing perfluoroalkyl acrylate in the shell was written by Liu, Quan;Tang, Weiming;Chen, Yichi;Huang, Min. And the article was included in Applied Mechanics and Materials in 2013.Recommanded Product: 4074-88-8 This article mentions the following:

Fluoroacrylic copolymer latexes with core-shell structure were synthesized by free-radical emulsion copolymerization, using fluorine-containing acrylic monomer of dodecafluoroheptyl methacrylate (DFMA) and fluorine-free acrylic monomers. The chem. composition was characterized by Fourier transform IR (FTIR) spectroscopy. The basic properties of the latexes including mainly hydrophobicity, chem. stability, chem.- and corrosion-resistance were investigated. Significant improvement in the chem.- and corrosion-resistance were observed for the fluorinated copolymer although only 5 weight% (based on the total monomers amount) of DFMA was copolymerized In the experiment, the researchers used many compounds, for example, Diethyleneglycoldiacrylate (cas: 4074-88-8Recommanded Product: 4074-88-8).

Diethyleneglycoldiacrylate (cas: 4074-88-8) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Alcohols may be oxidized to give ketones, aldehydes, and carboxylic acids. These functional groups are useful for further reactions. Oxidation of organic compounds generally increases the number of bonds from carbon to oxygen (or another electronegative element, such as a halogen), and it may decrease the number of bonds to hydrogen.Recommanded Product: 4074-88-8

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Organophotoredox assisted cyanation of bromoarenes via silyl-radical-mediated bromine abstraction was written by Shee, Maniklal;Shah, Sk. Sheriff;Singh, N. D. Pradeep. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2020.Electric Literature of C12H16BBrO2 This article mentions the following:

The insertion of a nitrile (-CN) group into arenes through the direct functionalization of the C(sp²)-Br bond is a challenging reaction. Herein, we report an organophotoredox method for the cyanation of aryl bromides using the organic photoredox catalyst 4CzIPN (1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene) and tosyl cyanide (TsCN) as the nitrile source. A photogenerated silyl radical, via a single electron transfer (SET) mechanism, was employed to abstract bromine from aryl bromide to provide an aryl radical, which was concomitantly intercepted by TsCN to afford the aromatic nitrile. A range of substrates containing electron-donating and -withdrawing groups was demonstrated to undergo cyanation at room temperature in good yields. Thus, e.g., Me 4-bromobenzoate → Me 4-cyanobenzoate (71%) employing 4CzIPN, TsCN, (TMS)₃SiOH as silyl radical source, K₃PO₄ as base, acetone as solvent and irradiation from blue LED. In the experiment, the researchers used many compounds, for example, 2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4Electric Literature of C12H16BBrO2).

2-(4-Bromophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 68716-49-4) belongs to alcohols. Alcohols are weak acids. The most acidic simple alcohols (methanol and ethanol) are about as acidic as water, and most other alcohols are somewhat less acidic. Tertiary alcohols cannot be oxidized at all without breaking carbon-carbon bonds, whereas primary alcohols can be oxidized to aldehydes or further oxidized to carboxylic acids.Electric Literature of C12H16BBrO2

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Sulfated zirconia as an efficient recyclable heterogeneous catalyst for selective aminolysis of epoxides and N-tosyl aziridines under solvent-free condition was written by Das, Biswanath;Thirupathi, Ponnaboina;Kumar, Rathod Aravind. And the article was included in Indian Journal of Heterocyclic Chemistry in 2008.Related Products of 40571-86-6 This article mentions the following:

Sulfated zirconia was an efficient catalyst for selective ring-opening of epoxides and N-tosyl aziridines with amines under solvent-free conditions to form the corresponding 2-amino alcs. and 1,2-diamines resp. in excellent yields. The catalyst was recovered and recycled. In the experiment, the researchers used many compounds, for example, Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6Related Products of 40571-86-6).

Trans-2-(benzylamino)cyclohexanol (cas: 40571-86-6) belongs to alcohols. Because alcohols are easily synthesized and easily transformed into other compounds, they serve as important intermediates in organic synthesis. Grignard and organolithium reagents are powerful tools for organic synthesis, and the most common products of their reactions are alcohols.Related Products of 40571-86-6

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Quality Evaluation of Tetrastigmae Radix from Two Different Habitats Based on Simultaneous Determination of Multiple Bioactive Constituents Combined with Multivariate Statistical Analysis was written by Chen, Haijie;Zhou, Yongyi;Xue, Jia;Yuan, Jiahuan;Cai, Zhichen;Wu, Nan;Zou, Lisi;Yin, Shengxin;Yang, Wei;Liu, Xunhong;Cheng, Jianming;Tang, Li. And the article was included in Molecules in 2022.Formula: C14H12O4 This article mentions the following:

Tetrastigmae Radix, also known as Sanyeqing (SYQ) in Chinese, is an important traditional Chinese medicine with a long history. Tetrastigma hemsleyanum Diels et Gilg mainly grows in the south of the Yangtze River and is widely distributed. The content of bioactive constituents in SYQ varies greatly in different habitats, and there are obvious differences in the content of bioactive constituents between southwestern SYQ (WS) and southeastern SYQ (ES). To distinguish and evaluate the quality of ES and WS, an anal. method based on ultrafast performance liquid chromatog. coupled with triple quadrupole-linear ion trap mass spectrometry (UFLC-QTRAP-MS/MS) was established for the simultaneous determination of 60 constituents including 25 flavonoids, 9 phenolic acids, 15 amino acids, and 11 nucleosides in 47 samples from ES and WS. In addition, orthogonal partial least squares discriminant anal. (OPLS-DA), t-test, and gray correlation anal. (GRA) were used to discriminate and evaluate the ES and WS samples based on the contents of 60 constituents. The results showed that there were significant differences in the bioactive constituents between ES and WS, and ES was superior to WS in terms of quality evaluation. This study not only provides basic information for differentiating ES and WS but also provides a new perspective for the comprehensive evaluation and quality control of SYQ from two different habitats. In the experiment, the researchers used many compounds, for example, (E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6Formula: C14H12O4).

(E)-4-(3,5-Dihydroxystyryl)benzene-1,2-diol (cas: 10083-24-6) belongs to alcohols. The oxygen atom of the strongly polarized O―H bond of an alcohol pulls electron density away from the hydrogen atom. This polarized hydrogen, which bears a partial positive charge, can form a hydrogen bond with a pair of nonbonding electrons on another oxygen atom. Converting an alcohol to an alkene requires removal of the hydroxyl group and a hydrogen atom on the neighbouring carbon atom. Dehydrations are most commonly carried out by warming the alcohol in the presence of a strong dehydrating acid, such as concentrated sulfuric acid.Formula: C14H12O4

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts